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Levothyroxine Dose and Fracture Risk According to the Osteoporosis Status in Elderly Women

  • Ko, Young-Jin;Kim, Ji Young;Lee, Joongyub;Song, Hong-Ji;Kim, Ju-Young;Choi, Nam-Kyong;Park, Byung-Joo
    • Journal of Preventive Medicine and Public Health
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    • v.47 no.1
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    • pp.36-46
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    • 2014
  • Objectives: To evaluate the association between fracture risk and levothyroxine use in elderly women with hypothyroidism, according to previous osteoporosis history. Methods: We conducted a cohort study from the Korean Health Insurance Review and Assessment Service claims database from January 2005 to June 2006. The study population comprised women aged ${\geq}65$ years who had been diagnosed with hypothyroidism and prescribed levothyroxine monotherapy. We excluded patients who met any of the following criteria: previous fracture history, hyperthyroidism, thyroid cancer, or pituitary disorder; low levothyroxine adherence; or a follow-up period <90 days. We categorized the daily levothyroxine doses into 4 groups: ${\leq}50{\mu}g/d$, 51 to $100{\mu}g/d$, 101 to $150{\mu}g/d$, and > $150{\mu}g/d$. The hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated with the Cox proportional hazard model, and subgroup analyses were performed according to the osteoporosis history and osteoporosis-specific drug prescription status. Results: Among 11 155 cohort participants, 35.6% had previous histories of osteoporosis. The adjusted HR of fracture for the > $150{\mu}g/d$ group, compared with the 51 to $100{\mu}g/d$ group, was 1.56 (95% CI, 1.03 to 2.37) in osteoporosis subgroup. In the highly probable osteoporosis subgroup, restricted to patients who were concurrently prescribed osteoporosis-specific drugs, the adjusted HR of fracture for the > $150{\mu}g/d$ group, compared with the 51 to 100 ${\mu}g/d$ group, was 1.93 (95% CI, 1.14 to 3.26). Conclusions: While further studies are needed, physicians should be concerned about potential levothyroxine overtreatment in elderly osteoporosis patients.

Developing Lessons and Rubrics to Promote Computational Thinking (Computational Thinking역량 계발을 위한 수업 설계 및 평가 루브릭 개발)

  • Choi, Hyungshin
    • Journal of The Korean Association of Information Education
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    • v.18 no.1
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    • pp.57-64
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    • 2014
  • This study aims to suggest lesson plans and evaluation methods for primary pre-service teachers by reviewing the concept of computational thinking(CT) skills and its sub components. To pursue this goal, a literature review has been conducted in regards to CT and the effectiveness of programming courses. In addition, the Scratch educational programming functions were analyzed yielding six CT elements(data representation, problem decomposition, abstraction, algorithm & procedures, parallelization, simulation). With these six elements, one semester lesson plans for 15 weeks that represent the connections with six CT elements were designed. Based on the PECT(Progression of Early Computational Thinking) model and the CT framework a rubric to evaluate learners' proficiency levels(basic, developing, proficient) revealed in their final projects was developed as well. Upon a follow-up empirical study, the lesson plans and the rubric suggested in the current study are expected to be utilized in teachers' colleges.

A Case of Parotid Metastasis from Sebaceous Carcinoma of the Eyelids (이하선으로 전이된 안검의 피지샘 암종 1예)

  • Chae, Hee Sung;Yang, Hui Joon;Paik, Seung Won;Kim, Ji-Hoon
    • Korean Journal of Head & Neck Oncology
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    • v.36 no.2
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    • pp.21-25
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    • 2020
  • Sebaceous carcinoma is a relatively rare and aggressive malignant tumor. Periocular area (especially eyelid) is the most common lesion to occur, and the most common extraocular lesion is the parotid gland. Because the lesion also mimic other benign inflammatory diseases, this leads to delayed diagnosis or misdiagnosis. Here, we report a 58-year-old male patient who presented with a non-tender painless left parotid mass after wide excision of sebaceous carcinoma in the left eyelid two years ago. When he was diagnosed with sebaceous carcinoma of left eyelid, there was a small left parotid tumor on the computed tomography. But no further examination and treatment were performed. Two years later, physical examination revealed growing parotid tumor and multiple neck nodes on the left side. After radical parotidectomy and neck dissection, histological examination showed a sebaceous carcinoma and neck node metastasis. Considering the aggressiveness of sebaceous carcinoma, further evaluation for parotid glands should be considered when sebaceous carcinoma of the eyelid was discovered. Postoperative chemoradiotherapy was performed for disease control. Follow up after two years, and computed tomography showed no sign of recurrence.

The review of Cinnamomum camphora SIEB.'s mistake in historical documents (문헌을 통해 본 녹나무[장(樟)]의 오류 고찰)

  • Kim, Kyou-Sub;Lee, Chang-Hun;Kim, Se-Ho
    • Journal of the Korean Institute of Traditional Landscape Architecture
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    • v.33 no.2
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    • pp.58-66
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    • 2015
  • This study is to review the historical documents about Cinnamomum camphora SIEB. in Goryeo and Joseon Dynasty. First of all, we defined it's feature and used case by the most appropriate word 'Jang(樟)' meaning Cinnamomum camphora SIEB. We also discovered some illusions and should suggest a new possibility. First, we analyzed the definition and examples of Cinnamomum camphora SIEB. and come to the conclusion that 'Jang(樟)' seems to be the most appropriate word. Second, we confirmed that Cinnamomum camphora SIEB. grew in extralimital area. It is believed that it's because of making a mistake. Third, we confirmed that it is confused Cinnamomum camphora SIEB. with Koelreuteria paniculata in Yi, Gyu-Gyeong's records. However, it's required to verify the other cases of the Cinnamomum camphora SIEB.'s records. We expect a follow-up study about it by classifying modern feature and comparing literature matching.

A prediction model of low back pain risk: a population based cohort study in Korea

  • Mukasa, David;Sung, Joohon
    • The Korean Journal of Pain
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    • v.33 no.2
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    • pp.153-165
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    • 2020
  • Background: Well-validated risk prediction models help to identify individuals at high risk of diseases and suggest preventive measures. A recent systematic review reported lack of validated prediction models for low back pain (LBP). We aimed to develop prediction models to estimate the 8-year risk of developing LBP and its recurrence. Methods: A population based prospective cohort study using data from 435,968 participants in the National Health Insurance Service-National Sample Cohort enrolled from 2002 to 2010. We used Cox proportional hazards models. Results: During median follow-up period of 8.4 years, there were 143,396 (32.9%) first onset LBP cases. The prediction model of first onset consisted of age, sex, income grade, alcohol consumption, physical exercise, body mass index (BMI), total cholesterol, blood pressure, and medical history of diseases. The model of 5-year recurrence risk was comprised of age, sex, income grade, BMI, length of prescription, and medical history of diseases. The Harrell's C-statistic was 0.812 (95% confidence interval [CI], 0.804-0.820) and 0.916 (95% CI, 0.907-0.924) in validation cohorts of LBP onset and recurrence models, respectively. Age, disc degeneration, and sex conferred the highest risk points for onset, whereas age, spondylolisthesis, and disc degeneration conferred the highest risk for recurrence. Conclusions: LBP risk prediction models and simplified risk scores have been developed and validated using data from general medical practice. This study also offers an opportunity for external validation and updating of the models by incorporating other risk predictors in other settings, especially in this era of precision medicine.

The effect of the entry programming course on the flow of elementary pre-service teacher (엔트리 프로그래밍 교육이 초등예비교원의 몰입에 미치는 영향)

  • Han, Kyujung
    • Journal of The Korean Association of Information Education
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    • v.21 no.4
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    • pp.403-413
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    • 2017
  • The purpose of this paper is to verify whether the entry programming course applied with the flow based learning type is to affect the flow of students' learning. The subjects of the study were the students in the 3rd grade of the National University of education who had not experienced the coding before, and conducted two hours of programming lessons per week for three months. Learning contents and learning materials of beginner course in Entry Homepage were used as learning materials. The teaching and learning process consisted of clear goals setting, motivation, follow-up and immediate feedback, providing application problems, and providing reflection time for students. As a result of the study, the nine factors of flow were compared before and after the experiment. The seven factors - A balance between challenges and skills, Immediate feedback, Action and awareness are merged, Distractions are excluded from consciousness, No worry of failure. Self-consciousness disappears, The activity becomes autotelic-were obtained.

The Impact of Selection Attributes of School Cafeteria Consumers on Satisfaction and Behavioral Intentions - Focused on University Cafeteria Consumers (급식업체 소비자의 선택속성이 만족 및 행동의도에 미치는 영향에 관한 연구: 대학교 급식업체 소비자를 중심으로)

  • Choi, Soon-Tae;Lee, Soo-Bum
    • Culinary science and hospitality research
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    • v.17 no.3
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    • pp.65-75
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    • 2011
  • The purpose of the study was to explore the relationship between satisfaction and future behavior intention of cafeteria users. Respondents of the research were cafeteria users in major colleges in Kyunggi province. A total of 300 questionnaires were distributed between October 1, 2010 and October 20, 2010 but only281 questionnaires were used for the analysis. Based on 14 selection attributes, factor analysis showed that the KMO value of 0.634, which was extracted by Verimax vertical rotation, and=610.084(p<0.001). In addition, the distributional explanation showed a total of 61.685%. Five factors were obtained as ingredients, food, menu, maintenance, and internal environment factors according to the feature of each variable. The Cronbach value according to confidence and validity tests was 0.703. The explanation was 16.3% and the influence on satisfaction included ingredients, maintenance, and internal environment. The effect on future behavior intention was significant at the level of p<0.001. This study has limitations in that it has generalized the findingson consumers of university cafeterias; therefore, follow-up studies must be conducted.

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Study on Soil Physico-Chemical Properties Criteria for Improving Ecosystem Services in Urban Parks (도시공원의 생태기능 향상을 위한 토양 이화학적 특성 기준에 대한 연구)

  • Kong, Minjae;Kwon, Taeguen;Kim, Changhyun;Kim, Namchoon;Shin, Yukyung;Ahn, Nanhee;Lee, Sangmin;Son, Jinkwan
    • Journal of Environmental Science International
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    • v.29 no.4
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    • pp.325-337
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    • 2020
  • The purpose of this study was to analyze the soil environment of urban neighborhood parks and to use them as basic data for evaluating the ecological functions of urban parks such as groundwater regeneration, flood control, microclimate regulation, adsorption and purification. The landscape design criteria were generally evaluated as advanced, and further monitoring and studies are needed to evaluate the various ecological functions. It is also necessary to improve the phosphoric acid and nitrogen contents, which tended to be low. In addition, continuous monitoring is needed to assess the proper soil environment according to the biological species, and to evaluate the ecological functions. The results of this study can be used to evaluate the groundwater recharge of urban parks. In particular, when the land of the neighboring park is used for various purposes, the level of access of the user may be increased. Therefore, factors that may adversely affect the user's health, such as heavy metals and organic matters, should be selected and selected as management criteria. In addition, follow-up studies considering fertilization standards suitable for trees and growth of introduced vegetation, etc. are needed urgently to improve the soil environment.

Power Estimation and Follow-Up Period Evaluation in Korea Radiation Effect and Epidemiology Cohort Study (원전 코호트 연구의 적정 대상규모와 검정력 추정)

  • Cho, In-Seong;Song, Min-Kyo;Choi, Yun-Hee;Li, Zhong-Min;Ahn, Yoon-Ok
    • Journal of Preventive Medicine and Public Health
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    • v.43 no.6
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    • pp.543-548
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    • 2010
  • Objectives: The objective of this study was to calculate sample size and power in an ongoing cohort, Korea radiation effect and epidemiology cohort (KREEC). Method: Sample size calculation was performed using PASS 2002 based on Cox regression and Poisson regression models. Person-year was calculated by using data from '1993-1997 Total cancer incidence by sex and age, Seoul' and Korean statistical informative service. Results: With the assumption of relative risk=1.3, exposure:non-exposure=1:2 and power=0.8, sample size calculation was 405 events based on a Cox regression model. When the relative risk was assumed to be 1.5 then number of events was 170. Based on a Poisson regression model, relative risk=1.3, exposure:non-exposure=1:2 and power=0.8 rendered 385 events. Relative risk of 1.5 resulted in a total of 157 events. We calculated person-years (PY) with event numbers and cancer incidence rate in the nonexposure group. Based on a Cox regression model, with relative risk=1.3, exposure:non-exposure=1:2 and power=0.8, 136 245PY was needed to secure the power. In a Poisson regression model, with relative risk=1.3, exposure:non-exposure=1:2 and power=0.8, person-year needed was 129517PY. A total of 1939 cases were identified in KREEC until December 2007. Conclusions: A retrospective power calculation in an ongoing study might be biased by the data. Prospective power calculation should be carried out based on various assumptions prior to the study.

A New Disability-related Health Care Needs Assessment Tool for Persons With Brain Disorders

  • Kim, Yoon;Eun, Sang June;Kim, Wan Ho;Lee, Bum-Suk;Leigh, Ja-Ho;Kim, Jung-Eun;Lee, Jin Yong
    • Journal of Preventive Medicine and Public Health
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    • v.46 no.5
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    • pp.282-290
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    • 2013
  • Objectives: This study aimed to develop a health needs assessment (HNA) tool for persons with brain disorders and to assess the unmet needs of persons with brain disorders using the developed tool. Methods: The authors used consensus methods to develop a HNA tool. Using a randomized stratified systematic sampling method adjusted for sex, age, and districts, 57 registered persons (27 severe and 30 mild cases) with brain disorders dwelling in Seoul, South Korea were chosen and medical specialists investigated all of the subjects with the developed tools. Results: The HNA tool for brain disorders we developed included four categories: 1) medical interventions and operations, 2) assistive devices, 3) rehabilitation therapy, and 4) regular follow-up. This study also found that 71.9% of the subjects did not receive appropriate medical care, which implies that the severity of their disability is likely to be exacerbated and permanent, and the loss irrecoverable. Conclusions: Our results showed that the HNA tool for persons with brain disorders based on unmet needs defined by physicians can be a useful method for evaluating the appropriateness and necessity of medical services offered to the disabled, and it can serve as the norm for providing health care services for disabled persons. Further studies should be undertaken to increase validity and reliability of the tool. Fundamental research investigating the factors generating or affecting the unmet needs is necessary; its results could serve as basis for developing policies to eliminate or alleviate these factors.