• 제목/요약/키워드: flux control coefficient

검색결과 50건 처리시간 0.029초

In Silico Analysis of Lactic Acid Secretion Metabolism through the Top-down Approach: Effect of Grouping in Enzyme kinetics

  • Jin, Jong-Hwa;Lee, Jin-Won
    • Biotechnology and Bioprocess Engineering:BBE
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    • 제10권5호
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    • pp.462-469
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    • 2005
  • A top-down approach is known to be a useful and effective technique for the design and analysis of metabolic systems. In this Study, we have constructed a grouped metabolic network for Lactococcus lactis under aerobic conditions using grouped enzyme kinetics. To test the usefulness of grouping work, a non-grouped system and grouped systems were compared quantitatively with each other. Here, grouped Systems were designed as two groups according to the extent of grouping. The overall simulated flux values in grouped and non-grouped models had pretty similar distribution trends, but the details on flux ratio at the pyruvate branch point showed a little difference. This result indicates that our grouping technique can be used as a good model for complicated metabolic networks, however, for detailed analysis of metabolic network, a more robust mechanism Should be considered. In addition to the data for the pyruvate branch point analysis, Some major flux control coefficients were obtained in this research.

Dynamic Modeling of Lactic Acid Fermentation Metabolism with Lactococcus lactis

  • Oh, Euh-Lim;Lu, Mingshou;Choi, Woo-Joo;Park, Chang-Hun;Oh, Han-Bin;Lee, Sang-Yup;Lee, Jin-Won
    • Journal of Microbiology and Biotechnology
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    • 제21권2호
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    • pp.162-169
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    • 2011
  • A dynamic model of lactic acid fermentation using Lactococcus lactis was constructed, and a metabolic flux analysis (MFA) and metabolic control analysis (MCA) were performed to reveal an intensive metabolic understanding of lactic acid bacteria (LAB). The parameter estimation was conducted with COPASI software to construct a more accurate metabolic model. The experimental data used in the parameter estimation were obtained from an LC-MS/MS analysis and time-course simulation study. The MFA results were a reasonable explanation of the experimental data. Through the parameter estimation, the metabolic system of lactic acid bacteria can be thoroughly understood through comparisons with the original parameters. The coefficients derived from the MCA indicated that the reaction rate of L-lactate dehydrogenase was activated by fructose 1,6-bisphosphate and pyruvate, and pyruvate appeared to be a stronger activator of L-lactate dehydrogenase than fructose 1,6-bisphosphate. Additionally, pyruvate acted as an inhibitor to pyruvate kinase and the phosphotransferase system. Glucose 6-phosphate and phosphoenolpyruvate showed activation effects on pyruvate kinase. Hexose transporter was the strongest effector on the flux through L-lactate dehydrogenase. The concentration control coefficient (CCC) showed similar results to the flux control coefficient (FCC).

Analysis of Orbital Lifetime Prediction Parameters in Preparation for Post-Mission Disposal

  • Choi, Ha-Yeon;Kim, Hae-Dong;Seong, Jae-Dong
    • Journal of Astronomy and Space Sciences
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    • 제32권4호
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    • pp.367-377
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    • 2015
  • Atmospheric drag force is an important source of perturbation of Low Earth Orbit (LEO) orbit satellites, and solar activity is a major factor for changes in atmospheric density. In particular, the orbital lifetime of a satellite varies with changes in solar activity, so care must be taken in predicting the remaining orbital lifetime during preparation for post-mission disposal. In this paper, the System Tool Kit (STK$^{(R)}$) Long-term Orbit Propagator is used to analyze the changes in orbital lifetime predictions with respect to solar activity. In addition, the STK$^{(R)}$ Lifetime tool is used to analyze the change in orbital lifetime with respect to solar flux data generation, which is needed for the orbital lifetime calculation, and its control on the drag coefficient control. Analysis showed that the application of the most recent solar flux file within the Lifetime tool gives a predicted trend that is closest to the actual orbit. We also examine the effect of the drag coefficient, by performing a comparative analysis between varying and constant coefficients in terms of solar activity intensities.

DSP를 이용한 영구 자석형 선형 동기전동기의 직접 추력 제어 (Direct Thrust Control of Permanent Magnet Type Linear Synchronous Motor by using Digital Signal Processor)

  • 우경일;김덕진;권병일
    • 대한전기학회논문지:전기기기및에너지변환시스템부문B
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    • 제49권8호
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    • pp.514-521
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    • 2000
  • This paper presents a direct thrust control scheme for permanent magnet linear synchronous motor(PMLSM) by using digital signal processor(DSP). And a simulation method for the direct thrust control of a permanent magnet linear synchronous motor using the equivalent circuit is presented. The detent force that was obtained by cubic spline method is considered in the simulation. Thrust correction coefficient is utilized to estimate actual thrust on the direct thrust control, which considers the longitudinal end effect due to the finite core length of the permanent magnet linear synchronous motor. The motor self inductance, the initial flux linkage by the permanent magnet is calculated in advance by the finite element analysis, and then the direct control simulation is carried out. As the results, thrust, current and speed are shwon.

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Study on the mixing performance of mixing vane grids and mixing coefficient by CFD and subchannel analysis code in a 5×5 rod bundle

  • Bin Han ;Xiaoliang Zhu;Bao-Wen Yang;Aiguo Liu;Yanyan Xi ;Lei Liu ;Shenghui Liu;Junlin Huang
    • Nuclear Engineering and Technology
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    • 제55권10호
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    • pp.3775-3786
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    • 2023
  • Mixing Vane Grid (MVG) is one of the most important structures in fuel assembly due to its high performance in mixing the coolant and ultimately increasing Critical Heat Flux (CHF), which avoids the temperature rising suddenly of fuel rods. To evaluate the mixing performance of the MVG, a Total Diffusion Coefficient (TDC) mixing coefficient is defined in the subchannel analysis code. Conventionally, the TDC of the spacer grid is obtained from the combination of experiments and subchannel analysis. However, the processing of obtaining and determine a reasonable TDC is much challenging, it is affected by boundary conditions and MVG geometries. In is difficult to perform all the large and costing rod bundle tests. In this paper, the CFD method was applied in TDC analysis. A typical 5 × 5 MVG was simulated and validated to estimate the mixing performance of the MVG. The subchannel code was used to calculate the TDC. Firstly, the CFD method was validated from the aspect of pressure drop and lateral temperature distribution in the subchannels. Then the effect of boundary conditions including the inlet temperature, inlet velocities, heat flux ratio between hot and cold rods and the arrangement of hot and cold rods on MVG mixing and TDC were studied. The geometric effects on mixing are also carried out in this paper. The effect of vane pattern on mixing was investigated to determine which one is the best to represent the grid's mixing performance.

Gas sparged gel layer controlled cross flow ultrafiltration: A model for stratified flow regime and its validity

  • Khetan, Vivek;Srivastava, Ashish;De, Sirshendu
    • Membrane and Water Treatment
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    • 제3권3호
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    • pp.151-168
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    • 2012
  • Gas sparging is one of the techniques used to control the concentration polarization during ultrafiltration. In this work, the effects of gas sparging in stratified flow regime were investigated during gel layer controlling cross flow ultrafiltration in a rectangular channel. Synthetic solution of pectin was used as the gel forming solute. The liquid and gas flow rates were selected such that a stratified flow regime was prevalent in the channel. A mass transfer model was developed for this system to quantify the effects of gas flow rates on mass transfer coefficient (Sherwood number). The results were compared with the case of no gas sparging. Gas sparging led to an increase of mass transfer coefficient by about 23% in this case. The limitation of the developed model was also evaluated and it was observed that beyond a gas flow rate of 20 l/h, the model was unable to explain the experimental observation, i.e., the decrease in permeate flux with flow rate.

과전류 및 단락사고 방지용 전기안전 제어장치에 관한 연구 (A Study on Electric Safety Control Device for Prevention of Over Current and Short Circuit Faults)

  • 조시환;곽동걸;정도영;심재선;김정숙
    • 대한전기학회:학술대회논문집
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    • 대한전기학회 2008년도 제39회 하계학술대회
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    • pp.2100-2101
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    • 2008
  • This paper is studied on a protective control system for electrical fire and electrical faults due to over current or electric short circuit faults by using electrical thermal characteristics of PTC (Positive Temperature Coefficient) thermistor and current response characteristics of high sensitive reed switch. The PTC thermistor has characteristic of positive resistivity temperature coefficient according to the temperature variation, which is construction of a regular square and cube demarcation with BaTiO3_Ceramics of positive temperature coefficient. Also PTC thermistor shows the phenomenon which is rapidly increased in the resistivity if the temperature is increased over Curie temperature point, and reed switch, which is used for electrical fault current sensing devices, have a excellent characteristic of response velocity in degree of ${\mu}s{\sim}ms$ that sensing magnetic flux in proportion to dimension of line current. This paper is proposed on a protective control system use PTC thermistor and reed switch for sensor which is protected from electrical fire due to overload faults or electric short circuit faults. Some experimental results of the proposed electric safety control device are confirmed to the validity of the analytical results.

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한국형 SPAR(Soil-Plant-Atmosphere-Research) 시스템에서 대용량 관측 자료의 처리 및 품질관리 (Processing and Quality Control of Big Data from Korean SPAR (Soil-Plant-Atmosphere-Research) System)

  • 상완규;김준환;신평;백재경;서명철
    • 한국농림기상학회지
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    • 제22권4호
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    • pp.340-345
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    • 2020
  • 본 연구에서는 첨단 옥외환경조절시설인 SPAR 시스템의 작물 및 환경 관측 자료의 품질 관리와 보증 방법을 최초로 제시하였다. 특히 실시간 군락 CO2플럭스의 경우에는 수집되는 자료의 특성을 고려하여 이상치의 제거와 보정이 병행되어야 함을 확인하였다. 본 연구를 통해 구축된 자료 처리 방법들은 향후 SPAR 자료를 통한 작물 생육 모형 개선에 매우 중요하게 활용될 수 있을 것으로 보인다. SPAR 내 작물과 환경 관련 10분 평균 자료는 국립식량과학원 내 작물 연구 통합 정보시스템(Crop Research Information System, CRIS) 웹사이트(www2.nics.go.kr/cris)에서 이용 가능하다.

플럭스 타워 설치 유역을 대상으로 탄소수지 분석을 위한 위성영상자료기반의 CO2 정량화 연구 (Quantitative Study of CO2 based on Satellite Image for Carbon Budget on Flux Tower Watersheds)

  • 정충길;이용관;김성준;장철희
    • 한국농공학회논문집
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    • 제57권3호
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    • pp.109-120
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    • 2015
  • Spatial heterogeneous characteristics of solar radiation energy from Climate Change gives rise to energy imbalance in the general ecological system including water resources. This study is to estimate the $CO_2$ flux of South Korea using Terra MODIS image and to assess the reliability of MODIS data from the ground measured $CO_2$ flux by eddy covariance flux tower data at 3 locations (two at mixed forest area and one at rice paddy area). The MODIS Gross Primary Productivity (GPP) product (MOD17A2), 8-day composite at 1-km spatial resolution was adopted for the spatial $CO_2$ flux generation. The MOD17A2 data by noise like cloud and snow in a day were tried to fill by Inverse Distance Weighted (IDW) method from valid pixels and the damping effect of MOD17A2 data were corrected by Quality Control (QC) flag. The MODIS $CO_2$ flux was estimated as the sum of GPP and Re (ecosystem respiration) by Lloyd and Taylor method (1994). The determination coefficient ($R^2$) between MODIS $CO_2$ and flux tower $CO_2$ for 3 years (2011~2013) showed 0.55 and 0.60 in 2 mixed forests and 0.56 in rice paddy respectively. The $CO_2$ flux generally fluctuated showing minus values during summer rainy season (from July to August) and maintaining plus values for other periods. The MODIS $CO_2$ flux can be a useful information for extensive area, for example, as a reliable indicator on ecological circulation system.

일중 피복온실의 관류열전달계수 산정 (Estimation of Overall Heat Transfer Coefficient for Single Layer Covering in Greenhouse)

  • 황영윤;이종원;이현우
    • 생물환경조절학회지
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    • 제22권2호
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    • pp.108-115
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    • 2013
  • 본 연구의 목적은 일중피복온실의 피복재에 대하여 우리나라 환경에 적합한 관류열전달계수를 산정하는 방법을 찾아내고 검증하여 다양한 온실조건 및 환경조건에서 관류열전달계수를 산정할 수 있는 모델을 제시하는 것이다. 온실내부 및 외부온도와 피복재 표면온도와의 상관관계를 분석한 결과 주간 및 야간 온도를 모두 고려하였을 때보다 야간온도만을 고려하였을 경우가 상관성이 훨씬 더 높은 것으로 나타났다. 피복재의 표면온도가 온실의 외부온도보다는 내부온도와 상관성이 더 높은 것으로 나타났다. 관류열전달계수를 산정하는데 사용된 5가지 종류의 대류 및 복사열전달계수 산정식을 비교한 결과 Kittas가 제안한 대류 및 복사열전달계수 산정식이 가장 적합한 것으로 나타났다. 피복재 표면온도의 측정값과 계산 값의 상관성을 분석한 결과 직선의 기울기는 1.009이고 절편은 0.001이며 결정계수가 0.98로 나타나 본 연구에서 제시된 관류열전달계수 산정모델이 신뢰성이 있음을 확인할 수 있었다. 온실내부로부터 피복재 내부표면으로 전달되는 열흐름량의 경우 모든 풍속구간에 대해 대류열전달량이 복사열전달량보다 더 컸으며 풍속이 증가할수록 그 차이가 증가하였다. 외부표면에서 손실되는 열흐름량의 경우 풍속이 낮을 때에는 대류열전달량에 비해 복사열전달량이 더 컸으나 풍속이 증가함에 따라 그 차이는 점점 줄어들어 풍속이 높을 때에는 대류열전달량이 더 커지는 것으로 나타났다. 피복재 외부 표면의 대류열전달량은 내부표면의 대류열전달량에 직선적으로 비례하여 증가하는 것으로 나타났다. 풍속이 증가함에 따라 관류열전달계수는 증가하고 피복재의 표면 온도는 감소하는 것을 확인할 수 있었고, 변화추세를 보면 관류열전달계수는 거듭제곱함수와 그리고 표면온도는 로그함수와 잘 일치하였다.