• Title/Summary/Keyword: flavonoid glycoside

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Anti-inflammatory Effect of Hederagenin Glycoside Isolated from Lonicera japonica

  • Son, Kun-Ho;Chang, Hyun-Wook;Kim, Hyun-Pyo;Kang, Sam-Sik
    • Proceedings of the PSK Conference
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    • 2002.10a
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    • pp.136-137
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    • 2002
  • Lonicera japonica Thunb. is a twining shrub that has been used as an antidote and to treat urinary disorders, fever and headache. It has been known as an anti-inflammatory agent in Korea from ancient times and is used widely for treating upper-respiratory tract infections, diabetes mellitus and rheumatoid arthritis. In the previous research, we isolated several flavonoid derivatives from the EtOAc soluble fraction. (omitted)

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Separation and Identification of Cirsimarin from Cirsium Pendulum $F_{ISCH}$ (한국산(韓國産) 엉겅퀴(Cirsium Pendulum $F_{ISCH}$)에서 Cirsimarin의 분리(分離) 및 확인(確認))

  • YunChoi, Hye-Sook;Chang, Il-Moo
    • Korean Journal of Pharmacognosy
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    • v.9 no.3
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    • pp.145-147
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    • 1978
  • Whole plant of Cirsium Pendulum $F_{ISCH}$ was extracted with methanol and a flavonoid glycoside was isolated from the methanol extract. The glycoflavonoid was identified as cirsimarin, $4',5-dihydroxy-6,7-dimethoxyflavone-4'-{\beta}-D-glucopyranoside$.

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Flavonoids from the Leaves of Alnus hirsuta (물오리나무 잎의 플라보노이드 화합물)

  • 이민원;정동욱;이연아;박명신;도상학
    • YAKHAK HOEJI
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    • v.43 no.5
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    • pp.547-552
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    • 1999
  • Phytochemical examination of the leaves of Alnus hirsuta, one of the indigenous species grows in Korea, has led to the isolation of one flavan 3-ol and two flavonol glycosides. Structures of these compounds are identified as (-)-epicatechin (1), quercetin $3-O-{\beta}-D-galactopyranoside$ (2), quercetin $3-O-{\beta}-D-galactopyranoside$ (3) by means of physico-chemical and spectral evidences.

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Saponins and Flavonoid Glycosides from Yellow Sweetclover

  • Kang, Sam-Sik;Lee, Young-Soon;Lee, Eun-Bang
    • Archives of Pharmacal Research
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    • v.11 no.3
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    • pp.197-202
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    • 1988
  • A new saponin, 3-O-[${\alpha}$-L-rhamnopyranosyl$(1{\rightarrow}2)$-${\beta}$-D-glucopyranosyl$(1{\rightarrow}2)$-${\beta}$-D-glucuronopyranosyl]soyasapogenol B carboxylate (6) has been isolated from the medicinal plant yellow sweetclover together with azukisaponin II(7), robinin(8), and clovin(9). 7,8, and 9 are reported for the first time from this plant. The new saponin(6) exhibited inhibitory action on leucocyte migration in inflammation.

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Seasonal variation of flavonoid glycosides in Epimedium koreanum (삼지구엽초(三枝九葉草) Flavonoid Glycoside의 계절적(季節的) 변동(變動))

  • Kang, Sam-Sik;Kim, Ju-Sun
    • Korean Journal of Pharmacognosy
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    • v.22 no.2
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    • pp.85-90
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    • 1991
  • The seasonal variation of two flavonol glycosides, icariin and epimedoside A, in the aerial parts and underground parts of Epimedium koreanum from June through September was investigated. The icariin concentration was decreased with time in both parts. Epimedoside A concentration was fluctuated, being highest in June and lowest in July in the underground parts. In the aerial parts, however, it was almost same in concentration. Determinations were made of the occurrence of two new flavonol glycosides, 2‘-O-rbamnosyl ikarisoside A and 2’-O-rhamnosyl icarisid II in the aerial parts and their changes in concentration were similar to those in the underground parts, being highest in July in both parts.

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Determination of the Structure for Polysubstituted Flavonoid and 6-C-Glucosyl Flavonoids using $^{13}C-^{1}H$ Long Range Couplings

  • Lee, Min-Won
    • Archives of Pharmacal Research
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    • v.17 no.6
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    • pp.487-489
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    • 1994
  • A flavone glycoside was isolated from the leaves of Betula platyphylla var. latifolia and characterized as $4, 6-Dimethoxy-5-hydroxyflavone-7-O-{\beta}-D-glucoside(pectolinarigenin-7-O-{\beta}-D-glucopy-ranoside)$ by method of chemical and NMR spectral analysis. $^13C-^1H$ long range coupling was confirmative for determination of its substituted position. In connection with this study, 6-C-Glucosylnalingenin and 6-C-Glucosylaromadendrin were confirmed its structures using this technique.

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Inhibitory Effects of Kaempferol-7-O-β-D-glucoside on LPS-induced NO, PGE2 and Inflammatory Cytokines Production in RAW264.7 Macrophages (LPS유도 대식세포에서 Kaempferol-7-O-β-D-glucoside의 NO, PGE2 및 염증성 사이토카인 생성 저해 효과)

  • Park, Jong Cheol;Han, Hee-Soo;Lee, Seung-Bin;Lee, Kyung-Tae
    • Korean Journal of Pharmacognosy
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    • v.47 no.4
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    • pp.295-300
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    • 2016
  • Flavonoids are widely reported to be beneficial to human health. Among flavonoids, in general, flavonoid aglycons have better biological activities than flavonoid glycosides, in that aglycons can easily penetrate through cell membrane because of their low polarity. Therefore, kaempferol, quercetin and various their glycosides were evaluated for their abilities to inhibit NO and $PGE_2$ productions in LPS-induced RAW 264.7 cells. Of these flavonoids and flavonoid glycosides, kaempferol-7-O-${\beta}$-D-glucoside(kp-7-glu) which possesses a glycoside at C-7 position of the A ring in kaempferol, potently inhibited NO, $PGE_2$ and $TNF-{\alpha}$, $IL-1{\beta}$, IL-6 productions in LPS-induced RAW 264.7 macrophages.

Isolation of Flavone Glycoside from Circium japonicum var ussuriense and Biological Activity on the Cardiovascular System (엉겅퀴 지상부의 심혈관 작용활성 및 후라본 배당체의 분리)

  • Lim, Sang-Sun;Lee, Jong-Ho;Park, Jong-Cheol
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.26 no.2
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    • pp.242-247
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    • 1997
  • A flavone glycoside was separated from the aerial part of Circium japonicum var ussuriense Kitamura and the effect on cardiovascular system was investigated. The cadiovascular contractility of this compound was observed in the artria and aortae from normal rats. It increased the spontancous beat in right atria and the contractile force in left atria, and caused the contraction of thoracic aortae. For the blood pressure, it had ascending effect. The effective component, which acted on stimulation and contraction in the artria and aortae of rats was fractionated with n-BuOH, separated and identified by column chromatography, UV, IR, $^1H-NMR$ and $^{13}C-NMR$. The chemical structure for this component was determined to be $hispidulin-7-{\alpha}-rhamnopyranosyl(1{\rightarrow}2)-{\beta}-D-glucopyranoside$.

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