• Journal of Yeungnam Medical Science
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• v.39 no.3
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• pp.181-189
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• 2022

Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative condition characterized by loss of motor neurons, resulting in motor weakness of the limbs and/or bulbar muscles. Pain is a prevalent but neglected symptom of ALS, and it has a significant negative impact on the quality of life of patients and their caregivers. This review outlines the epidemiology, clinical characteristics, underlying mechanisms, and management strategies of pain in ALS to improve clinical practice and patient outcomes related to pain. Pain is a prevalent symptom among patients with ALS, with a variable reported prevalence. It may occur at any stage of the disease and can involve any part of the body without a specific pattern. Primary pain includes neuropathic pain and pain from spasticity or cramps, while secondary pain is mainly nociceptive, occurring with the progression of muscle weakness and atrophy, prolonged immobility causing degenerative changes in joints and connective tissue, and long-term home mechanical ventilation. Prior to treatment, the exact patterns and causes of pain must first be identified, and the treatment should be tailored to each patient. Treatment options can be classified into pharmacological treatments, including nonsteroidal anti-inflammatory drugs, antiepileptic drugs, drugs for cramps or spasticity, and opioid; and nonpharmacological treatments, including positioning, splints, joint injections, and physical therapy. The development of standardized and specific assessment tools for pain-specific to ALS is required, as are further studies on treatments to reduce pain, diminish suffering, and improve the quality of life of patients with ALS.

• Journal of the Korean Society for Precision Engineering
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• v.14 no.11
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• pp.135-146
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• 1997

This paper describes fault diagnosis method in complex system with hierachical structure similar to human body structure. Complex system is divided into unit, item and component. For diagnosing this hierarchical complex system, it is necessary to implement special neural network. Fault diagnosis system can forecast faults in a system and decide from current machine state signal information. Comparing with other diagnosis system for single fault, the developed system deals with multiple fault diagnosis comprising Hierarchical Neural Network(HNN). HNN consists of four level neural network, first level for item fault symptom classification, second level for item fault diagnosis, third level for component symptom classification, forth level for component fault diagnosis. UNIX IPC(Inter Process Communication) is used for implementing HNN wiht multitasking and message transfer between processes in SUN workstation with X-Windows(Motif). We tested HNN at four units, seven items per unit, seven components per item in a complex system. Each one neural newtork operate as a separate process in HNN. The message queue take charge of information exdhange and cooperation between each neural network.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.22 no.3
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• pp.167-177
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• 2009

Objective : Bell's palsy is common and has many clinic study. but bell's palsy sequela is not enough study until now. So this study was evaluated bell's palsy sequela, catamnesis, demonstrator and herb. Methods : From December 2007 to November 2008, patients who visited Dong-seo Oriental Medicine ENT. A clinic study was done on patient who were diagosed bell's palsy, onset 2months over when first visited OPD and treated 3weeks over in Dong-seo Oriental Medicine Cental. To evaluate grade of paralysis, House-Brackman Scale was used. We classified period of improving, sequelas symptom except of facial muscle paralysis, Oriental Medicine diagnosis and herb. Results & Conculsion : 1. The distribution of sex : male 38.88%, female 61.11%. The distribution of age was presented that forty to fifty was the most in 10case(55.55%) 2. The distribution of the region of facial palsy : Rt(55.55%), Lt(44.44%) 3. In distribution of period of first HB-Scale improving : 1~2month was most in 10case(55.55%) 4. In distribution of symptom except of facial muscle paralysis : Dryness of eye 33.33%, Tearling 22.22%, Facial hypoesthesia 22.22%, Mastoid pain 22.22% 5. The distribution of demonstrator : Gi Deficiency and Deficiency of Both Gi and Blood was most in 11case(50%) 6. The distribution of treatment : Palmul-tang and Bojungikki-tang was the most herb in 6case(33.33%) and only acupuncture treatment and rehabilitation treatment was 5case(27.77%).

• Korean Journal of Biological Psychiatry
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• v.2 no.2
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• pp.281-286
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• 1995

Objects : Manic phase of bipolar disorder is treated with a combination of mood stabilizer and antipsychotic drug, especially in the acute phase. Such combined treatment is often required for the clinical management of manic symptoms until therapeutic effects of mood stabilizer become evident. The present study was the first open trial to evaluate the efficacy of risperidone, and safety of the combination of mood stabilizer and risperidone in the treatment of acute manic patients. Method : This study was performed as an open clinical study. The subjects of this study were 42 patients who had been admitted with first manifestations or acute exacerbations of illness were selected, using DSM-III-R criteria for bipolar disorder, manic episode. Patients were rated using the the Brief Psychiatric Rating Scale (BPRS), Clinical Global Impression (CGI), Extrapyramidal Symptom Rating Scale(ESRS). Other adverse events were assessed by a symptom checklist and by observation by medical personnel. Vital signs were monitored in a standard way and electrocardiography, routine laboratory analysis were performed. Results : Thirty patients(67%) completed the 12-week trial period. The CGI showed a good therapeutic effect with a minimal incidence or severity of side effects. The majority of patients showed a continuos reduction in their BPRS scores. The extrapyramidal symptoms assessed on ESRS generally showed mild to moderate degree. laboratory porameters showed no significant changes during the course of treatment. Conclusion : The results of the study showed a good efficacy of the risperidone in manic patients and further controlled studies are warranted.

• Childhood Kidney Diseases
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• v.21 no.1
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• pp.15-20
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• 2017

Purpose: Febrile urinary tract infection (UTI) is one of the commonest bacterial infections in children. The purpose of this study is to investigate the clinical characteristics of the first episode of febrile UTI occurring in children over 5 years compared to those in infants younger than a year. Methods: We retrospectively reviewed the medical records of 10 patients over 5 years, having febrile UTI, and 25 controls under 1 year. Clinical characteristics including symptoms at admission, the time interval between symptom onset and hospital visit and/or diagnosis, duration of fever, urinalysis, and other laboratory and imaging test results were compared between the two groups. Results: Most patients in the control group showed only high fever at the time of presentation to the hospital. However, 60% of the case group had fever along with gastrointestinal (GI) symptoms such as abdominal and flank pain, vomiting, as well as relatively mild pyuria. The case group showed a longer duration between symptom onset and hospital visit and/or diagnosis. Conclusions: Delay in diagnosis and initiation of treatment of UTI increases the risk of permanent renal scarring and associated complications. Therefore, early diagnosis and treatment of febrile UTI is vital for very young infants, as well as children considering that febrile UTI could be an important cause of febrile illness in children over 5 years.

• Journal of Acupuncture Research
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• v.26 no.2
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• pp.49-58
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• 2009

Objectives : The aim of this study was to investigate whether Doppler ultrasound device is applicable for the evaluation of facial palsy patients. Methods : A total of 25 patients participated in the first assessment and 22 of them finished a follow-up assessment one week later. An assessment comprised of a Minimax-Doppler-K device examination on bilateral acupoints $ST_5$, $SI_{19}$, $ST_2$, and $BL_1$, House-Brackmann grading, and subjective symptom questionnaire. Measurement reliability was assessed and clinically meaningful variations of Doppler measurement values were explored. Results : Doppler ultrasound examination revealed a significant difference of some measurement values between values of the symptom side and the contralateral side, between groups of severe paralysis and moderate paralysis, and between groups of short duration(0-3 weeks) and long duration (3 weeks-5 months) by non-parametric analyses (p<0.05). Several re-examination values showed a significant correlation with the first examination values by Spearman's correlation tests (p<0.05). Conclusions : This study revealed several possibilities for the clinical application of this device. Further validity tests and device improvements for a user's convenience would be helpful for its practical application.

• Research in Plant Disease
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• v.17 no.3
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• pp.402-404
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• 2011

The Sclerotium blight was found on Phalaenopsis spp. at Dong-du-cheon city, and Hwa-seong city, Gyenggido, Korea in September 2009. The symptom included yellowing on lower leaves and wilt of a whole plant. Severely infected plants were blighted and died eventually. White mycelial mats appeared on the surface of basal stem and bulbs and the sclerotia were formed on stems, roots, and sphagnum moss. The sclerotia were spherical, 1-3 mm and white to brown. The optimum temperature for the growth and sclerotia formation was $25-30^{\circ}C$ on PDA. On the pathogenicity test, the first symptom appeared 5 days after inoculation and developed to severe stem rot and blight. On the basis of mycological characteristics and pathogenicity, the causal fungus was identified as Sclerotium rolfsii. This is the first report on the sclerotium blight on Phalaenopsis spp. caused by Sclerotium rolfsii in Korea.

• Women's Health Nursing
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• v.5 no.2
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• pp.162-175
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• 1999

The study was intended to investigate and explore the preimenstrual symptoms, their severity levels, their patterns and the relationships of the age to those symptoms and patterns among Korean women. The data were collected from 844 women in one highschool, one Nursing college and one Korea National Open University in Seoul, from Nov, 1997 to Jun. 1998. The instruments were the Menstrual Symptoms Questionnaire developed by Chesney and the Center for Epidemiologic studies Depression scale developed by Radloff. the data were analyzed by descriptive statistics, ANOVA, Duncan's multiple comparison test, $X^2$-test, simple regression analysis and logistic regression analysis using pc-SAS program. The results were as follows ; 1. Korean women had more symptoms of abdominal bloating, fatigue, abdominal discomfort and backache in perimenstrual period. There Teenages had more symptoms of depression and uterine cramps in the day before or the first day of menstruation. Women in their twenties had more symptoms of abdominal pain or abdominal discomfort, backache, abdominal bloating and the sensitiveness /discomforts in the lower back, abdomen and inner part of thighs. women in their thirties had more symptoms of abdominal bloating, fatigue, tension and nervousness before the menstruation, abdominal discomfort and backpain in the first day of menstruation. Women in their forties had more symptoms of backache, breast discomforts, abdominal pain and discomforts. 2. The severity levels of the perimenstrual symptoms showed the highest score(mean=2.73) in twenties and the lowest score)mean=1.96) in forties The perimenstrual symptom patterns were prevailed the spasmodic menstrual symptoms in teenage and twenties and the congestive menstrual symptoms in thirties and forties. The age was a determinant of perimenstrual symptom patterns and the precipitative equation was log[p(age)/(1-p(age)]=2.7356-0.0982 age. 3. The relationship of the age to perimenstrual symptoms was vanished or lessened, controlling for parity as a test factor. this finding supports the notion that parity is an extraneous variable.

• The Plant Pathology Journal
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• v.18 no.3
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• pp.121-125
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• 2002

This study was conducted to determine the causal virus that naturally infected hollyhock (Althaea rosea) plant showing mild mosaic symptom in 1999. Flexuous virus particles were found in the cytoplasm of plant tissue from infected hollyhock under transmissible electron microscopy. A virus from the genus Potyvirus under the family Potyviridae was isolated and was maintained on Chenopodium quinoa for three passages. Chlorotic local legions were used to inoculate 20 species of indicator plants. The virus infected all the tested cucurbit plants, but failed to infect Nicotiana benthamiana. Based on the host range test and RT-PCR analysis, the potyvirus was identified as a strain of Zucchini yellow mosaic virus-A (ZYMV-A), one of the major pathogens of cucurbits. Infectivity analysis showed that ZYMV-A induced faster systemic symptom than ZYMV-Cu on squash and other cucurbit plants, suggesting that ZYMV-A was a more severe strain. To better characterize ZYMV-A, Western blot assay was carried rout to the coat protein (CP) of the virus using ZYMV-specific antiserum with ZYMV-Cu and other potyviruses. The CP of the virus reacted strongly with the antiserum against ZYMV, and other tested antisera did not react with the CP of ZYMV-A. Results strongly suggest that the potyvirus infecting hollyhock was a novel strain of ZYMV. This is the first report on ZYMV as the causal virus infecting hollyhock in Korea.

• Journal of Physiology & Pathology in Korean Medicine
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• v.35 no.2
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• pp.47-55
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• 2021

In order to ensure the fact that eight principle pattern differentiation is used clinically as a basic guideline for Korean medicine practice, the definition, role and method of yin-yang pattern differentiation with its case report were explored at first. Yinyang Pattern Differentiation is a method of discriminating human tendencies or morbidity based on the yin and yang characteristics expressed in living bodies. And yin and yang are the two contrasting characteristics and aspects of the interaction when certain physical conditions that have a lasting effect on the human physiological metabolic function are correlated with the morbidity. Specific methods of yinyang pattern differentiation can be divided into several types of yin and yang indicators. First, time and space factors like day and night, hot and cold seasons, above and below, topographical districts. Second, colors and pulse and their/or relative clearness and muddiness, hardness and softness, moving and resting. Third, diagnose yin and yang patterns through distinguishing the true and false of a fever and cold in an emergency phase such as increase of brain pressure and shock state. Fourth, general characteristics of the propensity and constitution of a subject such as body type, speech, behavior, and physiological metabolism. And for clinical use, these were summarized again as a symptom indicators of physical signs and color, pulse, tongue and questionnaire indicators of propensity, body type, and space-time characteristics. Conclusively, it was confirmed that yinyang pattern differentiation has its own diagnostic significance which is distinct from exterior-interior, cold-heat and deficiency-excess pattern differentiation.