• Biomedical Science Letters
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• v.26 no.3
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• pp.157-163
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• 2020

Long-term exposure to environmental pollutants can impair the human skin's barrier function and promote skin aging mechanisms. The visible consequences of these effects are dryness, wrinkles, black spots and worsening skin sensitivity. As awareness of the effects of environmental stressors on the skin has recently increased, consumers' demand for cosmetics that can provide anti-pollution effects is increasing. In this study, the possibility of anti-pollution cosmetic material was investigated by measuring the inhibitory effect of free radicals using a mixture of Nypa fruticans Wurmb (NF), Saussurea neoserrata (SN), Codium fragile (CF) and Enteromorpha compressa (EC), which has anti-inflammatory and antioxidant effects against irritation caused by dust. Combining the experimental results of a mixture of NF, SN, CF and EC by induction of fine dust stimulation, inhibition of inflammatory factors (PGE₂) and intracellular free radicals (ROS) by inhibiting effects were significant, indicating the possibility of use as anti-pollution cosmetics. The most plants used as sources of anti-pollution cosmetic ingredients contain antioxidants as active substances. In our highly industrialized and chemically polluted world, it is not surprising that most plants used as sources of anti-pollution cosmetic ingredients contain antioxidants as active substances. Considering our results, it can be suggested that this anti-pollutant consisting of NF, SN, CF and EC may be a good ingredient for skincare products for the cosmetic industry due to their antioxidant properties, which may especially alter skin aging.

• Korean Journal of Veterinary Research
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• v.34 no.2
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• pp.219-227
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• 1994

The development of abomasum in fetuses between 60, 90, 120 days of gestation and neonates of Korean native goats was investigated by light, scanning and transmission electron microscopy. The results obtained were summarized as follows ; 1. The abomasum wall appeared to be differentiated into the epithelium, lamina propria, muscle layer, and serosa at 60 days of gestation. The epithelium was stratified columnar and these nuclei were located near the apical two thirds portion of the cell at 60 days of gestation, and then transformed into simple columnar epithelium with the flat basal nuclei. 2. The inner circular and outer longitudinal muscle layers were observed at 90 days of gestation and the blood vessels had become quite well developed as various arterioles, venules and capillaries of different size during this age. 3. Gastric pits were seen at 90 days of gestation and continued gradually to increase depth during gestation. 4. The mucous, parietal and chief cells appeared in epithelium at 90 days of gestation and continued gradually to increase in number during gestation. In 120 days fetuses and neonates, muscle layer had become very thickeness. 5. Scanning electron microscopically, the inner surface of the abomasum already consisted of wavy spiral folds which had many fine wrinkles at 60 days of gestation. In 90 day old fetuses, each spiral fold was enlarged and its surface was tended to be split into many straight longitudinal ridges and among these ridge were found shallow grooves, At 120 days, the subdivided swellings of ridges were progressively complicated in shape. In the neonates, the inner surface was flat and holed with many gastric pits. 6. Transmission electron microscopically, the epithelium was straified columnar and these nuclei were irregular shape at 60 days fetus. The parietal, chief and mucous cells were observed in 90 day old fetuses and continued gradually to increase in number during gestation. 7. The development of the abomasum was relatively slow at early stages, it was accelerated greatly in the last of gestation.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.43 no.3
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• pp.247-254
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• 2017

Optical Coherence Tomography (OCT) is a non-invasive imaging method that utilizes the optical scattering and interference for visualizing the surface as well as cross-sectional structures of tissue. OCT has been used for diagnosing diseases in early stage in various medical fields, but an application in cosmetics is still at early stage. In this study, OCT was adopted to evaluate skin texture and wrinkle. Results showed similar patterns of evaluation with PRIMOS in the assessment using replica. In addition, OCT produced smaller errors at different angles compared to the PRIMOS in the assessment using 3-dimensional models of wrinkles. The resolution of the image was also high enough to differentiate the images of before and after the application of makeup products. Possible use of OCT in the evaluation of fine wrinkle assessment was studied in this research. Further development of methods is necessary to provide more evidences of the effectiveness.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.11 no.3
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• pp.479-485
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• 2007

In this paper, a hierarchical simulation with an approximate implicit method is proposed in order to efficiently and plausibly animate mass-spring based cloth models. The proposed hierarchical simulation method can generate realistic motion of extremely fine mesh in interactive rate. The proposed technique employs a fast and stable simulation method which approximates the implicit integration. Although the approximate method is efficient, it is extremely inaccurate and shows excessively damped behavior. The hierarchical simulation technique proposed in this paper constructs multi-level mesh structure in order to represent the realistic appearance of cloth model and performs simulation on each level of the mesh with constraints that enforce some of the mass-points of current level to follow the movement of the previous level. This hierarchical method efficiently generates a plausible movement of a cloth model composed of large number of mass points. Moreover, this hierarchical method enables us to generate realistic wrinkles on the cloth, and the wrinkle pattern on the cloth model can be easily controlled because we can specify different contraction resistance force of springs according to their hierarchical level.

• Journal of Broadcast Engineering
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• v.27 no.3
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• pp.369-377
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• 2022

Recent deep learning-based face synthesis research shows the result of generating a realistic face including overall style or elements such as hair, glasses, and makeup. However, previous methods cannot create a face at a very detailed level, such as the microstructure of the skin. In this paper, to overcome this limitation, we propose a technique for synthesizing a more realistic facial image from a single face label image by controlling the types and intensity of skin microelements. The proposed technique uses Pix2PixHD, an Image-to-Image Translation method, to convert a label image showing the facial region and skin elements such as wrinkles, pores, and redness to create a facial image with added microelements. Experimental results show that it is possible to create various realistic face images reflecting fine skin elements corresponding to this by generating various label images with adjusted skin element regions.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.33 no.3
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• pp.139-144
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• 2007

In the previous study, we reported the antioxidative activity of Equisetum arvense extracts. In this study, its inhibitory effect on elastase and components were investigated. Aglycone fractions obtained from the deglycosylation reaction of ethylacetate fraction among the Equisetum arvense extracts, showed 4 bands and 4 peaks in TLC and HPLC experiments, respectively. Four components were identified as luteolin(composition ratio, 19.12%), quercetin(12.87), apigenin(15.81) and kaempferol(52.20). TLC chromatogram of ethylacetate fraction of Equisetum arvense extract revealed 7 bands and HPLC chromatogram showed 8 peaks, which were identified as kaempferol-3,7-O-diglucoside(composition ratio, 15.74%), luteolin-5-O-glucoside(galuteolin, 11.91), apigenin-5-O-glucoside(12.91), kaempferol-3-O-glucoside(astragalin, 27.94), quercetin-glycoside(10.81, structure was not determined), kaempferol-glycoside (12.33, structure was not determined), luteolin(3.72) and apigenin(4.62) in the order of elution time. The inhibitory effect of aglycone fraction on elastase($IC_{50}$, $9.8{\mu}g/mL$) was very high. But ethylacetate fraction(flavonoid glycosides) rarely exhibited the inhibitory activity on elastase. Combined with the previous results of the antioxidative activity of Equisetum arvense extracts, it is concluded that the inhibitory activity on elastase of the aglycone fraction could be applicable to new functional cosmetics for smoothing wrinkles.

• Microbiology and Biotechnology Letters
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• v.41 no.4
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• pp.449-455
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• 2013

Human skin is constantly exposed to environmental conditions such as UV rays, polluted air, and chemical products. UV rays, in particular, affect skin in many ways causing wrinkles, fine wrinkles, rough skin, and xeroderma through a skin aging process. The purpose of this study was to investigate the anti-wrinkling effect of Juniperus rigida Sieb., derived from a common cedar tree found the world over. Measuring the elastase to investigate wrinkling efficacy, it was shown that at a concentration level of $1,000{\mu}g/ml$ of the two extracts, the water extract exhibited a lower than 10% inhibition activity, while the ethanol extract exhibited a 68.5% inhibition activity. Collagenase inhibition activity in the water extract and ethanol extract were 44.9% in the former and 97.2% in the latter extract, which in the case of the ethanol extract, is similar to ascorbic acid (99.6%). Moreover, measuring the biosynthesis of collagen by fibroblast, a concentration level of $50{\mu}g/ml$ of ethanol extract produced 151.52% of biosynthetic promotion, proving that the ethanol extract acts as a superb anti-wrinkling agent. The result of an investigation conducted on the influence of the ethanol extract on MMP-1 caused by UVA showed that at a concentration level of $1,00{\mu}g/ml$ of the ethanol extract of J. rigida Sieb a 67.1% inhibition activity was noted. At a concentration level of $50{\mu}g/ml$ of the ethanol extract of J. rigida Sieb a 35% and 39% inhibition ratio to MMP-1 protein and mRNA were observed respectively, thereby restraining the appearance of the collagen breakdown enzyme MMP-1 and wrinkle creation by skin photo-aging.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.44 no.3
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• pp.211-218
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• 2018

Instant face lifting cosmetics contain various film forming agents for stretching the wrinkles on the skin surface. But, most of the film-forming polymers have sticky feels. And they are easily scrubbed out when skin is rubbed on. In this study, we focused on the influence of sodium silicate that has rapid film forming effect on skin surface and immediate wrinkle reducing effect. Sodium silicate, also known as water glass or soluble glass, is a compound containing sodium oxide and silica. Sodium silicate is a white powder that is readily soluble in water, producing an alkaline solution. Sodium silicate is stable in neutral and alkaline solutions. The sodium silicate solution hardens by drying in air and rapidly forms a thin film. When the solution is applied to the skin, the fine membrane coating is formed by water evaporation and ionic bond re-formation. It also makes the strong siloxane (Si-O) bonding on the skin surface. When these fixation properties are applied to cosmetics, they can give remarkable skin tightening effect. The sodium silicate solution can provide the lifting effect by forming a film on skin at a proper concentration. But, skin irritation may be caused with too high concentration of sodium silicate. We studied a desirable range of the sodium silicate concentration and combination with other fixatives for skin care formulation that has no sticky feels and no scrubbing out phenomenon. Immediate lifting gel was developed by using sodium silicate and various thickening systems. Among of the various thickeners, aluminum magnesium silicate showed the best compatibility with sodium silicate for rapid lifting effect. This instant physical lifting gel was confirmed as a low stimulating formula by skin clinical test.

• Journal of Physiology & Pathology in Korean Medicine
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• v.28 no.2
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• pp.206-216
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• 2014

To investigate the anti-photoaging effect of fermented Red Ginseng(RG) in SKH-1 mice. We examined the effects of extracts of non-fermented RG(NRG group), fermented RG(FRG group) and fortified fermented RG(FFRG group) on skin wrinkles formation, histological changes related to the number of epidermal cell layers, epidermal thickness, neutrophil infiltration into dermis, degradation of collagen fibers, and the number of mast cells, and immunohistochemical changes related to cytokines and enzymes in photoaging skin caused by UVB irradiation of SKH-1 mice. The oral administration(300 mg/Kg B.W./day) and topical application($100{\mu}{\ell}/mouse/day$) of extracts of NRG, FRG and FFRG inhibited increases in epidermal thickness and wrinkle formation compared to control group in dorsal skin induced by UVB irradiation. We observed more increased stainability of acid fuschin and aniline blue in dermis of FFRG group than those of other groups. Furthermore, NRG, FRG and FFRG prevented the disruption of collagen fibers within papillary layer of dermis, and decreased number of mast cells in the dorsal skins induced by UVB irradiation. We observed fine wrinkle formation in FFRG group. Treatment with NRG, FRG and FFRG decreased immunohistochemical density of myeloperoxidase related to inflammation in the photoaging skin. We observed more decreased immunohistochemical density of myeloperoxidase in FFRG group than those of other groups. Immunohistochemical density of PCNA and Ki-67 in FFRG group was more decreased than those of other groups. Our study suggests that fermented red ginseng extracts participates in inhibitory effects in the morphological processes related to photoaging skin on UVB irradiated SKH-1 mice.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.30 no.1
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• pp.85-91
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• 2004

In this study, we evaluated the crow's feet of 152 Korean women by using visual assessment established by our research group and mechanical assessment, Skin Visiometer SV 600. The volunteers were divided into 3 groups according to age; the group I of 30's was 43, the group II of 40's was 75, the group III of 50's was 34. The wrinkle score by visual assessment showed tendency to increase according to age and was statistically significant different among those three age groups (P 〈 0.05). But there was no significant difference between the left and the right of crow's feet. The 5 wrinkle parameters (RI, R2, R3, R4, R5) of mechanical assessment varied as age and the Rl, R4, and R5 showed statistically significant difference among three age groups (P 〈 0.05). However there was no significant difference between the left and the right of crow's feet. The volunteers were divided into 3 groups according to wrinkle score; (0-3 grade for group A, 4-6 grade for group B, 7-9 grade for group C). Only R4 and R5 showed significant difference between group A and group C (P 〈 0.05). It was suggested that visual scoring criteria applied in this study was related to R4 and R5 and was useful in investigating in fine wrinkles.