• 한국산학기술학회논문지
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• 제16권3호
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• pp.2020-2028
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• 2015

본 연구는 Mercer의 어머니되기 이론적 모델에서 제시한 태아애착행위의 영향 변수(임신스트레스, 자존감, 결혼적응도, 자아통제감, 산전우울)를 고려하여 임부의 태아애착행위에 영향을 미치는 요인을 파악하기 위해 수행되었다. 산전검사를 위해 산부인과와 보건소에 방문한 임부 140명을 대상으로 2014년 8월 23일에서 11월 25일에 걸쳐 자가보고식 형태의 설문조사를 하였다. 자료는 SPSS 20을 이용하여 평균과 표준편차, t-test, ANOVA, Pearson의 상관관계, 단계적 회귀분석을 통해 분석되었다. 연구결과는 다음과 같다. 태아애착행위는 30세 이하 임부에서 31세 이상 임부보다 유의하게 높았고(t=2.79, p=.004), 초임부에서 경임부보다 유의하게 높은 것으로 나타났다(F=3.27, p=.041). 태아애착행위는 임신스트레스(r=-0.22, p=.009)와 역상관관계를 보였고, 자존감(r=0.45, p<.001), 결혼적응도(r=0.42, p<.001), 자아통제감(r=0.24, p=.005)과는 정상관관계를 나타냈다. 임부의 태아애착행위에 영향을 미치는 요인은 자존감, 결혼적응도, 나이로 밝혀졌으며, 전체 모형의 26.1%를 설명하였다. 본 연구결과는 산전관리를 통해 임부의 자존감과 결혼적응도에 대한 이해 및 사정이 필요하고, 고령 임부의 태아애착행위 증진 중재의 개발 및 적용이 필요함을 시사한다.

• Journal of Genetic Medicine
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• 제13권2호
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• pp.65-71
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• 2016

Cell-free nucleic acids (cf-NAs) originate in trophoblasts and are detected in the maternal plasma. Using innovative bioinformatic technologies such as next-generation sequencing, cf-NAs in the maternal plasma have been rapidly applied in prenatal genetic screening for fetal aneuploidy. Amniotic fluid is a complex and dynamic fluid that provides growth factors and protection to the fetus. In 2001, the presence of cf-NA in amniotic fluid was reported. Amniotic fluid is in direct contact with the fetus and is derived from fetal urine and maternal and fetal plasma. Therefore, these genetic materials have been suggested to reflect fetal health and provide real-time genetic information regarding fetal development. Recently, several studies evaluated the global gene expression changes of amniotic fluid cell-free RNA according to gestational age. In addition, by analyzing the transcriptome in the amniotic fluid of fetal aneuploidy, potential key pathways and novel biomarkers for fetal chromosomal aneuploidy were identified. Here, we review the current knowledge of cell-free RNA in amniotic fluid and suggest future research directions.

• 여성건강간호학회지
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• 제17권4호
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• pp.359-368
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• 2011

Purpose: To examine delivery type of mother who have had a previous cesarean and identify maternal factors related to type of delivery. Methods: The study sample included 60,504 mothers who had delivered through cesarean section. Related variables were categorized as sociodemographic factors (age, residence, health insurance type, income level) and clinical characteristics (14 maternal factor, 4 fetal factor and pre-term). For data analysis, $x^2$ and multivariate logistic regression were conducted. Results: Among the 60,504mothers, 3,075 were delivered through Vaginal Birth After C-Section (VBAC) and the VBAC rate was 5.1%. Underage 34, the VBAC rate increased according to age increases up to 3%. Mothers residing in urban areas had VBAC more frequently than mothers in rural area. Mothers in the high and middle income levels had a greater possibility of having VBAC than mothers in lower income levels. A greater likelihood of increase in repeated cesarean section were found in mothers with maternal and fetal factors. Conclusion: Evidence based nursing practice guidelines and education programs for previous cesarean section mothers and health policy are needed to increase VBAC.

• 대한간호학회지
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• 제29권4호
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• pp.940-950
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• 1999

One hundred two high-risk women(HRW) and 115 low-risk women(LRW) were studied at post-partal hospitalization and at 1, 4, and 8 months after giving birth to determine whether they would differ in the achievement of perceived maternal acquisition and whether predictors of maternal acquisition would differ for the two groups over time. The subjects were 102 HRW and 115 LRW, all in the above 27 weeks, admitted to two hospitals and to two clinic in the Kyoungnam area between July 1, 1998 and May 4, 1999. The data were analyzed by a SPSS program and the results are as follows ; 1) Predictors of Maternal role acquisition in the HRW were fetal attachment, maternal attachment, state anxiety, relationships of partner, social support in the early postpartum, maternal attachment, relationships of partner, depression, infant's health status in the postpartal 1 month, relationships of partner, self-esteem, educational degree in the postpartal 4 month, and maternal attachment, social supports in the postpartal 8 month. 2) Predictors of Maternal role acquisition in the LRW were fetal attachment, social supports, perceived experience about labor and delivery in the early postpartum, maternal attachment, sense of mastery in the postpartal 1 month, sense of mastery, experience with infants, relationships of partner in the postpartal 4 month and maternal attachment, experience with infants, social supports in the postpartal 8 month. 3) The hypothesis that HRW would score significantly lower on maternal competency than LRW was rejected. 4) The hypothesis that maternal acquisition would be significantly related to maternal attachment was accepted.

• Journal of Nutrition and Health
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• 제5권2호
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• pp.75-82
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• 1972

Fifteen cases of primiparas and their offsprings (fetal cord) were investigated with regard their serum total, free and esterified cholesterol by means of Liberman Buchard reaction. The serum ${\alpha}-and\;{\beta}-lipoprotein$ were analyzed by cellulose acetate electrophoresis, and the serum atherolipid numbers were calculated on the bases of the serum total cholesterol and ${\beta}-/{\alpha}-$ lipoprotein ratio, with the following conclusion. 1.Total, free and esterified cholesterol are $178.9{\pm}25.3$, $45.1{\pm}12.6$ and $133.7{\pm}20.6\;mg.%$ in the normal control women, $201.5{\pm}29.5,\;58.7{\pm}42.1$ and $157.1{\pm}26.2\;mg.%$ in the maternal blood, showing hypercholesterolemia in the latter as compared to the former. 2. The serum total, free and esterified cholesterol in the cord blood are $94.5{\pm}20.4$, $32.9{\pm}1.5$ and $61.2{\pm}18.9mg.%$, showing hypocholesterolemia as compared to the control women and maternal blood. 3. The serum ${\alpha}-$, $pre-{\beta}$, ${\beta}-lipoprotein$ and chylomicron are $24.2{\pm}4.2$, $17.3{\pm}3.4$, $51.8{\pm}4.8$ and $6.0{\pm}1.6%$ in the normal women, whereas $14.9{\pm}2.1$, $22.2{\pm}5.1$, $58.7{\pm}3.3 and 3.1{\pm}1.2%$ in the maternal serum, $32.4{\pm}8.1$, $28.8{\pm}2.4$, $25.8{\pm}7.0$ and $3.1{\pm}0.9%$ in the cord serum, showing $hyper-{\beta}-lipoproteinemia$ in the former and $hypo-{\beta}-lipoproteinemia$ in the latter. 4. The serum atherolipid number of the normal control women, maternal cord blood are $4.21{\pm}1.24$, $8.02{\pm}1.42$ and $1.12{\pm}0.37$, showing hyperlipemia in the former and hypolipemia in latter. 5. The relative ratio of the serum free and esterified cholestrol of both normal control women and maternal blood is about 1 : 3, while that of the fetal blood about 1 : 2. 6. The relative ratioes of the serum ${\alpha}-and$ ${\beta}-lipoprotein$ in the control women is about 1 : 2, that of materna blood about 1 : 3 and that of the fetal blood about equal magnitude. 7. The serum esterified cholesterol, ${\alpha}-lipoprotein,\;{\beta}-/{\alpha}-lipoprotein$ ratio and atherolipid number fluctuates are proportionally between the maternal and fetal blood, while the serum free, total cholesterol and ${\beta}-lipoprotein$ between the two vary inversely with statistically significant corelations. 8. It is apparent from the above results that the fetal nutritional demand for lipids resulted from hypocholesterolemia and hypo ${\beta}-lipoproteinemia$ seems to be met satisfactorily by maternal hypercholesterolemia and hyper ${\beta}-lipoproteinemia$, which seems to pose a significant maternal-infant nutritional relationship. A brief ciscussion was made on these conciusion in the light of biochemistry and endocrinology.

• 여성건강간호학회지
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• 제22권2호
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• pp.71-77
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• 2016

Purpose: This study was a comparative study to understand the levels of anxiety, pain and maternal-fetal attachment between women who became pregnant after infertility treatment and became pregnant naturally. Methods: This study used a comparative survey design. Data were collected by 50 couples of natural pregnancy and of who became pregnant after infertility treatment who visited delivery room in C Medical hospital, Seoul. These couples were to have first baby, and cervix dilatation of women was less than 3 cm regardless of diagnosis. Results: The score of anxiety of infertile women was significantly higher than that of naturally pregnant women; however, that of spouses showed no difference. The pain score for infertile women was significantly higher in both the active and transition phases. Pain scores that reported by their spouses did not show differences in either phase. The score of maternal-fetal attachment showed no difference between two groups of women. Conclusion: The result showed the importance of nursing intervention to reduce women's anxiety and pain, through both antenatal-childbirth education programs and assertive nursing interventions. It is necessary to develop and evaluate new intervention which would be more effective for reducing pain and anxiety for couples who became pregnant after infertility treatment.

• 대한방사선기술학회지:방사선기술과학
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• 제45권4호
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• pp.331-339
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• 2022

The purpose of this study was to evaluate maternal organ and fetal doses by week of pregnancy for pregnant women nuclear medicine practitioners in the nuclear medicine field. In addition, we intend to present basic data for the management of exposure doses of female nuclear medicine practitioners. In this study, phantoms of childbearing women, 3, 6, 9 months pregnant women were simulated using MCNPX(Monte Carlo N-Particle Extended) among the Monte Carlo methods. First, volume source was constructed based on 10 cm of the anterior part of the lower abdomen of the phantom, and the organ and fetal doses were evaluated for each week of the pregnant woman according to the type of radioactive isotope. Second, the organ and fetal dose of pregnant women were evaluated by increasing the distance between the source and the abdominal surface by 50 and 100 cm. As a result, ¹⁸F sources showed high organ and fetal doses in pregnant women 0 to 3 months, and the dose distribution gradually decreased in 6 to 9 months pregnant women. The distribution of organ and fetal doses for ⁹⁹mTc and ¹²³I sources showed the same tendency as that of ¹⁸F, and the overall absorbed dose distribution was relatively lower than that of ¹⁸F. Through this study, it is considered that workers in the early stages of pregnancy within 3 months will need appropriate management to minimize occupational exposure dose.

• 여성건강간호학회지
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• 제24권2호
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• pp.196-208
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• 2018

Purpose: To identify the characteristics and health-care needs of high-risk pregnant women in maternal-fetal intensive care units (MFICU). Methods: A mixed-methods design was adopted. Data were collected from 78 high-risk pregnant women admitted to the MFICU. Qualitative data included ten participants' experiences with hospitalization and childbirth, which were analyzed using mixed content analysis. Quantitative data were analyzed using at-test and one-way ANOVA testing. Results: The average score for pregnancy and childbirth health-care needs was 3.54 points. Average score by area was before-admission health care (3.70), health care of baby (3.67), health of childbirth (3.61), postpartum health (3.51), and pregnancy health care during hospitalization (3.48). Qualitative results showed diverse feelings and experiences of high-risk pregnant women and their need for health care, which was expressed in three themes and 11 sub-themes. Conclusion: Nurses should recognize high-risk mothers' feelings and needs for pregnancy and childbirth-focused health care to help patients accept their vulnerability and cope positively.

• Asian-Australasian Journal of Animal Sciences
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• 제22권12호
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• pp.1633-1639
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• 2009

This study investigated the effect of maternal undernutrition during late pregnancy on the growth and development of ovine fetal visceral organs. One hundred Mongolian ewes were mated at a synchronized oestrus and divided into three groups and offered 0.175 MJ ME $kgw^{-0.75}\;d^{-1}$ (Restricted Group1; RG1), 0.33 MJ ME $kgw^{-0.75}\;d^{-1}$ (Restricted Group2; RG2) and ad libitum access to feed (Control Group; CG) during late pregnancy (90 days). Selected animals in each group were slaughtered immediately at d 90 of pregnancy and after parturition (neonatal lambs), and major visceral organs were removed and weighed separately. The results indicated that the weights of lung (p<0.01), spleen (p<0.01), heart (p<0.05), liver (p<0.05) and abomasum (p<0.01) in RG1 were significantly lighter than those of CG. For RG2, only the weights of the lung (p<0.05) and spleen (p<0.01) were significantly lighter than those of CG; when expressed as a percentage of body weight, significance was retained in the spleen (p<0.01) for both restricted groups, but the percentage of brain in RG1 was significantly higher than that in CG (p<0.01). For lung and spleen, the amount of DNA was significantly lower (p<0.01) in both groups of restricted neonatal lambs compared to CG; however, there was a significant difference only between RG1 and CG for protein: DNA ratio (p<0.01). The DNA content of kidney, abomasum and jejunum were decreased (p<0.05) in RG1 neonatal lambs, but protein: DNA ratio in the liver was decreased compared with that of CG (p<0.05). The plane of maternal undernutrition during late pregnancy had a significant effect on the growth and development of fetal visceral organs, which altered ontogeny of fetal organ growth and development. These perturbations in fetal visceral development may have significant implications on postnatal growth and adult health.

• Toxicological Research
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• 제19권3호
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• pp.227-234
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• 2003

2-Bromopropane (2-BP), a halogenated propane analogue, is a substitute for chlorofluorocarbones (CFCs) which have a great potential to destroy the ozone layer and to warm the earth's environment. The present study was undertaken to evaluate the potential adverse effects of 2-BP on pregnant dams and embryo-fetal development after maternal exposure during the gestational days (GD) 6 through 17 in ICR mice. The test chemical was administered subcutaneously to pregnant mice at dose levels of 0, 313, 625 or 1,250 mg/kg/day. All dams were subjected to caesarean section on GD 18 and their fetuses were examined for external, visceral and skeletal abnormalities. In the 1,250 mg/kg group, maternal toxicity included an increase in the incidence of abnormal clinical signs and a decrease in the maternal body weight, body weight gain, and corrected body weight. Developmental toxicity included a decrease in the fetal body weight, a reduction in the placental weight, an increase in the fetal skeletal variation and ossification delay. There were no adverse effects on either pregnant dams or embryo-fetal development in the 313 and 625 mg/kg groups. These results suggest that a 12-day subcutaneous dose of 2-BP is embryotoxic at a maternally toxic dose (i.e., 1,250 mg/kg/day) in ICR mice. In the present experimental condition, the no-observed-adverse-effect level of 2-BP is considered to be 625 mg/kg/day for dams and embryo-fetuses, respectively.