• Herbal Formula Science
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• 제16권1호
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• pp.65-78
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• 2008

Objectives : this study was to access the effect of Hyeonggaeyeongyotang water extracts, a polyherbal formula has been used as folk medicine, on the fertility and early embryonic development of male and female Wistar rats when administered by oral gavage. Methods : In male rats, Hyeonggaeyeongyotang extract were dosed 4 weeks before pairing and 2 weeks after mating including the mating periods up to termination after necropsy of the majority of the females. In female rats, they were dosed 2 weeks before pairing, and from Day 0 to Day 7 of gestation. This study was conducted in accordance with the recommendations of the KFDA Guideline [2005-60] for Detection of Toxicity to Reproduction for Medicinal Products. Results: 1. No Hyeonggaeyeongyotang extract treatment-related changes on the clinical signs and mortalities, the Food consumptions, the Body weights and gains were demonstrated in all dosed levels tested in this study except for 500ml/kg-dosing male group in which a significant(p<0.05) increase of body gains was detected during day 0-7 after dosing. 2. No Hyeonggaeyeongyotang extract treatment-related changes on the pre-coital intervals, the estrus cycles, the mating index, conception rate and fertility index were demonstrated in all dosed levels tested in this study. 3. No Hyeonggaeyeongyotang extract treatment-related gross findings on reproductive organs, the weights of reproductive organs, histopathological findings on reproductive organs, the corpora lutea number, implantation site number, live fetus number, number of resorpted embryo and pre-and post-implatation loss were demonstrated in all dosed levels tested in this study. Conclusions : Base on the results, it is considered that the NOAEL (No-Observed-Adverse-Effect Level) for fertility and early embryonic development toxicity of Hyeonggaeyeongyotang extract was under 2000ml/kg/day in Wistar male and female rats because there no treatment-related changes on the fertility and early embryonic developmental index were demonstrated in all dosed levels tested.

• Clinical and Experimental Reproductive Medicine
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• 제42권4호
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• pp.143-148
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• 2015

Objective: The aim of the current study was to determine the predictive value of anti-$M{\ddot{u}}llerian$ hormone (AMH) levels for pregnancy outcomes in patients over 40 years of age who underwent in vitro fertilization or intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET) cycles. Methods: We retrospectively analyzed the medical records of 188 women aged 40 to 44 years who underwent IVF/ICSI-fresh ET cycles due to unexplained infertility in the fertility center of CHA Gangnam Medical Center. Patients were divided into group A, with AMH levels <1.0 ng/mL (n=97), and group B, with AMH levels ${\geq}1.0ng/mL$ (n=91). We compared the clinical pregnancy rate (CPR) in the two groups and performed logistic regression analysis to identify factors that had a significant effect on the CPR. Results: The CPR was significantly lower in group A than group B (7.2% vs. 24.2%, p<0.001). In multivariate logistic regression analysis, AMH levels were the only factor that had a significant impact on the CPR (odds ratio, 1.510; 95% confidence interval, 1.172-1.947). The area under the receiver operating characteristic curve for AMH levels as a predictor of the CPR was 0.721. When the cut-off level of AMH was set at 1.90 ng/ mL, the CPR was 6.731-fold higher in the group with AMH levels ${\geq}1.90ng/mL$ than in the group with AMH levels <1.90 ng/mL (p<0.001). Conclusion: Our study showed that AMH levels were predictive of clinical pregnancy in infertility patients over 40 years of age. Further prospective studies should be conducted to validate the predictive capability of AMH levels for the outcome of clinical pregnancy.

• Korea journal of population studies
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• 제8권1호
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• pp.118-138
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• 1985

This paper is aimed to analyse the recent changes in family planning as a step in an evaluation of the results of the population control policy which has been strenuously pursued by the government since December 1981. The data used in this analysis comes from the 1985 national fertility and family planning survey conducted by the Korea Institute for Population and Health (KIPH) in May 1985. According to the 1985 survey data, there have been great changes in both the contraceptive practice and fertility rates since the strengthening of the government's population control policy in 1 981. The contraceptive practice rate for married women aged 15-44 has increased from 57.7% in 1982 to 70.3% in 1985, an increase of 12.6% points in the short span of only 3 years. During the same period, the total fertility rate has declined from 2.7 in 1982 to the population replacement level which was planned to achieve by 1 988. More than 80% of women aged over 30 or with two children or more are practicing contraception, while the practice rates of women with 0-1 children are 14.0% and 45.1% respectively. The survey has revealed that the increase of contraceptive practice rate during 1982-1985 has mainly attributed to the high acceptance of sterilization procedures which practice rate of the married women has increased from 28.1% to 40.3% for the period. Also, the survey data shows that 24.7% of those women with only one child is practicing contraception for thepurpose of fertility termination. The government, taking into account of rapid changes in contraceptive practice and fertility rates, is formulating a population plan during the sixth fiveyear economic and social development plan (1987-1991) to achieve 1% ofpopulation growth rate by 1993, which was planned to realize by 2000. In order to meet this demographic goal, the existing population control policy measures should be improved to be suited to the recent contraceptive use and fertility changes. From this standpoint, the following considerations should be put forth; 1) improvement of the current program management systems including target allocation and evaluation schems for recruiting new acceptors in the young 20s groups to use contraceptives for birth spacing and to increase high continuation rates through the strengthening of follow-up services for the acceptors, 2) increase of self-supporting contraceptive users by promoting commercial advertisements on contraceptives through mass media including T.V. and radio, 3) development of social support policies including incentive schems, and strengthening of IE & C activities for increasing the proportion of the one-child family, 4) strengthening of population and family planning education in and out school youth, and 5) strengthening of management capabilities at the provincial and local program managers.

• Korean Journal of Soil Science and Fertilizer
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• 제43권6호
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• pp.962-967
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• 2010

The influences of the different mixture of urea fertilizer and pig manure compost as a nitrogen (N) source on Chinese cabbage yield, N uptake, and N agronomic efficiency (AE) were evaluated in two soils having different soil fertility levels. Increasing urea application level was very effective to improve yield and N uptake of Chinese cabbage, and the highest yield was obtained by urea fertilization alone in two soils. On the other hand, the lowest yield and N uptake was obtained from compost alone application in two soils. There was no significant difference in terms of the nitrogen AE between low and high fertility soils that were fully applied with urea. The AE values of Chinese cabbage applied by compost alone were significantly higher in the soil having a low fertility (28.8 g $g^{-1}$) than that in soil with high fertility (16.2 g $g^{-1}$), suggesting that N in compost was more responsive in improving the yield of Chinese cabbage in low fertility soils.

• Korean Journal of Culture and Social Issue
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• 제18권1호
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• pp.111-125
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• 2012

The total fertility rate of our nation has been in the world's lowest level with constant falling since it reached an all-time low in 1983. The increase in economic participation of women, difficulties to balance work and family life, and traditional gender role and family norms in our society have been blamed for causing low birth rates. In addition, the current economic recession and increased polarization of wealth make it more difficult for working families to balance work and family life, resulting in lowering fertility rates. The Korean government has recently prepared the second five-year basic plan(2011-2015) to deal with low fertility and population ageing. The basic plan aims at providing support for working families in balancing work and family life and helping people ease the burden of marriage, childbirth, and raising their children. The work-family balance policies based on gender equality will do much to increase fertility rates in the future. In this context, this study examined current status and problems of balancing work and family life in our society, the Korean government and corporate policies for work-family balance, and the effects of policies on childbirth. Suggestions for future directions are presented.

• The Korean Journal of Community Living Science
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• 제17권1호
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• pp.23-37
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• 2006

As the fertility rate of Korea has recently decreased to the lowest level in the world, the recognition of the needs for social support for the child-care has been increased. This resulted in the announcement of National Policy of Child-Rearing Support in 2004. This study attempted to propose the activation of the family child-care for the preparation of the introduction of the National Policy of Child-Rearing Support. Using literature review and interview, the following research questions were addressed. Firstly, the actual situation of the family child-care was compared with that of the other types of child-care. Secondly, the policies of child-rearing support and the family child-care systems in other countries such as United Kingdom, Sweden and Japan were introduced. Finally, activations of the family child-care were discussed in terms of the introduction of the National Policy of Child-Rearing Support. The results of this study implies that the family child-care in Korea is different from that of other countries as well as other types of child-care in Korea. Also, it suggests that key factors of the activation of the family child-care in Korea are to identify as the small, informal and family-like child-care, to differentiate as the infant-care and non-standard time child-care from other types of child-care, and to increase the level of professionalization. In conclusion, family child-care should become an alternative for the low fertility problem.

• Journal of the Korean Home Economics Association
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• 제45권2호
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• pp.77-90
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• 2007

Using 2004 Household Income & Expenditure Survey, this study investigated difference in consumption pattern among the households with the different number of children, and estimated the monetary cost of rearing children. The findings were as following. First, the major consumption categories for raising children included the expenditures for education, food materials, utility, health, and communication. Second, the potential consumption needs for clothing & foot ware and culture & entertainment were not fully satisfied for the households with children compared to the households without children. Third, in the households with one child, the level of consumption was about two thirds of that in the households without children. It was slightly above half in the households with two children. Lower consumption level of the households with children was mainly due to the burden of the educational expenditure. Forth, the average monthly cost of raising children was estimated by 680 thousands Won for one child, and 104 thousand Won for two children. Lastly, the implications for the fertility policy and the methods for the estimation of the child cost were suggested based on the results.

• Clinical and Experimental Reproductive Medicine
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• 제46권2호
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• pp.50-59
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• 2019

Anti-$M{\ddot{u}}llerian$ hormone (AMH), a peptide growth factor of the transforming growth $factor-{\beta}$ family, is a reliable marker of ovarian reserve. Regarding assisted reproductive technology, AMH has been efficiently used as a marker to predict ovarian response to stimulation. The clinical use of AMH has recently been extended and emphasized. The uses of AMH as a predictive marker of menopause onset, diagnostic tool for polycystic ovary syndrome, and assessment of ovarian function before and after gynecologic surgeries or gonadotoxic agents such as chemotherapy have been investigated. Serum AMH levels can also be affected by environmental and genetic factors; thus, the effects of factors that may alter AMH test results should be considered. This review summarizes the findings of recent studies focusing on the clinical application of AMH and factors that influence the AMH level and opinions on the use of the AMH level to assess the probability of conception before reproductive life planning as a "fertility test."

• Journal of Family Resource Management and Policy Review
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• 제12권3호
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• pp.81-101
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• 2008

The purpose of this study is to examine support policies regarding work and family reconciliation, to suggest plans to improve workplace policies, and to suggest directions for further studies. This study looks at OECD's work-life reconciliation policies as well as family friendly workplace policies in Korea to find a way to enhance business' receptiveness and implementation of the policies. By examining women's labor conditions, this study finds that family friendly workplace policies are necessarily imminent in our society of low fertility and ageing. Along with the evaluation of benefit level and the effectiveness of current policies, this study uses data from interviews with working mothers who have had the experience of family friendly benefits. The results of the analyses suggest that the government should focus on improving the workplace environment in companies that do not show bias against the use of family friendly policies. In order to farm more successful policies, future studies are needed to analyze the changes of fertility, working conditions, support programs, and benefits.

• Analytical Science and Technology
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• 제35권1호
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• pp.8-14
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• 2022

Many studies have shown that advanced glycation end-products (AGEs) and glycation adducts are significantly linked to aging and disease. Particularly, the level of glycation in human milk is important because the AGE intake is closely related to AGE levels in infants. In this study, we used human milk samples obtained from four primiparae and four multiparae. We isolated proteins using acetone and trichloroacetic acid (TCA) precipitation. A total of 67 glycated proteins and 122 glycated peptides was quantified; among them, 19 glycated peptides were differentially expressed. We confirmed that the degree of glycation differed according to fertility. The study provides a foundation for using proteomics to evaluate the mother's milk quality and link between maternal health and human milk quality.