• Journal of Family Resource Management and Policy Review
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• v.12 no.2
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• pp.95-120
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• 2008

The purpose of this study is to find the factors that facilitate married female immigrants' early adjustment in Korea. For this purpose, 14 immigrated female participants living in Daegu were interviewed in-depth by using an open-ended questionnaire. The major findings are as follows: Through content analysis of participants' responses, three major factors were found to influence successful adjustment of married female immigrants personal factors, familial support and the social support system. Among the personal factors, having a conservative marital attitude, optimism and liking the partner rather than economic concern for the reason of marital decision making are contributing factors to the successful marital adjustment. Above all, familial support, a husband's good personality, care, and active support are the important factors in a foreign wife's adjustment and life satisfaction. Parent-in-law's help and tolerance playa role in a foreign daughter-in-law's successful adjustment. In the social support system, joined activities and the support of mends from the homeland make a contribution to decreasing the sense of isolation and to giving mental well-being for married female immigrants. The center for support of multicultural family gives them the opportunity to meet people from their homelands and to expand the social network.

• Journal of Genetic Medicine
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• v.2 no.2
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• pp.65-70
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• 1998

Lysosomal acid lipase (LAL) plays a central role in the intracellular degradation of neutral lipids derived from plasma lipoproteins. In this study, we investigated the missense mutation within exon 2 of human LAL gene changing of codon -6 of prepeptide from threonine to proline. The Thr-6Pro mutation was detected by the HaeIII restriction fragment length polymorphism (RFLP) and single-strand conformation polymorphism (SSCP). We analyzed the mutation in subjects with 221 unrelated randomly selected control samples and 86 patients with familial hypercholesterolemia (FH) in Korea. We observed that mutation is present with high frequency in Korea compared to other populations studied previously. The frequency of PP homozygote in the FH group was observed considerably higher than that of control. However, there was no significant difference of genotype frequency between two groups. These results, together with the fact that plasma lipids and lipoproteins levels between genotypes showed no statistical difference, suggest that the Thr-6Pro mutation in the LAL gene may have no association with the increased risk of FH development.

• Clinical and Experimental Pediatrics
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• v.52 no.5
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• pp.611-614
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• 2009

Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease characterized by the production of a wide range of autoantibodies, resulting in tissue damage. Although the susceptibility to SLE has been attributed to complex interactions between genetic and environmental factors, the influence of a genetic predisposition to SLE is supported by observations of familial aggregations. Family studies have found that siblings with an SLE-affected relative have a 20-fold higher risk of developing SLE compared with the general population. Here, we present a rare case of two male siblings with SLE. The clinical, laboratory, and histopathological findings of these individuals showed the characteristic features of SLE. Human leukocyte antigen (HLA) typing revealed that the brothers and their mother shared the common HLA haplotype of DRB1*1501 and DQB1*0602, which is significantly associated with disease susceptibility in both family-based and casecontrol studies. This report provides an opportunity to reveal the role of genetic factors in the development of SLE.

• Journal of Genetic Medicine
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• v.7 no.1
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• pp.24-36
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• 2010

Colorectal cancer is one of the most steeply increasing malignancies in Korea. Among 398,824 new patients recorded by the Korea Central Cancer Registry between 2003 and 2005, 47,915 cases involved colorectal cancers, accounting for 12.0 % of all malignancies. In 2002, total number of colorectal cancer cases had accounted for 11.2 % of all malignancies. Hereditary syndromes are the source of approximately 5% to 15% of overall colorectal cancer cases. Hereditary colorectal cancers are divided into two types: hereditary nonpolyposis colorectal cancer (HNPCC), and cancers associated with hereditary colorectal polyposis, including familial adenomatous polyposis (FAP), Peutz-Jeghers syndrome, juvenile polyposis, and the recently reported hMutYH (MYH)-associated polyposis (MAP). Hereditary colorectal cancers have unique clinical features distinct from sporadic cancer because these are due to germline mutations of the causative genes; (i) early age-of-onset of cancer, (ii) frequent association with synchronous or metachronous tumors, (iii) frequent association with extracolonic manifestations. The management strategy for patients with hereditary colorectal cancer is quite different from that for sporadic cancer. Furthermore, screening, genetic counseling, and surveillance for at-risk familial member are also important. A well-organized registry can plays a central role in the surveillance and management of families affected by hereditary colorectal cancers. Here, we discuss each type of hereditary colorectal cancer, focusing on the clinical and genetic characteristics, management, genetic screening, and surveillance.

• Korean Journal of Radiology
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• v.23 no.1
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• pp.101-111
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• 2022

Objective: Familial intracranial aneurysms (FIAs) are found in approximately 6%-20% of patients with intracranial aneurysms (IAs), suggesting that genetic predisposition likely plays a role in its pathogenesis. The aim of this study was to identify possible IA-associated variants using whole exome sequencing (WES) in selected Korean families with FIA. Materials and Methods: Among the 26 families in our institutional database with two or more IA-affected first-degree relatives, three families that were genetically enriched (multiple, early onset, or common site involvement within the families) for IA were selected for WES. Filtering strategies, including a family-based approach and knowledge-based prioritization, were applied to derive possible IA-associated variants from the families. A chromosomal microarray was performed to detect relatively large chromosomal abnormalities. Results: Thirteen individuals from the three families were sequenced, of whom seven had IAs. We noted three rare, potentially deleterious variants (PLOD3 c.1315G>A, NTM c.968C>T, and CHST14 c.58C>T), which are the most promising candidates among the 11 potential IA-associated variants considering gene-phenotype relationships, gene function, co-segregation, and variant pathogenicity. Microarray analysis did not reveal any significant copy number variants in the families. Conclusion: Using WES, we found that rare, potentially deleterious variants in PLOD3, NTM, and CHST14 genes are likely responsible for the subsets of FIAs in a cohort of Korean families.

• Journal of Korean Home Economics Education Association
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• v.22 no.3
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• pp.77-94
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• 2010

The purpose of this study was to develop a practical problem-based lesson plan for the "Understanding Myself and My Family" unit and to examine the effects of the lesson plan. Learning objectives and contents were selected, and a practical problem-based lesson plan for five sessions was developed and implemented. With 150 students participating in the study, a pre-test and post-test comprised of a questionnaire were conducted to explore the effectiveness of the lesson plan on the students' sex role characteristics, awareness of gender-role equity in occupational, familial and societal settings and of participation in household chores. Results from the post-test revealed that the students displayed androgynous sex-role characteristics, a heightened awareness of gender-role equity and a higher degree of participation in household chores after the five sessions. Assessment of the class was found to be very positive. Consequently the study showed that the lesson proved to be helpful for the students.

• Child Health Nursing Research
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• v.10 no.1
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• pp.117-125
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• 2004

Purpose: The research was conducted to investigate the experience of maternal role attainment of mothers of premature infants admitted in NICU and to conceptualize the phenomena. Method: The grounded theory method was utilized for data collection and analysis. 8 mothers of premature infants were selected and in-depth interview was performed. Paradigm model was utilized for data analysis and presentation. Result: The central category was 'unstable maternal identity'. The properties of the core phenomena was 'ambivalent feeling to baby' 'negative emotion' 'commitment to baby'. The loss of control due to premature delivery was the causal condition. contextual condition was the 'perceived threats' due to severity of the premature infant and uncerainty of the baby's life. The mother's health status, economic status, and familial and social support was recognized as intervening conditions during the process of maternal role attainment. The strategic action/interactions were emotion-focused coping, reappraisal of the situation, problem-focused coping, and information seeking. The consequence was the maternal role attainment with competence and expectation. Conclusion: The process of maternal role attainment was affected by threats due to severity of the baby and intervening factors and interaction strategy. Further research is recommended to develop adequate intervention method during the process of maternal role attainment.

• Journal of Life Science
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• v.11 no.3
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• pp.279-283
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• 2001

Amyotrophic lateral sclerosis(ALS) is a progressive neurologic disorder resulting from the degeneration of upper and lower motor neurons, and is inherited in 10% of cases. About 20% of familial ALS, clinically indistinguishable from sporadic ALS, is caused by mutations of Cu/Zn superoxide dismutase on chromosome 21q22.21 inherited as an autosomal dominant trait. We now report a new locus in the non-SOD1 dominantly inherited ALS. We screened a large ALS family with 11 affected individuals and one obligate gene carrier with genome-wide ABI polymorphic markers using the ABI 377 automated system. No evidence of linkage was obtained with the autosomal markers. We next screened this family with X chromosome markers as there was no evidence of male-to-male tran-smission of the disease. Linkage was established with several X chromosome markers with a lod score up to 3.8; almost the maximum possible score in this family. Our finding imply that a gene for the dominant expression of a neuronal degeneration is coded on X chromosome and raise the question of the role of X-linked genes that escape inactivation in this pathogenesis. More importantly, our finding that a gene causing ALS is localized on X-chromosome has direct investigational relevance to sporadic ALS, where epidemiological studies show male gender predominance(1.3:1) and earlier onset in men by 5-10 years.

• Journal of the Korean Home Economics Association
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• v.44 no.8
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• pp.143-150
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• 2006

Life Science or Home Economics has its own history of scholarship. In South Korea, the School of Home Economics was regarded as the best school of 'producing best brides' in the early stage of its academic history. Since the 1980s when South Korean society went through a speedy economic growth with development of culture and service industry, the school was transformed to educating highly professional career women in the field of industry which deals with everyday lives. As an applied science in nature, the school of Home Economics has had a heavy emphasis on engineering the familial and social life. It also has heavily depended on imported theories and statistical researches. In the crisis of familial and social disintergration, the role of School of Home Economics needs to be redefined. Reexamination of the premises of Home Economics and methodology is necessary. Decolonializaton of the scholarship in the changed condition of global capitalism is particularly urgent in the late modern era of reflexion.

• Journal of the Korean Home Economics Association
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• v.36 no.6
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• pp.27-40
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• 1998

The purpose of this study was to examine the role of children's characteristics, family environment and child care quality in socio-emotional development of children among dual-worker families. The sample consisted of 138 children aged 5-7 and their parents. Descriptive statistics, t-tests, correlation analysis, one-way ANOVAs, and stepwise regression were used to analyze data. Results showed that there were significant sex differences in children's temperament and popularity. Mother's marital satisfaction had a negative correlation with peer rejection. Low maternal role conflict and child's age had effects on children's self-perception. Moreover, sex and age of the child, mothers' responsive parenting, number of teachers in the classroom were significant predictors for children's peer rejection.