• Journal of the Computational Structural Engineering Institute of Korea
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• v.33 no.2
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• pp.121-128
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• 2020

The purpose of this study is to investigate the distribution patterns of displacement and acceleration fields in a nonlinear soil ground based on the interaction of high-speed train, wheel, rail, and ground. For this purpose, a high-speed train in motion was modeled as the actual wheel, and the vertical contact of wheel and rail and the lateral contact, caused by meandering motion, were simulated; this simulation was based on the moving mass analysis. The soil ground part was given the nonlinear behavior of the upper ground part by using the modified the Drucker-Prager model, and the changes in displacement and acceleration were compared with the behavior of the elastic and inelastic grounds. Using this analysis, the displacement and acceleration ranges close to the actual ground behavior were addressed. Additionally, the von-Mises stress and equivalent plastic strain at the ground were examined. Further, the equivalent plastic and total volumetric strains at each failure surface were examined. The variation in stresses, such as vertical stress, transverse pressure, and longitudinal restraint pressure of wheel-rail contact, with the time history was investigated using moving mass. In the case of nonlinear ground model, the displacement difference obtained based on the train travel is not large when compared to that of the elastic ground model, while the acceleration is caused to generate a large decrease.

• Tuberculosis and Respiratory Diseases
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• v.42 no.4
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• pp.610-617
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• 1995

Sleep apnea occurs in approximately 50% of patients with acromegaly, and sleep apnea is associated with increased cardiovascular diseases and mortality. In view of these findings, sleep apnea may be a factor in the increased incidence of cardiovascular deaths in acromegaly patients. We experienced a case of active acromegaly patient, 54-yr-old man, associated with obstructive sleep apnea syndrome, congestive heart failure with dilated cardiomyopathy and serious cardiac arrhythmias. He was treated for obstructive sleep apnea syndrome, diagnosed by overnight polysomnography, with nasal continuous positive airway pressure(CPAP) for 4 months, which successfully controlled his loud snoring, sleep apnea, nocturnal hypoxemia and apnea-related symptoms. And also he was treated for underlying acromegaly and cardiac complications with bromocriptine and cardiogenic drugs for 4 months, but still had elevated growth hormone(GH) and insulin like growth factor-1(IGF-1) levels and serious cardiac arrhythmias. We describe our experience about the effect of CPAP treatment in an active acromegaly patient associated with obstructive sleep apnea syndrome and cardiac complications with review of literature.

• Tuberculosis and Respiratory Diseases
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• v.43 no.2
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• pp.274-279
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• 1996

Pulmonary veno-occlusive disease is a rare cause of pulmonary hypertension in which the primary abnormality is obliterative obstruction of pulmonary veins, especially venules. Clinicaly, we should suspect this disease in the case of congestive cardiac failure with pulmonary hypertension, chronic interstitial pulmonary edema, and normal or elevated wedge pressure on cardiac catheterization. We experience a case of pulmonary hypertension due to pulmonary veno-occlusive disease. A 55-years -old woman developed progressive dry cough and dyspnea for 3 months. Physical examination showed normal heart sounds, diffuse crackles in the whole lung fields. The liver was not palpable and pitting edema was absent. The diagnosis was made by chest HRCT, 2-D echocardiography, normal pulmonary capillary wedge pressure on cardiac catheterization, and confirmed by thoracoscopic lung biopsy. This patient was treated with vasodilator(calcium antagonist) and with mild symptomatic improvement. We reported a case of pulmonary veno-occlusive disease with review of literatures.

• Journal of the Korean Geotechnical Society
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• v.28 no.9
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• pp.23-30
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• 2012

This paper is research results of slope stability analysis associated with seepage infiltration for unsaturated soil in debris-flow occurrence slopes. Site investigations were carried out in two slopes, located at Inje in Kangwon province where debris flow occurred in 2006 and at Yangpyung in Kyeunggi province where it occurred in 2010. For unsaturated soil sampled at the zone of debris-flow initiation, soil water characteristic curves with tempe pressure cells and shear strength parameters with newly designed shear strength apparatus were obtained respectively. The commertially available software SEEP/W was used to analyze seepage infiltration in unsaturated soil, based on their properties obtained from test results and the actual rainfall data at the moment of debris flow occurrence, and slope stability analysis with the program of SLOPE/W, associated with results of seepage analysis, was performed to simulate slope failure. As results of this research, seepage infiltration to unsaturated soil due to intensive rainfall was found to cause increase of ground water table as well as degree of saturation. Through this research slope stability analysis for unsaturated soil, considering the actual rainfall characteristic, might be a reasonable method of investigating characteristics of debris flow behavior, in particular, the moment of debris flow occurrence.

• Journal of the Korean Institute of Gas
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• v.14 no.6
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• pp.15-20
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• 2010

Compressed Natural Gas (CNG) buses have been supplied since the year 2000 in order to resolve severe atmospheric pollution in metropolitan area and contributed on the improvement of urban atmospheric environment. However, it is indispensible to take an adequate measure to guarantee the safety of CNG vehicles because of the possibility of huge fire accident. A receptacle, connecting device between high pressure fuel supply tank and fuel line, plays an important role in CNG supply system. In recent, leakage of CNG from receptacles has been reported. So, the concern about the security and reliability of receptacles has been arisen. Therefore, a lot of efforts to prevent leakage are invested among researchers and the durability of this component should be guaranteed despite repeated operation. This research has performed durability tests of a CNG receptacle regarding the repeated usage, extreme chattering, and continuous full flow test. Although a receptacle used for CNG vehicle satisfies validation requirements in the test results, it has been found that failure in the function of leakage prevention in a receptacle could take place in the case of prolonged exposure to high supply pressure in common quick charging environment on site.

• Nuclear Engineering and Technology
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• v.27 no.2
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• pp.203-215
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• 1995

A continued operation of RCPs during a certain small break LOCA may increase unnecessary inventory loss from the RCS causing a severe core uncovery which might lead to a fuel failure. After TMI-2 accident, the CEOG developed RCP trip strategy called “Trip-Two/Leave-Two” (T2/L2) in response to NRC requests and incorporated it in the generic EPG for CE plants. The T2/L2 RCP trip strategy consists of tripping the first two RCPs on low RCS pressure and then tripping the remaining two RCPs if a LOCA has occurred. This analysis determines the RCP trip setpoint and demonstrates the safe operational aspects of RCP trip strategy during a small break LOCA for YGN 3&4. The trip setpoint of the first too RCPs for YGN 3&4 is calculated to be 1775 psia in pressurizer pressure based on the limiting small break LOCA with 0.15 ft$^2$ break size in the hot leg. The analysis results show that YGN 3&4 can maintain the core coolability even if the operator fails to trip the second too RCPs or trips at worst time. Also, the YGN 3&4 RCP trip strategy demonstrates that both the 10 CFR 50.46 requirements on PCT and the ANSI standards 58.8 requirements on operator action time can be satisfied with enough margin. Therefore, it is concluded that the T2/L2 RCP trip strategy with a trip setpoint of 1775 psia for YGN 3&4 can provide improved operator guidance for the RCP operation during accidents.

• Journal of the Korean Geotechnical Society
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• v.25 no.4
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• pp.19-29
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• 2009

In this study, a numerical analysis was performed to predict the sequential behavior of anchored retaining wall where the failure accident took place, and verified accuracy of prediction through the comparisons between prediction and field measurement. The emphasis was given to the wall behaviors and the variation of sliding surface based on the two different methods of elasto-plastic and finite element (shear strength reduction technique). Through the comparison study, it is shown that the bending moment and the soil pressure at construction stages produce quite similar results in both the elasto-plastic and finite element method. However, predicted wall deflections using elasto-plastic method show underestimate results compared with measured deflections. This demonstrates that the elasto-plastic method does not clearly consider the influence of soil-wall-reinforcement interaction, so that the tension force (anchor force and earth pressure) on the wall is overestimated. Based on the results obtained, it is found that finite element method using shear strength reduction method can be effectively used to perform the back calculation analysis in the anchored retaining wall, whereas elasto-plastic method can be applicable to the preliminary design of retaining wall with suitable safety factor.

• Journal of Microbiology and Biotechnology
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• v.17 no.12
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• pp.2005-2017
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• 2007

Diabetic nephropathy remains a major cause of morbidity and mortality in the diabetic population and is the leading cause of end-stage renal failure. Despite current therapeutics including intensified glycemic control and blood pressure lowering agents, renal disease continues to progress relentlessly in diabetic patients, albeit at a lower rate. Since synthetic drugs for diabetes are known to have side effects, fungal mushrooms as a natural product come into preventing the development of diabetes. Our previous report showed the hypoglycemic effect of extracellular fungal polysaccharides (EPS) in streptozotocin (STZ)-induced diabetic rats. In this study, we analyzed the differential expression patterns of rat kidney proteins from normal, STZ-induced diabetic, and EPS-treated diabetic rats, to discover diabetes-associated proteins in rat kidney. The results of proteomic analysis revealed that up to 500 protein spots were visualized, of which 291 spots were differentially expressed in the three experimental groups. Eventually, 51 spots were statistically significant and were identified by peptide mass fingerprinting. Among the differentially expressed renal proteins, 10 were increased and 16 were decreased significantly in diabetic rat kidney. The levels of different proteins, altered after diabetes induction, were returned to approximately those of the healthy rats by EPS treatment. A histopathological examination showed that EPS administration restored the impaired kidney to almost normal architecture. The study of protein expression in the normal and diabetic kidney tissues enabled us to find several diabetic nephropathy-specific proteins, such as phospholipids scramblase 3 and tropomyosin 3, which have not been mentioned yet in connection with diabetes.

• Journal of the Korean Society of Hazard Mitigation
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• v.8 no.6
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• pp.31-36
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• 2008

A water distribution system should be constructed reasonably to supply water for the customer with proper quality and pressure as demands at nodes fluctuate with time. Also it should be reliable to minimize undesirable effects on the customer when various accidents happen such as pipe failures. A new method is presented here to reduce damages by pipe failures. For the work, two methods, namely, the method for estimating practical extent of damage by pipe failures and for estimating water distribution reliability, are adopted to analyze a water distribution system and to explore the damage reduction by pipe failures. As the results from the analysis of the model, the damage can be reduced effectively by increasing durability of each pipe in minimum cutsets according to the order of priority. The suggested method was applied to the Cherry-Hill network to verify its applicability.

• Geotechnical Engineering
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• v.11 no.3
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• pp.139-162
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• 1995

The possibility of the development of gas driven hydrofractures at the Waste Isolation Pilot Plant(WIPP) is investigated through analytical and numerical calculations and through laboratory experiments. First, an investigation of the chemical reactions involved shows that a large volume of gas could potentially be generated through the oxidation of iron in the waste. Simple ground water'flow calculations then show that unless regions of high permeability has been created, this gas volume will build up the pressure high enough to cause tensile damage in the horizontal planes of weakness or in the halite itself. The analytical calculations were performed using the concepts of linear elastic fracture mechanics and the numerical calculations were done using the finite element method. Also, laboratory tests were conducted to illustrate possible failure mechanisms. It is possible that after growing horizontal crack in the weaker anhydride layer, the crack could break out of this layer and propagate upward into the halite and toward the ground surface at an inclined argle of around 53$^{\circ}$ above horizontal. To prevent this latter phenomenon the anhydrite must have a fracture toughness less than 0.5590 times than that of the halite. Through the tests, three types of crack(radial vertical cracks, horizontal circular cracks and cone -shaped cracks) were observed.