• Journal of the Society of Cosmetic Scientists of Korea
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• v.25 no.1
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• pp.23-36
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• 1999

Medimin A is a derivative of vitamin A which has been developed by coupling retinoic acid with polyethylene glycol(PEG) to enhance skin permeability and stability. We carried out the collagen synthesis and clinical test to examine the reducing effect of wrinkles by Medimin A. In vitro collagen synthesis was evaluated by quantitative assay of ($^3$H)-proline incorporation into collagenase sensitive protein in fibroblast cultures. Clinical test was evaluated by image analysis of skin replica, visual observation and self-estimated response of volunteers for 10 weeks. Medimin A stimulated about 40% in collagen synthesis. The area of main deep wrinkle on the skin replica was reduced 38.4% with topical application of O/W emulsion containing 0.2% Medimin A. The wrinkles on the eye region was also reduced 25.4%-44.1% by the visual observation and 93% of all volunteers responded that topical application of the O/W emulsion was showed some reducing effect of wrinkles after 10 weeks. From these results, we suggest that Medimin A is a potent anti-wrinkle agent by objective evaluation methods(in vitro collagen synthesis and image analysis of skin replica) and subjective evaluation methods(visual observation and self-estimated response of volunteers).

• Journal of Institute of Control, Robotics and Systems
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• v.11 no.12
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• pp.1020-1026
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• 2005

In the era of ubiquitous computing, human-friendly man-machine interface is getting more attention due to its possibility to offer convenient services. For this, in this paper, we introduce a 'Half-Mirror Interface System (HMIS)' as a novel type of human-friendly man-machine interfaces. Basically, HMIS consists of half-mirror, USB-Webcam, microphone, 2ch-speaker, and high-speed processing unit. In our HMIS, two principal operation modes are selected by the existence of the user in front of it. The first one, 'mirror-mode', is activated when the user's face is detected via USB-Webcam. In this mode, HMIS provides three basic functions such as 1) make-up assistance by magnifying an interested facial component and TTS (Text-To-Speech) guide for appropriate make-up, 2) Daily weather information provider via WWW service, 3) Health monitoring/diagnosis service using Chinese medicine knowledge. The second one, 'display-mode' is designed to show decorative pictures, family photos, art paintings and so on. This mode is activated when the user's face is not detected for a time being. In display-mode, we also added a 'healing-window' function and 'healing-music player' function for user's psychological comfort and/or relaxation. All these functions are accessible by commercially available voice synthesis/recognition package.

• Proceedings of the Korean Information Science Society Conference
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• 2006.06a
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• pp.121-123
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• 2006

얼굴의 표정은 얼굴의 구성요소 같은 기하학적 정보와 조명이나 주름 같은 세부적인 정보들로 표현된다. 얼굴 표정은 기하학적 변형만으로는 실감적인 표정을 생성하기 힘들기 때문에 기하학적 변형과 더불어 텍스쳐 같은 세부적인 정보도 함께 변형해야만 실감적인 표현을 할 수 있다. 표정비율이미지 (Expression Ratio Image)같은 얼굴 텍스처의 세부적인 정보를 변형하기 위한 기존 방법들은 조명에 따른 피부색의 변화를 정확히 표현할 수 없는 단점이 있다. 따라서 본 논문에서는 이러한 문제를 해결하기 위해 서로 다른 조명 조건에서도 실감적인 표정 텍스처 정보를 적용할 수 있는 비선형 피부색 모델 기반의 표정 합성 방법을 제안한다. 제안된 방법은 동적 외양 모델을 이용한 자동적인 얼굴 특징 추출과 와핑을 통한 표정 변형 단계, 비선형 피부색 변화 모델을 이용한 표정 생성 단계, Euclidean Distance Transform (EDT)에 의해 계산된 혼합 비율을 사용한 원본 얼굴 영상과 생성된 표정의 합성 등 총 3 단계로 구성된다. 실험결과는 제안된 방법이 다양한 조명조건에서도 자연스럽고 실감적인 표정을 표현한다는 것을 보인다.

• Bulletin of the Korean Chemical Society
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• v.33 no.1
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• pp.183-188
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• 2012

A blue phosphorescent $Ir(dfpypy)_3$ (dfpypy:fluorinated pyridine-pyridine ligand) complex with meridional configuration has been synthesized by newly developed effective method and its solid state structure and photoluminescence are characterized. For this complex, mer-$Ir(dfpypy)_3$, the glass-transition and decomposition temperatures appear at $160^{\circ}C$ and $384^{\circ}C$ respectively in TGA and DSC experiments, which indicates that this complex has high thermal stability. In a crystalline structure, an average Ir-C bond length of mer-$Ir(dfpypy)_3$ is slightly longer than that of fac-$Ir(dfpypy)_3$, which assumed to be due to the weak trans-influence. The absorption and emission spectra are observed more red-shifted in mer-$Ir(dfpypy)_3$ than fac-$Ir(dfpypy)_3$. In addition, the former is readily oxidized than the latter in electrochemical behavior.

• Bulletin of the Korean Chemical Society
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• v.19 no.4
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• pp.457-462
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• 1998

A chiral pentadentate bis-amide ligand, 1,9-bis(S)-pyrrolidinyl-2,5,8-triazanonane-1,9-dio ne$(S,S-prodienH_2)$ has been synthesized from the reaction of bis(2-aminoethyl)amine(dien) and S-proline, and the structure of $[Co(S,S-prodien)H_2O]ClO_4$ has be en determined by single crystal X-ray diffraction. The geometrical structure of the Co(III) complex has been an αβ -form, where the dien moiety of ligand chelates to a facial in metal center, and the aqua ligand coordinates a cis site to the secondary nitrogen of dien. The Co-N(1), Co-N(3) distances of two amide moiety in S,S-prodien are shorter than the other Co-N(2), Co-N(4), and Co-N(5) distances because of the increased basicity of nitrogen in amide. The complex crystallizes in the monoclinic space group $P2_1$(#4), with a=7.838(1), b=12.675(1), c=9.710(1) Å, β=100.39(1) and z=2. Refinement gives the final R and $R_w$ values of 0.045 and 0.057, respectively for 2130 observed reflections. Based upon the CD and X-ray data, it is identified that the absolute configuration of the αβ -$[Co(S,S-prodien)H_2O]ClO_4$ has a Λ-form.

• 한국정보컨버전스학회:학술대회논문집
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• 2008.06a
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• pp.53-56
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• 2008

This paper reports on the ACQA(Animated agent for Conversational Question Answering) project conducted at LIMSI. The aim is to design an expressive animated conversational agent(ACA) for conducting research along two main lines: 1/ perceptual experiments(eg perception of expressivity and 3D movements in both audio and visual channels): 2/ design of human-computer interfaces requiring head models at different resolutions and the integration of the talking head in virtual scenes. The target application of this expressive ACA is a real-time question and answer speech based system developed at LIMSI(RITEL). The architecture of the system is based on distributed modules exchanging messages through a network protocol. The main components of the system are: RITEL a question and answer system searching raw text, which is able to produce a text(the answer) and attitudinal information; this attitudinal information is then processed for delivering expressive tags; the text is converted into phoneme, viseme, and prosodic descriptions. Audio speech is generated by the LIMSI selection-concatenation text-to-speech engine. Visual speech is using MPEG4 keypoint-based animation, and is rendered in real-time by Virtual Choreographer (VirChor), a GPU-based 3D engine. Finally, visual and audio speech is played in a 3D audio and visual scene. The project also puts a lot of effort for realistic visual and audio 3D rendering. A new model of phoneme-dependant human radiation patterns is included in the speech synthesis system, so that the ACA can move in the virtual scene with realistic 3D visual and audio rendering.

• Journal of Periodontal and Implant Science
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• v.26 no.4
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• pp.799-821
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• 1996

The ultimate goal of periodontal treatment has been to facilitate regeneration of diseased periodontal tissues, destroyed by inflammatory periodontal disease. For regeneration of the periodontium to occur, all of component tissues must be restored to their original position and architecture. Growth factors which were known to promote the cellular processes, ie, proliferation, migration and matrix synthesis, have been in the spotlight of current periodontics. Platelet-derived growth factor(PDGF) stimulates collagen and non collagen protein synthesis, migration and proliferation of periodontal ligament cells. Insulin-like growth factor(IGF) has potentials to induce collagen and bone matrix synthesis so that it regulates normal bone remodeling. Application of the combination have been known to facilitate formation of bone and cementum, and to synergistically interact to promote coronal migration and proliferation of periodontal ligament cells. These two growth factors have been reported to exhibit positive effect in the periodontally diseased teeth or class m furcation defects. The aim of the present study was to test the hypothesis that PDGF-BB alone or the combination of PDGF-BB and IGF-I can predictably enhance regeneration of the periodontium in the dehiscence defect. Following the resection of premolars, roots were embedded. After 12 weeks of healing period, standardized experimental $4{\times}4mm$ dehiscence defects were created on the mid-facial of the premolar roots in each of 4 young adult dogs. In control group, only methylcellulose gel was inserted in the defects. In experimental group I and II, gel with $2{\mu}g$ of PDGF-BB or $2{\mu}g$ of PDGF-BB and $1{\mu}g$ of IGF-I was inserted in the defects, respectively. At 8 weeks postsurgery, the dogs were sacrificed. The results were observed histologically and analyzed histomorphometrically.The results of this study were as follws. 1. The new cementum formation was $1.26{\pm}0.69mm$ in the control group, $1.80{\pm}0.84mm$ in the experimental group I, $1.93{\pm}0.51mm$ in the experimental group II. The experimental group III, the experimental group I, the control group were in the order of cementum formation without statistically significant differences between control and all experimental groups. 2. The new bone formation was $1.00{\pm}0.53mm$ in the control group, $1.53{\pm}0.63mm$ in the experimental group I, $l.33{\pm}0.45mm$ in the experimental group II. The experimental group I, the experimental group II, the control group were in the order of bone formation without statistically significant differences between control and all experimental groups. 3. The root resorption was $1.12{\pm}0.64mm$ in the control group, $1.34{\pm}0.73mm$ in the experimental group I, $0.79{\pm}0.59mm$ in the experimental group II without statistically significant differences between control and all experimental groups. These results suggested that the use of PDGF-BB alone or PDGF-BB and IGF-I in the dehiscence defects might facilitate periodontal regeneration in some degree, but has not shown statistically significant results.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.34 no.2
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• pp.129-135
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• 2008

In this study, the potential anti-aging properties of Prunella vulgaris extract were investigated. According to our results, Prunella vulgaris extract increased collagen synthesis(74.7% at 250 ${\mu}g/mL$) and decreased on MMP-1 synthesis(90.2% at 200 ${\mu}g/mL$) and elastase activity(43.7% at 2.0%). Furthermore, it also showed free radical scavenging activity(76.9% at 2.0%) and reduced $H_2O_2$-induced cytoxicity(49.9% at 2.0%). A double-blind clinical study to investigate the effect of Prunella vulgaris extract on the skin's surface was conducted with 22 healthy volunteers, aged 34 to 48 years. The volunteers applied a cream formula with 4.0% of Prunella vulgaris extract, or placebo cream, on each crow's feet twice a day for 12 weeks. Skin wrinkles were evaluated with the naked eye and instrumental image analysis of silicone replicas, followed by statistical analysis. Twelve weeks after application of cream formula with 4.0% of Prunella vulgaris extract, we found significant improvement of facial wrinkle. Moreover, silicone replica analysis confirmed notable improvement in average of R2 and R3 at 12 weeks(p<0.05). These results demonstrate that Prunella vulgaris provides a remarkable and significant tensor and anti-wrinkle effect on the skin, which could be of great use in anti-aging skin care products.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.28 no.1
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• pp.35-41
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• 2006

It is well known that concentration of C-reactive protein(CRP) in the serum increase as nonspecific reaction of the various tissue injury. The CRP, synthesized in the hepatocyte, is one of 'acute phase proteins' in the serum. The main signal patterns of this protein are regulated by synthesis of interleukin-I secreted from macrophage in the area of tissue injury. Many studies were performed for quantitative analysis for CRP according to various surgical operation, but the study for fracture patients associated with trauma, especially in mandible, are rare. The mandible fracture have intrinsic danger for infection in oral bacteria associated with open wound in oral cavity, and, are difficult for detection of tissue reaction between surgical swelling and infection by facial swelling. In this study, quantitative analysis for CRP associated tissue injury in mandibular fracture and surgical intervention was done, the results were as follows: 1. After initial mandibular trauma, the value of serum CRP diminished sequentially, most high value was presented in post-traumatic 2 days. 2. The CRP was diminished significantly 2 days after surgical intervention, and maintained normal value in 5 days after surgery. 3. The change of CRP are higher value in surgical intervention than initial trauma, it suggested that tissue injury from surgery was severe than trauma. 4. The high value of CRP was obtained in mandibular fracture combined soft tissue injury than no associated soft tissue injury. 5. In measurement of CRP according to surgical approach, highest serum value in patients of combined intra-oral and extra-oral approach was showed, and intra-oral approach, extra-oral approach, in sequential orders. 6. The CRP value are more higher in patient of 2 fracture site than only one fracture site. From the results obtained in this study, CRP has showed different values in mandibular fracture associated with severity of tissue injury and surgical intervention, and quantitative analysis of CRP value in serum can be applied to the clinical management of mandibular fracture.

• 한국HCI학회:학술대회논문집
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• 2006.02b
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• pp.362-369
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• 2006

3 차원 그래픽스에 적용하는 한국어 립씽크 합성 체계를 연구하여, 말소리에 대응하는 자연스러운 립씽크를 자동적으로 생성하도록 하는 디자인 시스템을 연구 개발하였다. 페이셜애니메이션은 크게 나누어 감정 표현, 즉 표정의 애니메이션과 대화 시 입술 모양의 변화를 중심으로 하는 대화 애니메이션 부분으로 구분할 수 있다. 표정 애니메이션의 경우 약간의 문화적 차이를 제외한다면 거의 세계 공통의 보편적인 요소들로 이루어지는 반면 대화 애니메이션의 경우는 언어에 따른 차이를 고려해야 한다. 이와 같은 문제로 인해 영어권 및 일본어 권에서 제안되는 음성에 따른 립싱크 합성방법을 한국어에 그대로 적용하면 청각 정보와 시각 정보의 부조화로 인해 지각의 왜곡을 일으킬 수 있다. 본 연구에서는 이와 같은 문제점을 해결하기 위해 표기된 텍스트를 한국어 발음열로 변환, HMM 알고리듬을 이용한 입력 음성의 시분할, 한국어 음소에 따른 얼굴특징점의 3 차원 움직임을 정의하는 과정을 거쳐 텍스트와 음성를 통해 3 차원 대화 애니메이션을 생성하는 한국어 립싱크합성 시스템을 개발 실제 캐릭터 디자인과정에 적용하도록 하였다. 또한 본 연구는 즉시 적용이 가능한 3 차원 캐릭터 애니메이션뿐만 아니라 아바타를 활용한 동적 인터페이스의 요소기술로서 사용될 수 있는 선행연구이기도 하다. 즉 3 차원 그래픽스 기술을 활용하는 영상디자인 분야와 HCI 에 적용할 수 있는 양면적 특성을 지니고 있다. 휴먼 커뮤니케이션은 언어적 대화 커뮤니케이션과 시각적 표정 커뮤니케이션으로 이루어진다. 즉 페이셜애니메이션의 적용은 보다 인간적인 휴먼 커뮤니케이션의 양상을 지니고 있다. 결국 인간적인 상호작용성이 강조되고, 보다 편한 인간적 대화 방식의 휴먼 인터페이스로 그 미래적 양상이 변화할 것으로 예측되는 아바타를 활용한 인터페이스 디자인과 가상현실 분야에 보다 폭넓게 활용될 수 있다.