• 한국조리학회지
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• 제14권1호
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• pp.21-38
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• 2008

This research aimed to analyze the differences in financial variables classifying chain restaurants. A total of 126 samples were drawn from financial statements for $2001{\sim}2006$. As a result of analysis, there was a significant difference in Pillai's Trace, Wilks' Lambda, Hotelling's Trace, and Roy's Largest Root values at the significant probability value(p<0.05) based on F value in terms of stability among chain restaurants. Difference was found only in current rate and liabilities in ANOVA. There was a great difference in current rate among institutional restaurants, fast food restaurants, and cafeterias. There was a significant difference in Pillai's Trace, Wilks' Lambda, Hotelling's Trace, and Roy's Largest Root values at the significant probability value(p<0.05) based on F value in terms of restaurants' profitability. In ANOVA, difference was found only in net profits to net sales. It was revealed that all factors showed no significant differences in multiple comparison. All multi-variant test statistics showed a significant difference in growth and turnover. ANOVA showed a significant difference in net sales growth rate, net profit growth rate, and total assets growth rate.

• 대한기계학회논문집A
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• 제36권11호
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• pp.1327-1334
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• 2012

본 논문은 4차 동적 시스템인 구동기를 구성하는 부품들의 변량 및 공기외란의 변량으로 인해 구동기 성능에 변량이 존재할 때, 구동기의 성능을 순응도 기반으로 최적화한 설계 결과를 제시하였다. 구동기는 BLDC 모터와 평기어 및 웜기어 조립체, 카나드로 구성된다. 구동기의 성능은 시간에 따라 변화하는 카나드 각도 정보를 이용하여 평가하였다. 고차 시스템의 성능은 해석적 접근을 통해 시스템 변수들의 함수로 표현하기 어렵기 때문에 반응표면모델을 기반으로, F-검정을 수행하여 유효한 시스템 변수들을 선정한 후 성능을 유효한 시스템 변수들의 함수로 근사화하였다. 본 연구에서 변량을 가지는 구동기 성능의 규격에 대한 순응도를 확률값으로 정의하였다. 순응도를 최적화하여 구한 설계변수는 부품 및 공기외란에 변량이 존재하더라도 고려한 규격을 모두 만족시킬 수 구동기를 제공할 수 있다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권17호
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• pp.7935-7941
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• 2015

The aim of this study was to implement massive parallel sequencing (MPS) technology in clinical genetics testing. We developed and tested an amplicon-based method for resequencing the BRCA1 and BRCA2 genes on an Illumina MiSeq to identify disease-causing mutations in patients with hereditary breast or ovarian cancer (HBOC). The coding regions of BRCA1 and BRCA2 were resequenced in 96 HBOC patient DNA samples obtained from different sample types: peripheral blood leukocytes, whole blood drops dried on paper, and buccal wash epithelia. A total of 16 random DNA samples were characterized using standard Sanger sequencing and applied to optimize the variant calling process and evaluate the accuracy of the MPS-method. The best bioinformatics workflow included the filtration of variants using GATK with the following cut-offs: variant frequency >14%, coverage ($>25{\times}$) and presence in both the forward and reverse reads. The MPS method had 100% sensitivity and 94.4% specificity. Similar accuracy levels were achieved for DNA obtained from the different sample types. The workflow presented herein requires low amounts of DNA samples (170 ng) and is cost-effective due to the elimination of DNA and PCR product normalization steps.

• Asian-Australasian Journal of Animal Sciences
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• 제16권8호
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• pp.1212-1217
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• 2003

Fifty-two Holstein cows with different phenotypes of $\kappa$-casein ($\kappa$-CN) and $\beta$-lactoglobulin ($\beta$-LG) were selected to provide weekly milk samples for heating at 30, 70, 75 and $80^{\circ}C$ for 2 min. Coagulating properties of heated milk samples measured as rennet clotting time, rate of curd firming and curd firmness at cutting were determined by a Formagraph. Milk samples were analysed for fat and casein. Least squares analyses of data, after adjustments were made for effect of milk casein and fat contents, indicated that although an increase in heating temperatures resulted in less desirable coagulating properties, the effect of milk types was inherent irrespective of heating temperatures. The shortest rennet clotting time (6.06 min), fastest rate of curd firming (5.61 min) and firmest curd (38.05 mm) were obtained from milk with the B variant for $\kappa$-CN and B variant for $\beta$ -LG when preheated at $30^{\circ}C$. It appears that milk bearing $\kappa$-CN B is more resistant to heat perturbation. All milk samples having the $\kappa$-casein AA (milk types AA/AA, AA/AB, AA/BB) did not have a measurable K20 value when preheated at $70^{\circ}C$. This effect was observed for $\kappa$-casein AB (milk types AB/AA, AB/AB, AB/BB) at $75^{\circ}C$ and $\kappa$-casein BB (milk types BB/AA, BB/AB, BB/BB) at $80^{\circ}C$.

• Asian Pacific Journal of Cancer Prevention
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• 제16권3호
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• pp.1151-1157
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• 2015

Human papillomavirus (HPV) is responsible for one of the most frequent sexually transmitted infections. The first phylogenetic analysis was based on a LCR region fragment. Nowadays, 4 variants are known: African (Af-1, Af-2), Asian-American (AA) and European (E). However the existence of sub-lineages of the European variant havs been proposed, specific mutations in the E6 and LCR sequences being possibly related to persistent viral infections. The aim of this study was a phylogenetic study of HPV16 sequences of endocervical samples from C${\acute{o}}$rdoba, in order to detect the circulating lineages and analyze the presence of mutations that could be correlated with malignant disease. The phylogenetic analysis determined that 86% of the samples belonged to the E variant, 7% to AF-1 and the remaining 7% to AF-2. The most frequent mutation in LCR sequences was G7521A, in 80% of the analyzed samples; it affects the binding site of a transcription factor that could contribute to carcinogenesis. In the E6 sequences, the most common mutation was T350G (L83V), detected in 67% of the samples, associated with increased risk of persistent infection. The high detection rate of the European lineage correlated with patterns of human migration. This study emphasizes the importance of recognizing circulating lineages, as well as the detection of mutations associated with high-grade neoplastic lesions that could be correlated to the development of carcinogenic lesions.

• Journal of Interdisciplinary Genomics
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• 제3권1호
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• pp.21-24
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• 2021

Purpose: Activating mutations of the calcium-sensing receptor (CASR) are a rare genetic disorder, and result in autosomal dominant hypocalcemia with hypercalciuria (ADHH). ADHH exhibited varying degrees of hypocalcemia. In this study, we report the clinical and molecular characteristics of activating variants in CASR patients diagnosed in Korea. Methods: This study included three patients with activating variants of CASR confirmed by biochemical and molecular analysis of CASR. Clinical and biochemical findings were reviewed chart retrospectively. Mutation analysis of CASR was performed by Sanger sequencing. Results: Subject 1 showed severe symptoms from the neonatal period and had difficulty in controlling the medications that were administered. Subject 2 was identified as having a novel variant of CASR with hypocalcemia and a low parathyroid hormone that were found in the neonatal period. During a course without medication, hypocalcemia occurred suddenly around 2 years of age. Subject 3 was diagnosed with hypoparathyroidism with hypocalcemic seizures starting from the neonatal period. About 4 years without taking medication with any symptom. However, at 10 years old revisited by repetitive hypocalcemic seizure events. Subject 1 and 3, were heterozygous for c.2474A>T (p.Y825F), c.2395G>A (p.E799K) located in the transmembrane domain (TMD) of CASR. Subject 2 was heterozygous for c.403A>C (S430L) located in the extracellular domain (ECD) of CASR. Conclusion: We reported 3 patients who have activating CASR variant with different onset and severity of symptoms. In the future, further study is needed to determine how the protein level according to the location of the mutation of CASR affects the degree of symptoms.

• Advances in Computational Design
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• 제2권1호
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• pp.1-13
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• 2017

This paper presents a variant of the Harmony Search Algorithm (HS) and its application to discrete optimization. The main proposed modifications regarding original HS are related to stopping criterion and reinitialization of population, called Harmony Memory. In order to investigate the efficiency of the algorithm, it was applied for obtaining optimal sections of reinforced concrete columns subjected to uniaxial flexural compression. To minimize the cost of the section, the amount and diameters of the reinforcement bars and the dimensions of the columns cross sections were considered as design variables. The obtained results were compared to those generated by other optimization methods. Since, to the examples, Harmony Search reached the same results achieved by Simulated Annealing, some additional analysis are presented in order to compare these methods regarding success rate and number of iterations to reach the optimum.

• 자원환경지질
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• 제31권6호
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• pp.519-526
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• 1998

A high-resolution seismic survey was conducted at the northeastern boundary of Pungam basin, one of the Cretaceous sedimentary basins in Korea. A 100 kg weight was used as an energy source and was found to be better than a sledge hammer in mapping deeper geologic structures. Several processing techniques such as f-k filtering, predictive deconvolution, and time-variant filtering are useful to enhance the signal-to-noise ratio by suppressing unwanted seismic energy. Four seismic units are recognized where many vertical faults are developed. The boundary fault between sedimentary rocks and Precambrian gneiss is identified along with a fracture zone of approximately 30 m wide. Bedding planes of the sedimentary rocks dipping westward are interpreted to be limbs of a syncline or volcanic flow. There faults and tilted bedding planes indicate that the basin had undergone significant tectonic deformation.

• 한국철도학회:학술대회논문집
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• 한국철도학회 2007년도 추계학술대회 논문집
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• pp.1599-1604
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• 2007

LIMs propelling the MAGLEV which has been developed in Korea have 3-series and 2-parallel connection, so that 6 LIMs per one vehicle are fed by one inverter. Thrust performance of the parallel-operated LIMs can be different from each other because of variant magnetic air gaps and electrical impedance. The thrust difference between the parallel LIMs cause a twist force on the vehicle. This paper proposes an algorithm to measure thrust of the parallel-operated LIMs. The method uses a digital signal processor(TMS320F2812), voltage and current sensors. As a result, thrust, flux and currents of the parallel-operated small LIMs which are manufactured in our laboratory are monitored by the developed measurement system.

• 방사성폐기물학회지
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• 제16권1호
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• pp.1-10
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• 2018

A simplified flowsheet for pyroprocessing commercial spent fuel is proposed in which the only salt treatment step is actinide drawdown from electrorefiner salt. Actinide drawdown can be performed using a simple galvanic reduction process utilizing the reducing potential of gadolinium metal. Recent results of equilibrium reduction potentials for Gd, Ce, Nd, and La are summarized. A description of a recent experiment to demonstrate galvanic reduction with gadolinium is reviewed. Based on these experimental results and material balances of the flowsheet, this new variant of the pyroprocessing scheme is expected to meet the objectives of minimizing cost, maximizing processing rate, minimizing proliferation risk, and optimizing the utilization of geologic repository space.