• Asian Pacific Journal of Cancer Prevention
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• v.13 no.6
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• pp.2909-2912
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• 2012

Aim: To evaluate efficacy and tolerability of topotecan treatment for recurrent small cell lung carcinoma. Patients and Methods: A total of 62 patients were evaluated retrospectively. Statistical analysis was performed using GraphPad Instat (version 3.05). Results: DFifty five of patients (89%) were male and 7 (11%) were female. Median age was $56.7{\pm}9.3$ (34-75). Forty eight of patients (80%) were extensive stage (ES) at the time of diagnosis. Fifty of the patients (80.6 Medical Oncology Clinic) were given median 5.36 cycles of cisplatin-etoposide (2-8 cycles). Time to recurrence was $15.6{\pm}6.13$ weeks in patients with limited stage (LS) and $6.3{\pm}3.82$ weeks in extensive stage (ES) (p<0.0001). Overall survival was $14.0{\pm}6.08$ months in ES and $17.9{\pm}6.88$ months in LS. The difference between two groups was statistically meaningful (p=0.0447). The overall survival of the patients was $14.8{\pm}6.43$ months (4.5-40 months). In terms of survival, there was no difference between males and females (p=0.1171). In 17 (27%) patients who were refractory to topotecan or in whom progression occurred other chemotherapies were used. Conclusion: Small cell lung cancer is chemosensitive, but recurrences occur in short time. Other chemotherapy regimens are used in progression. Topotecan is one of them. Patients who were young and in whom recurrences occur late had given better response to topotecan. Because of the retrospective nature of the study, we couldn't reach the records exactly and consequently, rate and duration of response couldn't be calculated. In recurrent SCLC topotecan is one of the treatment choices. But both hematological and non hematological side effects should be taken into consideration.

• Journal of Powder Materials
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• v.22 no.1
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• pp.6-9
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• 2015

In this study, the behavior of densification of copper powders during high-pressure torsion (HPT) at room temperature is investigated using the finite element method. The simulation results show that the center of the workpiece is the first to reach the true density of copper during the compressive stage because the pressure is higher at the center than the periphery. Subsequently, whole workpiece reaches true density after compression due to the high pressure. In addition, the effective strain is increased along the radius during torsional stage. After one rotation, the periphery shows that the effective strain is increased up to 25, which is extensive deformation. These high pressure and severe strain do not only play a key role in consolidation of copper powders but also make the matrix harder by grain refinement.

• Journal of Korean Traditional Oncology
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• v.17 no.1
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• pp.1-7
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• 2012

Objective : The association of cancer survival and components of the systemic inflammatory response, combined to form inflammation-based prognostic scores (modified Glasgow Prognostic Score (GPS), Neutrophil Lymphocyte Ratio, Platelet Lymphocyte Ratio) is reviewed in this article. Methods and Results : With extensive research of papers in the PubMed, there is good evidence that preoperative measures of the systemic inflammatory response predict cancer survival, independent of tumor stage, in primary operable cancer. GPS also shows its prognostic value as a predictor of survival, independent of tumor stage, performance status and treatment in a variety of advanced cancer. GPS is associated with chemotherapy related toxicities as well as response to treatment and C-reactive protein shows its clinical value as a monitor of chemotherapy response. The systemic inflammatory response is closely related to cachexia and may be suitable measure for the clinical definition of cancer cachexia. Conclusion : Anticipated survival using the inflammation-based prognostic score is a major factor to be taken into consideration when deciding whether active intervention including surgery and chemotherapy or palliation therapy including acupuncture and herb medication is appropriate.

• Industrial Engineering and Management Systems
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• v.16 no.1
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• pp.64-79
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• 2017

Identifying disease genes from human genome is a critical task in biomedical research. Important biological features to distinguish the disease genes from the non-disease genes have been mainly selected based on traditional feature selection approaches. However, the traditional feature selection approaches unnecessarily consider many unimportant biological features. As a result, although some of the existing classification techniques have been applied to disease gene identification, the prediction performance was not satisfactory. A small set of the most important biological features can enhance the accuracy of disease gene identification, as well as provide potentially useful knowledge for biologists or clinicians, who can further investigate the selected biological features as well as the potential disease genes. In this paper, we propose a new stepwise random forests (SRF) approach for biological feature selection and disease gene identification. The SRF approach consists of two stages. In the first stage, only important biological features are iteratively selected in a forward selection manner based on one-dimensional random forest regression, where the updated residual vector is considered as the current response vector. We can then determine a small set of important biological features. In the second stage, random forests classification with regard to the selected biological features is applied to identify disease genes. Our extensive experiments show that the proposed SRF approach outperforms the existing feature selection and classification techniques in terms of biological feature selection and disease gene identification.

• Proceedings of the KSR Conference
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• 2004.06a
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• pp.1007-1013
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• 2004

A three-arch NATM tunnel with a total length of 53.5m has been constructed for a metropolitan subway station in Daejon, Korea. The tunnel, whose crown is located 22m below the ground, crosses the old Daejon station underneath. Since the tunnel comprises a very large section (10${\times}$28 m; largest in Korea), it shows complicated mechanical behaviors, especially near portal, due to its short length relative to width. As far as its construction step is concerned, the center tunnel is excavated with pre-excavated pilot tunnel, which is a unique feature of this tunnel (first in Korea) to secure safety during construction and prevent excessive settlements. The both side tunnels are then excavated along with the center tunnel. Since significant amount of settlement was predictable from the design stage, extensive monitoring was performed during construction. During excavation of the side tunnels, unexpected large settlements up to ${\~}$140mm (estimated 41.8 mm at design stage) was measured at the center tunnel. In this paper, we study the causes of this unusually large ground settlement. We believe that the extra-wide tunnel excavation increases the stress influence zone of portal in longitudinal direction and consequently add more settlements to the existing due to excavation and consolidation.

• The Journal of Korea Assosiation for Disability and Oral Health
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• v.1 no.1
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• pp.33-36
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• 2005

Manifestations in tuberous sclerosis such as seizure, mental retardation, end-stage renal disease (ESRD), and heart problems present a number of challenges to the dentist and anesthesiologist. Lack of cooperation in addition to the severe medical condition makes dental treatment more difficult. General anesthesia is often required for mentally and physically handicapped patients undergoing extensive dental treatment. We experienced a case of dental treatment under general anesthesia in a 36-year-old male patient with tuberous sclerosis associated with ESRD and mental retardation. He was treated on an outpatient basis followed by hemodialysis without any complications.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.11 no.11
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• pp.5392-5418
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• 2017

The primary aim of this paper is to propose a non-linear regression based technique for mapping different network Quality of Service (QoS) factors to an integrated end-user Quality of Experience (QoE) or Mean Opinion Score (MOS) value for an online video streaming service on a mobile phone. We use six network QoS factors for finding out the user QoE. The contribution of this paper is threefold. First, we investigate the impact of the network QoS factors on the perceived video quality. Next, we perform an individual mapping of the significant network QoS parameters obtained in stage 1 to the user QoE based upon a non-linear regression method. The optimal QoS to QoE mapping function is chosen based upon a decision variable. In the final stage, we evaluate the integrated QoE of the system by taking the combined effect of all the QoS factors considered. Extensive subjective tests comprising of over 50 people across a wide variety of video contents encoded with H.265/HEVC and VP9 codec have been conducted in order to gather the actual MOS data for the purpose of QoS to QoE mapping. Our proposed hybrid model has been validated against unseen data and reveals good prediction accuracy.

• Journal of Korean Academy of Nursing
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• v.50 no.1
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• pp.81-100
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• 2020

Purpose: The purpose of this study was to define and clarify the concept of political competence for nurses. Methods: A hybrid model method was used to investigate the dimensions, attributes, and definitions of the concept. In the theoretical stage of the study, literature on nursing, politics, and other discipline were reviewed. In the fieldwork stage, individual in-depth interviews and focus groups interviews were conducted with politically seasoned experts or activists who had an understanding of the concept of political competence for extensive descriptions in nursing and field of health care. Results: The concept of political competence was represented in four dimensions as political knowledge, political efficacy, political interaction, and political activity. In the political knowledge dimension, there were three attributes, namely, political knowledge, political information and systematic analysis ability. The political efficacy dimension had three attributes of internal political efficacy, external political efficacy, and self-pride of nursing profession. The political interaction dimension had three attributes of organizations and community service, networking, and persuasive power. The political activity dimension had six attributes of political leadership, political expression, assertive behavior, political advocacy, political participation, and policy intervention. Conclusion: This concept development might provide a basic understanding of developing a measurement tool and for constructing a theory promoting nurses' political competence.

• Journal of Acupuncture Research
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• v.22 no.2
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• pp.211-217
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• 2005

Objectives : Terminal stage cancer patient from primary hepatocellular carcinoma metastasized into lungs was administered with cultivated wild ginseng herbal acupuncture for 5 months and observed progression. Methods : Cultivated wild ginseng herbal acupuncture was administered 5 times a week at about 150cc dosage per week. Dynamic CT was taken and interpreted at a university hospital. Results : Above patient was diagnosed with hepatocellular carcinoma and received one procedure of lobectomy and three procedures of TACE, but because of metastasis, chance of improvement was very obscure. Intensive treatment of cultivated wild ginseng herbal acupuncture five times a week for five months in association with moxibustion was done on the patient. Near elimination of the cancer cells metastasized into lungs were confirmed in terms of radiological impression through dynamic CT. Conclusion: From the results obtained in this study, cultivated wild ginseng herbal acupuncture can be an effective measure against terminal stage cancer. But this is a single case study and lack of extensive follow-up must be compensated by further researches.

• Smart Structures and Systems
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• v.12 no.3_4
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• pp.291-308
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• 2013

A novel concept of transmissibility based on a wavelet transform for structural damage detection is presented in this paper. The main objective of the research was the development of a method for detecting slight damage at the incipient stage. As a vibration-based approach, the concept of transmissibility has attracted considerable interest because of its advantages and effectiveness in damage detection. However, like other vibration-based methods, transmissibility-based approaches suffer from insensitivity to slight local damage because of the regularity of the traditional Fourier transform. Therefore, the powerful signal processing techniques must be found to solve this problem. Wavelet transform that is able to capture subtle information in measured signals has received extensive attention in the field of damage detection in recent decades. In this paper, we first propose a novel transmissibility concept based on the wavelet transform. Outlier analysis was adopted to construct a damage detection algorithm with wavelet-based transmissibility. The feasibility of the proposed method was numerically investigated with a typical six-degrees-of-freedom spring-mass system, and comparative investigations were performed with a conventional transmissibility approach. The results demonstrate that the proposed transmissibility is more sensitive than conventional transmissibility, and the former is a promising tool for structural damage detection at the incipient stage.