• 한국광학회지
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• 제28권1호
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• pp.16-21
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• 2017

고광도 섬광에 의하여 사람 눈에 미치는 영향을 체계적으로 이해하는 것은 고섬광의 사용상에나 눈의 보건의학적인 관점에서 큰 가치가 있다. 본 논문에서는 고섬광의 안전지표로서 노출제한거리를 제안하고, 섬광의 특성으로부터 노출제한 노출제한거리를 구하는 방법을 제시한다. 본 연구에서 고려한 고섬광에 대한 노출제한을 결정하는 요인은 망막에서 투영되는 열적 에너지이며 이는 망막의 열적위험을 나타내는 열적유효복사휘도로 표현된다. 고섬광의 노출제한거리는 열적 유효복사휘도 또는 광도와 광원 반경에 거의 비례하나 지속시간에는 거의 의존하지 않는다. 고섬광의 노출제한거리가 지속시간에 비례하지 않는다는 점은 눈에 미치는 영향이 노출되는 시간에 비례할 것이라는 기대와는 다른 중요한 발견으로 생각된다. 본 연구에서 제안된 노출제한거리는 고섬광의 연구개발과 활용에서 뿐만 아니라 눈을 보호하는 보건의학 분야에서도 안전지표로서 중요하게 활용될 것으로 기대된다.

• 한국패류학회지
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• 제31권2호
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• pp.143-150
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• 2015

본 연구는 염화니켈 노출에 따른 북방전복의 염화니켈 축적 농도, 생존율 및 탈락률, 조직학적 지표 변화에 대하여 알아보고자 하였다. 실험은 1개의 대조구와 5개의 니켈 노출구 (5.9, 8.8, 13.3, 20.0, 30.0 mg/L) 였다. 염화니켈에 노출된 북방전복의 체내 염화니켈 축적 농도는 모든 니켈 노출구에서 농도의 존적으로 증가하는 결과를 보였다. 생존률 및 탈락률은 대조구에 비해 니켈 노출구에서 농도의존적으로 나타났다. 북방전복의 발, 아가미, 간췌장의 조직학적 변화는 시간이 경과함에 따라 대조구보다 니켈 노출구에서 뚜렷하게 나타났다.

• 대한방사선기술학회지:방사선기술과학
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• 제41권6호
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• pp.533-538
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• 2018

As the use of digital radiographic system has been expanded, there are some concerns an increase about in patient of radiation dose. Therefore, International Electro-technical Commission (IEC) has been proposed a standard foe exposure index (EI). In this study, the EI was measured on human chest model using computed radiography (CR). Radiation quality used RQA5 of IEC62494-1. After acquiring the chest anterior posterior image (Chest AP) by using the phantom, the EI was obtained by applying the system response. In this study, we have analyzed the images with the detector size (Full filed ROI) and the optimized image (Fit filed ROI). The EI increased proportionally with radiation dose increase. Due to the discrete increase in pixel value, the EI showed an exponential increase. The discrete increase in noise equivalent quanta (NEQ) resulted in a discrete increase in the EI. The EI of the two images used in this study increased with increasing NEQ but showed different increments. For the measurement of the EI, IEC standards must be followed. The EI should be used as an index to evaluate the image quality for quality control of X-ray image rather than as an indicator of exposure dose. When calculating the EI, the system response should be applied depending on whether or not the grid is used. The size of the field should be obtained by including only the necessary parts.

• Tuberculosis and Respiratory Diseases
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• 제73권4호
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• pp.210-218
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• 2012

Background: The level of urine cotinine is an indicator of tobacco smoke exposure. The purpose of this study is to investigate urine cotinine for the purpose of assessing the smoking status of Korean smokers and non-smokers exposed to tobacco smoke. Methods: The subjects were identified from the 2007-2009 and the 2010 data sets of the Korea National Health and Nutrition Examination Survey (KNHANES). They were assigned as non-smokers, current smokers and ex-smokers. Non-smokers were also divided into three subset groups according to the duration of smoke exposure. Each group was stratified by gender prior to analysis. Results: The median value of urine cotinine in the male current smokers was 1,221.93 ng/mL which was the highest among all groups. The difference between levels of urine cotinine for male and the female groups was statistically significant (p<0.01). In the female group, passive smoke exposure groups reported higher urine cotinine levels than non-exposure groups (p=0.01). The cutoff point for the discrimination of current smokers from non-smokers was 95.6 ng/mL in males and 96.8 ng/mL in females. The sensitivity and specificity were 95.2% and 97.1%, respectively, in males, 96.1% and 96.5% in females. However, the determination of urine cotinine level was not useful in distinguishing between passive smoke exposure groups and non-exposure groups. Conclusion: Urine cotinine concentration is a useful biomarker for discriminating non-smokers from current smokers. However, careful interpretation is necessary for assessing passive smoke exposure by urine cotinine concentration.

• 환경영향평가
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• 제29권2호
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• pp.93-111
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• 2020

현행 국내 건강영향평가는 환경영향평가제도 내 특정 개발사업에 한해서 수행된다. 하지만 건강영향평가가 개발사업의 시행 단계에서 수행됨에 따라 심각한 건강 악영향이 예상됨에도 불구하고 적절한 조치를 취하지 못하는 경우가 있다. 특히 산업단지 개발사업의 경우에 운영으로 인한 건강 악영향 예상 및 개발단계에서의 건강영향평가로 인해 환경갈등이 자주 발생하고 있다. 이 연구는 산업단지 개발에 있어 건강영향을 고려한 계획 적정성 평가 방법을 제안하고 이를 실제 개발사업들에 적용하고자 하였다. 이 연구는 US EPA의 CalEnviroScreen 3.0 및 US ATSDR의 Public Health Assessment를 참조해서 건강영향을 고려한 계획 적정성 평가 방법을 제안하였다. 평가 방법으로는 지역사회 특성, 배경노출, 그리고 개발부담으로 구분한 지표 사용을 제안하였다. 문헌조사 등을 통해 지역사회 특성 지표 5개, 배경노출 지표 3개, 개발부담 지표 7개를 선정하였으며, 건강영향평가 관련 전문가들에게 계층적 의사결정법 설문조사를 통해 각 지표의 가중치를 산출하였다. 과거 국가 주도의 3개 국가산업단지 개발사업에 대해 시범 적용하였으며, 이를 통해 각 지표들에 대한 활용자료 및 평가값을 세분화하여 평가 방법을 구체화하였다. 건강영향을 고려한 계획 적정성 기준은 산업단지 개발에 대한 정부의 정책방향과 연계하여 첫째 총점기준, 둘째 총점 및 지역사회 특성기준, 그리고 개발부담 지표에 예외를 둔 총점 및 지역사회 특성기준으로 제안하였다.

• 대한수의학회지
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• 제41권1호
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• pp.99-104
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• 2001

불의의 방사선 피폭 환자의 체내 방사선 피폭선량의 예측을 위한 방사선 생물학적 선량측정 개발의 일환으로 저선량 피폭환자의 체내 피폭선량 측정 지표로서의 미소핵 분석법 이용 가능성을 평가하기 위하여 코발트-60 감마선을 0.25 Gy에서 1 G의 선량을 인체 말초 혈액에 조사한 후 임파구내에 미소핵의 수적 변화를 형태학적으로 관찰하였다. 저선량에 피폭된 임파구에서 미소핵이 관찰되었으며, 선량에 따른 수적인 변화도 나타났다. 저선량 피폭에 대한 미소핵의 수적 변화에 대한 선량-반응 곡선은 $Y=(0.02{\pm}0.0009)+(0.033{\pm}0.010)D+(0.012{\pm}0.012)D^2$의 식을 얻었으며, linear quadratic model 이였다. 이상의 결과에서 미소핵의 발생 빈도와 피폭 선량간에 유의한 효과가 있는 것으로 확인되었다. 그리고 정상대조군에서는 세포당 $0.02{\pm}0.0009$개가 관찰되었다. 따라서 말초 임파구를 이용한 미소핵 분석법은 저선량 피폭환자의 체내 피폭선량 측정은 물론 방사선 방호제의 검색 및 방사선 민감도 검사를 위한 방사선 생물학적 지표로 이용 가능하며, 특히 이 방법은 간편하고 정확하며 재현성이 있는 방법으로 불의의 방사선 피폭 사고시 체내 피폭선량을 예측하는 좋은 지표로 사용되어질 수 있을 것으로 사료됨.

• 한국환경보건학회지
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• 제32권1호
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• pp.67-70
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• 2006

A gas chromatography/mass spectrometric method was developed for the determination of formaldehyde in hair. 0.3mg of hair was placed in 10ml headspace vial. 1.5mM pentafluorophenylhydrazine solution (pH 2) in 0.03 M phosphoric acid and $20\;{\mu}l$ of 500 mg/l $acetone-d_6$ as internal standard were added in vial and sealed tightly with cap. The solution was heated for 30 min at $90^{\circ}C$ in heating block. The extraction, the derivatization and the evaporation were performed simultaneously. After heating of the solution, 0.5 ml of headspace was taken up and analyzed by gas chromatography-mass spectrometry (GC-MS). Low limit of detection (LaD) and Low limit of quantitation (LOQ) of formaldehyde were 0.5 and 1.5 ng/g, respectively. The method was used to analyze formaldehyde in rat hair after oral exposure. The developed method may be valuable to be used to analyze formaldehyde in human hair.

• 한국환경과학회지
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• 제13권6호
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• pp.519-525
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• 2004

Air pollution from the Daegu industrial complex (Die) in Korea has been a common nuisance and cause of complaints for nearby residents. The current study measured the indoor and outdoor levels of six VOC (benzene, toluene, ethylbenzene, and three isomeric xylenes) at two residential areas with a different proximity to the ODIC, plus the ambient levels at two industrial areas within the boundary of the DDIC. The QA/QC program included the range of correlation coefficient (0.94-0.99) for calibration curves, within the permissible range. Toluene was the most abundant VOC in the ambient air both in residential and industrial areas. Both indoor and outdoor air concentrations of all target VOC except benzene were higher in residential area near the DIC compared to that further away from the DIC. Moreover, the ambient air concentrations of all target VOC except benzene for two industrial sites (A and B) were significantly higher than the outdoor or indoor air concentrations in the two residential areas. The findings further suggested that VOC ambient levels measured in a residential area near the DIC be used as a potential indicator of odor-causing unidentified air pollutants transported from the DIC. Moreover, it was found that the elevated ambient toluene levels outweighed the indoor sources with respect to the environmental exposure of residents nearby the DIC. However, in the residential area further away from the DIC, the toluene indoor sources outweighed the outdoor sources.

• 한국물환경학회지
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• 제18권4호
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• pp.395-400
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• 2002

Lead is one of the most toxic metal and is detectable in practically all phases of environment and in all biological system. Transport, industrial and domestic waste products are the main sources of this pollutant. Ingested lead is rapidly absorbed and widely distributed throughout the body, causing extensive tissue damage. In this study, we chose the freshwater decapods Maceobrachium nipponnese as a sensitive indicator organism for environmental pollution. In order to investigate the possibility in use of $Na^+/K^+ATPase$ activity as a biomarker of lead pollution, we tested the acute toxicity of lead to Maceobrachium nipponnese. The $LC_{50}(96hr)$ value for lead in Maceobrachium nipponnese was found to be $446{\mu}g/L$ with the 95% confidence limits. The lead exposure group at $LC_{50}$ showed a significant $Na^+/K^+ATPase$ inhibition, depending on the exposure time. Comparision of several concentrations of lead revealed that the $Na^+/K^+ATPase$ activity in Maceobrachium nipponnese was significantly decreased in a concentration dependent manner. These results suggest that $Na^+/K^+ATPase$ activity in Maceobrachium nipponnese may possibly be used as a biomarker of lead pollution in aquatic ecosystem.

• Journal of Korean Biological Nursing Science
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• 제15권2호
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• pp.74-81
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• 2013

Purpose: This study was conducted to explore the health effects of exposure to oil-contaminated water in G village near the area of Daecheon beach on which air force had test fired. Methods: Eighty residents consented and were divided into three groups; 33 residents(drinking well water and still living there), 23 residents(drinking well water but do not live there any more), and 24 residents(did not drink well water but live there now: control group). Data were collected from August to September, 2010 from the survey questionnaires, general health examination, specific functional test, and biological marker tests. Results: Current residents showed higher levels of body mass index, blood pressure, and fasting blood glucose that are related to adult diseases. 64 participants received specific test for cancer. Only one person had esophageal cancer. Perchloroethylene was not found in the Urine Samples. Current residents showed a higher level of 8-hydroxydeoxyguanosine, an indicator of oxidative damage, and there was a statistically significant difference after correcting the confounding variables. Conclusion: We need education programs for managing the risk factors that are related to adult diseases in people who are now living in this village. We also need to expand further studies for investigating oxidative damage indicators.