• Journal of Microbiology and Biotechnology
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• 제1권3호
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• pp.163-168
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• 1991

A new angiogenesis inhibitor, FR-118487 was obtained by chemical modification of FR-111142 which was isolated from the fermentation products of Scolecobasidium arenarium F-2015. The antiangiogenic activity of FR-118487 was compared with that of the parent compound, FR-111142. In the endothelial cell proliferation test in vitro and the angiogenesis in the chick embryo chorioal-lantoic membrane assay, FR-118487 had about 5∼10 times stronger antiangiogenic activities than FR-111142. In addition, FR-118487 inhibited the angiogenesis in the rabbit corneal assay and suppressed the solid tumor growth in mice. These findings showed that FR-118487 would be a unique antiangiogenic agent with promising antitumor activity.

• 한국산학기술학회논문지
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• 제17권11호
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• pp.302-313
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• 2016

본 연구는 기업에서 CEO의 내 외부 활동(정보, 지식경영, 학습조직)이 혁신활동(활용적, 탐색적)과 경영성과에 미치는 영향을 알아보기 위하여 국내 기업의 CEO 300명을 대상으로 설문조사를 토대로 통계분석을 하였다. 분석 결과 정보와 학습조직 활동은 활용적 혁신활동과 탐색적 혁신활동에 유의한 정(+)의 영향을 미치는 것으로 나타났으나, 지식경영 활동은 탐색적 혁신활동에서 통계적으로 유의미한 영향을 끼치지 못하였다. 또한, CEO 내 외부 활동에서 정보, 지식경영, 학습조직 활동의 영향을 받은 활용적, 탐색적 혁신활동은 기업의 경영성과에 유의한 정(+)의 영향을 미쳤으나 영향력의 세기는 차이를 보였다. 따라서 기업의 경영에서 CEO의 내 외부 활동 중에서 정보, 지식경영, 학습조직 활동에 의한 활용적 혁신과 탐색적 혁신활동 발현으로 경영성과를 극대화시키기 위한 모색은 선행 연구에서 지각된 활동을 기반으로 하여 기업의 경영 환경을 고려하여 유리한 활동을 추출하고 이를 경영 전략에 반영하는 것이 기업에서 최상의 경영성과 목표달성에 유리함을 본 연구결과에서 시사하고 있다.

• 농촌지도와개발
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• 제22권4호
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• pp.395-404
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• 2015

The purpose of this study was to examine the structural relationships between attributes, satisfaction, and behavioral intention of rural tourism activity. For this study, an onsite survey was conducted to tourists of 35 rural tourism farms. A total of 408 samples were collected for the analysis. The SPSS 20.0 and AMOS 18.0 statistical package were used for frequency, reliability, exploratory factor, confirmatory factor, and path analysis. Through exploratory factor analysis, four dimensions of rural tourism activity attribute were identified from 20 variables: 'human resource', 'activity', 'rural culture', and 'facility and environment'. The results of structural equation modelling indicate that 'human resource', 'activity', 'rural culture' had positive effect on behavioral intention. Through the results, agritourism farm operators will be able to develop effective marketing strategy and management skill.

• 융합경영연구
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• 제5권2호
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• pp.33-39
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• 2017

As the aging population geworsened by the a of the low fertility rate in the wake of the birth of the low birth rate, the rapid increase in the retirement age of the baby boomers in the wake of the birth of the Korean War is a significant indication of the separation of the aged and the role of the economically rich and the role of the role of the economically rich. Therefore, this study aims to address issues and countermeasures. The study aims to provide basic data for the future life of the baby boom generation by examining the problems and responses to the economic activity after the retirement activity of the baby boomers. The research suggests that the limit was limited to the retirement age of the baby boomer generation in order to boost the employment of the elderly. Due to the lack of exploration of the exploratory research, the lack of analysis of exploratory facts is the biggest limitation of the analysis. So, further analysis of this will lead to meaningful studies. Looking at the composition of this study, the introduction of the study included the necessity and purpose of the study. The focus on the point was on the concepts and characteristics of the baby boomer, and analyzed the characteristics of the economic activity and analyses and analyses of domestic and international cases. In conclusion, the issue was drawn up and the alternatives were sought.

• 대한수학교육학회지:수학교육학연구
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• 제19권1호
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• pp.163-183
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• 2009

본 연구는 2007년 개정 교육과정에 따라 초등학교 수학 실험용 교과서에 신설된 활동인 탐구 활동과 이야기 마당을 다루는 수업에서 교사와 학생의 수학적 의사소통이 어떻게 이루어지는지 알아보기 위한 것이다. 이를 위하여 초등학교 1, 2학년 각각 두 교실의 수업을 관찰하고 수학적 의사소통을 질문하기, 설명하기, 수학적 아이디어의 근원의 세 요소로 나누어 분석하였다. 분석 결과, 학생들의 사고과정에 초점을 두고 학생들의 아이디어를 탐색한 교실이 있는 반면에, 정답을 도출하는데 초점을 두거나 학생들의 아이디어를 깊이 탐구하지 않고 교사가 직접 아이디어를 평가하는 교실이 있었다. 특히, 탐구 활동보다는 이야기 마당을 다루는 수업에서 이러한 경향이 더 많이 나타났으며 이는 교사들이 이야기를 통하여 수학 수업을 진행하는데 익숙하지 않고 교사용 지도서에도 구체적인 발문이나 학생들의 예상 답안을제시하지 않은데 원인이 있다고 볼 수 있다. 실험 적용에서 드러나는 수학적 의사 소통을 면밀히 분석함으로써 추후 탐구 활동과 이야기 마당 관련 수업에서의 지도 방향에 대한 시사점을 도출하였다.

• Natural Product Sciences
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• 제9권4호
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• pp.260-263
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• 2003

Ethanol extract of the root of Clitoria ternatea Linn (CTEE) was evaluated for different neuropharmacological actions, such as general behaviour, exploratory behaviour, muscle relaxant activity and phenobarbitone induced sleeping time, in rats and mice. The extract was found to cause reduction in spontaneous activity, decrease in exploratory behavioural pattern by the head dip and Y- maze test, reduction in the muscle relaxant by rotarod, $30^{\circ}C$ inclined screen and traction tests. In addition CTEE significantly potentiated the phenobarbitone-induced sleeping time. Preliminary tests indicate that the ethanol extract of Clitoria ternatea Linn. At the doses of 100 and 150 mg/kg showed significant neuropharmacological activity.

• Advances in Traditional Medicine
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• 제6권3호
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• pp.221-231
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• 2006

The aim of the present study is to investigate central nervous system (CNS) activity of the methanol extracts of leaves of Caesalpinia bonducella (MECB) and stem bark of Bauhinia racemosa (MEBR) (Caesalpinaceae) in Swiss albino mice and Wistar albino rats. General behavior, exploratory behavior, muscle relaxant activity and phenobarbitone sodium-induced sleeping time were studied. The results revealed that the methanol extracts of leaves of Caesalpinia bonducella at 100 - 200 mg/kg and stem bark of Bauhinia racemosa 100 - 200 mg/kg caused a significant reduction in the spontaneous activity (general behavioral profile), remarkable decrease in exploratory behavioral pattern (Y-maze and head dip test), a reduction in muscle relaxant activity (rotarod and traction tests), and also significantly potentiated phenobarbitone sodium-induced sleeping time. The results suggest that MECB and MEBR exhibit CNS depressant activity in tested animal models.

• 한국의류학회지
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• 제43권3호
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• pp.384-404
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• 2019

This study investigates the multidimensional structure of apparel design evaluation criteria and the details of each criterion by exploring how female college students majoring in apparel design in their 20s evaluate apparel design based on an exploratory approach. Data were analyzed through a categorization method of qualitative data after collecting from a literature review and three focus group interviews. The results identified the six evaluation criteria of apparel design (functional usefulness, convenience, aesthetics, psychological self suitability, social activity usefulness, and fashion trend). Functional usefulness and convenience assessed the extent to which primary features of apparel are reflected in apparel design, and aesthetics evaluated the aesthetic beauty of apparel design. Psychological self suitability estimated the extent to which apparel design expressed psychological self properly, and social activity usefulness appraised the extent to which apparel design contributed to the social activities of wearers. Last, fashion trend assessed the extent to which apparel design reflected fashion trend. The study results provide meaningful implications towards an apparel industry that wants to develop apparel design that appeals to consumers, educational institutions that aim to cultivate well-trained professionals in the apparel industry, and consumers who want to purchase clothes of satisfactory design.

• The Korean Journal of Physiology and Pharmacology
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• 제2권6호
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• pp.677-685
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• 1998

To investigate the effects of neonatal stress on behavior and neurochemistry, rats were exposed to the footshock stress on postnatal day (PND) 14 or PNDs 14 and 21. Rats were exposed to uncontrollable electric shocks delivered to the floor with a constant current (0.8 mA) for 5 sec period. Daily sessions consisted of 60 trials on a random time schedule with an average of 55 sec. The first exposure to footshocks on PND 14 decreased body weight gain for 1 day. However, the second exposure to footshocks on PND 21 did not affect body weight gain. Exploratory activity was measured by exposing a rat to a novel environment 24 h after experience of footshocks. Similar to the body weight changes, a decreased activity was noted after the first exposure to footshocks, while no changed activity was noted after the second exposure to footshocks. However, the Bmax value of $5-HT_{2A/2C}$ receptors in the cortex decreased by the second exposure to footshocks, but not by the first exposure to footshocks. Moreover, an autoradiographic study revealed that the density of $[^3H]dexamethasone$ binding in hippocampus decreased in rats exposed to footshocks 4 times during PND $14{\sim}20.$ These results suggest that the uncontrollable footshock stress changes 5-hydroxytryptamine and glucocorticoid receptor systems acutely and that the repeated exposure to the same stress may not elicit behavioral alterations by the compensatory activity of young brain although changes in some neurochemistry exist.

• Advances in Traditional Medicine
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• 제5권4호
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• pp.301-307
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• 2005

The roots of the plant Korean ginseng have been extensively used in the traditional Chinese herbal medicine. We investigated the standardized extract of Korean ginseng on animal models of anxiety based on exploratory behavior. Korean ginseng extract (KGE) (3, 10 and 30 mg/kg) was administered intra-peritoneally. The anxiolytic activity was studied using elevated plus maze (EPM) paradigm, light/dark apparatus (LDA), open field apparatus (OFA) and the hole board apparatus (HBA). Diazepam (1mg/kg) was used as a standard anxiolytic drug. In EPM, KGE (10 mg/kg) significantly (P < 0.05) increased the time spent in open arms and the number of entries in open arms. In LDA, KGE (10 mg/kg) increased the number of transitions. In OFA, KGE (3 and 10 mg/kg) significantly increased (P < 0.05) the number of squares traversed. In HBA the number of head pokes were significantly increased with KGE (3 and 10 mg/kg). KGE at all selected doses did not affect the motor coordination. Thus, the study suggests that saponin containing standardized Korean ginseng extract possess anxiolytic activity.