• 제목/요약/키워드: ethnic differences

검색결과 210건 처리시간 0.021초

DNA Repair Gene Polymorphisms at XRCC1, XRCC3, XPD, and OGG1 Loci in the Hyderabad Population of India

  • Parine, Narasimha Reddy;Pathan, Akbar Ali Khan;Bobbarala, Varaprasad;Abduljaleel, Zainularifeen;Khan, Wajahatullah;Alanazi, Mohammed
    • Asian Pacific Journal of Cancer Prevention
    • /
    • 제13권12호
    • /
    • pp.6469-6474
    • /
    • 2012
  • Background: DNA repair is one of the crucial defense mechanism against mutagenic exposure. Inherited SNPs of DNA repair genes may contribute to variation in DNA repair capacity and susceptibility to cancer. Due to the presence of these variants, inter-individual and ethnic differences in DNA repair capacity have been established in various populations. India harbors enormous genetic and cultural diversity. Materials and Methods: In the present study we aimed to determine the genotypes and allele frequencies of XRCC1 Arg399Gln (rs25487), XRCC3 Thr241Met (rs861539), XPD Lys751Gln (rs13181), and OGG1 Ser326Cys (rs1052133) gene polymorphisms in 186 healthy individuals residing in the Hyderabad region of India and to compare them with HapMap and other populations. Results and Conclusions: The genotype and allele frequency distribution at the four DNA repair gene loci among Hyderabad population of India revealed a characteristic pattern. Comparison of these gene polymorphisms with other populations revealed a distinctiveness of Hyderabad population from the Deccan region of India. To the best of our knowledge, this is the first report of such DNA repair gene polymorphisms in the Deccan Indian population.

Theoretically Informed Correlates of Hepatitis B Knowledge among Four Asian Groups: The Health Behavior Framework

  • Maxwell, Annette E.;Stewart, Susan L.;Glenn, Beth A.;Wong, Weng Kee;Yasui, Yutaka;Chang, L. Cindy;Taylor, Victoria M.;Nguyen, Tung T.;Chen, Moon S.;Bastani, Roshan
    • Asian Pacific Journal of Cancer Prevention
    • /
    • 제13권4호
    • /
    • pp.1687-1692
    • /
    • 2012
  • Background: Few studies have examined theoretically informed constructs related to hepatitis B (HBV) testing, and comparisons across studies are challenging due to lack of uniformity in constructs assessed. The present analysis examined relationships among Health Behavior Framework factors across four Asian American groups to advance the development of theory-based interventions for HBV testing in at-risk populations. Methods: Data were collected from 2007-2010 as part of baseline surveys during four intervention trials promoting HBV testing among Vietnamese-, Hmong-, Korean- and Cambodian-Americans (n = 1,735). Health Behavior Framework constructs assessed included: awareness of HBV, knowledge of transmission routes, perceived susceptibility, perceived severity, doctor recommendation, stigma of HBV infection, and perceived efficacy of testing. Within each group we assessed associations between our intermediate outcome of knowledge of HBV transmission and other constructs, to assess the concurrent validity of our model and instruments. Results: While the absolute levels for Health Behavior Framework factors varied across groups, relationships between knowledge and other factors were generally consistent. This suggests similarities rather than differences with respect to posited drivers of HBV-related behavior. Discussion: Our findings indicate that Health Behavior Framework constructs are applicable to diverse ethnic groups and provide preliminary evidence for the construct validity of the Health Behavior Framework.

Clinical and Biochemical Profile of Monoclonal Gammopathies in Caribbean Patients in a Resource-limited Setting

  • Buchner-Daley, Loretta;Brady-West, Doreen;McGrowder, Donovan
    • Asian Pacific Journal of Cancer Prevention
    • /
    • 제13권12호
    • /
    • pp.6501-6504
    • /
    • 2012
  • Background: Multiple myeloma is the most common malignant plasma cell dyscrasia and ranks second among primary haematological malignancies. This study describes the epidemiologic, clinical and pathologic profile of monoclonal gammopathies seen in the University Hospital of the West Indies (UHWI), a tertiary care referral centre. Materials and Method: A retrospective analysis of 85 cases diagnosed at UHWI over the 5-year period 2003-2007 was conducted. The cases were identified from the bone marrow records as well as the computerized database of the Medical Records Department. Clinical presentation, family and personal history and demographic data were retrieved. Haematological and biochemical results were also analyzed. Results: There were 85 patients diagnosed with monoclonal gammopathies. The M:F ratio was 1.2:1 and the mean age was $65.7{\pm}1.3$ years. Eighty percent of the patients had skeletal pain and 40% experienced weight loss. Of the patients experiencing bone pain 56.7% had multiple lytic lesions, 26.7% had pathological fractures and 26.7% had compression fractures. Seventy-four patients (87.1%) had a haemoglobin level <12.0 g/dL with 52.9% having values <8.0 g/dL. Renal impairment was evident at diagnosis in 36.5%. Hypercalcemia was seen in 26.5% and hyperuricemia in 45.9%. Of the 79 patients who had serum protein electrophoresis performed, 77.2% had at least one monoclonal band and of these 24.6% had a monoclonal protein also present on urine protein electrophoresis. Conclusions: The demographic profile in this group of patients is largely similar to other studies in predominantly Caucasian populations; however there was a notable increase in prevalence of severe disease at presentation, with the majority of patients presenting at the most advanced stage. It is probable that these differences reflect socioeconomic factors and not merely inherent ethnic variation in disease biology.

Ethnic Differences in the Adjustment to Poverty and Disability among Unmarried Elderly Americans : An Analysis of Multi-State Transitions in Living Arrangements from 1984-1990

  • 박경숙;프랜시스골드샤이더;로저애버리
    • 한국인구학
    • /
    • 제22권1호
    • /
    • pp.123-151
    • /
    • 1999
  • 미국사회에서 노인의 거주지 적응양식은 인종간에 차이가 크다. 일반적으로 소수인종노인은 백인 노인에 비하여 자녀와 함께 사는 경향이 강하다. 이에 대하여 문화적 입장에서는 소수인종은 백인에 비하여 가족부양규범이 강하다고 주장한다. 다른 한편 경제적 입장에서는 소수인종은 그들의 생애를 지배하는 빈곤 때문에 규모의 경제를 통하여 가계비용을 줄이기 위하여 확대가족을 유지할 수밖에 없다고 주장한다. 본 연구는 노인이 질병과 빈곤에 적응하는 방식에 있어 인종간 차이를 검토함으로써 기존의 경제학적 논의와 문화적 논의의 적합성을 검정하는데 목적을 두고 있다. 이를 위하여 노인의 거주지 적응에 대한 문화적 영향과 관련하여 두가지 가설을 검정하고 있다. 첫째, 소수인종 노인은 백인노인에 비하여 빈곤과 질병상황에서 가족으로부터 더 오랜기간 보호를 받는지를 검토한다. 둘째, 소수인종 노인은 백인노인에 비하여 건강이 악화될 때 더욱 신속하게 가족으로부터 보호를 받을 수 있는지를 검토한다. 분석을 위해서 1984년에서 1990년기간 동안 실시된 "고령화에 대한 종단적 조사(Longitudinal Survey on Aging)"를 이용하여 마르코비안 다중생명표 모형과 사건분석을 수행하였다. 본 연구결과에 따르면 소수인종 노인은 가족부양규범의 문화적 이점을 그다지 크게 다지고 있지 않다. 인종간 사망력과 시설입소의 차이를 통제할 때, 소수인종 노인은 백인노인에 비하여 보다 흔하게 자녀동거에서 단독거주형태로 혹은 그 반대방향으로 거주지 변화를 경험하고 있다. 백인 노인은 소수인종에 비하여 질병상태와 관련하여 자녀와 동거하는 경향이 더 강하다. 사망력과 시설입소의 인종간 차이를 통제할 때 소수인종노인이 백인노인보다 쉽게 자녀동거에서 단독거주로 이행하는데 이는 소수인종에서 가족부양체계가 불안정함을 의미한다. 또한 빈곤시에 소수인종 노인은 백인노인에 비하여 쉽게 자녀와 떨어져 살게 된다. 이러한 결과는 소수인종 노인에 대한 가족의 지원은 그 가족의 경제적 제약속에서 매우 안정적이지 못함을 시사한다. 못함을 시사한다.

  • PDF

반사회적 의식이 반영된 시대복식의 특성에 관한 연구 - 18세기 상-뀔로뜨와 1960, 70년대 히피 스타일의 비교를 중심으로 - (A Study of Dress Characteristics with Respect to Anti-Social Resisting Consciousness - Focus on the Relationship between 18th Century Sans-Culotte and a Hippy Style During the 1960s and 1970s as a Comparative Perspective -)

  • 전여선;김영삼
    • 복식
    • /
    • 제62권6호
    • /
    • pp.112-126
    • /
    • 2012
  • The style of a dress allows important characterization of an era since they reflect contemporary politics, society, culture and arts. Within a same category, period costumes develop into styles that reflect specific consciousness. The research method and the scope of the study are as follows: the research adopts a historical study method and a comparative research from a microscopic point. The scope includes resistance costumes that proceed with sans-culotte that comprises of the resistance party during the 18th French Revolution (1783-1799), and also a Hippy style which was popularized during the 1960s and 1970s for its anti-war movement. We researched both similarities and differences of design factors reflecting resisting consciousness in costumes that affected costume characteristics related to their socio-cultural background. Sans-culotte and the Hippie style reflect a common denominator in anti-social resisting customs. First, they show common characteristics that combine fashion trends of resistant element and design features. Second, they have common features which are the characteristics of deviation. On the other hand, these two customs also present a discriminative denominator in anti-social resisting customs. In the case of sans-culotte, they tend to symbolize confrontation by dividing into two equal parts: the old and new mode. Sans-culotte confronts the conventional mode and promotes practical costume styles based on justice standpoints. First, hippies pursue an exposition of individual emotions that disclose internal meanings of love and desire. Second, they focus on subjective characteristics and chase after masteries and pleasures by expressing intensity. Third, it extends and develops folk costumes from many countries that reveal ethnic trends. Therefore, this research compares and contrasts different changes in the fashions of revolutionary periods, and aims to recognize the relationship between design and costume characteristics, thus contributing to the predictions of future changes in fashion.

SNP Analysis of the Human LDL Receptor and CETP Gene in Korean Subjects with Hypertension

  • Shin, Jae-Hyun;Kang, Byung-Yong;Lee, Kang-Oh;Eo, Hyun-Shun;Bae, Joon-Seol;Kim, Ki-Tae;Kim, Hyun-Sup;Lee, Chung-Choo
    • 한국환경성돌연변이발암원학회지
    • /
    • 제22권1호
    • /
    • pp.47-53
    • /
    • 2002
  • Essential hypertension is complex disorder influenced by multiple genetic and environmental factors. Alterations of lipid metabolism in plasma have been reported to be related to an increased risk of essential hypertension. The aim of this study was to investigate the relationship between two SNPs of the human LDL receptor and CETP gene and hypertension in Korean population. There were no significant differences in allele and genotype frequencies of two SNPs in normotensives and hypertensives. With respect to Hinc II RFLP in the LDL receptor gene, pooled odds ratio value indicated the significant heterogeneity among populations studied by meta-analysis (Breslow-Day test df = 2, P<0.05). In the case of Bam HI RFLP in the CETP gene,. our study is the first report of an association between the SNP of the CETP gene and hypertension, although our result failed to demonstrate the significant association between the Bam HI RFLP of the CETP gene and hypertension in Korean population. Further work, using larger sample sizes and various ethnic groups, is required to establish the precise role of these two candidate gene polymorphisms on hypertension.

  • PDF

콩 발효 식품(청국장, 물두시, 낫또)의 특성, In Vitro 항돌연변이 및 항암 효과 (Comparisons of Properties, In Vitro Anti-Mutagenicity, and Anti-Cancer Effects of Short-Term Fermented Soybean Foods (Chungkukjang, Shuidouchi, and Natto))

  • 조흔;주재현;박건영
    • 한국식품영양과학회지
    • /
    • 제46권10호
    • /
    • pp.1253-1257
    • /
    • 2017
  • 본 연구에서는 콩에서 유래한 단기 발효식품인 청국장, 물두시, 낫또 제품 중 대표적인 제품을 각각 하나씩 선택하여 이들의 일반적 특성과 항돌연변이 효능 및 항암 효능을 비교 연구하였다. 청국장은 아미노태 질소 및 암모니아태 질소의 함량이 높았으나, 낫또는 그 함량이 낮게 나타났다. 물두시의 경우 여타 발효식품에 비해 pH가 낮고 산도가 높았다. Ames test 및 HT-29 인체 대장암세포를 이용한 실험에서는 청국장이 우월한 항돌연변이 및 항암 효능을 나타냈다. 이상의 결과로 볼 때 청국장은 전반적으로 기능성이 우수한 것으로 나타났으며, 물두시는 낫또에 비해 기능성이 더 나은 것으로 나타났다. 이는 발효 기간의 차이, 제조방식, 원재료의 품질 등에 의한 것으로 여겨지며, 향후 각국의 식문화 및 조리 방식 등의 차이에 기초를 둔 추가적인 연구가 필요할 것으로 여겨진다.

1990년대 패션에 나타난 오리엔탈리즘에 관한연구 (A Study on the Orientalism Expressed in the Fashion of 1990's)

  • 은영자
    • 복식
    • /
    • 제43권
    • /
    • pp.259-282
    • /
    • 1999
  • To analyze the characteristics of Orientalism which is expressed in the fashion of the 1990's this study was examined according to three aspects such as form textiles and pattern and the aspects was considered with regard to Chinese Indian Japanese Korean, Southeas Asian and North African style. 1. In form Orientalism which is influenced by latest other fashion trend; Naturalism and Minimalism is expressed as a comfortable casual style which simplifies the way of wearing and mixes the characteristic elements of folk costume with western costume. The way of layerd wearing like knotting wrapping draping and the symbolic from which is inspired by the unique are of each country are shown. 2. In textiles Chinese Japanese and Indian silk as well as Southeast Asian and North African cotton show a splendid oriental impression using vivid color. On the other hand the linens of Korea like hemp and ramie emphasize natural characteristics and show a simple and unartificial oriental beauty. But in the use of material and color it shows a remarkable tendency to break the preconceived idea by coordinating a luxurious silk with a practical denim or harmonizing technical new-masterials with traditional materials. 3. In pattern the decorative elements of Orientalism such as a traditional pattern skills to dye embroidery and other decorations are emphasized on the form of western costume. The sketchy patterns of Chinese Korean and Japanese styles which include the pattern of a flower a bamboo and a butterfly are expressed using embroidery or textile printing. The geometrical seriate patterns of Southeast Asian and North African styles use traditional dyeing methods like Batik. Also the Indian technique of decoration like Mirro Work satisfies handcrafted royalty and feminine romantic taste in modern minimal fashion. The Orientalism expressed in the fashion of 1990's emphasizes the characteristics of people wearing colthing which break the preconceived idea by simplifying the form harmonizing differences between oriental and western cultures and mixing the elements of traditional costumes among countries. Most of all. Ethno using geonmetrical seriate pattern and technical new metal material and Romantic Ethnic using flower embroidery precious stones and beads are appearing as a distinctinve feature.

  • PDF

Hypodontia and Hyperdontia of Permanent Teeth in Korean Schoolchildren

  • Moon Hyock-Soo;Cho Sun-Chul;Choung Pill-Hoon
    • 대한구순구개열학회지
    • /
    • 제4권2호
    • /
    • pp.19-27
    • /
    • 2001
  • This study was performed to determine the prevalence of hypodontia and hyperdontia of permanent teeth among Korean schoolchildren, and to compare differences in the prevalence between Korea, other country, and other ethnic groups. The sample consisted of 346 girls aged 6.9~0.3 yr and 375 boys aged 6.8~0.4 yr on whom a panoramic radiograph was taken at Yeonchun-Gun community in Korea. The prevalence of congenitally missing teeth (third molars excluded) was 6.7% in boys and somewhat higher, 9.5% in girls, and 8.0% for both sexes combined. On the average, number of missing teeth per affected child was 1.9 teeth. The most commonly congenitally missing teeth were the mandibular second premolar (32.7%), followed by the mandibular incisor (28.7%), the maxillary second premolar (16.7%), and the maxillary lateral incisors (10.2%). The prevalence of supernumerary teeth was 2.1 % in boys, 1.4% in girls, and 1.8% for both sexes combined. The most common supernumerary teeth were the mesiodens (76.9%), followed by the supernumerary premolar (23.1 %). The affected male-female ratio was 1.6: 1.0. The prevalence of congenital missing teeth in this study was similar to in studies of Japanese, Danish, American and German. The frequency of hyperdontia was lower in this study than in studies of Chinese children, Japanese and American.

  • PDF

한국인 무치악환자의 인공치아선택방법에 관한 연구 (A STUDY ON THE SELECTION OF ARTIFICIAL TEETH FOR THE EDENTULOUS PATIENTS IN KOREANS)

  • 김성훈;신상완
    • 대한치과보철학회지
    • /
    • 제34권3호
    • /
    • pp.457-463
    • /
    • 1996
  • An esthetically pleasing result in denture service is dependent upon several consideration. Esthetic considerations for the edentulous patient include tooth size, shape, arrangement, positioning, gingival contour, age, sex, personality differences, and ethnic type. Especially, the form of anterior artificial teeth is an important factor on the esthetics. The selection of artificaial teeth requires understanding and knowledge on physical and biologic factors and has to meet the indivisul esthetics and functional needs of each patient. However, the selection of artificial teeth is based on the large degree of subjective judgement of the dentist, Therefore, this is one of the most unscientific processes. Many attempts have been made to find a guideline for the selection of artificial teeth. Temperamental theory by White and Hall utillized with the physical characteristics such as body size, body form, color of eyes and hair, and disposition. SPA theory by Frush and Fisher utilized with the basis of sex, personalities, and age of the indivisual. There has not been provided for a guideline and study on the selection of artificial teeth for Koreans yet. This study was aimed to evaluate the William's typal matching theory in Koreans. 1. The facial forms of korean adult were ovoid(46.3%), square(36.7%) and tapered(17.0%) form. 2. The anatomic forms of natural maxillary incisors were ovoid(45.3%), tapered(31.3%), square(23.3%) form. 3. The forms of face and natural maxillary incisors were ovoid(21.9%), squared(11%), tapered(6.3%). 4. The natural maxillary incisors were similar in form to the facial form only in 39%. There was no correlation between the form of the face and the form of natural maxillary central inisors in Koreans. 5. Artificaial teeth which was selected according to the typal matching theory did not represent the form of the natural teeth in 61 per cents of the fatal, but it felt that they harmonized with the form of the patient's face and produced good results.

  • PDF