• Title/Summary/Keyword: ergosta-5,24(28)-dien-$3{\beta}$-ol

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Development of Biologically Active Compounds from Edible Plant Sources XVIII. Isolation of Derivatives of Ergosterol from the Fruit Body of Phellinus linteus (식용 식물자원으로부터 활성물질의 탐색-XVIII. 상황버섯 (Phellinus linteus) 자실체로부터 Ergosterol 유도체의 분리)

  • Lyu, Ha-Na;Yoo, Jong-Su;Song, Myoung-Chong;Lee, Dae-Young;Kim, Dong-Hyun;Rho, Young-Duk;Kim, In-Ho;Baek, Nam-In
    • Applied Biological Chemistry
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    • v.50 no.1
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    • pp.57-62
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    • 2007
  • The fruiting body of Phellinus linteus was extracted with 80% aqueous MeOH, and the concentrated extract was partitioned with EtOAc, n-BuOH and $H_2$O. The repeated silica gel and ODS column chromatographies of the EtOAc fraction led to isolation of four sterols. From the result of spectral data including NMR, MS and IR, the chemical structures of the sterols were determined as ergosta-7,24(28)-dien-3${\beta}$-ol (episterol, 1), 5${\alpha}$,8${\alpha}$-epidioxyergosta-6,9(11),22-trien-3${\beta}$-ol (dehydrop-eroxyergosterol, 2), 5${\alpha}$,8${\alpha}$-epidioxyergosta-6,22-dien-3${\beta}$-ol (ergoterol peroxide, 3), and $3{\beta}$,$5{\alpha}$-dihydroxy-6${\beta}$-methoxyergosta-7,22-diene (6-O-methylcerevisterol, 4). The ergosterols have been first isolated from this mushroom in this study.

Chemical Constituents from the Stony Coral Alveopora japonica

  • Youn, Ui-Joung;Lee, Yoo-Jin;Jeon, Ha-Rim;Shin, Hyun-Ji;Son, Young-Min;Nam, Joo-Won;Han, Ah-Reum;Song, Jun-Im;Won, Yong-Jin;Seo, Eun-Kyoung
    • Natural Product Sciences
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    • v.17 no.1
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    • pp.1-4
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    • 2011
  • Chemical investigations of the stony coral Alveopora japonica Eguchi (Poritidae) resulted in the isolation of four known compounds (1 - 4). The structures of 1 - 4 were identified as a sterol, ergosta-5,24(28)-dien-$3{\beta}$-ol (1), a mixture of monoacyl glycrols (2), eicosanoic acid and tetracosanoic acid, and two nucleosides, thymine (3) and 2'-deoxythymidine (4), respectively, on the basis of spectroscopic and physicochemical analyses including 1D- and 2D- NMR techniques as well as by comparison of their data with the published values. Compounds 1 - 4 were isolated from this species for the first time. Moreover, these compounds (1 - 4) were found in the genus Alveopora and the family Poritidae for the first time.