• Journal of the Korea Convergence Society
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• v.10 no.12
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• pp.387-397
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• 2019

The purpose of this study is to analyze the relationship between health related physical fitness, cognitive function, depression and quality of life variables of elderly people in a comprehensive way based on quantitative evaluation. The subjects of this study were 385 people who voluntarily participated in the elderly welfare center in Gyeonggi and Seoul the elderly people. As for the data collection methods, were measured the characteristics, depression and quality of life, cognitive function questionnaires along with measures of lower and upper body strength, dynamic equilibrium and agility, total endurance and grip strength. As a result, the first was a statistically significant correlation between integrated health of the elderly, cognitive function, quality of life and depression. Second, the analysis of cognitive function, elderly integrated health, quality of life, and depression revealed statistical significance among all variables. Third, there was the partial intervention effect of function in the quality of life and depression of the elderly.

• Journal of the Korean Electrochemical Society
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• v.2 no.2
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• pp.70-74
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• 1999

The electrode kinetic parameters at the Pd/0.5 M LiOH electrolyte interface have been qualitatively studied using the phase-shift method. The phase shift $(\phi)$ depends on both the cathode potential (E>0) and frequency (f), and $\theta$ is inversely proportional to the fractional surface coverage $\theta$. At an intermediate frequency (10 Hz), the phase-shift profile $(\phi\;vs.\;E)$ can be related to the fractional surface coverage $(\theta\;vs.\;E)$. The phase-shift method can be used to estimate or plot the Frumkin adsorption isotherm. The rate (r) of change of the free energy of adsorption with $({\theta})$ is 22.3 kJ/mol. The equilibrium constant (K) for adsorption and the standard free energy $({\Delta}G_{\theta})$ of the adsorbed hydrogen atom $(H_{ads})$ are $3.7\times10^{-3}{\Delta}G_{\theta}>-8.4kJ/mol$, respectively. For 1$0.38>\theta>0$, the energy liberation or the exothermic reaction for hydrogen adsorption at the Pd cathode can be occurred. The electrode kinetic parameters $(r,\;K,\;{\Delta}G_{\theta}$ depend on the fractional surface coverage $({\theta})$ or the phase shift $(\phi)$.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.5 no.1
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• pp.123-132
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• 1985

The flexibility of base material gives considerable influences on seismic responses of a structure. The effects of relative stiffness between super-structure and base material on dynamic soil-structure interaction are evaluated by parametric studies. Two 5-story buildings are used for the study; one is shearwall structure with relatively higher fundamental frequency and the other is frame structure with relatively lower fundamental frequency. The structures are modeled as beam-sticks coupled with springs and dashpots representing the base material. Dynamic equilibrium equations of the soil-structure interaction system are sloved by mode superposition method using Rosset modal damping values. Soil-structure interaction effect is found to be major concern in seismic analysis of shearwall structure in most cases while it seldom becomes engineering problem in frame-type structure. It is also found that seismic responses at lower elevation of the super-structure are amplified though they decrease at higher elevation as soil-structure interaction effects of the system increase.

• The Korean Journal of Petroleum Geology
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• v.7 no.1_2 s.8
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• pp.1-6
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• 1999

Natural gas hydrate, a solid compound of natural gas (mainly methane) and water in the low temperature and high pressure, is widely distributed in permafrost region and deep sea sediments. Gas hydrate stability field (GHSF), which corresponds to the conditions of a stable existence of solid gas hydrate without dissociation, depends on temperature, pressure, and composition of gas and interstitial water. Gas hydrate-saturated sediment are easily recognized by the bottom simulating reflector (BSR), a strong-amplitude sea bottom-mimic reflector in seismic profiles. It is known that BSR is associated with the basal boundary of the GHSF, The purpose of this study is to define the GHSF and its occurrence in the southwestern part of Ulleung Basin, East Sea. The hydrothermal gradient is measured using the expandable bathythermograph (XBT) and the geothermal gradient data are utilized from previous drilling results for the adjacent area. By the laboratory work using methane and NaCl $3.0 wt{\%}$ solution, it is shown that the equilibrium pressures of the gas hydrate reach to 2,920.2 kPa at 274.15 K and to 18,090 kPa at 289.95 K for the study area. Consequently, it is interpreted that the lower boundary of the GHSF is about 210 m beneath 400-m-deep sea bottom and about 480 m beneath 1,100-m-deep sea bottom. The resultant boundary is well matched with the depth of the BSR obtained from the seismic data analysis for the study area.

• Pediatric Infection and Vaccine
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• v.15 no.2
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• pp.195-201
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• 2008

Purpose : We hypothesized that the mannose binding lectin gene (MBL2), a key molecule of innate immunity may contribute to the development of Kawasaki disease (KD) in early childhood. This study was performed to investigate the polymorphisms of MBL2 and the risk of developing KD in Korean children. Methods : The study subjects were 112 children with KD who were admitted to the Seoul National University Bundang Hospital between October 2003 and March 2005. The control subjects consisted of 224 anonymous, healthy Korean blood donors. Extracted genomic DNA was amplified for codon 54 of MBL2 exon 1 and alleles (a and b) were assigned via sequencing analysis. The frequency of the alleles of the MBL2 exon 1 was compared between the case and control groups. Results : The median age of patients was 27 months (range, 3 months-7 years), 45.5% were <24 months of age and 54.5% were ${\geq}2$ years. The genotype distribution reached Hardy-Weinberg equilibrium in both cases and control subjects. In the cases with KD, the genotypic frequencies of codon 54 polymorphisms were 67.9% for aa, 29.5% for ab, and 2.6% for bb. There were no significant differences in the overall distribution of the polymorphisms between the cases and the control subjects. In addition, the genotype distribution was not different according to age. Conclusions : Our findings indicate that the codon 54 polymorphism of the MBL2 gene is not likely to contribute to the risk of developing KD in Korean children. Further studies on the development of coronary artery lesions with regard to MBL2 genotypes are warranted.

• Journal of the Korean Chemical Society
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• v.58 no.6
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• pp.560-568
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• 2014

The contribution of electrostatic interactions to protein folding reaction was studied by using mutant ubiquitin with lysine to alanine mutation at residue position 29. Based on the three dimensional structure of ubiquitin, lysine 29 is located close to negatively charged glutamate 16 and aspartate 21 and considered to stabilize the native state of ubiquitin by electrostatic interactions between these residues. The equilibrium unfolding experiment showed that the native stability was decreased by about ~20% upon mutation. This observation indicates lysine 29 indeed forms electrostatic interactions with nearby residues. Folding kinetics measurements using stopped-flow device and quantitative analysis of kinetics data indicate that ubiquitin folds from unfolded state to native state via intermediate state as observed previously. This intermediate state was observed to form immediately after the initiation of folding reaction. The folding intermediate was shown to be destabilized considerably upon lysine to alanine mutation. These observations indicate that electrostatic interactions can form early stage of protein folding and hence lead the folding reaction.

• Korean Journal of Agricultural Science
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• v.23 no.1
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• pp.25-38
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• 1996

To investigate the stability problem of irrigation-drainage channel excavation slope on soft ground, analyzed the behavior of the soft ground with excavation slope by the limit equilibrium method and the finite element method, and compared with field tests. The results of this study were summarized as follows; 1. When rapid drawdown the water level, the crack was occurred by the effect of the excess pore water pressure, and the pore water pressure was decreased slowly. 2. As the width of excavation was larger, the crack width was larger. And, excavated depth was deeper, the progressive failure was appeared. 3. When the soft ground excavation was small-scale, the minimum safety factor was more effected by cohesion(1.0, 1.5, 2.0, 2.5, 3.0) than excavated slope inclination(1:l, 1:1.5, 1:2). 4. As excavation was progressed, the settlement occurred on the top-slope due to plastic domain, and heaving was occurred at the bottom of excavation. 5. The maximum shear stress was appeared greatly as the base part of slope went down. Because of the increase of the maximum shear stress, tension area occurred and local failure possibility was increased. 6. As the excavation depth was increased, the maximum shear strain was appeared greatly at the base of slope and distribution pattern was concentrated beneath the middle of slope.

• Journal of the Korean Geotechnical Society
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• v.27 no.3
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• pp.41-54
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• 2011

The present study analyzes the stability of waterfront quay wall under the combined action of earthquake and tsunami. Adopting the limit equilibrium method, the stability of waterfront quay wall is checked for both the sliding and overturning. Forces due to tsunami are compared with the proposed formula and the 3-D one-field Model for immiscible TWO-Phase flows (TWOPM-3D). Variations of the stability of wall are also proposed by the parametric study including tsunami water height, horizontal seismic acceleration coefficient, internal friction angle of soil, friction angle between the wall and the soil and the pore water pressure ratio. The present study about the stability of wall is also compared with the case when earthquake and tsunami are not considered. As a result, the result of numerical analysis about the tsunami force is similar to that of proposed formula. When earthquake and tsunami are simultaneously considered, the stability of wall in passive case significantly decreases and tsunami forces in active case are affected as a resistance force on the wall and so the stability of wall increases.

• Journal of the Korean GEO-environmental Society
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• v.4 no.2
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• pp.77-91
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• 2003

The Hoek-Brown failure criterion for rock masses developed first in 1980 is widely accepted and has been applied in a variety of rock engineering problems including slope analyses. The failure criterion was modified over the years because rock mass strength by the original failure criterion in 1980 was overestimated. The modified failure criterion, named Generalized Hoek-Brown Failure Criterion, was proposed with a new classification called the Geological Strength Index(GSI) in 1994. Generally, Hoek-Brown failure criterion is applied in numerical analyses of rock mass behaviors using equivalent Mohr-Coulomb parameters estimated by linear regression method. But these parameters estimated by this method have some inaccuracies to be applied and to be incorporated into numerical models and limit equilibrium programs. The most important issue is that this method cannot take account of non-linear characteristics of Hoek-Brown criterion, therefore, equivalent Mohr-Coulomb parameters is used as constant values regardless of field stress distribution in rock masses. In this study, the numerical analysis on rock slope stability considering non-linear characteristics of Hoek-Brown failure criterion was carried out. Futhermore, by the latest Hoek-Brown failure criterion in 2002, the revised estimating method of equivalent Mohr-Coulomb parameters was applied and rock mass damage criterion is introduced to account for the strength reduction due to stress relaxation and blast damge in slope stability.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.12
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• pp.5069-5073
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• 2015

The single nucleotide polymorphism (SNP) rs1053004 in Signal transducer and activator of transcription 3 (STAT3) was recently reported to be associated with chronic hepatitis B (CHB)-related hepatocellular carcinoma (HCC) in a Chinese cohort. This study was aimed at investigating whether the SNP might also contribute to HCC susceptibility in the Thai population. Study subjects were enrolled and divided into 3 groups including CHB-related HCC (n=211), CHB without HCC (n=233) and healthy controls (n=206). The SNP was genotyped using allelic discrimination assays based on TaqMan real-time PCR. Data analysis revealed that the distribution of different genotypes was in Hardy-Weinberg equilibrium (P>0.05). The frequencies of allele T (major allele) in HCC patients, CHB patients and healthy controls were 51.4%, 58.6% and 61.4%, respectively, whereas the frequencies of C allele (minor allele) were 48.6%, 41.4% and 38.6%. The C allele frequency was higher in HCC when compared with CHB patients (odds ratio (OR)=1.34, 95% confidence interval (CI)=1.02-1.74, P=0.032). The genotype of SNP rs1053004 (CC versus TT+TC) was significantly associated with an increased risk when compared with CHB patients (OR=1.83, 95% CI=1.13-2.99, P=0.015). In addition, we observed a similar trend of association when comparing HCC patients with healthy controls (OR=1.77, 95% CI=1.07-2.93, P=0.025) and all controls (OR=1.81, 95% CI=1.19-2.74, P=0.005). These findings suggest that the SNP rs1053004 in STAT3 might contribute to HCC susceptibility and could be used as a genetic marker for HCC in the Thai population.