• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제27권2호
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• pp.79-87
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• 2024

Purpose: Recently, the prevalence of eosinophilic gastrointestinal disease (EGID) has shown an increasing trend worldwide. As the diagnosis of EGID requires invasive endoscopy with biopsy, noninvasive markers for detecting EGID in suspected patients, particularly children, are urgently needed. Therefore, this study aimed to evaluate the diagnostic accuracy of serum eosinophil cationic protein (ECP) beyond peripheral eosinophil counts in pediatric patients with EGID. Methods: Overall, 156 children diagnosed with EGID were enrolled and 150 children with functional abdominal pain disorder (FAPD) were recruited as controls. All participants underwent endoscopic biopsy in each segment of the gastrointestinal (GI) tract and serum ECP measurement, as well as peripheral eosinophil percent and absolute eosinophil count. Results: Comparing EGID (n=156) with FAPD (n=150) patients, serum ECP levels were significantly higher in pediatric patients with EGID than in those with FAPD (25.8±28.6 ㎍/L vs. 19.5±21.0 ㎍/L, p=0.007), while there was no significant difference in peripheral eosinophil percent and absolute eosinophil counts between the two groups. Serum ECP levels were correlated with peripheral eosinophil percent (r=0.593, p<0.001) and the absolute eosinophil count (r=0.660, p<0.001). The optimal cutoff value of serum ECP for pediatric EGID was 10.5 ㎍/mL, with a sensitivity of 69.9% and a specificity of 43.4% with an area under the receiver operating characteristic curve of 0.562. Conclusion: The combination of serum ECP levels and peripheral eosinophil counts, when employed with appropriated thresholds, could serve as a valuable noninvasive biomarker to distinguish between EGID and FAPD in pediatric patients manifesting GI symptoms.

• 대한세포병리학회지
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• 제11권2호
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• pp.109-114
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• 2000

Amyloid golfer is a rare disease entity that is defined as a symptomatic mass or clinically detectable thyroid enlargement because of amyloid deposition. We present a case of amyloid golfer diagnosed in the fine needle aspiration cytology(FNAC) in a 73-year-old Korean woman presented with nephrotic syndrome and thyroid enlargement. The thyroid function was in normal range. Thyroid scan showed a nodule, $4{\time}2cm$ in the right lobe with underlying diffuse golfer. Aspirates revealed benign looking follicular cells and scattered eosinophilic material. The sections of the cell block showed nodular deposit of eosinophilic hyalinized material in the interfollicular area. It showed apple-green birefringence under polarization with Congo red stain. The renal biopsy also exhibited deposition of eosinophilic materials in the glomeruli and interstitial vascular wall, which were confirmed as amyloidosis. This material was morphologically distinct from the colloid.

• Investigative Magnetic Resonance Imaging
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• 제16권1호
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• pp.76-80
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• 2012

간 내 호산구 침윤은 드문 질환이 아니며 문맥기의 컴퓨터 단층촬영에서 대게 작고, 다수며, 형태가 명백하지 않으며 타원형 혹은 둥근 형태의 낮은 감쇠 병변으로 발현된다. 저자들은 간 내 호산구 침윤의 비특이적 소견의 간 분절침윤 형태의 소견을 보고하고자 한다.

• 대한의생명과학회지
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• 제23권1호
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• pp.44-47
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• 2017

S100A8 and S100A9 are associated with myeloid cell differentiation, chemotactic activities, adhesion of neutrophils, and apoptosis. In this study, we investigated the contribution of S100A8 and S100A9 to differentiation of the human eosinophilic leukemia cell line, EoL-1. S100A8 and S100A9 increased the number of vacuole per one cell and the protein expression of EPO and MBP. Rottlerin, an inhibitor of protein kinase C delta ($PKC{\delta}$), inhibited the EoL-1 cell differentiation induced by S100A8 and S100A9. These results suggest that S100A8 and S100A9 may regulate the differentiation of eosinophilic progenitors. Moreover, these findings may shed light on elucidation of eosinophil differentiation due to S100 proteins.

• Journal of Yeungnam Medical Science
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• 제28권2호
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• pp.192-195
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• 2011

Tracheal diverticulum is relatively rare. It results from congenital or acquired weakness of the tracheal wall. Most cases are asymptomatic, but when symptoms are present, they are usually nonspecific. A 54-year-old man complained of sputum lasting for several months. Chest computed tomography showed an air-containing cystic structure in the trachea. Fiberoptic bronchoscopy demonstrated ostium arising from the right posterolateral wall at the trachea. Reported herein is a case of eosinophilic bronchitis associated with tracheal diverticulum.

• 대한두개안면성형외과학회지
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• 제10권1호
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• pp.37-39
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• 2009

Purpose: Langerhans cell histiocytosis is a heterogenous group of Langerhans cell proliferative disorders and includes eosinophilic granuloma, Letterer-Siwe diseases, and Hand-Schuller Christian disease. We report a case of eosinophilic granuloma on frontal area. Methods: A 17-year-old male presented with swelling and tenderness on Lt. frontal and periorbital area. CT and MRI showed a $33{\times}25mm$ sized mass that involved Lt. frontal calvarium, frontotemporal meninges, and orbital roof. Results: Total excision of the mass and adjacent soft tissue, calvarium, and orbital roof was performed. Orbital roof defect was reconstructed with absorbable plate and calvarial defect was done with outer cortex of temporal bone flap. The histology revealed proliferation of histiocytes and eosinophils. Immunologically, these histiocytic cells expressed S-100 protein and CD1a. The patient is currently taking conservative treatment. Conclusion: The severity of these disease and their prognosis and treatments are various. For unifocal cranial Langerhans cell histiocytosis, complete excision is the treatment of choice. We report this case with review of literature.

• 한국임상수의학회지
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• 제29권3호
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• pp.247-249
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• 2012

8살된 코커스파니엘 수캐가 지속적인 혈뇨 때문에 강원대학교 대학병원에 진료의뢰 되었다. 진단검사상, 지속적인 혈뇨, 경미한 백혈구 증가증, 단백뇨 및 초음파상 불규칙한 모양의 코에코성 종괴가 관찰되었다. 종괴는 주변 방광조직으로부터 분리되어 있었고 결절 형태를 띠고 있었다. 조직검사상, 호산구를 주요 세포로 하는 염증세포 침윤과 출혈 및 상피비후 소견이 관찰되었다. 진단검사를 토대로 호산구성 폴립성 방광염으로 진단되었다. 환자에서 외과적으로 병소를 제거하였고 meloxicam과 amitriptyline을 이용하여 내과적으로 처치하였다. 치료는 성공적이였고 재발은 현재까지 되지 않고있다.

• Tuberculosis and Respiratory Diseases
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• 제75권4호
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• pp.161-164
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• 2013

Eosinophilic pleural effusion (EPE) is defined as a pleural effusion that contains at least 10% eosinophils. EPE occurs due to a variety of causes such as blood or air in the pleural space, infection, malignancy, or an autoimmune disease. Undifferentiated connective tissue disease (UCTD) associated with eosinophilic pleural effusion is a rare condition generally characterized by the presence of the signs and symptoms but not fulfilling the existing classification criteria. We report a case involving a 67-year-old man with UCTD and EPE, who has been successfully treated with a single intrapleural corticosteroid injection.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제23권3호
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• pp.231-242
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• 2020

Purpose: In East Asian countries, there are only a few epidemiologic studies of eosinophilic esophagitis (EoE) and no studies in children. We investigated the incidence and compared the clinical characteristics of EoE and eosinophilic gastroenteritis involving the esophagus (EGEIE) in Korean children. Methods: A total of 910 children, who had symptoms of esophageal dysfunction, from 10 hospitals in Korea were included. EoE was diagnosed according to diagnostic guidelines and EGEIE was diagnosed when there were >15 eosinophils in the esophagus per high power field (HPF) and >20 eosinophils per HPF deposited in the stomach and duodenum with abnormal endoscopic findings. Results: Of the 910 subjects, 14 (1.5%) were diagnosed with EoE and 12 (1.3%) were diagnosed with EGEIE. Vomiting was the most common symptom in 57.1% and 66.7% of patients with EoE and EGEIE, respectively. Only diarrhea was significantly different between EoE and EGEIE (p=0.033). In total, 61.5% of patients had allergic diseases. Exudates were the most common endoscopic findings in EoE and there were no esophageal strictures in both groups. The median age of patients with normal endoscopic findings was significantly younger at 3.2 years, compared to the median age of 11.1 years in those with abnormal endoscopic findings (p=0.004). Conclusion: The incidence of EoE in Korean children was lower than that of Western countries, while the incidence of EGEIE was similar to EoE. There were no clinical differences except for diarrhea and no differences in endoscopic findings between EoE and EGEIE.

• 한국동물학회지
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• 제28권3호
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• pp.194-208
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• 1985

실험에 사용한 플라나리아는 Dugesia japonicia Ichikawa et Kawakatsu로서 核型分析에 의하여 種을 확인하였다. 이 種의 表皮上皮을 구성하는 세포들의 세포화학적 및 미세구조적 특징을 밝히고자 본 실험을 行하였다. 세포화학적 방법으로는 hematoxylin-eosin, periodic acid-schiff(PAS)反應, alcian blue(pH 2.5), PAS-alcian blue反應 그리고 methylene blue-basic fuchsin 등으로 염색을 시행하였고, 체표면을 走査電子顯微鏡으로, 또한 各部位의 微細構造를 透過電子顯微鏡으로 관찰하여 다음과 같은 결과를 얻었다. 플라나리아의 表皮는 單層圓桂形上皮로 되어 있었고, 상피를 구성하는 세포들은 형태학적 및 세포화학적 특성에 의하여 6類型의 세포들도 區分되었다. 1) 纖毛上皮細胞 (Ciliated epithelial cell) : microtubule 배열이 9+2型인 섬모를 가지고 있었다. 2) 好酸性細胞(Eosinophilic cell) : 세포질에 소수의 큰 好酸性 顆粒을 가진 세포로서, 전자 현미경하에서는 顆粒들은 棒狀形이고, 전자밀도가 매우 낮은 基質에 섬유상 구조물이 분산되어 있었다. 3) 粘液細胞(Mucous cell) : 세포질에 PAS 반응에 강한 陽性을 보이는 다양한 모습의 과립($0.8\\times0.3 \\muM$) 들이 충만되어 있었다. 4) 棒狀體形成細胞(Rhabdite-forming cell) : 세포질쪽에 매우 강한 eosinophilia를 나타내는 다양한 크기의 棒狀體顆粒을 한 개 혹은 여러개 가지고 있었으며, 顆粒의 전자밀도는 높았다. 5) A型 好鹽基性顆粒細胞(Basophilic granule cell type A) 背腹部 상피에서 관찰되었고 그 세포질에는 alcian blue(ph2.5)에 강하게 염색되는 $1.5\\times1.0 \\mum$의과립들을 상당히 많이 포함하고 있었다. 과립들은 형태가 球形에 가깝거나 혹은 불규칙형이였고 전자밀도가 높았다. 이類型의 세포들은 柔組織에서 基底膜은 通過하여 表皮上皮로 이동되었다. 6) B型 好鹽基性細胞(Basophilic granule cell type B) 兩側部의 表皮上皮에서 관찰되었으며 세포질에는 PAS 반응에 강한 陽性을 보이는 $0.7\\times0.4 \\mum$의 과립들을 상당히 많이 包含하고 있었다. 전자밀도가 매우 높은 과립들의 형태는 비교적 불규칙하였다. 이類型의 세포들은 역시 柔組織에서 표피로 이동되었다.