• Biomolecules & Therapeutics
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• v.29 no.4
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• pp.399-409
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• 2021

1,2-Diacetylbenzene (DAB) is a metabolite of 1,2-diethylbenzene, which is commonly used in the manufacture of plastics and gasoline. We examined the neurotoxic effects of DAB in young and old rats, particularly its effects on hippocampus. Previously, we reported DAB impairs hippocampal neurogenesis but that the underlying mechanism remained unclear. In this study, we evaluate the toxicities exhibited by DAB in the hippocampi of 6-month-old (young) and 20-month-old (old) male SD rats by treating animals intraperitoneally with DAB at 3 mg/kg/day for 1 week. Hippocampal areas were dissected from brains and RNA was extracted and subjected to RNA-seq analysis. RNA results showed animals exhibited age-dependent sensitivity to the neurotoxic effects of DAB. We observed that inflammatory pathways were up-regulated in old rats but that metabolism- and detoxification-related pathways were up-regulated in young rats. This result in old rats, especially upregulation of the TREM1 signaling pathway (an inflammatory response involved in Alzheimer's disease (AD)) was confirmed by RT-PCR. Our study results provide a better understanding of age-dependent responses to DAB and new insight into the association between DAB and AD.

• Journal of Korean Library and Information Science Society
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• v.37 no.1
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• pp.3-28
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• 2006

The purpose of this study is to describe the problems. which academic libraries in the V.S., U.K., Australia, and Canada have faced since the 1990s. These problems are mostly caused by environmental changes in higher education. In this study, only discussed are the problems that academic libraries in various countries have commonly experienced. but not unique ones libraries in each country has due to its own national, societal, cultural, academic or informational situations. Major problems include continuing decrease in library expenditures, changing role of libraries themselves. changing nature of library collections, development of information technology and technological Infrastructure on campus, steep increase in prices of scholarly journals, and relative decrease in purchasing powers of libraries. These Problems are all closely inter-related, and seem to require more comprehensive and systematic strategic solutions carried out by the national or government intervention, rather than individual libraries.

• Journal of Environmental Science International
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• v.19 no.11
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• pp.1437-1444
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• 2010

This research was to find out the effectiveness of the horticultural therapy program based on the therapeutic factors and the most meaningful experiences of the clients. For this purpose "Green harmony" program focused on harmony through horticulture was implemented. It is based on the preposition that holistic health is promoted with harmonious relationships with oneself, other people, community and nature. The program has three-fold structure: In innermost it deals with the task of the late adolescent, i.e., self identity, secondly the experience of communication and solidarity in the group, and finally extension of interest to the community. For the therapeutic intervention, questions using the metaphor of the activity were given to the clients for the establishment of self-identity, while group activity and the donation of the works let the second and third purpose accomplished. Outdoor activity, 'Tire garden project', has provided the clients with chances of the contact with nature, cooperation with other group members, and a contest to provoke enthusiasm. Also recycling and greening of the community were possible by utilizing old tires for the containers and by donating the final works to the community. For the evaluation of the result, the effect of the program on the stress of the college students was tested, and the most meaningful experiences during the participation to the program were asked to identify the therapeutic factors acknowledged by clients. "Green harmony" program has brought positive effects on the stress of the clients in spite of relatively short period of five weeks. The clients has acknowledged plant/nature contact and interactions between group members for the most meaningful experiences. This research suggests "Green harmony" horticultural therapy program based on the therapeutic factors is highly applicable for the general populations.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.4
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• pp.2131-2136
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• 2016

Background: Cancer is currently one of the main public health problems all over the world and its economic burden is substantial both for health systems and for society as a whole. To inform priorities for cancer control, we here estimated years of potential life lost (YPLL) and productivity losses due to cancer-related premature mortality in Iran from 2006 to 2010. Materials and Methods: The number of cancer deaths by sex and age groups for top ten leading cancers in Iran were obtained from the Ministry of Health and Medical Education. To estimate the YPLL and the cost of productivity loss due to cancer-related premature mortality, the life expectancy method and the human capital approach were used, respectively. Results: There were 138,228 cancer-related deaths in Iran (without Tehran province) of which 76 % (106,954) were attributable to the top 10 ranked cancers. Some 63 % of total cancer-related deaths were of males. The top 10 ranked cancers resulted in 106,766,942 YPLL in total, 64,171,529 (60 %) in males and 42,595,412 (40%) in females. The estimated YPPLL due to top 10 ranked cancers was 58,581,737 during the period studied of which 32,214,524 (54%) was accounted for in males. The total cost of lost productivity caused by premature deaths because of top 10 cancers was 1.68 billion dollars (US$) from 2006 to 2010, ranging from 251 million dollars in 2006 to 283 million dollars in 2010. Conclusions: This study showed that the economic burden of premature mortality attributable to cancer is significant for Iranian society. The findings provide useful information about the economic impact of cancer for health system policy/decision makers and should facilitate planning of preventive intervention and effective resource allocation.

• Journal of Wetlands Research
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• v.22 no.3
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• pp.217-224
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• 2020

Waterlogging and unintended lake formation become the main problem in some parts of the world. Starting from 1989, the waterlogging problem was observed in the farmland of the Jarso community of Konso Woreda adjacent to the Segen River in Ethiopia. Therefore, the objectives are determining the extent and causes of unintended lake formation using GIS/RS in addition to a preliminary field survey to mitigate the problem. The analysis of satellite images revealed that over the years invasion of the irrigable land by unwanted water had increased, as, in 1989, the size of the wetland area was about 8 Km²; in 2000 the size of the un-intended lake was only 8.23 ㎢. Alarmingly the size of the lake increased to 19.68 Km² in 2014. Silting up of Weir and changing the flow of River Segen and Human Intervention and changing the natural flow of River Yanda were the main causes of this unwanted prolonged water-logging. The ecological and social environment has been degrading as the people of the waterlogged area have been experiencing some settlement and losing their land. Another problem encountered was flooding from River Barka and invasion of the farmland. Sediment control best management practices (BMPs) i.e, Removal of sediment, providing sandbags and well-scheduled maintenance; Changing the junction point of Yanda and Segen River were suggested for the long-term and short term possible remedial measures. Gabion retaining wall on the bank of the Segen River to the face of Barka River was suggested to protect the farmland from flooding.

• Geomechanics and Engineering
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• v.5 no.6
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• pp.575-594
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• 2013

Organic soils exhibit problematic properties such as high compressibility and low shear strength; these properties may cause differential settlement or failure in structures built on such soils. Organic soil removal or stabilization are the most important methods to overcome geotechnical problems related to peat soils' engineering characteristics. This paper presents soil mechanical intervention for stabilization of peat with sand columns and focuses on a comparison between the mechanical characteristics of undisturbed peat and peat stabilized with 20%, 30% and 40% of sand on the laboratory scale. Cylindrical columns were extruded in different diameters through a nearly undisturbed peat sample in the laboratory and filled with sand. By adding sand columns to peat, higher permeability, higher shear strength and a faster consolidation was achieved. The sample with 70% peat and 30% sand displayed the most reliable compressibility properties. This can be attributed to proper drainage provided by sand columns for peat in this specific percentage. It was observed that the granular texture of sand also increased the friction angle of peat. The addition of 30% sand led to the highest shear strength among all mixtures considered. The peat samples with 40% sand were sampled with two and three sand columns and tested in direct shear and consolidation tests to evaluate the influence of the number and geometry of sand columns. Samples with three sand columns showed higher compressibility and shear strength. Following the results of this laboratory study it appears that the introduction of sand columns could be suitable for geotechnical peat stabilization in the field scale.

• Health Policy and Management
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• v.30 no.4
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• pp.505-512
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• 2020

Background: In monitoring exposure to environmental smoke (ETS), biomarkers can overcome the subjectivity and inaccuracy of self-reporting measurements, and have the advantage of reflecting ETS exposure in all places. This study aims to evaluate the effectiveness of ETS exposure measurement using biomarkers such as urine cotinine. Methods: This study used the Korea National Health and Nutrition Survey data from 2009 to 2018. A total of 28,574 non-smokers with urine cotinine data were selected for the study. The cotinine concentration and ETS exposure rate using urine cotinine was estimated and then compared with the self-reporting measurements. The degree of agreement among measurements of ETS exposure was confirmed. Results: As a result of measuring ETS exposure with urine cotinine, 23,594 (83.8%) out of 28,574 subjects were classified as to exposure groups. This estimate differs significantly from measurements made by self-reporting. In addition, the average concentration of cotinine in non-smokers has decreased to a 10th level over the past 10 years. Based on the biomarker, the sensitivity of the self-reporting was 8.5%-29.0%, the specificity was 16.4%-19.5%, and the kappa value was 2.0%-5.8%. Conclusion: The findings of our study show that self-reporting measurement does not well reflect the extent to which non-smoker's exposure to smoking materials. Whereas cotinine concentration has decreased significantly over the past 10 years, the ETS exposure rate has not reduced. It strongly suggests the need for intervention in the group of non-smokers exposed to low concentrations of smoke. Therefore, an assessment using biomarkers such as cotinine-based measurement should be made in the Health Plan 2030.

• Smart Structures and Systems
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• v.29 no.1
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• pp.93-103
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• 2022

With the wider availability of sensor technology through easily affordable sensor devices, several Structural Health Monitoring (SHM) systems are deployed to monitor vital civil infrastructure. The continuous monitoring provides valuable information about the health of the structure that can help provide a decision support system for retrofits and other structural modifications. However, when the sensors are exposed to harsh environmental conditions, the data measured by the SHM systems tend to be affected by multiple anomalies caused by faulty or broken sensors. Given a deluge of high-dimensional data collected continuously over time, research into using machine learning methods to detect anomalies are a topic of great interest to the SHM community. This paper contributes to this effort by proposing a relatively new time series representation named "Shapelet Transform" in combination with a Random Forest classifier to autonomously identify anomalies in SHM data. The shapelet transform is a unique time series representation based solely on the shape of the time series data. Considering the individual characteristics unique to every anomaly, the application of this transform yields a new shape-based feature representation that can be combined with any standard machine learning algorithm to detect anomalous data with no manual intervention. For the present study, the anomaly detection framework consists of three steps: identifying unique shapes from anomalous data, using these shapes to transform the SHM data into a local-shape space and training machine learning algorithms on this transformed data to identify anomalies. The efficacy of this method is demonstrated by the identification of anomalies in acceleration data from an SHM system installed on a long-span bridge in China. The results show that multiple data anomalies in SHM data can be automatically detected with high accuracy using the proposed method.

• Safety and Health at Work
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• v.14 no.3
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• pp.325-331
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• 2023

Background: Heat stress is a harmful physical hazard in many occupational settings. However, consequences of occupational heat exposure among workers in a sugarcane factory in Ethiopia are not well characterized. This study aimed to assess the level of occupational heat exposure-related symptoms and contributing factors. Methods: In this cross-sectional study, five workstations were selected for temperature measurement. Heat stress levels were measured using a wet-bulb globe temperature index meter. A stratified random sampling technique was used to select 1,524 participants. Heat-related symptoms were assessed using validated questionnaires. Results: The level of occupational heat exposure was 72.4% (95% CI: 70.2%-74.8%), while 71.6% (95% CI: 69.3%-74.9%) of participants experienced at least one symptom related to heat stress. The most common heat-related symptoms were swelling of hands and feet (78%), severe thirst (77.8%) and dry mouth (77.4%). The identified risk factors were a lack of reflective shields (AOR: 2.20, 95% CI: 1.53, 3.17), not-enclosed extreme heat sources (AOR: 1.76, 95% CI: 1.23, 2.51), a lack of access to shade (AOR: 9.62, 95% CI: 6.20, 14.92), and inappropriate protective clothing provision (AOR: 1.58, 95% CI: 1.27, 2.71). Conclusions: The burden of occupational heat exposure and heat-induced symptoms was high. Lack of reflective shields, the absence of enclosed extreme heat sources, a lack of access to shade, and inappropriate protective clothing provision were considerable attributes of heat stress. Therefore, the use of mechanical solutions to stop heat emissions at their sources and the key factors identified were areas for future intervention.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.34 no.1
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• pp.35-47
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• 2024

Objectives: Many cases of lung cancer have been reported by school kitchen workers as occupational cancer. Twenty-eight schools in Gyeongsangnam-do Province were selected to evaluate the effect of improved kitchen ventilation systems. Ventilation characteristics before and after renovation were compared and design techniques were identified. Methods: In the design stage for kitchen ventilation systems, expert intervention was used to improve the designs. Ventilation characteristics and air quality were evaluated before and after the renovations. Hood face velocity and fan flow rate were measured and the smoke visualization technique was used to evaluate the capability of protecting worker's breathing zone. The concentrations of PM_0.3 were measured at points not adjacent to cooking equipment because these concentrations fluctuate greatly. Results: Mean hood face velocity increased from 0.29 m/s before renovation to 0.7m/s after renovation. The concentrations of PM_0.3 showed a roughly 95% reduction. Concentrations of CO showed more than a 75% reduction. Smoke visualization showed greater protection of workers' breathing zone. Conclusions: Advanced design techniques for school kitchen ventilation systems were applied to renovate old kitchen ventilation systems. The performance of the new kitchen ventilation systems was nearly excellent. Further improvement of design techniques is still needed, however.