• Molecular & Cellular Toxicology
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• v.1 no.4
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• pp.256-261
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• 2005

The recent DNA microarray technology enables us to understand gene expression profiling in cell line and animal models. The technology has potential possibility to comprehend mechanism of multiple genes were related to compounds which have toxicity in biological system. So, microarray system has been used for the prediction of toxicity through gene expression induced by toxicants. It has been shown that compounds with similar toxic mechanisms produce similar changes in gene expression in vivo system. Here we focus on the use of toxicogenomics for the determination of gene expression analysis associated with hepatotoxicity in rat liver and cell line (WB-F344). Methotrexate (MTX) is a chemotherapy agent that has been used for many years in the treatment of cancer because it affects cells that are rapidly dividing. Also it has been known the toxicity of MTX, in a MTX abortion, it stops embryonic cells from dividing and multiplying and is a non-surgical method of ending pregnancy in its early stages. We have shown DNA microarray analyses to assess MTX-specific expression profiles in vivo and in vitro. Male Sprague-Dawely VAF+ albino rats of 5-6 weeks old and WB-F344 cell line have been treated with MTX. Total RNA was isolated from Rat liver and cell line that has treated with MTX. 4.8 K cDNA microarray in house has been used for gene expression profiling of MTX treatment. We have found quite distinct gene expression patterns induced by MTX in a cell line and in vivo system.

• Journal of Internet Computing and Services
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• v.9 no.4
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• pp.11-20
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• 2008

IEEE 802.16e has adopted sleep mode to minimize energy consumption of mobile nodes with high speed mobility. If the Base Station (BS) has no data to be sent to a Mobile Subscriber Station (MSS) at the instant of ending sleep window of the MSS, the MSS increases its sleep window interval by double until the window interval reaches to the maximum sleep window interval. Thus, during the operation of sleep mode, MSS repeatedly performs switch on/off action until there exist frames to be received from BS. The switch on/off operation significantly consumes energy of MSS. To effectively deal with the energy of the MSS, this paper proposes an algorithm which decides the minimum sleep window interval that will be used in next sleep mode based on the current sleep window interval. We evaluate the performance of IEEE 802.16e sleep mode algorithm and our proposed algorithm in terms of energy consumption and blocking probability. Compared with the current sleep mode algorithm used in IEEE 802.16e, the proposed algorithm decreases the energy consumption by about 30% without increasing blocking probability.

• Journal of Biomedical Engineering Research
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• v.23 no.1
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• pp.1-8
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• 2002

Atrial fibrillation(AF). chronic or paroxysmal is the most frequent arrhythmia in human subjects Duration of P wave in signal-averaged electrocardiography(SAECG) reflects intra-atrial conduction time and therefore. could be used as an electrophysiological marker for atrial conduction chance at the earthy stave. So we apply the analysis method using SAECG to diagnose Paroxysmal atrial fibrillation(PAF) . Subjects Participated for the study consisted of two groups: a control group(n=34) of normal healthy volunteers and a group of AF Patients(n=38) with a documented history of PAF but no other history of cardiac disease. We evaluated the effect of several filtering and determination methods to find the starting and ending feints of the P wavy on its duration. To increase the measurement reliability of P wave duration. the automatic detection method was proposed. Also. to increase the detection rate for PAF risk, the decision threshold value was optimized using receiver operation characteristics(ROC) curve. Results showed that the highest statistical difference (p〈0.001) of the P wane duration between controls and subjects was obtained at the Processing condition, using absolute threshold vague(8.75 $\mu N$) , a least mean square(LMS) high pass filter and 30 Hz cutoff frequency. The most outstanding difference(sensitivity 88 % specificity 64.4 %) between controls and subjects was obtained at the decision threshold value of 112 ms.

• Convergence Security Journal
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• v.13 no.2
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• pp.67-73
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• 2013

This research is to define the Aesthetics of Karatedo as Security Guard Martial Art by explore the aesthetics of Karatedo being invigorated as security guard martial art. The first one is beauty of space. The offense and defense of Karatedo as Security Guard Martial art are to fill in, to come out and to move from side to side. It help to have higher judgment. Secondly, it is beauty of time. It is subjective time felt by people training Karatedo. The third on is beauty of unity. We can see formal beauty of unity such as white dogi or black suit of security guard and dynamic beauty of unity such as quick and slow, strong and soft or movement of hand and foot. The forth one is beauty of symmetry. It can be shown strongly by triangle or moving of team kata and triangle between athletes and referee at Kumite competition. The fifth one is beauty of balance. It can by shown well by continual Karatedo kick motion, jumping kick motion at Kumite, jumping motion, quick turning, or moving such as standing on one foot at kata. The sixth one is beauty of harmony. The whith Dogi and blue or red guard at Kumite competition shows harmony of yin and yang and we can see also various harmony such as strong and soft, quick and slow, or high and low at Kata competition. The seventh one is beauty of curve. We can see beauty of straight line and curve by watching line of hand and foot from starting point to ending point. Specially, moving line of white dogi shows strongly beauty. The eighth one is beauty of rhythm. The rhythm is specified in Kumite kata competition rules. It is also shown by basic step, left and right step, various moving of foot, continual offense of hand or continual rhythm of offense and defense. The last one is bezuty of ethics. It is manner, duty as human, and moderation being important in Karatedo.

• Korean Journal of Social Welfare
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• v.64 no.4
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• pp.57-87
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• 2012

The purpose of this study was to develop the first social work skills inventory in Korea. Based upon the literature review of social work skills, the examination of an existing scale, and the comments from professionals in this field, 57 preliminary items were developed. Preliminary items were evaluated with a total of 370 social workers who were working in various fields of social work in Seoul and surrounding areas. A series of exploratory factor analyses were conducted to find out the optimal structure of the scale. After deleting 30 items with low factor loadings or being cross-loaded, the scale is composed of five factors. Confirmatory factor analysis confirmed the factor structure of the scale obtained by exploratory factor analysis. The first factor was named preparatory and assessing skills to be mostly used in the beginning phase of th social work process, the second factor was named change facilitating skills to be used to strengthen motivation to change, third factor was named ending and evaluating skills to be used to terminate the professional relationship and evaluate the outcome of the relationship, the fourth factor was named resource linking and utilizing skills to be used to utilize resources in order to solve clients' problems and the fifth factor was named ethical practice skills. Each component of the social work skills inventory is found to be reliable and valid. In sum, the social work skills inventory is an instrument encompassing basic skills necessary for social work process, skills for ethical social work practice, and skills necessary for utilizing environmental resources.

• Korean Chemical Engineering Research
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• v.55 no.1
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• pp.48-53
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• 2017

Since the number and the amount of toxic substances handled by domestic companies have been increased, the possibility of serious chemical accidents has become severe. According to Chemistry Safety Clearing-house (CSC), the number of chemical accidents for the last five years has been rapidly raised. A representative example which shows the serious impact of a chemical accident is HF (Hydrogen Fluoride) accident generated in Gumi in 2012. In order to make effective responses for mitigating losses of accidents, the most suitable consequence model has to be selected and implemented throughout the considerations of chemical properties and environments. Even if each consequence model has been verified by the results of experiments, it is necessary to analyze and compare the usability of them according to various scenarios. In this study, the Gumi HF accident is simulated by HGSYSTEM, which is the most specialized model for the release and dispersion of HF. It is found that the ending point of ERPG-2 is about 1 km from the accident point. In order to investigate the usability of the most representative consequence models (ALOHA and CARIS), the results of them are compared with one of HGSYSTEM.

• Annual Conference on Human and Language Technology
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• 2004.10d
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• pp.251-258
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• 2004

본 연구는 연결어미가 글 이해와 기억에 미치는 영향을 조사하고, 연결어미의 효과와 글읽기 능력과는 어떤 관련성이 있는지를 조사하기 위해 실시되었다. 연결어미로는 인과 관계와 부가 관계를 나타내는 연결어미가 사용되었다. 앞뒤에 제시되는 두 문장의 국소적 응집성(Local coherence)을 형성하는데 연결어미가 도움을 준다면, 연결어미가 있는 경우에 문장을 이해하는 속도가 빨라지고 글 내용을 기억하는 데에도 도움을 줄 것으로 예측하였다. 만일에 글읽기 능력이 연결어미를 적절히 사용할 수 있는 능력에 의해서도 영향을 받는다면, 연결어미의 출현 여부와 읽기 능력간에 상호작용이 있을 것으로 예측하였다. 실험 1에서는 인과 관계 연결어미를 사용하여 문장 읽기 시간에 연결어미의 출현이 미치는 효과와 문장 회상에 미치는 효과를 조사하였다. 실험 결과, 인과 관계 연결어미는 뒤의 문장을 읽는데 촉진적인 효과를 주었으며, 이런 연결어미의 효과는 읽기 능력에 관계없이 일관된 촉진 효과를 나타냈다. 또한, 연결어미의 출현은 문장의 회상에 도움을 주었으며, 연결어미가 문장 회상에 미치는 효과는 읽기 능력의 상하에 관계없이 일관되게 나타났다. 실험 2에서는 부가 관계 연결어미가 문장 읽기 시간과 회상에 미치는 효과를 조사하였다. 실험 결과. 부가 관계 연결어미 역시 인과 관계 연결어미와 유사한 형태의 효과를 보였다. 실험 1과 실험 2의 결과는 인과 관계와 부가 관계 연결어미가 앞뒤 문장의 응집성 형성에 긍정적인 영향을 주고, 이런 연결어미의 글읽기에 대한 효과는 글읽기 능력에 관계없이 일정하다는 것을 시사한다.건이 복합 명사의 중심어 선택과 의미 결정에 재활용 될 수 있으며, 병렬말뭉치에 의해 반자동으로 구축되는 의미 대역 패턴을 사용하여 데이터 구축의 어려움을 개선하고자 한다. 및 산출 과정에 즉각적으로 활용될 수 있을 것이다. 또한, 이러한 정보들은 현재 구축중인 세종 전자사전에도 직접 반영되고 있다.teness)은 언화행위가 성공적이라는 것이다.[J. Searle] (7) 수로 쓰인 것(상수)(象數)과 시로 쓰인 것(의리)(義理)이 하나인 것은 그 나타난 것과 나타나지 않은 것들 사이에 어떠한 들도 없음을 말한다. [(성중영)(成中英)] (8) 공통의 규범의 공통성 속에 규범적인 측면이 벌써 있다. 공통성에서 개인적이 아닌 공적인 규범으로의 전이는 규범, 가치, 규칙, 과정, 제도로의 전이라고 본다. [C. Morrison] (9) 우리의 언어사용에 신비적인 요소를 부인할 수가 없다. 넓은 의미의 발화의미(utterance meaning) 속에 신비적인 요소나 애정표시도 수용된다. 의미분석은 지금 한글을 연구하고, 그 결과에 의존하여서 우리의 실제의 생활에 사용하는 $\ulcorner$한국어사전$\lrcorner$ 등을 만드는 과정에서, 어떤 의미에서 실험되었다고 말할 수가 있는 언어과학의 연구의 결과에 의존하여서 수행되는 철학적인 작업이다. 여기에서는 하나의 철학적인 연구의 시작으로 받아들여지는 이 의미분석의 문제를 반성하여 본다.반인과 다르다는 것이 밝혀졌다. 이 결과가 옳다면 한국의 심성 어휘집은 어절 문맥에 따라서 어간이나 어근 또는 활용형 그 자체로 이루어져

• The Journal of the Convergence on Culture Technology
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• v.6 no.2
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• pp.561-566
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• 2020

We propose to design and to implement a recreational and end - of - play robot for symptom relief in patients with depression. The main symptom of depression is the loss of interest and interest in life. The depression diagnosis patient confirms the emotional analysis revealed by his / her robot through the robot, and performs the greeting or ending play. After analyzing the emotions in the expressions after the play, the function of the embodying robot is confirmed by receiving the report. A simple play can not completely cure a patient with a diagnosis of depression, but it can contribute to symptom relief through gradual use. The design of the play-by-play robot is using Q.bo One, an open-source robot that can interact with Thecorpora. Q.bo One's system captures a user's face, takes a picture, passes the value to the Azure server, and checks the emotional analysis before and after the play with the accumulated data.Play is implemented in Rasubian, the OS of Q.bo One, using the programming language Python and interacting with external sensors. The purpose of this paper is to help the symptom relief of depressive patients in a relatively short time with a play robot.

• International Journal of Oral Biology
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• v.31 no.4
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• pp.113-118
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• 2006

In the primary sensory neuron of the mesencephalic trigeminal nucleus (MTN), the peripheral axon supplies a large number of annulospiral endings surrounding intrafusal fibers encapsulated in single muscle spindles while the central axon sends only a few number of synapses onto single ${\alpha}-motoneurons({\alpha}-MNs)$. Therefore, the ${\alpha}-{\gamma}$ linkage is thought to be very crucial in the jaw-closing movement. Spike activity in a ${\gamma}-motoneuron\;({\gamma}-MN)$ would induce a large number of impulses in single peripheral axons by activating many intrafusal fibers simultaneously, subsequently causing an activation of ${\alpha}-MNs$ in spite of the small number of synapses. Thus, the activity of ${\gamma}-MNs$ may be vital for modulation of jaw-closing movements. Independently of such a spindle activity modulated by ${\gamma}-MNs$, somatic depolarization in MTN neurons is known to trigger the oscillatory spike activity. Nevertheless, the trafficking of these spikes arising from the two distinct sources of MTN neurons is not well understood. In this short review, switching among multiple functional modes of MTN neurons is discussed. Subsequently, it will be discussed which mode can support the ${\alpha}-{\gamma}$ linkage. In our most recent study, simultaneous patch-clamp recordings from the soma and axon hillock revealed a spike-back-propagation from the spike-initiation site in the stem axon to the soma in response to a somatic current pulse. The persistent $Na^+$ current was found to be responsible for the spike-initiation in the stem axon, the activation threshold of which was lower than those of soma spikes. Somatic inputs or impulses arising from the sensory ending, whichever trigger spikes in the stem axon first, would be forwarded through the central axon to the target synapse. We also demonstrated that at hyperpolarized membrane potentials, 4-AP-sensitive $K^+$ current ($IK_{4-AP}$) exerts two opposing effects on spikes depending on their origins; the suppression of spike initiation by increasing the apparent electrotonic distance between the soma and the spike-initiation site, and the facilitation of axonal spike invasion at higher frequencies by decreasing the spike duration and the refractory period. Through this mechanism, the spindle activity caused by ${\gamma}-MNs$ would be safely forwarded to ${\alpha}-MNs$. Thus, soma spikes shaped differentially by this $IK_{4-AP}$ depending on their origins would reflect which one of the two inputs was forwarded to the target synapses.

• International Journal of Oral Biology
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• v.41 no.3
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• pp.133-139
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• 2016

The ultrastructural parameters related to synaptic release of endings which are presynaptic to tooth pulp afferent terminals (p-endings) were analyzed to understand the underlying mechanism for presynaptic modulation of tooth pulp afferents. Tooth pulp afferents were labelled by applying wheat-germ agglutinin conjugated horseradish peroxidase to the rat right lower incisor, whereafter electron microscopic morphometric analysis with serial section and reconstruction of p-endings in the trigeminal oral nucleus was performed. The results obtained from 15 p-endings presynaptic to 11 labeled tooth pulp afferent terminals were as follows. P-endings contained pleomorphic vesicles and made symmetrical synaptic contacts with labeled terminals. The p-endings showed small synaptic release-related ultrastructural parameters: volume, $0.82{\pm}0.45{\mu}m^3$ ($mean{\pm}SD$); surface area, $4.50{\pm}1.76{\mu}m^2$; mitochondrial volume, $0.15{\pm}0.07{\mu}m^3$; total apposed surface area, $0.69{\pm}0.24{\mu}m^2$; active zone area, $0.10{\pm}0.04{\mu}m^2$; total vesicle number, $1045{\pm}668.86$; and vesicle density, $1677{\pm}684/{\mu}m^2$. The volume of the p-endings showed strong positive correlation with the following parameters: surface area (r=0.97, P<0.01), mitochondrial volume (r=0.56, P<0.05), and total vesicle number (r=0.73, P<0.05). However, the volume of p-endings did not positively correlate or was very weakly correlated with the apposed surface area (r=-0.12, P=0.675) and active zone area (r=0.46, P=0.084). These results show that some synaptic release-related ultrastructural parameters of p-endings on the tooth pulp afferent terminals follow the "size principle" of Pierce and Mendell (1993) in the trigeminal nucleus oralis, but other parameters do not. Our findings may demonstrate a characteristic feature of synaptic release associated with p-endings.