• Bulletin of the Korean Chemical Society
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• 제25권3호
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• pp.400-402
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• 2004

• Bulletin of the Korean Chemical Society
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• 제25권12호
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• pp.1977-1979
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• 2004

• Bulletin of the Korean Chemical Society
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• 제29권9호
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• pp.1850-1852
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• 2008

• Bulletin of the Korean Chemical Society
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• 제25권11호
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• pp.1707-1710
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• 2004

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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• pp.215.1-215.1
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• 2003

A various ${\alpha}$-arylmethylpropionic acids(profen) have been widely used as non-steroidal anti-inflammatory drugs for the relief of acute and chronic rheumatoid arthritis and osteoarthritis, as well as for other connective tissue disorders and pains. Example is fenoprofen, ibuprofen, ketoprofen, and naproxen. All are chiral and, except for naproxen and ibuprofen, are marketed in racemic form. Enantioseparations of profens have been of considerable interest becaus their anti-inflammatory and analgesic effects have been attirbuted almost exclusively to their (S)-enantiomer. (omitted)

• Food Science and Biotechnology
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• 제18권1호
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• pp.18-24
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• 2009

The volatile compounds of dried sancho (Zanthoxylum schinifolium), an aromatic plant were extracted by simultaneous distillation and extraction (SDE) method and identified by gas chromatograph-mass spectrometry (GC-MS). Selected chiral constituents of sancho oil were characterized by enantiodifferentiation using multidimensional gas chromatograph (MDGC)-MS. A total of 57 compounds were identified and quantified, and the major compounds were identified estragole, nonanoic acid, octanoic acid, $\beta$-phellandrenene, and limonene. Among them, estragol (63.9%) was found as the predominantly abundant component of sancho. $\alpha$-pinene and nerolidol, and $\beta$-pinene and linalool were determined to be enantiomerically pure (100%) for their (S)-form and (R)-form, respectively. The enantiomeric composition of limonene in sancho revealed 83.9% purity for the (S)-enantiomer, whereas (E)- and (Z)-rose oxides showed mixtures of both enantiomers. The enantiomeric excess (%) for citronellal was 22.6% with the (R)-enantiomer as major enantiomer. The enantiomeric composition of these compounds can be used as parameter for authenticity control of sancho.

• KSBB Journal
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• 제25권5호
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• pp.449-452
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• 2010

크라운 에테르로부터 유도된 키랄고정상에서 역상용매를 이동상으로 사용하여 국내외에서 시판되고 있는 광학이성질체 의약품인 레보티록신 나트륨의 광학순도 측정을 위한 새로운 직접적인 광학분리 분석법을 개발하여 매우 좋은 결과를 얻었다 ($\alpha$ = 2.15, Rs = 4.05). 시판하고 있는 레보티록신 나트륨의 광학순도를 키랄고정상을 이용하여 직접적인 광학분리방법으로 측정하는 실험은 현재까지 한 편의 연구결과 외에는 보고되어 있지 않는데 [4] 본 연구에서 새롭게 개발한 전처리과정과 HPLC 분석조건을 이용하여 현재 국내외에서 판매되고 있는 레보티록신 나트륨 주성분의 의약품 정제의 광학순도를 측정하였다. 레보티록신 나트륨의 광학순도를 측정한 광학분리 실험결과에서 하나의 제품을 제외하고는 99% 이상의 높은 광학순도를 보여주고 있음을 확인할 수 있었다. 본 연구의 편리하고 용이한 신규 광학분리 분석법이 국내외에서 상용되는 레보티록신 나트륨 제품의 품질 확인과 양질의 키랄의약품을 개발하고 제품을 관리하는데 매우 도움이 되리라 기대한다.

• 분석과학
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• 제34권4호
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• pp.143-152
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• 2021

Capillary electrophoresis (CE) is an effective technique to study chiral recognition because it offers flexibility in adjusting vital factors. Currently, various available cyclodextrins (CDs) can be employed for the chiral separation of numerous analytes. Herein, we investigate the enantioseparation behavior of lipoic acid enantiomers in various types of single and dual CD systems through CE. Additionally, several impacted CE parameters were optimized through the systematic investigation based on the design of experiment (DoE) concept for a single system comprising a heptakis (2,3,6-tri-O-methyl)-β-CD and a dual system containing the combination of the single CD with a sulfated-β-CD. Consequently, absolute enantioresolution was obtained within 15 min on a common standard bare fused-silica capillary (64.5/56 cm in total/effective length, 50/365 ㎛ inner/outer diameter), maintained at 15 ℃ and at an applied voltage of 24 kV. The optimal background electrolyte consisted of 6 mM heptakis (2,3,6-tri-O-methyl)-β-CD dissolved in the solution of 58 mM borate buffer at pH 10. Furthermore, the results of apparent binding constant experiments indicated that the S-enantiomer-heptakis (2,3,6-tri-O-methyl)-β-CD complex exhibited a stronger affinity than its R-enantiomer counterpart. The obtained electrophoretic mobility values could be utilized to interpret the resolution achieved at various CD concentrations and the mobility behavior of the complexes elucidated the migration order of the enantiomers in an electropherogram.

• Archives of Pharmacal Research
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• 제21권2호
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• pp.212-216
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• 1998

A coupled achiral-chiral high-performance liquid chromatographic system has been developed for the determination of the enantiomers of salmeterol, S-(+)-salmeterol and R-(-)-salmeterol in urine. THe salmeterol was separated from the interfering components in urine and quantified on the silica column, and the enantiomeric composition was determined on a Sumichiral OA-4700 chiral stationary phase. The two columns were connected by a switching valve equipped with a silica precolumn. The two columns wer connected by a switching valve equipped with a silica precolumn. The precolumn was used to concentrate the salmeterol in the eluent from the achiral column before backflushing onto the chiral phase. The coupled system was validated.

• Archives of Pharmacal Research
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• 제18권2호
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• pp.69-74
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• 1995

In order to improve physico-chemical properties and to enhance stability of drugs, amino acid salt has been widely adoptd in pharmaceutical synthesis. Acetylsalicylic acid lysinate is one of the widely used analgesics and it is a good example of t5his synthesis. In the case of bacetylsalicylic acid lysinate synthesis, racemization of natrually occurred lysine is esential because the racemic lysine salt of the drug shows better yield, crystallinity and dryness than that of the L-lysine salt. To esatablish a simple, practical and economical process for L-lysine racemization, L-lysine treatments with phosphoric acid and with acetic acid were compared and the optimum conditions for its process and derivatization were investigated by chiral separation methods using GC_MS spectroscopy.