• Journal of Digestive Cancer Research
• /
• v.11 no.2
• /
• pp.85-92
• /
• 2023

Colorectal cancer (CRC) is one of the most prevalent cancers and is the leading cause of cancer-related mortality worldwide. Based on the current screening guidelines by the American Cancer Society and Korean multi-society expert committee, CRC screening is recommended in asymptomatic adults starting at the age of 45 years. Fecal immunochemical test-based screening programs reduce the development of CRC and related mortality in the general population. However, this most popular CRC screening strategy demonstrates a crucial limitation due to modest diagnostic accuracy. Colonoscopy may be considered as an alternative primary method for CRC screening; however, its implementation can still be challenging due to concerns regarding invasiveness, low adherence, cost-effectiveness, and quality assurance. To overcome the limitations of current screening tests, innovative noninvasive tests for CRC screening have been developed with advances in molecular biology, genetics, epigenetics, and microbiomics for detecting CRC, which may enhance the approach to CRC screening and diagnosis in clinical practice in the near future. This review explores the emerging screening methods and discusses their potential for integration into current practice.

• Pediatric Infection and Vaccine
• /
• v.12 no.2
• /
• pp.186-194
• /
• 2005

Purpose : Hepatitis A viral infections have been continued after re-emerging since mid 1990s in Korea. The incidence of this disease has been increased in young adults younger than 30 years of age since 2000. This study was performed to evaluate the prevalence of antibody to hepatitis A in Korea(two regions; Incheon and Changwon) in 2005, and was compared with the results of similar studies in mid 1990s. Methods : The study was conducted from January 2005 to June 2005, and consisted of 1,301 enrolled subjects, neonates to 50 years old, living in Incheon and Changwon in Korea. All sera were frozen and stored at $-70^{\circ}C$ until assayed. Anti-HAV IgG antibodies were measured by microparticle enzyme immunoassay(HAVAB, Abbott Lab., IL, USA). Results : The prevalence of anti-HAV IgG was 61.1% in infants younger than 1 year old, 30.5% in 1~5 years, 14.6% in 6~10 years, 1.7% in 11~15 years, 6.5% in 16~20 years, 36.6%in 21~30 years, 77.5% in 31~40 years, and 99.8% in 41~50 years. Statistical differences were not found between male and female, but there was statistical difference in 6~10 years old age group between the two areas. Conclusion : Our study indicate that the prevalence of antihepatitis A virus antibody has shifted from children to old adolescents and young adults. This result suggests that the risk of sudden outbreaks or increasing incidence of hepatitis A viral infections in young adults may be expected in our society. The preventive strategies of hepatitis A including vaccination should be prepared.

• Korean Journal of Ecology and Environment
• /
• v.33 no.3 s.91
• /
• pp.267-273
• /
• 2000

Temperature-associated emergence patterns for a hydropsychid caddisfly, Hydropsyche kozhantschikovi, were studied from the Wangsuk creek in Kyonggi-do from April to June in 1999. Emerging adults were quantitatively collected by pyramidshaped emergence traps. Water temperature was hourly monitored in 1999. The emergence began at April 15 when the daily mean water temperature rose to ca. $10^{\circ}C$: it rapidly increased and peaked in ca. 10 days, and continued to May 25, lasting 40 days since the starting date. The average number of emerged adults was $35.8\;inds./m^2$ and their sex ratio was male (M) : female (F) = 1 : 2.04. The emergence of males was ca. 2 days earlier than that of females. Daily, the emergence was a bigeminans pattern representing the major peak (66.7%) just after dark ($19:00{\sim}21:00$) and theminor peak (11.1%) just before dawn ($05:00{\sim}07:00$). According to our degree dayaccumulation (DD) model, it respectively required 453.89DD (M: 440.48DD and F: 473.97 DD), 615.71DD (M: 610.18DD and F: 622.09DD), and 820.24DD (M: 828.25DD and F: 804.71DD) to begin, to reach the peak, and to finish the emergence.

• Clinical and Experimental Pediatrics
• /
• v.50 no.10
• /
• pp.931-937
• /
• 2007

The hemolytic uremic syndrome (HUS) is a rare disease of microangiopathic hemolytic anemia, low platelet count and renal impairment. HUS usually occurs in young children after hemorrhagic colitis by shigatoxin-producing enterohemorrhagic E. coli (D+HUS). HUS is the most common cause of acute renal failure in infants and young children, and is a substantial cause of acute mortality and morbidity; however, renal function recovers in most of them. About 10% of children with HUS do not reveal preceding diarrheal illness, and is referred to as D- HUS or atypical HUS. Atypical HUS comprises a heterogeneous group of thrombomicroangiopathy (TMA) triggered by non-enteric infection, virus, drug, malignancies, transplantation, and other underlying medical condition. Emerging data indicate dysregulation of alternative complement pathway in atypical HUS, and genetic analyses have identified mutations of several regulatory genes; i.e. the fluid phase complement regulator Factor H (CFH), the integral membrane regulator membrane cofactor protein (MCP; CD46) and the serine protease Factor I (IF). The uncontrolled activation of the complement alternative pathway results in the excessive consumption of C3. Plasma exchange or plasma infusion is recommended for treatment of, and has dropped the mortality rate. However, overall prognosis is poor, and many patients succumb to end-stage renal disease. Clinical presentations, response to plasma therapy, and outcome after renal transplantation are influenced by the genotype of the complement regulators. Thrombotic thrombocytopenic purpura (TTP), another type of TMA, occurs mainly in adults as an acquired disease accompanied by fever, neurologic deficits and renal abnormalities. However, less frequent cases of congenital or hereditary TTP associated with ADAMTS-13 (a disintegrin and metalloprotease, with thrombospondin 1-like domains 13) gene mutations have been reported, also. Recent advances in molecular genetics better allow various HUS to be distinguished on the basis of their pathogenesis. The genetic analysis of HUS is important in defining the underlying etiology, predicting the genotype-related outcome and optimizing the management of the patients.

• Journal of the Korea Society of Computer and Information
• /
• v.29 no.2
• /
• pp.109-118
• /
• 2024

With the increasing number of social media users worldwide, cases of social media being abused to perpetrate various crimes are increasing. Specifically, drug distribution through social media is emerging as a serious social problem. Using social media channels, the curiosity of teenagers regarding drugs is stimulated through clever marketing. Further, social media easily facilitates drug purchases due to the high accessibility of drug sellers and consumers. Among various social media platforms, we focused on Instagram, which is the most used social media platform by young adults aged 19 to 24 years in South Korea. We collected four types of information, including profile photos, introductions, posts in the form of images, and posts in the form of texts on Instagram; then, we analyzed the similarity among each type of collected information. The profile photos and posts in the form of image were analyzed for similarity based on the SSIM(Structural Simplicity Index Measure), while introductions and posts in the form of text were analyzed for similarity using Jaccard and Cosine similarity techniques. Through the similarity analysis, the similarity among various accounts for each collected information type was measured, and accounts with similarity above the significance level were determined as the same drug sales account. By performing logistic regression analysis on the aforementioned information types, we confirmed that except posts in image form, profile photos, introductions, and posts in the text form were valid information for tracking the same drug sales account.

• The Journal of the Korea Contents Association
• /
• v.14 no.4
• /
• pp.37-46
• /
• 2014

Industrialization and urbanization have led automobiles to transform into more than just modes of transportation; they have become daily necessities as well as extensions of living spaces where a variety of activities can be done and automotive applications of the latest information technology are accelerated. Though material abundance has increased in the modern society, the conflicts and the stress emerging from a social structure focused on competition have increased as well. Such lifestyles generate a need for personal space and media content for healing the body and the mind. This research explores the automotive application of video content with the goal of refreshing the minds of the passengers. To this end, previous studies have investigated the emotional effect of videos, focusing on the responses of diverse groups of adults (age group of 20 to 60) who frequently used automobiles, which had video displays installed in them. The results showed that watching video contents on a full window inside a car influenced the creation of positive feelings7 and emotional satisfaction. The research attempts to study the methods of providing video contents and the effects of watching them that could aid the emotional well-being of passengers, and presents the possibility of emotional satisfaction created by a convergence of cars and multimedia contents in the future.

• Korean journal of applied entomology
• /
• v.59 no.4
• /
• pp.393-398
• /
• 2020

The blueberry gall midge, Dasineura oxycoccana (Johnson) (Diptera: Cecidomyiidae), is an emerging pest on cultivated blueberries in Korea. To develop a sensitive tool for monitoring this pest in blueberry orchards, we compared the attractiveness of host plant volatiles and sex pheromone to D. oxycoccana adults. We performed gas chromatography-mass spectrometry (GC-MS) analysis of solid-phase microextraction (SPME)-collected volatiles that were released from blueberry ('Darrow' cultivar). The analysis revealed two major volatiles, cinnamaldehyde and cinnamyl alcohol from flowers; and three major volatiles, β-caryophyllene, germacrene D, and α-farnesene from shoots and young fruits. In field tests conducted in Gunsan, Korea in 2019, commercialized cinnamaldehyde, cinnamyl alcohol, β-caryophyllene, and α-farnesene, used singly or in quaternary combination, were unattractive to the blueberry gall midge. However, traps baited with the known sex pheromone (2R,14R)-2,14-diacetoxyheptadecane attracted significantly more males than the treatments with plant volatiles or the control. No synergistic effect was observed between sex pheromone and plant volatiles. Male D. oxycoccana were captured in the pheromone traps from May to August, with three peaks in mid-May, late June, and late July in Gunsan blueberry fields in 2020.