• Current Optics and Photonics
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• 제4권1호
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• pp.31-43
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• 2020

The feasibility of the application of terahertz electromagnetic waves in the diagnosis of prostate cancer was examined. Four samples of incomplete cancerous prostatic paraffin-embedded tissues were examined using terahertz spectral imaging (TPI) system and the results obtained by comparing the absorption coefficient and refractive index of prostate tumor, normal prostate tissue and smooth muscle from one of the paraffin tissue masses examined were reported. Three hundred and sixty cases of absorption coefficients from one of the paraffin tissues examined were used as raw data to classify these three tissues using the Principal Component Analysis (PCA) and Least Squares Support Vector Machine (LS-SVM). An excellent classification with an accuracy of 92.22% in the prediction set was achieved. Using the distribution information of THz reflection signal intensity from sample surface and absorption coefficient of the sample, an attempt was made to use the TPI system to identify the boundaries of the different tissues involved (prostate tumors, normal and smooth muscles). The location of three identified regions in the terahertz images (frequency domain slice absorption coefficient imaging, 1.2 THz) were compared with those obtained from the histopathologic examination. The tissue tumor region had a distinctively visible color and could well be distinguished from other tissue regions in terahertz images. Results indicate that a THz spectroscopy imaging system can be efficiently used in conjunction with the proposed advanced computer-based mathematical analysis method to identify tumor regions in the paraffin tissue mass of prostate cancer.

• Asian Pacific Journal of Cancer Prevention
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• 제17권9호
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• pp.4259-4265
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• 2016

Background: Colorectal malignancies with high microsatellite instability (MSI-H), either hereditary (Lynch syndrome) or sporadic, demonstrate better prognosis and altered response to 5FU chemotherapy. It is now recommended to perform MSI testing for all new cases of colorectal cancer regardless of being categorized as hereditary or sporadic. For MSI detection, immunohistochemistry or PCR-based protocols using a cohort of various sets of STR markers are recommended. Here we aimed to evaluate a simplified protocol using just a single STR marker, MT1XT20 mononucleotide repeat, for detection of MSI in Lynch syndrome patients. A Promega five-marker MSI testing panel and immunohistochemistry (IHC) were used as the gold standard in conjunction with MT1XT20. Materials and Methods: Colorectal patients with a positive history of familial cancers were selected by evaluating medical records. Based on Amsterdam II criteria for Lynch syndrome 20 families were short listed. DNA was extracted from formalin fixed paraffin embedded tumour and adjacent normal tissues resected from the index case in each family. Extracted DNA was subjected to MT1XT20 mononucleotide marker analysis and assessment with a commercially available five marker MSI testing kit (Promega, USA). IHC also was performed on tissue sections and the results were compared with PCR based data. Results: Eight (40%), seven (35%) and five (25%) cases were MSI positive using with the Promega kit, IHC and MT1XT20, respectively. Among the markers included in Promega kit, BAT26 marker showed instability in all 8 samples. NR24 and NR21 markers showed instability in 7 (87.5%), and BAT25 and MONO 27 in 6 (75%) and 5 (62.5%). Conclusions: Although MT1XT20 was earlier reported as a valid standalone marker for MSI testing in CRC patients, we could not verify this in our Iranian patients. Instead BAT26 among the markers included in Promega MSI testing kit showed instability in all 8 MSI-H CRC samples. Therefore, it seems BAT26 could act well as a single marker for MSI testing in Iranian CRC patients.

• 대한소아치과학회지
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• 제34권1호
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• pp.106-121
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• 2007

본 연구는 치면열구전색술시 치과용 염료를 이용하여 초기 우식병소의 유무와 유기물의 잔재를 확인하고 산부식 액의 도포시 brushing방법을 이용하여 침투를 깊이 유도함으로써 열구내 법랑질의 산부식 상태를 유지력을 얻기 위한 최상의 상태로 만들고자 하는 목적으로 자연치를 대상으로 여러 가지 치면세마법과 비교하여 다음과 같은 결과를 얻었다. 1. 실험군은 기존의 치면세마법보다 변연누출이 적었으나 enameloplasty를 시행한 군과는 차이가 없었다. 2. 법랑질 산부식 형태의 질이 향상되었다. 3. 실험군은 다른 군에 비해 미세결합강도가 높았다. 4. 구강내 환경적 조건이 치면열구전색재의 성공실패를 좌우한다. 이상의 결과를 종합하면 치면열구전색술시 치과용 염료와 산부식 액의 도포시 brushing 방법을 이용하여 침투를 깊이 유도하므로써 수복물의 성공적인 도포를 제공할 수 있다고 사료된다.

• 정보보호학회논문지
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• 제26권3호
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• pp.725-734
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• 2016

SCADA 시스템은 국내 산업분야 전반에서 원격 감시 제어를 위해 이용되고 있는 만큼 제어시스템의 보안인증을 올바르게 확립해야 할 필요가 점차 커지고 있다. ISASecure에서 진행하는 EDSA-CRT 테스트는 장치가 정상적인 환경과 비정상적인 네트워크 프로토콜 트래픽 환경에서 핵심 서비스를 적절하게 제공할 수 있는지에 초점이 맞춰져 있기는 하지만 IP, ARP, TCP등 IP 기반 프로토콜을 대상으로 진행하고 있고, 제어 프로토콜에 적용한 테스트 연구는 전무하다. 따라서 본 논문에서는 제어 프로토콜 중 가장 널리 사용되는 DNP3 프로토콜에 대해 EDSA-CRT를 적용하여 테스트 요구사항을 도출하고자 한다. 이에 우리는 DNP3 프로토콜에 대한 33개의 테스트 케이스를 제시한다.

• 대한치과의사협회지
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• 제15권11호
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• pp.763-766
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• 1977

The Purpose of this study was to observe force required to remove some kinds of pin from dentin. The teeth were embedded within a resin cylinder and the occlusal surface was sectioned at a right angle to the axis of the cylinder to expose dentin surface. Thread mate system pin (minim and regular), friction Iocked pin and cemented pin were tested Pin holes were drilled by handpiece and depths of pin holes were tested 1,2 and 3mm. After insertion of the pins into pinhole, tensile loading was performed on the Instron testing machine at the speed of 0.5 inch/min. Results were follewed: 1. In retention, the cemented pins are the least, the friction locked pins intermediate and the self threading pins the greatest in all pins. In self threading pins, regalar pin has greater retention than minim pin 2. The deeper the depth of the pin hole is, the more the retention of the pin increases.

• 한국정보과학회:학술대회논문집
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• 한국정보과학회 2012년도 한국컴퓨터종합학술대회논문집 Vol.39 No.1(A)
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• pp.256-258
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• 2012

임베디드 소프트웨어를 실제 하드웨어 상에서 테스팅 하는 것은 하드웨어의 사용이 개발후반에 가능함에 따른 시간적인 제약으로 인해 테스트를 위한 충분한 시간 확보에 어려움이 있다. 이러한 문제점은 임베디드 소프트웨어 테스팅을 위한 시뮬레이션 기반 테스팅 환경의 구축으로 간단히 해결 할 수 있다. $\mu$-ITRON은 일본 임베디드 분야에서 활발히 사용되는 Real-Time Embedded OS로, 본 논문은 하드웨어 에뮬레이터 QEMU를 이용하여 임베디드 소프트웨어 테스팅을 위한 ARM Cortex-M3기반 $\mu$ITRON의 시뮬레이션 환경 구축에 대해 설명한다.

• 한국컴퓨터정보학회:학술대회논문집
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• 한국컴퓨터정보학회 2013년도 제47차 동계학술대회논문집 21권1호
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• pp.103-106
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• 2013

3D LCD Module은 기존 TFT-LCD에 Parallax Barrier 방식과 Passive Glasses 방식 및 Active Glass 방식의 기술을 적합하여 만들어 진다. 현재는 3D Module 제작 후 기타 ASSY 장치를 부착 하여 시제품 출시 전에 3D 패턴을 기반으로 출하 검사를 통해 제품 이상 유무를 검사하다 보니 제품 출하 검사 시 불량 요인으로 불량 제품에 대한 모든 Repair공정을 위해 많은 시간 및 인력, 자재 등의 많은 로스 부분이 발생 하여 생산성 절감 및 제품 원가 상승의 요인이 발생 한다. 따라서 본 논문에서 제안하고자 하는 내용은 기존의 2D TFT-LCD Module 검사장비에 3D Pattern 및 동영상을 구현하여 보다 신속 하고 정확한 임베디드 환경을 이용한 2D 및 3D LCD Module용 검사 시스템을 개발 하는데 있다.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2002년도 ITC-CSCC -1
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• pp.313-316
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• 2002

This paper presents the design and implementation of a crypto processor, a special-purpose microprocessor optimized for the execution of cryptography algorithms. This crypto processor can be used fur various security applications such as storage devices, embedded systems, network routers, etc. The crypto processor consists of a 32-bit RISC processor block and a coprocessor block dedicated to the SEED and triple-DES (data encryption standard) symmetric key crypto (cryptography) algorithms. The crypto processor has been designed and fabricated as a single VLSI chip using 0.5 $\mu\textrm{m}$ CMOS technology. To test and demonstrate the capabilities of this chip, a custom board providing real-time data security for a data storage device has been developed. Testing results show that the crypto processor operates correctly at a working frequency of 30MHz and a bandwidth o1240Mbps.

• 한국환경성돌연변이발암원학회지
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• 제17권2호
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• pp.71-77
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• 1997

The single cell gel electrophoressis(SCGE) assay, also known as the comet assay, is a rapid, simple, visual and sensitive technique for measuring and analysing DNA breakage in mammalian cells. The SCGE or comet assay is a promising test for the detection of DNA damage and repair in individnal cells. It has widespread potential applications in DNA damage and repair studies, genotoxicity testing and biomonitoring. In this microgel electrophoresis technique, cells are embedded in agarose gel on microscope slides, iysed and electrophoresed under alkaline conditions. Cells with increased DNA damage display increased migration of DNA from the nucleus towards the anode. The length of DNA migration indicates the amount of DNA breakage in the cell. The comet assay is also capable of identifying apoptotic cells which contain highly fragmented DNA. Here we review the development of the SCGE assay, existing protocols for the detection and analysis of comets, the relevant underlying principles determining the behaviour of DNA and the potential applications of the technique.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2000년도 하계종합학술대회 논문집(3)
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• pp.67-70
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• 2000

In a distributed real-time system(DRTS), testing and debugging are difficult and critical procedures since they implies several problems like probe effects, nondeterminism, and complex communication patterns. In this paper, we describe the design and implementation of a real-time monitor for ARM processors which are frequently used for embedded applications. The focus of design is to help users debug real-time programs while minimizing the probe effect. Our monitor provides cross debugging features like down-loading from host, break-point based debugging features, and watch-point debugging features for real-time applications. We developed the debugger for ARM processor and debugger has been used for kernel program.