• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제11권sup1호
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• pp.117-126
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• 2008

Trace elements compose a very small portion of the body, however they have a variety of essential functions. Various diseases are caused by trace element deficiencies, and sometimes they can be fatal. Long-term TPN is a risk factor of trace element deficiency, and trace elements need to be checked regularly while receiving TPN. It is important to provide sufficient requirements of trace elements regarding the clinical features and the problems of trace element excess or deficiency. Moreover extensive studies to establish the efficiency of examining human hair and nails, recent method to determine the trace elements, are required.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제11권2호
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• pp.122-129
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• 2008

목 적: 만성 설사, 흡수 장애 등의 소화기 질환에서 경구 영양 공급이 불충분할 경우 미량원소 결핍 발생의 빈도가 높으나, 이러한 환아에서 미량원소 결핍 증상에도 불구하고 혈액 검사 결과 정상으로 나타나기도 한다. 따라서 미량원소 결핍 고위험군 환아에서 결핍된 미량원소를 확인하고, 적절한 공급 및 추적 관찰 지표로서 모발 검사의 유용성을 알아보고자 하였다. 방 법: 서울대학교 어린이병원에 내원하여 만성 소화기 질환으로 경구 영양 장애 또는 성장 발육 부전을 보였던 13명을 대상으로 모발과 혈액의 미량원소 검사를 시행하여, 결핍 소견을 보인 모발과 혈액의 미량원소에 대해 장기 정맥영양군과 경구영양군, 그리고 증상군과 무증상군으로 나누어 비교, 분석하였다. 결 과: 전체 13명 중 11명에서 모발 또는 혈액 검사에서 미량원소 결핍이 있었으며, 결핍된 미량원소는 아연, 셀레늄, 구리였다. 모발 내 아연 결핍은 8명(62%), 모발 내 셀레늄 결핍은 6명(46%)이었고, 혈액 내 아연농도가 정상인 환자의 67% (8/12명), 혈액 내 셀레늄 농도가 정상 환자의 57% (4/7명)에서 각각 모발 내 아연, 모발 내 셀레늄 결핍을 보였다. 모발 내 아연 농도는 장기 정맥영양군에서 경구영양군에 비해 유의하게 낮았으며(p=0.015) 결핍 발생 빈도 또한 유의하게 높았다(Fisher's exact test, p=0.032). 모발 내 셀레늄 농도는 증상군에서 무증상군에 비해 유의하게 낮았다(p=0.034). 결 론: 만성 소화기 질환으로 경구 영양 장애 또는 성장 발육 부전이 있을 경우 증상 여부에 상관없이 혈액검사와 함께 모발 미네랄 검사로 결핍 여부를 평가하는 것이 필요할 것으로 보인다.

• 대한예방한의학회지
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• 제4권2호
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• pp.25-56
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• 2000

Trace element are involved in enzymatic activities, immunological reactions. physiological mechanisms. Deficiency in some trace elements, such as iron and iodine. is still an important health problem, The role of trace elements deficiency is suspected in various clinical situations and is now confirmed by well designed supplementation studies. However, the importance of trace elements as chinese herbal constituents is not sufficiently appreciated by the oriental medical profession, although in recent years a significant increase of new finding on their essential character in chinese herbal medicine occurred. It is well known that herbal medicine contains a variety of trace elements which would show therapeutic effects with active components in herbal medicine . In china, recent work showed some positive correlation between trace element and traditional chinese medicine (TCM) in terms of therapeutic effects even if their role in therapeutic effects is still obscure. In korea, not much attention has been on the therapeutic importance of trace element contained in herbal medicine Here, the therapeutic effects of trace element in TCM were reviewed and summarized. 1. Iron, copper, zinc and manganese are mainly contained in TCM. In addtion, chromium, magnesium, molybdenum, nickel, alminium, cobalt, arsenic and selenium has been studied for their therapeutic effects 2. Zinc, is decreased in patients who have deficiency of kindney(腎虛) and chronic disease. Fe is decreased in patients who have deficiency of blood(血虛). However copper is increased in patients who have chronic disease and hepatic disease.3 Iron concentration is high in herbs used for tonifying and nourishing yin or blood(補陰補血藥) Zinc concentration is high also in herb used for tonifying kidiney and vital essence(補腎補精藥). In addition. copper concentration Is high in herb used for replenishing qi(補氣藥) 4 In herbal drugs, the therapeutic substances in TCM are not only organic but also inorganic. It seems that trace elements would be one of components in herb for its therapeutic effects. This indicates that therapeutic effects of TCM should be extended not only to herb itself, bur also to trace elements contained in herb.

• 한국보건간호학회지
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• 제31권1호
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• pp.84-96
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• 2017

Purpose: Vitamin D is a fundamental element for bone metabolism. Recently vitamin D deficiency has been implicated in various diseases such as a cardiovascular disease, diabetes, and cancers. The aim of this study was to identify the risk factors associated with serum vitamin D deficiency among women office workers. Methods: We selected 369 women office workers using the secondary data of the 5th National Health & Nutrition Examination Survey 2010-2012. Data was analyzed by logistic regression of complex sampling design. Results: Women office workers with vitamin D deficiency, defined serum 25-hydroxyvitamin D concentration < 10ng/mL, were 12.5%. The risk factors for vitamin D deficiency were 20s aged group, married state and more than 40 working hours a week. The risk of vitamin D deficiency was decreased in those with alcohol drinking 1 to 4 times a month. The education level, income, region, smoking, physical activity and sun exposure time did not affect the risk of vitamin D deficiency significantly. Conclusion: Development of vitamin D deficiency prevention educational programs are required for women office workers who more than 40 hours a week in 20s. It should be considered health education including sun exposure duration and behavior.

• Structural Engineering and Mechanics
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• 제21권5호
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• pp.539-551
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• 2005

Finite elements based on isoparametric formulation are known to suffer spurious stiffness properties and corresponding stress oscillations, even when care is taken to ensure that completeness and continuity requirements are enforced. This occurs frequently when the physics of the problem requires multiple strain components to be defined. This kind of error, commonly known as locking, can be circumvented by using reduced integration techniques to evaluate the element stiffness matrices instead of the full integration that is mathematically prescribed. However, the reduced integration technique itself can have a further drawback - rank deficiency, which physically implies that spurious energy modes (e.g., hourglass modes) are introduced because of reduced integration. Such instability in an existing stiffness matrix is generally detected by means of an eigenvalue test. In this paper we show that a knowledge of the dimension of the solution space spanned by the column vectors of the strain-displacement matrix can be used to identify the instabilities arising in an element due to reduced/selective integration techniques a priori, without having to complete the element stiffness matrix formulation and then test for zero eigenvalues.

• Steel and Composite Structures
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• 제28권3호
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• pp.267-278
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• 2018

Structures may need retrofitting as a result of design and calculation errors, lack of proper implementation, post-construction change in use, damages due to accidental loads, corrosion and changes introduced in new editions of construction codes. Retrofitting helps to compensate weakness and increase the service life. Fiber Reinforced Polymer (FRP) is a modern material for retrofitting steel elements. This study aims to investigate the effect of deficiency location on the axial behavior of compressive elements of Circular Hollow Section (CHS) steel short columns. The deficiencies located vertically or horizontally at the middle or bottom of the element. A total of 43 control column and those with deficiencies were investigated in the ABAQUS software. Only 9 of them tested in the laboratory. The results indicated that the deficiencies had a significant effect on the increase in axial deformation, rupture in deficiency zone (local buckling), and decrease in ductility and bearing capacity. The damages of steel columns were responsible for resistance and stiffness drop at deficiency zone. Horizontal deficiency at the middle and vertical deficiency at the bottom of the steel columns were found to be the most critical. Using Carbon Fiber Reinforced Polymer (CFRP) as the most effective material in retrofitting the damaged columns, significantly helped the increase in resistance and rupture control around the deficiency zone.

• Journal of Nutrition and Health
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• 제51권5호
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• pp.379-385
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• 2018

Purpose: Zinc (Zn) is an essential trace element for bone mineralization and osteoblast function. We examined the effects of Zn deficiency on osteoblast differentiation and mineralization in MC3T3-E1 cells. Methods: Osteoblastic MC3T3-E1 cells were cultured at concentration of 1 to $15{\mu}M$ $ZnCl_2$ (Zn- or Zn+) for 5, 15 and 25 days up to the calcification period. Extracellular matrix mineralization was detected by staining Ca and P deposits using Alizarin Red and von Kossa stain respectively, and alkaline phosphatase (ALP) activity was detected by ALP staining and colorimetric method. Results: Extracellular matrix mineralization was decreased in Zn deficiency over 5, 15, and 25 days. Similarly, staining of ALP activity as the sign of an osteoblast differentiation, was also decreased by Zn deficiency over the same period. Interestingly, the gene expression of bone-related markers (ALP, PTHR; parathyroid hormone receptor, OPN; osteopontin, OC; osteocalcin and COLI; collagen type I), and bone-specific transcription factor Runx2 were downregulated by Zn deficiency for 5 or 15 days, however, this was restored at 25 days. Conclusion: Our data suggests that Zn deficiency inhibits osteoblast differentiation by retarding bone marker gene expression and also inhibits bone mineralization by decreasing Ca/P deposition as well as ALP activity.

• 한국초지조사료학회지
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• 제43권3호
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• pp.177-182
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• 2023

Iron (Fe) is a vital element for plants and other organisms, involving in several physiological processes including respiration, chlorophyll biosynthesis, and photosynthesis. Unfortunately, how Fe accumulation regulates in response to light quality has not been well established in plants. Therefore, the aim of the study was to explore the mechanism of Fe homeostasis by light quality. In this study, we found morpho-physiological attributes were significantly improved in response to blue (λmax: 450) compared to white (λmax: 500) and red (λmax: 660) light. The root-shoot length, plant biomass, photosynthesis efficiency (Fv/Fm) and leafgreen (SPAD) significantly declined in response to white and red light. However, these parameters were improved and iron deficiency was substantially alleviated by blue light exposure in alfalfa seedlings. This study might be useful to the forage breeders and farmers for improving alfalfa yield and nutritional benefits.

• 한국재료학회:학술대회논문집
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• 한국재료학회 1993년도 추계 학술발표 강연 및 논문 개요집
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• pp.112-112
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• 1993

• Journal of Acupuncture Research
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• 제18권6호
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• pp.240-249
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• 2001

Obejective : Based on ${\ll}$sixty-ninth Nan${\gg}$ (${\ll}$難經${\cdot}$六十九難${\gg}$) the interpromoting of the five element's balance method to discuss following 'when deficiency than should strengthen mother and when excessive than eliminate son' theories. Method : This strengthening and eliminating method is based on Jang-bu organ's balance method when 'east is excessive (liver excessive (肝實 )) and west is deficiency (lung deficiency (肺虛))' then 'eliminate the south and strengthen the north's method. Results : The seventy-fifth Nan (${\ll}$難經${\cdot}$七十五難${\gg}$) explains' son effects mother's excessive and mother effects son's deficiency' theory where it balance method of the inter-overacting five elements controlling Jang-bu organ's differentiations. The eighty-first Nan (${\ll}$難經${\cdot}$八十一難${\gg}$) explains strengthening-eliminating method of 'lung excessive and liver deficiency.' Since there are two different perspective of seventy-fifth and eighty-first Nan, we must compare and discuss to make right point of view. Conclusion : the treatment method in ${\ll}$Nan kyoung sixty ninth nan${\gg}$ could be understood as a view of five element constitutional theory (五行體質理論), the treatment method in ${\ll}$Nan kyoung seventyty-fifth nan${\gg}$ of eleminating fire and strengthning water in case of liver excess and lung defficiency and the treatment method in ${\ll}$Nan kyoung eighty-first nan${\gg}$ of strengthning liver and eleminating lung in case of lung excess and liver defficiency could be understood as a view of the yin-yan constitutional theory (陰陽體質理論).