• 재활복지공학회논문지
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• 제8권1호
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• pp.9-17
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• 2014

전기 자극 청신경 복합활동전위(electrical compound action potential; ECAP)는 인공와우로 청신경을 자극하고 동시에 반응을 기록한다. 이 연구는 인공와우에서 ECAP의 효용성을 높이기 위하여 자극과 기록에 대하여 연구하고자 한다. 대상은 문헌 또는 사례 연구를 제외한 연구 논문 34 편으로 하였다. 연구는 펄스 및 자극 조건, 잡파 억제 및 기록 조건 등을 분석하였다. 효과적인 신경 발화, 안정적인 역치 확인, 신경 퇴행 방지 등을 위해서는 펄스폭과 위상 간격이 가급적 짧고, (-)위상이 앞선 양위상 펄스를 사용하였다. 자극은 펄스 간격, 자극비율, 자극 방식 등을 정하여 와우의 첨부, 중간, 기저회전으로 C-level 정도로 하였다. 잡파는 전방차폐법, 거푸집소거법으로 제거하였고, 분명한 파형을 획득하기 위해서는 전극 간격, 증폭 정도, 평균 가산 회수 등의 추가 조절이 필요하다.

• PNF and Movement
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• 제18권3호
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• pp.393-401
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• 2020

Purpose: In recent years, there has been increasing interest in using blood flow-restricted exercise (BFRE) or KAATSU training. The KAATSU training method, which partially restricts arterial inflow and fully restricts venous outflow in the working musculature during exercise at reduced exercise intensities, has been proven to result in substantial increases in both muscle hypertrophy and strength. The purpose of this study was to investigate the proper level of pressure for KAATSU training using compound muscle action potential (CMAP) analysis. Methods: Twenty-two healthy adults voluntarily participated in this study. CMAP was conducted by measuring the terminal latency and amplitude using a motor nerve conduction velocity test. For reference-line, supramaximal electrical stimulation was applied to the median nerves of the participants to obtain CMAP for the abductor pollicis brevis. For baseline, the intensity of the electrical stimulation was decreased to a level at which the CMAP amplitude was about a third of the CMAP amplitude obtained by the supramaximal electrical stimulation. The pressure levels for the KAATSU were set as a systolic blood pressure (strong pressure), the median values of systolic and diastolic blood pressure (intermediate pressure), and diastolic blood pressure (weak pressure). In the KAATSU condition, CMAP was performed under the same conditions as baseline after low-intensity thumb abduction exercises were performed at the subjects' own pace for one minute. Results: As the pressure increased, the CMAP amplitude was significantly increased, signifying that more muscle fibers were recruited. Conclusion: This study found that KAATSU training recruited more muscle fibers than low-intensity exercise without the restriction of blood flow.

• 전자공학회논문지
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• 제50권6호
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• pp.287-293
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• 2013

인공와우는 유모세포의 손실로 청신격 자극이 되지 않을 경우, 삽입된 전극에 전기자극을 가함으로써 청감각을 회복하는 장치이다. 인공와우의 성능을 향상하기 위하여, 자극에 따른 정확한 신경반응을 이해하는 것이 매우 중요하고, 임상에서는 electrically evoked compound action potential (ECAP)을 측정하여 신경반응을 측정하고 있다. 본 연구에서는 실제 달팽이관과 유사한 3차원 달팽이관 유한요소 모델을 개발하고, 자극에 따른 신경반응을 측정할 수 있는 ECAP 알고리즘을 개발하였다. 개발된 3차원 달팽이관 모델을 이용하여, 전기 자극에 따른 ECAP 크기와 반응 잠복 시간을 측정하였으며, 측정된 결과 임상시험과 동물실험에서 측정된 ECAP 크기와 반응 잠복 시간과 유사한 값을 얻을 수 있었다. 본 3차원 달팽이관 모델은 전기 자극에 대한 신경 반응을 분석함으로써 인공 와우의 성능을 향상시키기 위한 전기자극 방식을 연구하는데 유용하게 이용될 수 있다.

• 전자공학회논문지SC
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• 제48권5호
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• pp.81-92
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• 2011

본 논문에서는 표면 근전도(surface electromyogram : SEMG)와 근육모델링을 이용하여 신경근육 접합부(neuromuscular junction, NMJ)의 종판(end plate) 폭(widths)과 분포(distribution)에 따른 운동단위(motor unit, MU)수를 추정하는 새로운 방법을 제안하였다. 이를 위하여 MU-시뮬레이터(motor unit simulator)와 EPZ-시뮬레이터(end plate zone simulator)를 설계하고, 본 연구에서 제안된 방법과 기존방법들을 비교하였다. 제안된 MU-시뮬레이터로 시뮬레이션 된 SMUAP(single motor unit action potential : 단일운동단위활동전위)와 CMAP(compound muscle action potential : 복합근활동전위)은 검출된 근신호와 유사하였다. EPZ-시뮬레이터는 신경근육 접합부의 종판 폭과 분포를 바꾸어 가면서 운동단위수를 추정하기 위하여 설계하였다. 실험결과 운동단위 수는 약 450 개, 근섬유수 약 340 개, 종판 폭은 약 6 mm이고, 종판분포는 불규칙하게 분포된 것 (randomly distributed)으로 추정되었다. 본 연구에서 제안된 방법은 인간 근육의 생체조직검사로 측정한 운동단위의 수와 비교 가능한 결과가 나왔다.

• 전기학회논문지
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• 제56권11호
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• pp.2040-2050
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• 2007

In this study, we present a novel method for estimating the information of MU(motor unit) which is the basic element of human muscle by using surface EMG. Some of the method developed in this field could only estimate the numbers of MU that is activated. However, in our study the MU-simulator based on the line source model was designed to estimate the MU information including the numbers of MU and muscle fiber, conduction velocity, MU diameter, fiber diameter, and end plate position. The SMUAP(single motor unit action potential) detector was designed and CMAP(compound muscle action potential) by electrical stimulus was recorded. With these data, the MU-simulator can estimate the MU information by varying muscle paramater settings through MSE(mean square error) method. Our results shows that the proposed method can be comparable with the method of anatomical studies. Moreover, our system can be utilized to build a tool for diagnosis and treatment assessment of neuromuscular patients.

• 한국전문물리치료학회지
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• 제14권3호
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• pp.57-63
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• 2007

The purpose of this study was to evaluate inter-rater reliability of the amplitude and first knee extension angles in deep tendon reflex test by using an electrical hammer. Twenty-five healthy adults participated in the study. Compound muscle action potential is elicited by tapping the knee tendon with an electrical hammer in deep tendon reflex tests. The amplitude and knee extension angle were simultaneously measured. The mean value of the amplitude and the knee extension angles through three time trials for each tester, are used for determining the inter-rater and Intra-class Correlation Coefficients (ICCs) reliabilities. According to the results, the ICCs of the amplitude is .280 and that of the knee extension angle is .789. Pearson correlation coefficients of the amplitude of the action potential and the knee extension angles are .685, showing significant statistically moderate correlation. Inter-rater reliability in the amplitude was not significant. More objective and quantitative deep tendon reflex tests should be done to obtain higher reliability in further studies.

• The Korean Journal of Physiology
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• 제15권2호
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• pp.73-81
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• 1981

Experiments were conducted in ischemic decerebrate cats to study the effects of electroacupuncture and electrical stimulation of peripheral nerve on pain reaction. Flexion reflex was used as an index of pain. The reflex was elicited by stimulating the sural nerve(20 V, 0.5 msec duration) and recorded as a compound action potential from the nerve innervated to the semitendinosus muscle. Electroacupuncture was performed, using a 23-gauge hyperdermic needle, on the tsusanli point in the lateral upper tibia of the ipsilateral hindlimb. The common peroneal nerve was selected as a peripheral nerve which may be associated with electroacupuncture action, as it runs through the tissue portion under the tsusanli point. Both for electroacupuncture and the stimulation of common peroneal nerve a stimulus of 20 V-intensity, 2 msec-duration and 2 Hz-frequency was applied for 60 min. The results are summerized as follows: 1) The electroacupuncture markedly depressed the flexion reflex; this effect was eliminated by systemic application of naloxone $(0.02{\sim}0.12\;mg/kg)$, a specific narcotic antagonist. 2) Similarly, the electrical stimulation of the common peroneal nerve significantly depressed the flexion reflex, the effect being reversed by naloxone. 3) When most of the afferent nerves excluding sural nerve in the ipsilateral hindlimb were cut, the effect of electroacupuncture on the flexion reflex was not observed. Whereas direct stimulation of the common peroneal nerve at the proximal end from the cut resulted in a significant reduction of the flexion reflex, again the effect was reversible by naloxone application. 4) Transection of the spinal cord at the thoracic 12 did not eliminate the effect of peripheral nerve stimulation on the flexion reflex and its reversal by naloxone, although the effect was significantly less than that in the animal with spinal cord intact. These results suggest that: 1) the analgesic effect of an electroacupuncture is directly mediated by the nervous system and involves morphine-like substances in CNS, 2) the site of analgesic action of electroacupuncture resides mainly in the brainstem and in part in the spinal cord.

• 한국전문물리치료학회지
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• 제9권3호
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• pp.101-111
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• 2002

The purpose of this study was to determine EMG biofeedback training effect on the muscle activities in 3 unilateral facial palsy patients along with multiple baseline design across subjects. The auditory feedback about facial muscles (orbicularis oris, orbicularis oculi, frontalis) was provided with each patient during facial exercise training. Electromyographic (EMG) activity during maximal voluntary contraction and maximal compound muscle action potential (CMAP) amplitude elected by supramaximal electrical stimulation on facial nerve of facial muscles were measured pre- and post- EMG biofeedback training to evaluate motor learning. EMG activity during maximal voluntary contraction was increased after EMG biofeedback training and CMAP amplitude elected by supramaximal electrical stimulation was not changed in all subjects. The results indicate that EMG biofeedback training is useful method to improve motor learning of facial excercise training in unilateral facial palsy patients.

• The Korean Journal of Physiology
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• 제19권2호
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• pp.227-232
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• 1985

Previously, we had reported that the electrical stimulation of peripheral nerve with stimlatory parameters of 20 V strength and 2 Hz frequency for 60 min resulted in reducing the pain reaction. The present study was performed to evaluate if the pain reaction was affected by the peripheral nerve stimulation with different stimulatory parameters in the decerebrated cat. The flexion reflex was used as an index of the pain reaction. The reflex was elicited by stimulating the sural nerve (stimulus strength of 20 $V\;\times\;0.5$msec) and recorded as a compound action potential from the motor nerve innervated to the posterior biceps femoris muscle. The common perneal nerve was selected as a peripheral nerve on which the electrical stimulation of various intensities and frequencies was applied. The results are summarized as follows : 1) The peripheral nerve stimulation with 100 mV strength, regardless of frequencies, did not affect the pain reaction induced by the sural nerve stimulation. 2) When the stimulus of 1V intensity and slow frequency (2 Hz) was applied to the peripheral nerve for 30 min or 60 min, the pain reaction was significantly reduced comparing to the control. However, this reduced pain reaction by the peripheral nerve stimulation was not reversed by the injection of naloxone (0.02 mg/kg) 3) High frequency stimulus (60 Hz) of 1V intensity for 30 or 60 min did not show any effects of affecting the pain reaction. These results suggest that the stimulus of relatively high intensity (at least 1V) and low frequency (2 Hz) is needed to elicite the analgesic effect by the peripheral nerve stimulation. By the 1V stimulus, $A\delta$ nerve fiber is activated. Therefore, an $A\delta$ or smaller nerve fibers must be activated for showing analgesia by the peripheral nerve stimulation. However, the mechanism of analgesia by the $A\delta$ nerve activation alone was not related to the endogeneous morphine system since the reduced pain reaction by the $A\delta$ fiber activation alone was not reversed by the treatment of naloxone.