• 지역연구
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• 제10권2호
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• pp.61-71
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• 1994

Despite of being the criteria to choose the efficient and reasonable alternatioves inactual planning process, the measure of accessibility rarely has applied to practices because each model has unexplicity concept of it and limitations in itself. Accessibility implies transportation system which offers opportunity of movement to overcome spatial separation and, simultaneously, land-use system which represents the location of each activity. Therefore, measures of accessibility have to represent the attractiveness of locations and the interactions of activities, that is, land-use and transportation, with an index. Considering that urban activity is based on the economic efficiency, costs and benfits, accessibility means the economic efficiency of the location of activity and the travel in view of land-use and transport repectively. Combined models that measure accessibility with considering land-use and tranportation simultaneously depend on reasonable concepts, but it is too simple for them to explain the accessibility which resulted from complex interaction of urban activities. Combined urban activity model developed by Kim (1983) and Rho (1989) explains the characteristics of activities in each regions and urban strcture in economic general equilibrium states in the long term of urban system. This model measures a regional accessibility with a dual variable which means the location surplus. This is a more systematic and comprehensive model for calculating the regional accessibility because it considers the interaction of each activity in urban system. It needs efforts to apply the accessibility index as a criterion in actual planning process through finding and quantitification of other explanatory variables to measure it in combined urban activity model.

• International Journal of Computer Science & Network Security
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• 제21권12호
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• pp.328-334
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• 2021

The article examines the economic essence and approaches to determining the efficiency of the enterprise. The author in the study considers the effectiveness and from the standpoint of qualitative analysis of the effectiveness of change and implementation of enterprise development goals. It is established that the tool for ensuring qualitative impacts on the efficiency of the enterprise is the innovative development of the economic space of the enterprise. The article considers the dominant innovations that have influenced the means and methods of production. An organizational and economic mechanism has been recommended to coordinate the costs of innovation activities in order to ensure the efficiency of enterprises. The object of management in the organizational and economic mechanism is the innovation process in the enterprise: from the design of strategic goals of innovation, search and commercialization of innovations, to building and implementing innovation potential. The efficiency of the enterprise under the condition of realization of innovative potential will be characterized by steady competitive advantages and strategically-oriented behavior in the market.

• Asian-Australasian Journal of Animal Sciences
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• 제11권5호
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• pp.498-502
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• 1998

The present study was designed, fIrst to develop the new methodology to measure the bioluminescence activity easily in live developing bovine embryos by photoncounting, and secondly to compare the expression efficiency of four luciferase reporter genes in bovine embryos at four- to 16-cell stages. In experiment 1, equimolar pSVlacZ and pSVEluc were microinjected into the pronucleus of fertilized bovine oocytes. At 2 days after micro injection, bioluminescence activity of these embryos was measured by photoncounting with a luminometer for 1 min, and lacZ gene expression in the same embryos was assayed by X-gal staining. All the luciferase-positive oocytes showed some bacterial ${\beta}$-galactosidase activity irrespective of the intensity. In experiment 2, four firefly luciferase genes (pTKEluc, pTK6WEluc, pSVEluc and pMiwluc) were introduced by micro injection, and the injected embryos were cultured for the following 2 days. Detection of the luciferase gene expression was done by photoncounting at 5 to 55 min. Over the measurement period, the luciferase activity was almost constant irrespective of the transgenes microinjected. The luciferase activity and expression efficiency at 2 days after microinjection were not significantly affected by the difference in the microinjected transgenes. The present results demonstrated that the bioluminescence activity in live developing bovine embryos could be measured quickly by photoncounting.

• Journal of Dental Anesthesia and Pain Medicine
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• 제18권4호
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• pp.223-233
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• 2018

Topical anesthetics are commonly used in oral & maxillofacial surgery to control pain in the oral cavity mucosa before local anesthetic injection. These anesthetic agents come in many forms, developed for different usages, to minimize adverse reactions, and for optimal anesthetic efficiency. Earlier studies have revealed that these agents may also limit the growth of microorganisms in the area of anesthetic application. Many topical anesthetic agents show different levels of antimicrobial activity against various bacterial strains and Candida. The dosage of local anesthetic agent used in some clinical preparations is too low to show a significant effect on microbial activity. Efficiency of antimicrobial activity depends on the local anesthetic agent's properties of diffusion within the bloodstream and binding efficiency with cytoplasmic membrane, which is followed by disruption of the bacterial cell membrane. The antimicrobial properties of these agents may extend their usage in patients to both control pain and infection. To develop the topical local anesthetic optimal usage and antimicrobial effect, a collaborating antiseptic agent may be used to benefit the local anesthetic. However, more research is required regarding minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of topical local anesthetic agents with drug interaction between anesthetics and antiseptic agents.

• 핵의학기술
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• 제13권3호
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• pp.193-195
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• 2009

Purpose: The work flow of international hospital's laboratory consists of rapid test and result report at the present day. However, the frequent inquiry of sample, which cause affairs to delay and efficiency to Lower, affects medical examination. In order to promote work's efficiency, we should improve the problem and make work smooth between a laboratory, outs and ward. Materials and Methods: This study runs as follows. First, Investigating test result, test schedule, test receipt, quick result, etc through the activity required from September to November 2007 about the inquiry of sample. After analysis of the problem in December, remaking the test schedule for improvement solution and reporting it to outs and ward. When the result is retest and dilution, we directly fill in a result space with the result situation of the patient to let them know beforehand. We also, prevent the omission of the result through checking the sample list and discriminate in vivo from in vitro by changing the laboratory's telephone number. We have improved the problem about the inquiry of sample through valuation and analysis since the improvement activity from January to March 2008. Result: The case about the frequent inquiry of sample has reduced by 57.8%. this improvement activity indicated that p-value<0.05 was statistically significant through paired t-test. This activity make study smooth and we rapidly report the result. Conclusion: By reducing the case regarding the inquiry of sample, work discontinuation, and concentration reduction, the work efficiency was increased.

• 약학회지
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• 제40권5호
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• pp.522-531
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• 1996

5-fluorouracil(5-FU) derivatives synthesized with four N-acyloxycarbonyl group such as 1-(N-t-butyloxycarbonyl)glycyloxymethyl-5-FU(BGFU), 1-(N-t-butyloxycarbonyl)leucyloxymethy l-5-FU(BLFU), 1-(N-t-carbobenzyloxymethyl)glycyoxymethyl-5-FU(CGFU) and 1-(N-t-carbobenzyloxymethyl)leucyloxymethyl-5-FU(CLFU) were entrapped into liposomes with different lipid compositions. The entrapment efficiency and release rate of drugs from each liposomes were evaluated. The particle size of liposomes, cytotoxicity and stability of drug-entrapped in liposomes were evaluated. The entrapment efficiency in 5-FU derivatives liposomes was dependent on the lipophilicity of N-acyloxymethyl derivatives. The drug entrapment efficiency also increased on the content of lipid increased up to 200mcmol of lipid per milliliter of liposomal solution. However, inclusion of additives such as cholesterol, dicetylphosphate and stearylamine decreased the entrapment efficiency. The mean particle size and size distribution were varied with lipid compositions and lipophilicity of prodrugs. The release rates of drugs from liposomes were not affected by additives, but those of BGFU and CGFU entrapped in liposomes with cholesterol decreased. Cytotoxicity of BLFU and CLFU entrapped in liposomes decreased by 3~5 fold compared with those of free two prodrugs. Liposome-entrapped 5-FU prodrugs were more stable either at pH 7.4 or in human plasma. Especially, 5-FU prodrugs entrapped in liposome with dipalmitoylphosphatidylcholine(DMPC) was the most stable in human plasma. Compared with free BLFU, BLFU entrapped in DMPC liposome showed a superior antitumor activity at all doses used. In contrast, CLFU entapped in liposomes were more toxic than free prodrug.

• Nuclear Engineering and Technology
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• 제36권2호
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• pp.121-126
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• 2004

3-PM liquid scintillation counting using the geometry-efficiency variation technique has been applied to the activity measurement of $^{204}T1$, which decays to $^{204}Hg\;and\;^{204}Pb\;by\;{\beta}^-$ and E.C., respectively. The TDCR values K have been derived over a wide range, 0.78 < K < 0.97, by displacing the detectors up to 50 mm away from an unquenched liquid scintillation sample $^{204}Tl$. The derived plots of the logic sums of double coincidences $N_D(K)$ very K vary linearly in the observed regions. The fractions of losses due to electron capture decay have been taken into account by employing a PENELOPE Monte Carlo simulation. The calibrated activity is 102.3 kBq at a reference date of July 1st, 2002 (UT) with a combined uncertainty of $0.63\%$. This is consistent with the value determined by means of the CIEMAT/NIST method at KRISS.

• 한국염색가공학회지
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• 제23권3호
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• pp.179-186
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• 2011

For the application of Jeju scoria scattered around the island as a natural dye, cotton fabrics were dyed with the dye and their properties were measured including dyeability, colorfastness, antibacterial activity, deodorization efficiency, ultraviolet protection, and far-infrared emission. The dyed cotton fabrics were in yellowish red and optimal dyeing conditions were obtained with a colorant concentration of 25%(o.w.b) at a temperature of $80^{\circ}C$ for the dyeing time of 120 minutes. The ratings of colorfastness to light, rubbing, perspiration, and washing were 8, 5, 5, and 4~5 respectively. After 15 wash cycles, colorfastness remained as much as 4~5 rating. The cotton fabric dyed with Jeju scoria demonstrated excellent antimicrobial activity and deodorization efficiency of 99.9% and 93.9% respectively. Ultraviolet protection factor was 50+. Far-infrared emission rate and far-infrared emission intensity were 90% and 362(W/$m^2{\cdot}{\mu}m$) respectively. The Jeju scoria can be introduced as a new colorant for the natural dyeing of cotton.

• Biotechnology and Bioprocess Engineering:BBE
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• 제11권1호
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• pp.84-87
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• 2006

Batch binding experiments were performed to assess the recovery performance of glyceraldehyde 3-phosphate dehydrogenase (G3PDH) bound to the unshielded and polymer (polyvinyl pyrrolidone. PVP)-shielded dye-ligand (Cibacron Blue 3GA) adsorbent. The adoption of a polymer-shielded, dye-ligand technique facilitated the elution efficiency of bound G3PDH. It was demonstrated that the recovery of G3PDH using polymer-shielded dye-ligand adsorption yielded higher elution efficiency, at 60.5% and a specific activity of 42.3 IU/mg, after a low ionic strength elution (0.15 M NaCl). The unshielded dye-ligand yielded lower elution efficiency. at 6.5% and a specific activity of 10.2 IU/mg.

• 기술혁신연구
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• 제27권2호
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• pp.73-98
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• 2019

본 연구는 특허출원이 기업 성과에 영향을 미친다는 가정 하에 중소중견기업을 위한 산업별 맞춤형 특허 활동성 제고 전략 5가지를 제안함으로서 향후 중소중견기업의 특허활동 성과 제고에 기여하고자 하였다. 연구대상은 특허 활동이 활발한 25개 산업을 대상으로 2010년부터 5년간의 특허 활동성 통계자료와 2014년도 기준 기업성과 통계자료를 활용하였다. 연구절차는 DEA-BCC 효율성 분석과 특허 활동성 분석, 그리고 특허 포트폴리오 분석을 각각 실시한 후, 이를 종합한 특허 활동성 제고 전략을 제안하는 순으로 진행하였다. 연구 결과, 특허 활동성이 높고 IRS(규모수익체증)형태를 보인 5개 산업의 경우, 특허 효율성이 높은 산업으로서 기업성과 향상에 실질적인 도움이 되고 있음을 확인하였다, 반면, 특허 활동성은 높으나 규모수익이 IRS(규모수익체중)/DRS(규모수익체감)형태로 나타난 12개 산업을 비롯, 특허 활동성도 낮고 규모수익이 DRS(규모수익체감)형태, CRS/IRS 혼합형태, 그리고 IRS 형태로 나타난 8개 산업 모두, 산업별 특성에 따라 특허 효율성도 다양한 형태로 나타날 수 있음을 확인하였다.