• 대한한의학회지
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• 제23권4호
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• pp.9-14
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• 2002

To assess the clinical efficacy of Chungpyesagan-tang on acute stroke, we prescribed this medicine to 88 acute stroke patients without thrombolytic treatment. The rate of progressive stroke type was 2.3%, remarkably lower than in previous reports. 1.1 % felt an itching sensation, and 17.0% complaxined of loose stool and diarrhea. Chungpyesagan-tang decreased Stroke-Pattern Identification and National Institute of Health Stroke Scale (NIHSS), and increased Modified Barthel Index (MBI). Thus, we could suggest that this medicine has a desirable effect to reduce the severity of stroke and improve functional recovery. As to the laboratory findings, ALT had anupward tendency and increased over normal value in 16 cases (18.2%). However, the mean serum level 2 weeks later was within the normal value and the other hepatic enzymes did not increase.

• 대한생식의학회:학술대회논문집
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• 대한불임학회 2006년도 The 5th Biannual Meeting of Pacific Rim Society for Fertility and Sterility
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• pp.165.1-165.1
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• 2006

• Journal of Hospice and Palliative Care
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• 제21권2호
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• pp.65-74
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• 2018

목적: 호스피스완화 간호사의 섬망에 대한 지식, 자기효능감 및 간호수행도 간의 관계를 파악하기 위함이다. 방법: 전국 19개 호스피스 완화의료 센터에 근무하는 간호사 174명을 대상으로 구조화된 설문지를 이용하였다. 결과: 첫째, 호스피스완화 간호사의 섬망에 대한 지식 정도는 45점 만점 중 평균 32.83점으로 73%의 정답률을 보였다. 섬망에 대한 지식은 4년제 대학 졸업 이하 군, 종교가 없는 군, 호스피스 경력이 59개월 미만 군에서 유의하게 낮았다. 둘째, 호스피스완화 간호사의 자기효능감 정도는 10점 만점 중 평균 7.08점이었다. 하위영역에서는 간호중재에 대한 자기효능감이 7.36점으로 가장 높았고, 간호사정에 대한 자기효능감이 6.79점으로 가장 낮았다. 자기효능감은 40세 이하, 미혼, 4년제 대학 졸업 군, 종교가 없는 군, 일반간호사 군, 임상경력이 120개월 미만 군과 호스피스 경력이 59개월 미만 군, 가족의 생애말기 돌봄 경험이 없는 군에서 유의하게 낮았다. 셋째, 호스피스 완화 간호사의 섬망에 대한 간호수행도는 4점 만점에 평균 2.95점이었다. 간호수행도는 23~29세, 미혼, 4년제 대학 졸업 군, 종교가 없는 군, 임상경력이 59개월 미만 군, 호스피스 경력이 낮은 군, 가족의 생애말기 돌봄 경험이 없는 군에서 유의하게 낮았다. 넷째, 섬망에 대한 간호수행도는 지식(r=0.28) 및 자기효능감(r=0.51)과 양의 상관관계를 보였다. 또한 지식은 자기효능감과 양의 상관관계를 나타내었다(r=0.24). 결론: 호스피스완화 간호사의 섬망에 대한 지식과 자기효능감, 간호수행도는 비교적 양호한 편으로 나타났지만 4년제 대학 졸업 이하군과 종교가 없는 군, 호스피스 경력이 5년 미만 군에서는 낮았다. 따라서 호스피스완화 간호에서 섬망 간호의 질적 향상을 위해서는 간호사의 지식 정도 및 요구를 선택적으로 반영한 양질의 섬망 교육프로그램을 개발하고 적용하여야 하며 섬망 간호 지식 및 수행도가 낮은 집단에 대한 중재전략 개발을 위한 연구가 필요할 것으로 사료된다.

• 생물정신의학
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• 제3권1호
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• pp.102-108
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• 1996

본 연구는 한국인의 우울증 환자에서 moclobemide가 효과적이며 안전하게 사용될 수 있음을 입증하였으며, 투약 방법으로 초기 권장량인 1일 300mg을 2회 분복시키는 방법이 추천될 수 있음을 확인하였다.

• 사상체질의학회지
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• 제15권2호
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• pp.137-150
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• 2003

The purpose of this study is to examine the toxic effects caused by glucose oxidase (GO) and the effects of Hyungbangjihwangtang (HJT) water extracts on the treatment of the toxic effects. For this purpose, experiments with the cultured hippocampal cells from new born mice were done. The results of these experiments were as follows. 1. GO decreased the survival rate of the cultured cells on MTT assay and NR assay. 2. HJT has the efficacy of decreasing the lipid peroxidation. 3. HJT has the efficacy of increasing the amount of neurofilaments. 4. HJT has the efficacy of decreasing the activation of protein kinase C(PKC). From the above results, it is concluded that HJT has marked efficacy as a treatment for the damages caused by the GO-mediated oxidative stress. Further clinical study of this pharmacological effects of H]T should be completed.

• 수산해양교육연구
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• 제27권5호
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• pp.1491-1498
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• 2015

In this study we investigated the effect of vaccine efficacy and immune activities by feeding additives several natural herbal remedies extracts of Sweet Wormwood (Artemisia annua), Galla Rhois, Oriental raisin tree (Havenia Dulicis) and 6-mixed herb to Oilve flounder, Paralichthys olivaceus. Each group of fish fed with the herbal remedies added feed and basic formula during the seven weeks and vaccinated with Edwardsiella tarda Formalin killed vaccine after 4 weeks feeding. Relative Percentage Survival values (RPS) in the group was assessed by the challenge with E.tarda. All groups with the herbal remedies added feed enhanced growth rate, but there were not significantly different in lysozyme activity and agglutination titer. In a challenge experiment with E.tarda, RPS in the all groups feeding additives natural herbal remedies was higher than that of the control group. These results suggest that the natural herbal remedies extracts of Sweet Wormwood (Artemisia annua), Galla Rhois, Oriental raisin tree (Havenia Dulicis) and 6-mixed herb would be effective to enhance efficacy of vaccination to Olive flounder.

• 한국식물병리학회:학술대회논문집
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• 한국식물병리학회 2003년도 정기총회 및 추계학술발표회
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• pp.88.2-89
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• 2003

Changes of control efficacy of metalaxyl to potato late blight caused by Phytophthora infestans were examined in potato fields from 2001 to 2003. In 2001 and 2002, control efficacy of metalaxyl was similar to those of dimethomorph and ethaboxam. However, the control efficacy of metalaxyl were decreased to 50.3％ in 2003. Total 366 isolates of P infestans obtained from several areas in Korea from 2001 to 2003 were examined for changes of sensitivity to metalaxyl. About 6.8％ of fungal isolates examined in 2001 were sensitive, 84.1％ were intermediate resistant, 9.1％ were resistant to metalaxyl. Among the isolates collected in 2002, 3.9％ were sensitive, 75.6％ were intermediate resistant, 20.6％ were resistant to the chemical. However, among the isolates obtained in 2003, 55.9％ were intermediate resistant, 44.1％ were resistant, but none of the isolates tested were sensitive. Both A1 and A2 mating type isolate were isolated in 2002∼2003. However, all isolates collected in 2001 were A1 mating type. About 87.5％ of the isolates collected in 2002, 89.8％ In 2003 were determined as A1 mating type. The majority of the p. infestans isolates were A1 mating types. Changes of control efficacy of metalaxyl to potato late blight might be caused by the occurrence rate of moderately resistant isolates within A1 mating type.

• 대한한의학회지
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• 제26권2호
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• pp.231-240
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• 2005

Objectives: In order to investigate the efficacy and safety of the newly developed herbal medicine Jetongdan, a placebo­controlled, randomized clinical trial of patients with osteoarthritis of the knee was undertaken. Methods: Data were obtained from 80 patients with OA of the knee. After enrollment, they were asked to answer a disease-specific questionnaire (Western Ontario and McMaster Universities (WOMAC) OA index) and analyzed with the erythrocyte sedimentation rate (ESR) in order to evaluate the efficacy of Jetongdan, and analyzed for aspartate transaminase (AST) level, alanine transaminase (ALT) level, blood mea nitrogen (BUN) level, and creatinine (Cr) level in order to evaluate the safety of Jetongdan. Results: The liver function and renal function did not deteriorate after treatment with Jetongdan. Composite WOMAC score and physical function subscale was improved, but pain subscale, stiffness subscale, and ESR were not improved by. This was possibly because the baseline characteristics of the two groups were not homogenized after randomization. Conclusions: Jetongdan could be a promising treatment option for osteoarthritis of the knee. Further study in a larger population with appropriate severity grades is recommended.

• Asian Pacific Journal of Cancer Prevention
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• 제15권22호
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• pp.9627-9630
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• 2014

Background: Although efficacy of aprepitant for suppressing emesis associated with single-dose cisplatin has been demonstrated, there are limited data on the antiemetic effect of this oral neurokinin-1 receptor antagonist during daily administration of cisplatin. Accordingly, we investigated the efficacy and safety of aprepitant in patients with head and neck cancer (HNC) receiving combination therapy with cisplatin and 5-FU (FP therapy). Materials and Methods: Twenty patients with HNC were prospectively studied who received a triple antiemetic regimen comprising granisetron ($40{\mu}g/kg$ on Days 1-4), dexamethasone (8 mg on Days 1-4), and aprepitant (125 mg on day 1 and 80mg on days 2-5) with FP therapy (cisplatin $20mg/m^2$ on days 1-4; 5-FU $400mg/m^2$ on days 1-5) (aprepitant group). We also retrospectively studied another 20 HNC patients who received the same regimen except for aprepitant (control group). Results: For efficacy endpoints based on nausea, the aprepitant group showed significantly better results, including a higher rate of complete response (no vomiting and no salvage therapy) for the acute phase (p=0.0342), although there was no marked difference between the two groups with regard to percentage of patients in whom vomiting was suppressed. There were no clinically relevant adverse reactions to aprepitant. Conclusions: This study suggested that a triple antiemetic regimen containing aprepitant is safe and effective for HNC patients receiving daily cisplatin therapy.

• 대한간호학회지
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• 제42권5호
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• pp.689-698
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• 2012

Purpose: This study was done to develop and evaluate a drug dosage calculation training program using cognitive loading theory based on a smartphone application. Calculation ability, dosage calculation related self-efficacy and anxiety were measured. Methods: A nonequivalent control group design was used. Smartphone application and a handout for self-study were developed and administered to the experimental group and only a handout was provided for control group. Intervention period was 4 weeks. Data were analyzed using descriptive analysis, ${\chi}^2$-test, t-test, and ANCOVA with the SPSS 18.0. Results: The experimental group showed more 'self-efficacy for drug dosage calculation' than the control group (t=3.82, p<.001). Experimental group students had higher ability to perform drug dosage calculations than control group students (t=3.98, p<.001), with regard to 'metric conversion' (t=2.25, p =.027), 'table dosage calculation' (t=2.20, p =.031) and 'drop rate calculation' (t=4.60, p<.001). There was no difference in improvement in 'anxiety for drug dosage calculation'. Mean satisfaction score for the program was 86.1. Conclusion: These results indicate that this drug dosage calculation training program using smartphone application is effective in improving dosage calculation related self-efficacy and calculation ability. Further study should be done to develop additional interventions for reducing anxiety.