• 대한한의학회지
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• 제24권3호
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• pp.155-164
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• 2003

Objective : Recently questionnaires that reflect the quality of life (QOL) in asthma patients were developed. We aimed to identify the clinical effects of Gamipaima-tang and the side effects of Gamipaimo-tang in asthmatic patients. Materials and Methods : The subjects are consisted of 34 patients with asthma who had been treated with Gamipaimo-tang for four weeks. Gamipaima-tang is an herbal decoction which has been used as a traditional therapeutic agent for asthma. Pulmonary function test (PFT) was checked before and after 4-week treatments. Quality of Life Questionnaire for Adult Korean Asthmatics (QLQAKA) was checked before and after 2 weeks and 4 weeks of treatment. Results : Treatment with Gamipaima-tang for four weeks resulted in significant increase in FVC%, $FEV_{1.0}%$, PEFR%, and QLQAKA. The total efficacy rate in the patient group was 52.9% after 4 weeks. The total efficacy rate of the step 4 group (n=18, 55.6%) classified by Global Initiative for Asthma (GINA) was higher than that of the step 3 group (n=13, 46.2%) classified by GINA. Conclusion : This study shows that Gamipaima-tang has the effects of improvement of pulmonary function and quality of life in asthmatic patients. Obviously further research concerning this is still necessary.

• 척추신경추나의학회지
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• 제13권1호
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• pp.1-10
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• 2018

Objectives: To evaluate the evidence supporting the effectiveness of Chuna manual therapy for rheumatoid arthritis. Methods: We conducted a search across 9 electronic databases to find all randomized controlled clinical trials (RCTs) that used Chuna manual therapy as a treatment for rheumatoid arthritis. The methodological quality of each RCT was assessed using the Cochrane risk of bias tool. Results: Our inclusion criteria were met by 5 RCTs. The meta-analysis showed positive results for the use of Chuna manual therapy combined with oriental usual care (UC) in terms of the efficacy rate, pain, and duration of morning stiffness when compared to western UC. Positive results were also obtained in terms of the efficacy rate, when Chuna manual therapy combined with medication was compared to medication treatments alone. Conclusions: Our systematic review found encouraging, but limited evidence of Chuna manual therapy for rheumatoid arthritis. However, to obtain stronger evidence without the drawbacks of trial design and the quality of studies, we recommend a comparative research to test the effectiveness of Chuna manual therapy.

• Journal of Breast Disease
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• 제6권2호
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• pp.46-51
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• 2018

Purpose: Endocrine therapy is the preferred treatment for hormone receptor (HR)-positive metastatic breast cancer (MBC). We investigated the efficacy of combined aromatase inhibitor (AI) and luteinizing hormone-releasing hormone (LHRH) agonist in premenopausal patients with HR-positive MBC. Methods: We retrospectively analyzed the medical records of 21 HR-positive premenopausal MBC patients treated with combined AI and LHRH agonist therapy. Results: The median follow-up period was 32.9 months. The overall response rate was 47.6%, with three complete responses (14.3%) and seven partial responses (33.3%). Nine patients (42.9%) achieved stable disease lasting more than 6 months; thus, the clinical benefit rate was 90.4%. The median time to progression was 45.4 months. No patients experienced grade 3 or 4 toxicity. Conclusion: Combined AI and LHRH agonist treatment safely and effectively induced remission or prolonged disease stabilization, suggesting that this could be a promising treatment option for HR-positive premenopausal patients with MBC.

• 말소리와 음성과학
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• 제10권4호
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• pp.163-171
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• 2018

A mixed dysarthria with combinations of hypokinetic, ataxic, and spastic components is a common clinical feature of multiple system atrophy (MSA). Due to the rapid progress of dysarthria after diagnosis, people with MSA experience difficulty with verbal communication, which eventually affects their quality of life negatively. In this study, SPEAK $OUT!^{(R)}$, an intensive 1:1 treatment of dysarthria for improving functional communicative ability, was provided to twelve people with MSA. To evaluate the efficacy of SPEAK $OUT!^{(R)}$ in people with MSA, aerodynamic, acoustic, and perceptual analyses were conducted. Pre-and post-therapy data included maximum phonation time, vocal intensity, and fundamental frequency during /a/ sustained phonation and passage reading; frequency range between high /a/ and low /a/ phonation; jitter, shimmer, and HNR for vocal quality; speech rate during passage reading; and perceptual evaluation scores for articulation precision and intonation. The participants achieved statistically significant improvement in vocal intensity, pitch range, vocal quality, speech rate, and speech intelligibility. In conclusion, SPEAK $OUT!^{(R)}$ is a feasible treatment for people with MSA to efficaciously improve their speech ability.

• 척추신경추나의학회지
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• 제14권1호
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• pp.39-47
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• 2019

Objectives : The purpose of this study was to evaluate the scientific literature demonstrating the effectiveness of Chuna manual therapy (CMT) in the treatment of spinal scoliosis. Methods : A literature search was conducted using eight electronic databases to identify all randomized controlled clinical trials (RCTs) that investigated CMT as a treatment for spinal scoliosis. The Cochrane risk of bias tool was used to assess the methodological quality of each RCT. Results : Five RCTs met our inclusion criteria and were included in the analysis. These studies demonstrated positive results of CMT with respect to the reduction of Cobb's angle, vertebral rotation angle score, bending test score, and efficacy rate compared with brace treatment. Positive results were also assured, in terms of the reduction of Cobb's angle, pulmonary function, and efficacy rate when comparing CMT combined with other therapy with brace treatment, gymnastic training, or traction therapy. Conclusions : This review has identified encouraging and limited evidence of CMT for the treatment of spinal scoliosis. However, to obtain stronger evidence, without the disadvantages of study design and quality, we recommend that treatment effectiveness of CMT for spinal scoliosis is investigated further using a well-designed RCT.

• Archives of Plastic Surgery
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• 제46권1호
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• pp.46-56
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• 2019

Background When performing lymphovenous anastomosis, it is sometimes difficult to find venules in the proximity of an ideal lymphatic vessel that have a similar diameter to that of the lymphatic vessel. In this situation, larger venules can be used. Methods The authors evaluated the efficacy of and patient satisfaction with lymphovenous bypass with sleeve-in anastomosis. Between January 2014 and December 2016, we performed this procedure in 18 patients (eight upper extremities and 10 lower extremities) with secondary lymphedema. Lymphovenous bypass with sleeve-in anastomosis was performed under microscopy after injecting indocyanine green dye. The circumferential diameter was measured before lymphovenous bypass and at 1, 2, and 6 months after the procedure. An outcomes survey that included patients' qualitative satisfaction with lymphovenous bypass was conducted at 6 months postoperatively. Results Almost all patients showed quantitative improvements after surgery. The circumferential reduction rate in patients with stage II lymphedema of both the upper and lower extremities was significantly greater than in their counterparts with stage III/IV lymphedema. The circumferential reduction rate was lower in lower-extremity patients than in upper-extremity patients. Conclusions Lymphovenous bypass surgery with sleeve-in anastomosis in lymphedema patients is beneficial, and appears to be effective, when adequately-sized venules cannot be found in the proximity of an ideal lymphatic vessel.

• Clinical and Experimental Pediatrics
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• 제65권5호
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• pp.214-221
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• 2022

Diagnosing and treating latent tuberculosis infection (LTBI) is an important part of efforts to combat tuberculosis (TB). The Korean guidelines for TB published in 2020 recommend 2 LTBI regimens for children and adolescents: 9 months of daily isoniazid (9H) and 3 months of daily isoniazid plus rifampicin. Isoniazid for 6-12 months has been used to effectively treat LTBI in children for over 50 years. However, a long treatment period results in poor patient compliance. This review summarizes pediatric data on the treatment completion rate, safety, and efficacy of 4 months of daily rifampicin (4R) and evaluates the pharmacokinetics and pharmacodynamics of rifampicin in children. The 4R regimen has a higher treatment completion rate than the 9H regimen and equivalent safety in children. The efficacy of preventing TB is also consistent with that of 9H when summarizing reports published to date. A shorter treatment period could increase patient compliance and, therefore, prevent TB in more patients. By using an effective, safe, and highly compliant regimen for the treatment of children with LTBI, we would become one step closer to our goal of eradicating TB.

• Clinical Endoscopy
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• 제56권1호
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• pp.92-99
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• 2023

Background/Aims: There are few studies assessed the efficacy and mortality of endoscopic retrograde cholangiopancreatography (ERCP) for the removal of common bile duct (CBD) stones in the elderly aged ≥90 years. We aimed to assess the safety and efficacy of endoscopic removal of CBD stones in nonagenarians. Methods: We retrospectively reviewed ERCP reports for CBD stone removal. The endoscopic and therapeutic outcomes were collected. The length of stay (LOS), the total number of adverse events, and mortality rate were compared between groups. Results: A total of 125 nonagenarians were compared with 1,370 controls (65-89 years old individuals). The mean LOS for nonagenarians was significantly higher than in controls (13.6 days vs. 6.5 days). Completed intended treatment was similar in the nonagenarians and controls (89.8% and 89.5%, respectively). The overall complication rate did not differ between the groups. However, nonagenarians had a higher incidence of post-ERCP pneumonia (3.9%). None of the nonagenarians were readmitted to the hospital within 7 days. Four nonagenarians (3.2%) and 25 (1.8%) controls died within 30 days. Conclusions: Advanced age alone did not affect the decision to perform the procedure. However, prompt diagnosis and treatment of post-ERCP pneumonia in nonagenarians could improve the outcomes and reduce mortality.

• 한국학교보건학회지
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• 제23권1호
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• pp.41-52
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• 2010

Purpose: The objective of this study is to investigate the relationship between middle and high school students' internet addiction, social support, self-efficacy and school life adjustment. Data were collected by self-administered questionnaires at middle and high school students located in Seoul and the metropolitan areas. Methods: The response rate is 94.8% (474 cases). The internet addition was measured by K Scale. The various methods of analysis were used, for example, frequency analysis, t-test, analysis of variance, and multiple regression analysis. Results: First, the mean score of internet addiction level is 2.07 in 5 Likert scale. the internet addiction level of the male students are higher than female students (p<.05). Second, as a result of classification of internet addiction groups by K Scale, 11 students (2.3%) are included in high risk group, 27 students (5.7%) are in potential risk group, 436 students (92.0%) are in general group. Third, the level of social support and self-efficacy of middle and high school students are very high. The difference of social support by internet addiction groups was not statistically significant. But, the difference of self-efficacy by internet addiction groups was statistically significant. The level of self-efficacy of the students in general groups are more higher than in high risk group and in potential risk group (p<.01). Fourth, the difference of school adjustment by internet addiction groups was very statistically significant. The level of school life adjustment of the students in general groups are more higher than in high risk group and in potential risk group (p<.01). Fifth, the internet addiction have a negative correlation with school life adjustment. And the social support and self-efficacy have a positive correlation with school life adjustment (p<.01). Finally, in stepwise multiple regression analysis, the internet addiction affects negatively on the school adjustment. And the support of teacher among three types of them affects positively on the school life adjustment. And the social self-efficacy among two types of them affects positively on the school adjustment (p<.01). Conclusion: to adjust desirably the school environment of the middle and high school students, optimal and efficient management of internet addiction was needed in the future and the improvement and promotion of social support and social self-efficacy of the students was also demanded.

• 치위생과학회지
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• 제14권2호
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• pp.167-175
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• 2014

본 연구는 노인의 구강보건행동에 따른 일반적 자기효능감, 신체적 자기효능감, 사회적 자기효능감을 파악하고 관련성 요인들을 조사하기 위하여 2013년 6월 1일부터 8월 30일까지 대구광역시와 경상북도 지역에 거주하는 만 60세 이상의 노인 500명을 대상으로 설문조사하였으며 응답을 하지 않거나 답변이 불성실한 73명을 제외한 427명(회수율 85.4%)의 자료를 분석하여 다음과 같은 결과를 얻었다. 조사대상자의 인구사회학적 특성에 따른 구강보건행동은 나이가 적을수록, 직업이 있는 경우, 학력이 높을수록, 이혼을 한 경우에 잘 실천하는 것으로 나타났다. 조사대상자의 인구사회학적 특성에 따른 자기 효능감은 나이가 적을수록, 학력이 높을수록, 기혼인 경우, 한 달 용돈이 많은 경우에 일반적 자기효능감과 신체적 자기효능감, 사회적 자기효능감 모두 높게 나타났으며 통계적으로 유의한 차이가 있었다(p<0.001). 구강보건행동을 잘 실천하는 군에서 일반적 자기효능감과 사회적 자기효능감이 높은 것으로 나타났으며 신체적 자기효능감은 보통인 군에서 높게 나타났으며 유의한 차이가 있었다(p<0.001). 구강보건행동과 관련성의 강도를 분석한 결과 일반적 자기효능감(${\beta}=0.184$)과 가장 연관성이 높았고, 다음은 사회적 자기효능감(${\beta}=0.162$), 신체적 자기효능감(${\beta}=0.101$) 순이었다. 이상의 결과를 미루어 볼 때 구강보건행동은 자기 효능감과 관련성이 있으며, 구강건강이 성공적 노화의 중요한 요소인 자기효능감에 밀접한 연관성이 있다는 것을 명백히 입증한 결과로서 더 이상 소홀히 취급되어서는 안 된다고 생각된다. 또한 구강건강저하가 사망의 직접적인 원인이 되지는 않지만 구강건강장애가 끊임없이 만성적으로 진행된다는 점에서 타 만성질환과 같이 발생되기 이전에 예방관리를 통해 구강건강을 유지 증진시켜 나가야 할 것으로 생각되며, 자기효능감을 높이고 원만한 대인관계를 위해서도 노년기 구강건강은 매우 중요하다고 할 수 있다.