• Gut and Liver
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• 제12권6호
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• pp.623-632
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• 2018

Intestinal Behçet's disease is a rare, immune-mediated chronic intestinal inflammatory disease; therefore, clinical trials to optimize the management and treatment of patients are scarce. Moreover, intestinal Behçet's disease is difficult to treat and often requires surgery because of the failure of conventional medical treatment. Administration of anti-tumor necrosis factor-${\alpha}$, a potential therapeutic strategy, is currently under active clinical investigation, and evidence of its effectiveness for both intestinal Behçet's disease and inflammatory bowel diseases has been accumulating. Here, we review updated data on current experiences and outcomes after the administration of anti-tumor necrosis factor-${\alpha}$ for the treatment of intestinal Behçet's disease. In addition to infliximab and adalimumab, which are the most commonly used agents, we describe agents such as golimumab, etanercept, and certolizumab pegol, which have recently been shown to be effective in refractory intestinal Behçet's disease. This review also discusses safety issues associated with anti-tumor necrosis factor-${\alpha}$, including vulnerability to infections and malignancy.

• Computers and Concrete
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• 제7권5호
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• pp.437-453
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• 2010

CFRP has been widely used for strengthening reinforced concrete members in last decade. The strain transfer mechanism from concrete face to CFRP is a key factor for rigidity, ductility, energy dissipation and failure modes of concrete members. For these reasons, determination of the effective CFRP bonding length is the most crucial step to achieve effective and economical strengthening. In this paper, generalizations are made on effective bonding length by increasing the amount of test data. For this purpose, ANSYS software is employed, and an experimentally verified nonlinear finite element model is prepared. Special contact elements are utilized along the concrete-CFRP strip interface for investigating stress distribution, load-displacement behavior, and effective bonding length. Then results are compared with the experimental results. The finite element model found consistent results with the experimental findings.

• 한국구조물진단유지관리공학회 논문집
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• 제4권4호
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• pp.219-223
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• 2000

The evaluation of habitability to building vibration is conducted by the values of natural frequency, amplitude displacement, damping ratio. These values can be obtained from test or analytical results. Data acquisition through test may be possible in existing building, however, to estimate the serviceability of the building, it is necessary to evaluate those values at the stage of design. The natural frequency is important and basic factor for the evaluation of the serviceability. Calculation method of the effective stiffness in RC slab is proposed. To prove the efficiency of the proposed method, sample results of the analysis and the test are compared. These results proved that the effective width proposed to calculate the effective stiffness is proper to evaluate the natural frequency.

• Bulletin of the Korean Chemical Society
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• 제21권7호
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• pp.697-700
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• 2000

A method of calculating the excess Helmholtz free energy from the average of the bent effective acceptance ratio for two-center-Lennard-Jones liquids has been presented. The bent effective acceptance ratio has been newly composed from the acceptan ce ratio for the potential energy difference between a configuration in the Metropolis Monte Carlo procedure and random virtual configuration generated by the separate parallel Monte Carlo procedure and the Boltzmann factor for half the potential energy difference. The excess Helmholtz free energy was calculated directly from the average of the bent effective acceptance ratio through a single Metropolis Monte Carlo run. Because the separate parallel Monte Carlo procedure was used, this method can be applied to molecular dynamics simulations. For two-center-Lennard-Jones liquids, the average of the bent effective acceptance ratio gave better results than use of the modified effective acceptance ratio in the previous work.

• 한국작물학회지
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• 제52권1호
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• pp.112-121
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• 2007

Grain filling is a crucial factor that determines grain yield in crops since it is the final process directly associated with crops' yield performance. Grain filling process can be characterized by the interaction of rate and duration of grain filling. This study was conducted, using 16 temperate japonica rice genotypes, with aims to (1) seek variations in grain filling duration and rate on area basis, (2) compare the contribution of grain filling duration and rate to grain yield, and (3) examine the influence of temperature and solar radiation for effective grain filling on grain yield in relation to grain filling duration and rate. Grain filling rate and duration exhibited highly significant variations in the ranges of $20.7{\sim}46.3\;g\;m^{-2}d^{-1}\;and\;11.2{\sim}35.5$ days, respectively, depending on rice genotypes. Grain yield on unit area basis was associated positively with grain filling duration but negatively with grain filling rate. Grain filling rate and duration were negatively correlated with each other. Final grain weight increased linearly with the rise in both cumulative mean temperature and cumulative solar radiation for effective grain filling. Higher cumulative mean temperature and cumulative solar radiation for effective grain filling were the results of longer grain filling duration, but not necessarily higher daily mean temperature and daily solar radiation for effective grain filling. Grain filling rate demonstrated an increasing tendency with the rise in daily mean temperature for effective grain filling but their relationship was not obviously clear. It was concluded that grain filling duration, which influenced cumulative mean temperature and cumulative solar radiation for effective grain filling, was the main factor that determined grain yield on unit area basis in temperate Japonica rice.

• 대한토목학회논문집
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• 제32권3C호
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• pp.113-120
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• 2012

진주 잔류토 사면의 실제 붕괴사례에 대한 해석을 수행하였다. 강우시 침투로 인하여 불포화층에서 유효응력과 전단 강도가 감소하여 안전율이 저하된다. 본 연구에서는 함수특성곡선을 이용하여 흡수응력에 기반한 유효응력을 산정하였다. 대상 현장에서 채취한 시료로부터 함수특성곡선, 투수계수, 전단강도와 관련한 불포화 물성들을 획득하였다. 실제 강우에 대한 불포화층의 침투해석을 수행하고 사면 지층의 간극수압 분포를 구할 수 있었다. 유한요소 응력장에서 탄성 해석으로 지층내 전응력을 계산하고 활동면에 작용하는 전단응력의 분포를 계산하였다. 활동면에 작용하는 흡수응력 및 유효응력을 산정하여 전단강도를 평가할 수 있었다. 이로부터 강우에 따른 안전율을 계산하였으며, 실제 강우에 의하여 사면이 활동이 일어나는 것을 모의할 수 있었다. 또한 활동면에서 흡수응력이 증가하고 유효응력이 감소하는 동시에 전단강도가 감소하는 것을 추적할 수 있었다.

• 한국디지털건축인테리어학회논문집
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• 제12권1호
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• pp.71-79
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• 2012

This study aims at finding relationships between the competitiveness of cities and the size or distance of them, based on some premises; (1) the competitiveness can be measured on the interval-ratio level, that is, factor scores, (2) a hypothesis that the spatial interaction model is valid for the relationships can be generally accepted. Based on the general recognition a research hypothesis that the more is the population or the nearer is the distance from a central city the higher is the competitiveness score is constructed. According to the premises 5-factor scores and composite score are calculated by means of regression method, and the scores are regressed on cities' populations and distances from Seoul city. Using bootstrapping method for the tests of significance is effective due to small sample of 21 cities. Results of the analyses show that most aspects of the hypothesis should be rejected or adjusted. Scores on Health-welfare factor, public service factor, and commercial vitality factor have no relation to the cities' sizes or distances. But the results also find the facts that the strong (negative) relationships exist between (1) educational base factor score and population, (2) density factor score and distance. Although this study improves systematic and analytic understanding of spatial interaction patterns, the understanding should be invalid for the general context because it has used the data on 21 cities in the capital region at the time of 2009.

• Steel and Composite Structures
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• 제19권6호
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• pp.1449-1466
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• 2015

Mixed structures consist of two parts: a lower part and an upper part. The lower part is usually made of concrete while the upper part is made of steel. Analyzing these structures is complicated and code-based design of them has many associated problems. In this research, the seismic behavior of mixed structures which have reinforced concrete frames and shear walls in their lower storeys and steel frames with bracing in their upper storeys were studied. For this purpose, seventeen structures in three groups of 5, 9 and 15 storey structures with different numbers of concrete and steel storeys were designed. Static pushover analysis, linear dynamic analysis and incremental dynamic analysis (IDA) using 15 earthquake records were performed by OpenSees software. Seismic parameters such as period, response modification factor and ductility factor were then obtained for the mixed (hybrid) structures using more than 4600 nonlinear dynamic analysis and used in the regression analysis for achieving proper formula. Finally, some formulas, effective in designing such structures, are presented for the mentioned parameters. According to the results obtained from this research, the response modification factor values of mixed structures are lower compared to those of steel or concrete ones with the same heights. This fact might be due to the irregularities of stiffness, mass, etc., at different heights of the structure. It should be mentioned that for the first time, the performance and seismic response of such structures were studied against real earthquake accelerations using nonlinear dynamic analysis, andresponse modification factor was obtained by IDA.

• The Journal of Asian Finance, Economics and Business
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• 제9권7호
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• pp.93-99
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• 2022

Nowadays, learning management systems (LMS) are an effective and efficient tool for providing students with a high-quality education. The current study examines the effect of different factors on the use of the blackboard application on mobile phones. The study selects four important factors after factor analysis, such as facilitating factor, performance factor, satisfaction factor, and difficulties factor. The data was collected through a structured questionnaire from 45 students as a sample in the college of business administration at Prince Sattam Bin Abdulaziz University. The study uses a logistic regression model to examine the empirical relationship between LMS adoption and different factors associated with blackboard adoption. The results show that 71 percent of the respondents are between the age of 18-20 years, and 100 percent of students have experience in using blackboard. The empirical results show that the satisfaction factor is positive and significant at the 10 percent level of significance and the difficulties factor is also positive and significant at the 1 percent level of significance. The results conclude that the students are satisfied with using the blackboard on mobile, nevertheless, the difficulties factor which is positive and significant shows that students are facing some difficulties in using the blackboard on their mobile.

• 대한간호학회지
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• 제21권1호
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• pp.50-62
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• 1991

The purposes of this study were to identify causal factors of Anxiety and to analyze correlation between perceived family support and anxiety in hemiplegic patients. The subjects of this study were 88 hospitalized hemiplegic patients at Kyung - Hee Oriental medicine Hospital. Data were collected by using interview with questionaire from Jan. 15 to Mar, 31, 1990. The measurement tools used by this researcher were Kang's family support scale, Spielberger's trait anxiety scale and the other anxiety scale which was developed by this researcher, approved it's reliability and validity. For the purposes of the study, the collected data were analyzed by frequency, t-test, ANOVA and the hypothesis was tested by pearson correlation, partial correlation. The results of the study were as follow. 1) The analysis of causal factor of anxiety higher anxiety these three cases ; \circled1 1st causal factor was the delayed recovery of paralyzed upper limbs(2.42$\pm$1.27). \circled2 End causal factor was the dysfunction of physical ability(2.30$\pm$1.29). \circled3 3rd causal factor was difficulty for walking(2.30$\pm$0.83) and the anxiety level(2.02$\pm$0.83) of physical factor was the highest level than any other factors. 2) The hypothesis that the more perceived family support level is the less anxiety level of patient was supported(r＝-.29, p＝.003). 3) The analysis of the general characteristics exerting influences on anxiety level patients ; (sex, age, marrital status, religious, education level, occupation, economic status, experience of hospitalization, care giver, the period of hospitalizatiot side of paralysis). In this analysis, any factor has not a statistical significance.(p＞.05). 4) The analysis of the relationship about effective factors of family support level by the general characteristics of patient (sex, age, marrital status, religious, education level, occupation, economic status, experience of hospitalization, care giver, the period of hospitalization, side of paralysis). In this analysis, there was significant difference on perceived family support between married and bereaved patients(t＝-2.68, p＝ .009) As a result of this study, anxiety level of physical factor was higher than any other factors (psychological factor, social factor) and the delayed recovery of paralyzed upper limbs is the largest causal factor of anxiety of physical factor. Meanwhile, the relationship between the degree of family support and the level of anxiety was negatively correlated but the degree of relationship was low. Therefore, one can infer from this study that sufficient information about recovery of physical problems and family support were effective in preventing and reducing anxiety in hemiplegic patient.