• Title/Summary/Keyword: effect modification

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Modification and Inactivation of Human Ceruloplasmin by Oxidized DOPA

  • Kang, Jung-Hoon
    • Bulletin of the Korean Chemical Society
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    • v.25 no.5
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    • pp.625-628
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    • 2004
  • Ceruloplasmin (CP), the blue oxidase present in all vertebrates, is the major copper-containing protein of plasma. It has been proposed that oxidation of L-3,4-dihydroxyphenylalanine (DOPA) may contribute to the pathogenesis of neurodegenerative disorders. The effect of the oxidized products of DOPA on the modification of human CP was investigated. When CP was incubated with the oxidized L-DOPA, the protein was induced to be aggregated and ferroxidase activity was decreased in a time-dependent manner. Radical scavengers and catalase significantly inhibited the oxidized DOPA-mediated CP aggregation. Copper chelatrors, Diethylenetriaminepenta acetic acid (DTPA) and Diethyldithiocarbamic acid (DDC), also inhibited the oxidative modification of CP. The results suggested that DOPA oxidation led to the formation of free radical and induced the CP aggregation.

Improvement of Interior Booming Noise in the Vehicle Using the Structural Dynamic Modification (구조물 동특성 변경을 이용한 실내 부밍 소음 개선)

  • Kim, Young-Ha;Lee, Jae-Woong;Kim, Sung-Gi
    • Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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    • 2012.04a
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    • pp.354-359
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    • 2012
  • Improvement of structure-borne noises in the vehicle compartments has been one of the primary concerns in the development of vehicles. The booming is an annoying low frequency interior noise and vibration in vehicle. But it is difficult to reduce the structure-born booming noise in traditional method - trial and error within the shorten development schedule. So in present, the structure dynamic modification (SDM) method helpful to predict the effect of the local mass, stiffness, and damping is introduced. So in order to reduce the interior booming noise, the SDM was performed, and verified with modal test result. It was shown that the interior booming noise was reduced as predicted.

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Hydrophilic Modification of Polypropylene Hollow Fiber Membrane by Dip Coating, UV Irradiation and Plasma Treatment

  • Kim Hyun-Il;Kim Jin Ho;Kim Sung Soo
    • Korean Membrane Journal
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    • v.7 no.1
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    • pp.19-27
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    • 2005
  • PP hollow fiber membrane was hydrophilized by EVOH dip coating followed by low temperature plasma treatment and UV irradiation. EVOH coating attained high water flux without any prewetting but its stability did not guaranteed at high water permeation rate. At high water permeation rate, water flux declined gradually due to swelling and delamination of the EVOH coating layer causing pore blocking effect. However, plasma treatment reduces the swelling, which suppress delamination of the EVOH coating layer from PP support result in relieving the flux decline. Also, UV irradiation helped the crosslinking of the EVOH coating layer to enhance the performance at low water permeation rate. FT-IR and ESCA analyses reveal that EVOH dip coating performed homogeneously through not only membrane surface but also matrix. Thermogram of EVOH film modified plasma treatment and W irradiation show that crosslinking density of EVOH layer increased. Chemical modification by plasma treatment and UV irradiation stabilized the hydrophilic coating layer to increase the critical flux of the submerged membrane.

Effects of Melt Treatments on Microstructures and Mechanical Properties of A357 Alloy (A357합금에서 용탕처리가 미세조직 및 기계적 특성에 미치는 영향)

  • Lee, Jung-Moo;Lee, Sung-Hak;Yoon, Ji-Hyun;Kim, Kyung-Hyun
    • Journal of Korea Foundry Society
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    • v.23 no.2
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    • pp.69-76
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    • 2003
  • The present work was undertaken to investigate the mutual effect of the individual melt treatment commonly applied in aluminum foundries such as grain refining, modification, degassing and filtration on the microstructures and the mechanical properties. A357 alloys were fabricated through various melt treatments such as degassing by gas bubbling filtration, modification via the addition of Al-Sr master alloy, grain refining through the addition of Al-Ti-B master alloy and filtration before pouring of the melt. Each melt treatment was performed at its optimum condition reported in the literatures. The effects of each melt treatment and their interactions on the microstructures and mechanical properties of A357 alloy were examined.

Feasibility Study for Wear Resistance of Rails (레일의 내마모성에 대한 타당성 연구)

  • Chang, Seky;Pyun, Young Sik
    • Journal of the Korean Society of Manufacturing Technology Engineers
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    • v.23 no.6
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    • pp.576-579
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    • 2014
  • Rails are continuously exposed to severe environments due to increases in train service frequency, passing tonnage, and speed. Wear is one of the most common types of damage observed on rails. The surface of railsis heat treated to secure safety at critical sites, such as curved tracks or turnouts. Ultrasonic nanocrystal surface modification (UNSM), a new approach for rails, was examined to strengthen the rail surface. The effect of UNSM on the wear resistance of rail specimens was compared with that of heat treatment. Wear resistance was improved after UNSM treatment due to increased hardness and surface compressive residual stress.

Effect of Laser Surface Modification of Cemented Carbide Substrates on the Adhesion of Diamond Films (Cemented Carbide기판의 레이저 표면 개질이 다이아몬드 박막의 접합력에 미치는 영향)

  • Lee, Dong-Gu
    • Journal of the Korean Society for Heat Treatment
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    • v.13 no.3
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    • pp.170-176
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    • 2000
  • A novel method for improving the adhesion of diamond films on cemented carbide tool inserts has been investigated. This method is based on the formation of a compositionally graded interface by developing a microrough surface structure using a pulsed laser process. Residual stresses of diamond films deposited on laser modified cemented carbides were measured as a function of substrate roughness using micro-Raman spectroscopy. The surface morphology and roughness of diamond films and cemented carbides were also investigated at different laser modification conditions. It was found that the increasing interface roughness reduced the average residual stress of diamond films, resulting in improved adhesion of diamond films on cemented carbides.

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The Need for Research about Buckling Strength of Arch and Beam (보와 아치의 좌굴강도에 관한 연구의 필요성)

  • Lim, Nam-Hyoung;Lee, Chin-Ok;Ryu, Hyo-Jin;Lee, Woo-Chul;Koo, So-Yeun
    • Proceedings of the Computational Structural Engineering Institute Conference
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    • 2007.04a
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    • pp.223-226
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    • 2007
  • In current specification, modification factor(B) for web-tapered beam is used to account for the stress gradient and the restraining effect for adjacent spans. However, because these effects are considered together in modification factor, this paper revaluate the accuracy of the modification factor used in current specification. Also this paper investigate the flexural torsional buckling strength of laterally fixed thin-walled arch with doubly symmetric section using the analytical and numerical method. From this investigate the concept of effective length to consider the out-of-plane boundary condition for straight column or beam is not applicate for the flexural-torsional buckling of laterally fixed arches.

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The Effect of Surface Modification with La-M-O (M = Ni, Li) on Electrochemical Performances of Li[Ni0.8Co0.15Al0.05]O2 Cathode

  • Ryu, Jea-Hyeok;Kim, Seuk-Buom;Park, Yong-Joon
    • Bulletin of the Korean Chemical Society
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    • v.30 no.3
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    • pp.657-660
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    • 2009
  • The surface of $Li[Ni_{0.8}Co_{0.15}Al_{0.05}]O_2$ cathode particle was modified by lanthanum based oxide to improve electrochemical property and thermal stability. The XRD pattern of surface layer was indexed with that of $La_4NiLiO_8$. The discharge capacity of modified electrode was higher than that of pristine sample, specially at fast charge-discharge rate and high cut-off voltage. In the DSC profile of the charged sample, the generation of heat by exothermic reaction was decreased by surface modification. Such enhancement may by attributed to the presence of stable lanthanum based oxide, which effectively suppressd the reaction between electrode and electrolyte on the surface of $Li[Ni_{0.8}Co_{0.15}Al_{0.05}]O_2$ electrode.

Effect of Astragali Radix on Low Density Lipoprotein Oxidation (황기의 저밀도지질단백질 (LDL)산화에 미치는 영향)

  • 김은정;양기숙
    • YAKHAK HOEJI
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    • v.45 no.5
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    • pp.529-536
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    • 2001
  • The root of Astragalus membranaceus Bunge (Leguminosae), which has been used for the treatment of hypertension, chronic hepatitis, duodenal ulcers, chronic nephritis and promotion of immunity in folk remedies. Several lines of evidence indicate that oxidative modification of low-density lipoprotein (Ox-LDL) may play an important role in atherogenesis. Hence, the role of antioxidants in the prevention of LDL oxidation needs to be determined. To investigate the antioxidant activity. we determined the MeOH ex. and fractions of Astragali Radix on the inhibition of LDL oxidation. The CH$_2$C1$_2$ and EtOAc orations inhibited the oxidative modification of LDL by a decrease in the lipid peroxide content and the electrophoretic mobility of LDL. Calycosin-7-0-$\beta$-D -glucoside which was isolated from EtOAc fraction inhibits the oxidative modification of LDL.

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Surface Modification of PET with Ethoxylated Alkylaminoanthraquinone - Effect of Spacer on the Adsorption Behavior - (Ethoxylated Alkylaminoanthraquinone에 의한 PET의 표면개질 - Spacer의 길이에 따른 흡착거동 -)

  • 최영주;윤남식
    • Textile Coloration and Finishing
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    • v.15 no.3
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    • pp.185-191
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    • 2003
  • Surface modification of poly(ethylene terephthalate) (PEI) films by treatment with ethoxylated alkylaminoanthraquinoes which was synthesized by the reaction of 1-aminoanthraquinone with poly(ethylene glycol) via a series of methylene spacer were investigated. The synthesized ethoxylated alkylaminoanthraquinones showed definite cloud point as in nonionic surfactants, and the adsorption of the compounds on PET increased near the cloud point. At same temperature the adsorption increased with the length of methylene spacer; hexyl-octyl-, and decyl-. The adsorption was limited to the extreme surface of PET film, which made the surface of PET film hydrophillic by reducing water contact angle.