• BMB Reports
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• 제56권9호
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• pp.469-481
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• 2023

The gut microbiome is widely recognized as a dynamic organ with a profound influence on human physiology and pathology. Extensive epidemiological and longitudinal cohort studies have provided compelling evidence that disruptions in the early-life microbiome can have long-lasting health implications. Various factors before, during, and after birth contribute to shaping the composition and function of the neonatal and infant microbiome. While these alterations can be partially restored over time, metabolic phenotypes may persist, necessitating research to identify the critical period for early intervention to achieve phenotypic recovery beyond microbiome composition. In this review, we provide current understanding of changes in the gut microbiota throughout life and the various factors affecting these changes. Specifically, we highlight the profound impact of early-life gut microbiota disruption on the development of diseases later in life and discuss perspectives on efforts to recover from such disruptions.

• 대한가정학회지
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• 제49권3호
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• pp.55-66
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• 2011

The purpose of this study was to examine the effects of We Start home visiting intervention program on the positive changes of infants and their low-income families. The subjects were 171 18~36-month olds and their mothers living in We Start and non We Start areas. The instruments used were Developmental Profile, Cleminshaw-Guidubaldi Parent Satisfaction Scale(CGPSS) and Home Observation for Measurement of the Environment(HOME). The results were as follows: First, the result of Developmental Profile showed positive changes in all domains(physical development, self-help skills, social development, cognitive development, and communication ability). Second, the result of CGPSS showed positive effects on parent-child relationships. Third, the result of HOME showed positive effects on mothers' emotional and language responses. In conclusion, We Start home visiting program for infants from low-income families is an effective early intervention program to end intergenerational transition of poverty in Korea.

• Human Ecology Research
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• 제52권2호
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• pp.189-198
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• 2014

The purpose of this study was to examine the effects of the We Start center visiting intervention program on the positive changes in the developmental areas and literacy interests of young children from low-income families. The subjects were 195 young children (109 in the experimental group, M=71.7 months; 86 in the control group, M=73.3 months) living in We Start areas (Ansan, Gwangmyeong, and Suwon cities) of Gyeonggi-do. The We Start center visiting intervention programs were conducted for 30-34 weeks in each city, and pre-tests and post-tests were conducted before and after the intervention programs. The instruments used were the developmental checklist and the literacy interests test The developmental checklist consisted of 7 domains (personality & sociality; language, reading, & writing; scientific thinking; mathematical thinking; arts; social learning; and physical development). The literacy interests test consisted of 2 factors (interest in literacy and interaction during activity). The scores on the developmental checklist showed positive changes in several domains (personality & social development; language, reading, & writing ability; scientific thinking; and social learning), but not in mathematical thinking, arts, and physical development. Second, the results of the literacy interests test showed positive effects on interaction during activity and the total score. In conclusion, the We Start center visiting program for young children from low-income families is an effective early intervention program to end the intergenerational transference of poverty in Korea.

• 보건교육건강증진학회지
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• 제26권1호
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• pp.15-26
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• 2009

Objectives: The current study evaluated the effects of an integrated breast health program according to levels of breast cancer risk appraisal on knowledge on breast cancer, early detection behaviors, and diet patterns and attitudes in Korean healthy women. Method: A nonequivalent control group pre-posttest design was used. A total of 413 women aged 40-59, registering at the Life Long Health Center in two cities, were classified into intervention groups of 179 women and control groups of 234 women. The integrated breast health program included education, counseling on breast cancer, early detection behaviors, and appropriate diet with multimedia and individual practice session using breast models, reflecting characteristics of each level according to levels of risk appraisal. The knowledge on breast cancer, early detection behaviors, and diet were investigated using questionnaires at baseline and three months after intervention. Results: In both normal and borderline-risk group, intervention groups reported significantly higher scores of knowledge on breast cancer and higher stages of BSE behaviors than control groups. Conclusion: The results showed positive effects on knowledge and early detection behaviors of breast cancer in normal and borderline-risk groups. Further studies should investigate longitudinal effects of the intervention program on dietary change.

• 벤처창업연구
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• 제16권6호
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• pp.1-16
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• 2021

본 연구의 목적은 지금까지 한국 정부가 벤처캐피탈 시장에 어떻게 개입해 왔는지 살펴보고, 정부의 벤처캐피탈 정책이 벤처캐피탈의 초기 투자를 촉진했는지 실증적으로 규명하는 것이다. 이를 위해 본 연구에서는 관련 문헌을 연구하고 국내 사례를 적용 분석하여 벤처캐피탈 시장에 대한 정부의 시장개입을 단계적으로 분류하였다. 그리고 본 연구는 정부개입의 가장 중요한 목적인 벤처캐피탈의 초기투자 활성화를 위한 우리 정부의 정책 효과를 실증적으로 분석하였다. 실증분석을 위해 한국벤처캐피탈협회와 한국펀드에서 제공한 2004년부터 2018년까지의 연도별 자료를 시계열 통계분석과 거시역학을 이용하여 분석하였다. 사례연구 결과 한국 정부는 25년 동안 직접투자를 통해 벤처캐피탈 시장에 개입했고, 이후 18년 동안 간접투자를 통해 개입해왔다. 시계열 통계분석 결과, 벤처캐피탈펀드 조성을 늘리기 위한 정부의 재정투자와 일정비율의 초기투자를 의무화하는 특수목적펀드의 비율이 높아지면서 벤처캐피털의 초기투자가 증가했다. 그러나 거시역학은 2016년부터 이 시계열 통계분석과 반대 방향의 경향을 보였다. 결론적으로, 본 연구는 시계열 통계분석 결과와 반대 방향의 경향을 정부의 벤처캐피탈 투자방법에 대한 잘못된 규제로 해석하고, 최근 정부의 간접투자 방식을 통한 직접개입의 실효성이 부족하다. 또한 본 연구에서는 사례연구와 실증연구 결과를 바탕으로 정부의 간접개입에 필요한 여섯 가지 정책제안을 제시하였다.

• 대한불안의학회지
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• 제5권2호
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• pp.75-79
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• 2009

In this article, we review the efficacy of early interventions after traumatic incidents and during acute stress disorder (ASD). There are some evidences that psychopharmacological medications such as propronolol, morphine, and hydrocortisone are effective in the prevention of posttraumatic stress disorder (PTSD). Considering the role of selective serotonin reuptake inhibitors in hippocampal neurogenesis and an animal model of PTSD, early administration of selective serotonin reuptake inhibitors is also fairly promising. Other pharmacological treatments including benzodiazepines did not treat ASD nor prevent PTSD. There are good evidences that cognitive behavioral therapy including cognitive therapy and prolonged exposure is a valuable intervention for ASD and the most effective prevention for PTSD. No contolled researches on eye movement desensitization&reprocessing, psychodynamic psychotherapy and hypnotherapy have performed. Recent randomized controlled studies using psychological debriefing did not prove as a useful intervention for the prevention of PTSD until now, although the efficacy of debriefing has been at the centre of controversy.

• Archives of Plastic Surgery
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• 제42권2호
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• pp.173-178
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• 2015

Background Various focal heating devices are popular in Korea under the cultural influence of the traditional ondol under-floor method of home heating. These devices can cause severe burn-like injuries resulting from device malfunction or extended with low heat contact. In addition to injuries under these high heat contact, burns can be occurred by low heat exposure with prolonged periods despite the devices are properly functioning. In order to develop strategies to reduce the duration of periods of illness due to low-temperature burns, we analyzed and compared treatment methods and therapeutic periods for this type of injury. Methods This retrospective study included 43 patients burned under low heat conditions. Patients were divided into an operative group and a conservative group. The patients in the operative group underwent at least one surgical excision, and were further subdivided into early and late visit groups. The conservative group was treated only with dressings. We compared the treatment periods between the operative group and the conservative group, and also compared the preparation periods and treatment periods between the two operative groups. Results The average treatment period was significantly shorter in the operative group (P=0.02). In the early visit operative group, both wound preparation and treatment were briefer than in the late visit group. Conclusions We recommend that early proper burn care and early surgical intervention, including appropriate excision, are feasible ways to reduce the treatment period of lowtemperature burn patients.

• 생물정신의학
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• 제18권4호
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• pp.197-202
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• 2011

Subsyndromal anxiety disorder indicates mental states of having anxiety symptoms not fulfilling criteria for anxiety disorders. Despite of the lack of previous objective findings of the subsyndromal anxiety disorder, its clinical importance has increased. It can cause many kinds of clinical anxiety symptoms and functional disabilities. But the early intervention and early treatment make it possible not only to attenuate the anxiety symptoms and functional disabilities but also to prevent disease progression to a full syndromal anxiety disorder. In this article, we will review the previous studies about the subsyndromal anxiety disorder and discuss its clinical characteristics and importance.

• The Journal of Korean Physical Therapy
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• 제31권3호
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• pp.141-146
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• 2019

Purpose: To investigate the effect of an augmented reality (AR) system on muscle strength and function level of the paretic lower limb and the balance ability in the early rehabilitation program of acute stroke patients. Methods: The participants (30 or fewer days after stroke) were randomly assigned to receive intervention with an early rehabilitation program using an AR system (n=1) or an early rehabilitation program consisting of functional electrical stimulation and tilt table use (n=1). Patients in both subjects received interventions 4-5 times a week for 3 weeks. Results: In the paretic limb muscle strength, AR subject was increased from 15 to 39.6 Nm and Control subject was increased from 5 to 30.2 Nm. The paretic limb function of AR subject motor function was increased from 8 to 28 score and Control subject motor function was increased from 6 to 14 score. But sensory function was very little difference between the two subjects (AR subject: from 4 to 10 score, Control subject: from 3 to 10 score). In the balance ability, AR subject had more difference after intervention than control subject (AR subject: 33 score, Control subject: 22 score). Conclusion: The early rehabilitation program using the AR system showed a slightly higher improvement in the motor function of the paretic lower limb and balance ability measurement than the general early rehabilitation program. The AR system, which can provide more active, task-oriented, and motivational environment, may provide a meaningful environment for the initial rehabilitation process after stroke.

• 성인간호학회지
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• 제25권2호
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• pp.113-124
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• 2013

Purpose: Purposes of this study were to develop a reliable and valid checklist to assess and manage post-stroke dysphagia and to identify its utilization. Methods: The first step was to develop checklist through systematic literatures reviews, to test the content validity from 11 clinical experts, and to test the construct validity and the internal consistency from 97 patients with post-stroke dysphagia. The second step was to identify clinical use of the checklist from the same 97 patients. Results: A total of 18 items compromised the assessment checklist and 64 items for intervention checklist. Internal consistencies of assessment checklist and intervention checklist were .84 and .98, respectively. In both checklists, level of utilization of general appearance was the highest, while that of early signs of aspiration was the lowest. The utilization levels of two checklists were significantly higher among patients who were less than 60 years old, and had liquid diet, facial paralysis, and previous history of aspiration pneumonia. Conclusion: We found that the checklists were reliable and valid. Further study is needed to develop specific strategies to improve nurses' use of assessment and intervention checklists for post-stroke dysphagia.