• 한국작물학회:학술대회논문집
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• 한국작물학회 2017년도 9th Asian Crop Science Association conference
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• pp.72-72
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• 2017

We found a new stay-green mutant from 'Pyeongwon' which is an early-maturing rice variety in Korea. The mutant showed green leaves after grain ripening period and it maintained higher SPAD value than wild type rice plant and original variety 'Pyeongwon'. The stay-green trait in rice, three genes have been identified up to date. The non-yellow coloring1 (NYC1) gene encodes a chloroplast-localized short-chain dehydrogenase/reductase (SDR) with three transmembrane domains. The non-yellow coloring3 (NYC3) gene encodes a plastid-localizing alpha/beta hydrolase-fold family protein with an esterase/lipase motif. The Sgr gene encodes a novel chloroplast protein and regulates the destabilization of the light-harvesting chlorophyll binding protein (LHCP) complexes of the thylakoid membranes, which is a prerequisite event for the degradation of chlorophylls and LHCPs during senescence. After sequencing the PCR products, we found a single nucleotide variation($A{\rightarrow}T$) in the NYC1 gene, which changes the amino acid lysine to methionine. The NYC1 gene encodes a short-chain dehydrogenase/reductase(SDR) protein. And we confirmed the co-segregation between SNP and stay-green trait from genotyping the progenies of the mutant.

• Asian Pacific Journal of Cancer Prevention
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• 제16권4호
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• pp.1599-1603
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• 2015

Background: Epigenetic silencing of tumor suppressor genes due to promoter hypermethylation is one of the frequent mechanisms observed in cancers. Hypermethylation of several tumor suppressor genes involved in cell cycle regulation has been reported in many types of tumors including oral squamous cell carcinomas. LATS1 (Large Tumor Suppressor, isoform 1) is a novel tumor suppressor gene that regulates cell cycle progression by forming complexes with the cyclin dependent kinase, CDK1. Promoter hypermethylation of the LATS1 gene has been observed in several carcinomas and also has been linked with prognosis. However, the methylation status of LATS1 in oral squamous cell carcinomas is not known. As oral cancer is one of the most prevalent forms of cancer in India, the present study was designed to investigate the methylation status of LATS1 promoter and associate it with histopathological findings in order to determine any associations of the genetic status with stage of differentiation. Materials and Methods: Tumor chromosomal DNA isolated from biopsy tissues of thirteen oral squamous cell carcinoma biopsy tissues were subjected to digestion with methylation sensitive HpaII enzyme followed by amplification with primers flanking CCGG motifs in promoter region of LATS1 gene. The PCR amplicons were subsequently subjected to agarose gel electrophoresis along with undigested amplification control. Results: HpaII enzyme based methylation sensitive PCR identified LATS1 promoter hypermethylation in seven out of thirteen oral squamous cell carcinoma samples. Conclusions: The identification of LATS1 promoter hypermethylation in seven oral squamous cell carcinoma samples (54%), which included one sample with epithelial dysplasia, two early invasive and one moderately differentiated lesions indicates that the hypermethylation of this gene may be one of the early event during carcinogenesis. To the best of our knowledge, this is the first study to have explored and identified positive association between LATS1 promoter hypermethylation with histopathological features in oral squamous cell carcinomas.

• Radiation Oncology Journal
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• 제35권1호
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• pp.32-38
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• 2017

Purpose: Several accelerated partial breast radiation (APBR) techniques have been investigated in patients with early-stage breast cancer (BC); however, the optimal treatment delivery techniques remain unclear. We evaluated the feasibility and toxicity of APBR delivered using intensity-modulated radiation therapy (IMRT) in elderly patients with stage I BC, using a novel fractionation schedule. Materials and Methods: Forty-two patients aged ${\geq}65$ years, with stage I BC who underwent breast conserving surgery were enrolled in a phase I/II study evaluating APBR using IMRT. Forty eligible patients received 40 Gy in 4 Gy daily fractions. Patients were assessed for treatment related toxicities, and cosmesis, before APBR, during, and after completion of the treatment. Results: The median age was 73 years, median tumor size 0.8 cm and the median follow-up was 54 months. The 5-year locoregional control was 97.5% and overall survival 90%. Erythema and skin pigmentation was the most common acute adverse event, reported by 27 patients (69%). Twenty-six patients (65%) reported mild pain, rated 1-4/10. This improved at last follow-up to only 2 (15%). Overall the patient and physician reported worst late toxicities were lower than the baseline and at last follow-up, patients and physicians rated cosmesis as excellent/good in 93% and 86 %, respectively. Conclusion: In this prospective trial, we observed an excellent rate of tumor control with daily APBR. The acceptable toxicity profile and cosmetic results of this study support the use of IMRT planned APBR with daily schedule in elderly patients with early stage BC.

• 한국수자원학회논문집
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• 제47권9호
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• pp.813-824
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• 2014

본 연구에서는 가뭄지수를 이용하여 북한지역의 가뭄분석을 수행하였다. 분석 대상지점으로는 평양 등 27개 지점을 선정하였으며, 월 강수량 및 평균기온 자료를 수집하여 분석에 이용하였다. 가뭄분석을 위한 가뭄지수로는 SC-PDSI를 이용하였으며, 27개 지점별로 1984~2013년(30년)의 월 단위 가뭄지수를 산정하였다. 가뭄지수를 이용하여 과거 가뭄에 대해 검토한 결과, 대부분의 지점에서 2000년대 초반과 중반에 심각한 가뭄이 발생하였음을 확인할 수 있었다. 북한의 과거 가뭄사상에 대한 정량적 평가를 위해 6개 지점(평양, 함흥, 청진, 원산, 해주, 신의주)을 대상으로 지속기간별 최대 가뭄심도 자료계열을 구성하였으며, 빈도분석을 통해 지점별 가뭄심도-지속기간-재현기간(Severity-Duration-Frequency, SDF) 곡선을 유도하였다. 6개 지점의 과거 주요 가뭄사상을 추출한 후 SDF 곡선을 이용하여 각 사상별 재현기간을 추정한 결과, 2000년대 초반과 중반에 발생했던 가뭄은 최대 20~50년의 재현기간을 갖는 가뭄사상인 것으로 나타났다.

• 한국건축시공학회지
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• 제13권4호
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• pp.351-359
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• 2013

고로슬래그는 콘크리트의 적용시 효율적인 가치향상과 관련하는 많은 장점도 있으나, 고로슬래그의 사용량 증대에 따른 부작용도 나타나고 있다. 따라서 고로슬래그 미분말의 활용성 증대를 위해 High Volume Slag를 자극제 종류별, 치환율별, 조강제 혼입율별, NaOH, $Na_2SiO_3$ 혼합사용시, 폐알칼리자극제 혼입율별 특성을 알아보기 위해 실험하였다. 실험결과, 압축강도의 경우 수산화나트륨을 제외한 모든 알칼리자극제에서 치환율이 증가함에 따라 강도가 증진되었다. 알칼리자극제 중 규산나트륨이 동탄성계수와 흡수율 등에서 높게 나타났으며, 조강제의 경우 혼입율 1.5%와 고로슬래그 치환율 75%가 높은 강도증진을 나타내었다. 폐알칼리 자극제의 경우 모든 실험에서 각기 다른 결과를 나타내었다.

• Annals of Rehabilitation Medicine
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• 제39권6호
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• pp.897-904
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• 2015

Objective To investigate differences in plantar pressure distribution between a normal gait and unpredictable slip events to predict the initiation of the slipping process. Methods Eleven male participants were enrolled. Subjects walked onto a wooden tile, and two layers of oily vinyl sheet were placed on the expected spot of the 4th step to induce a slip. An insole pressure-measuring system was used to monitor plantar pressure distribution. This system measured plantar pressure in four regions (the toes, metatarsal head, arch, and heel) for three events: the step during normal gait; the recovered step, when the subject recovered from a slip; and the uncorrected, harmful slipped step. Four variables were analyzed: peak pressure (PP), contact time (CT), the pressure-time integral (PTI), and the instant of peak pressure (IPP). Results The plantar pressure pattern in the heel was unique, as compared with other parts of the sole. In the heel, PP, CT, and PTI values were high in slipped and recovered steps compared with normal steps. The IPP differed markedly among the three steps. The IPPs in the heel for the three events were, in descending order (from latest to earliest), slipped, recovered, and normal steps, whereas in the other regions the order was normal, recovered, and slipped steps. Finally, the metatarsal head-to-heel IPP ratios for the normal, recovered, and slipped steps were $6.1{\pm}2.9$, $3.1{\pm}3.0$, and $2.2{\pm}2.5$, respectively. Conclusion A distinctive plantar pressure pattern in the heel might be useful for early detection of a slip event to prevent slip-related injuries.

• 영어영문학
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• 제58권2호
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• pp.279-304
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• 2012

Since the publication of Foucault's Discipline and Punish, theatricality has become one of the key concepts in New Historicism. By defining theatricality as the most definitive feature of early modern society and culture, New Historicists have promoted the idea that theatrical practices in every day life were eventually replaced by textual practices as the western society started to undergo modernization with the advent of print culture and technologies. This paper questions this linear model of English literature, the shift of literary practices from theatricality to textuality in the event of modernization, by closely looking at the ways in which newsbooks and playlets during the English civil wars appealed to their target readers. The early print-based literary commodities during the English civil war (i.e. newsbooks and playlets) were able to win the attention of their audience not by breaking away from theatrical energy and creativity but instead by embracing and taking advantage of them through the use of dramatic conventions, dialogues, and many others. The newsbooks and the playlets during the time, however, did not simply replicate the dramatic forms and experiences of the previous generation. Instead, as the case study of Craftie Cromwell exemplifies, they went further to produce a different mode of theatricality by reshaping everyday lives into serialized drama, whose resolution is always already delayed and postponed into the ever-receding future. In conclusion, the study of the newsbook and playlets during the civil wars suggests that the textuality of modern times, materialized in print forms, have been co-evolved with the development of new theatricality, whose contents and forms are susceptible to the changes of everyday reality.

• Journal of Korean Neurosurgical Society
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• 제65권1호
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• pp.114-122
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• 2022

Objective : Early descent of the diaphragm sellae (DS) during endoscopic endonasal transsphenoidal surgery (EETS) for pituitary macroadenoma surgery is occasionally a troublesome event by blocking the surgical field. Here we introduce an alternative technique with the new pituitary retractor and present our clinical experiences. Methods : We designed a simple and rigid pituitary retractor with the least space occupation in the nasal cavity to be compatible in EETS. The pituitary retractor was held by external holder system to support the herniated DS stably. We retrospectively reviewed a clinical 22 cases of pituitary macroadenomas underwent EETS using the pituitary retractor. Results : The pituitary retractor stably pushed up the herniated DS in all cases, and the surgeon proceeded the procedure with bimanual maneuver. The pituitary retractor was helpful to remove tumors around the medial cavernous sinus and behind the DS in 16 and seven cases, respectively. In four cases, the meticulous hemostasis was completed with the direct visualization by the DS elevation with this retractor. Gross total tumor resection was performed in 20/22 patients (91%). The impaired visual function and hypopituitarism were improved in 18/20 (90%) and 7/14 (50%) patients after surgery, respectively. There was no complication related with the pituitary retractor. Conclusion : During EETS for pituitary macroadenomas, the novel pituitary retractor reported in this study is a very useful technique when the herniated DS block the surgical field and bimanual maneuver. This pituitary retractor can help to result in the excellent surgical outcomes with minimal morbidity.

• 자원환경지질
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• 제55권6호
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• pp.563-570
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• 2022

이 조사는 지상에 존재하는 지하수의 잠재오염원(저장탱크)으로부터 오염물질 누출 시, 이를 조기 진단하기 위한 지하수 오염관측망의 설계 인자로서 부지 규모 지하수환경의 시공간적 변동성을 파악하고자 시행되었다. 부지 내 위치한 저장탱크 주변에 22~25 m 심도로 3개의 관측공을 설치하고, 이들로부터 약 22개월 동안 2분 간격으로 지하수위와 수온 변화를 관측하였으며, 이 자료는 주변 기상관측소의 강수 및 기온 자료와 비교 분석되었다. 조사기간 동안 지하수위의 연 변화와 강수 현상에 대한 반응, 지하수온의 변동과 기온에 대한 지연시간 등은 비교적 작은 규모의 부지에서도 지하수 흐름과 유동 경로의 복잡성을 지시한다. 따라서 오염누출 감시를 위한 지하수 관측망은 상세한 부지특성화 조사 결과에 근거하여 부지 지하수환경의 복잡성을 충분히 고려하여 설계되어야 한다.

• 문화기술의 융합
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• 제9권6호
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• pp.551-556
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• 2023

본 연구에서는 존 버닝햄의 그림책 2권(『셜리야, 물가에 가지 마!』, 『셜리야, 목욕은 이제 그만!』)을 Bakhtin의 대화주의 이론 중 카니발의 개념을 이용하여 분석했다. 존 버닝햄의 그림책에서는 주인공 '셜리'의 일탈에 대한 무의식적인 소망이 기상천외한 상상세계에서의 모험으로 전환되어 웃음이 곁들여진 축제와 같은 사건으로 묘사되고 있다. 그림책을 통해서 유아들은 현실에서 금지된 행동을 상상세계에서의 사건으로 전환 시켜 간접적으로 체험하면서 만족한다. 이러한 간접 경험은 유아가 현실에서의 불만을 자연스럽게 해소하면서 자기만의 독창적인 내적 발달을 하는데 매우 중요하다. 본 연구는 가정이나 유아교육기관에서 유아들에게 다양한 그림책을 쉽게 접할 수 있는 환경을 제공하는 것이 그들의 성장에 매우 중요한 역할을 한다는 것도 또한 시사하고 있다.