• Title/Summary/Keyword: eIF4E

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Environmental Cost and Benefit Analysis Pollutant Reduction Facilities of the using the Emergy (Emergy를 이용한 오염물질 저감시설의 환경 비용/편익 분석)

  • Kim, Jin Lee;Hwang, Ha-Sun;Kim, Sang-Soo;Lee, Jae Kwan
    • Journal of Korean Society on Water Environment
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    • v.29 no.5
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    • pp.591-597
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    • 2013
  • The input emergy of an advanced treatment plant for reducing the 1 kg of TN and TP was estimated 4.14E+14 sej/kg, 5.02E+15 sej/kg, respectively. In addition, the input emergy of constructed wetland for reduction of the 1 kg of TN and TP reduction was estimated to be 2.48E+14 sej/kg, 3.38E+15 sej/kg, respectively. The cost reducing 1 kg of TN and TP for an advanced treatment plant was estimated 197,466 won and 2,388,739 won respectively and constructed wetland was estimated 117,976 won and 1,609,213 won respectively. As a result, All of the emergy source of constructed wetland for reducing non-point source is renewable resource. If we use the constructed wetland, it results in enhancing economic value by reducing of non-point pollution, controlling a flood and providing the habitat of animals or plants. Improving water quality program in the Nakdong River Basin should be changed into an ecological treatment facilities from expansion of the sewage treatment facilities and advanced treatment plant using high cost and non-renewable energies.

Comparison Between TCDD and 3MC Action on CYP1A1 Expression and EROD Activity in the Isolated Perfused Female Rat Liver

  • Ahn, Mee R.;Sheen, Yhun Y.
    • Toxicological Research
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    • v.14 no.4
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    • pp.587-594
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    • 1998
  • In order to understand the mechanism if the regulation of CYP 1A1 gene expression and ethoxyresorufin deethylase (EROD) activity in ex vivo system, we have studied the action of TCDD and 3MC in the isolated perfused female rat liver. CYP1A1 mRNA level and EROD activity were measured in rat liver that was isolated and perfused with various chemicals such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), 3-methylcholanthrene (3MC), 17$\beta$-estradiol (E$_2$), morin. TCDD or 3MC alone perfusion into female rat liver resulted in increase of CYP 1A1 mRNA level and the magnitude of stimulation was six times higher with TCDD treatment than 3MC treatment. However E$_2$ perfusion into female rat liver showed inhibition of CYP 1A1 mRNA level. When 10$^{-8}$ M E$_2$ was administered concomitantly with either 10$^{-9}$ M TCDD or 10$^{-9}$ M 3MC, stimulated CYP 1A1 mRNA by either TCDD or 3MC was inhibited. Morin was examined for its effects on CYP 1A1 mRNA level and result was similar to that was observed with estrogen. EROD activity was also stimulated with either TCDD or 3MC perfusion, and the magnitude of EROD stiumlation was smaller than that of CYP 1A1 mRNA stimulation in response to TCDD or 3MC perfusion. Unlike CYP1A1 mRNA level, stimulation of EROD activity was greater with 3MC than TCDD. Concomitant perfusion either E$_2$ or morin with TCDD or 3MC inhibited 3MC perfusion or TCDD perfusion stimulated EROD activity. These data suggested that TCDD and 3MC might act diffrently in terms of regulation of CYP 1A1 gene expression in rat liver.

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Effect of SPZZC, a Composition of Herb Extracts, on Atopic Dermatitis in BALB/c and NC/Nga Mouse (BALB/c 및 NC/Nga 마우스의 아토피성 피부질환모델에서 생약조성물 SPZZC의 치료효능)

  • Lee, Geum-Seon;Pena, Ike Dela;Choi, Ji-Young;Yoon, Seo-Young;Choi, Jong-Hyun;Kang, Tae-Jin;Oh, Se-Koon;Cheong, Jae-Hoon
    • YAKHAK HOEJI
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    • v.52 no.3
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    • pp.232-239
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    • 2008
  • The aim of this study was to evaluate if a composition of herb extracts, PLX-PLS was effective to treat atopic dermatitis (AD) in mice. SPZZC is a composition of herb extracts containing the roots of Scopolia parviflora and Paeonia lactiflora, the herb of Zizania caudiflora, the fruit of Ziziphus jujuba and the leaf of Chinese arborvitae. AD in BALB/c mouse was induced by patching ovoalbumin on the backside, while it in NC/Nga mouse was induced by repeated application of 1-chloro 2,4-dinitrobenzene (DNCB). Mice were topically treated with SPZZC or Domohorn ointment on the backside for 2 weeks (BALB/c) or 1 week (NC/Nga). Scratching behavior, clinical skin severity and the levels of WBC, neutrophil, eosinophil and total serum IgE were measured. After AD induction, scores of scratching behavior and clinical skin severity and the levels of WBC, neutrophil, eosinophil and total serum IgE were increased. Treatment with SPZZC significantly decreased scores of scratching behavior and clinical skin severity in a dose dependent manner in NC/Nga and BALB/c mice. Treatment with SPZZC 2% significantly decreased also the levels of WBC, neutrophil, eosinophil and total serum IgE. Especially, treatment of SPZZC 2% reduced more rapidly score of clinical skin severity than clobetasol cream. These results suggest that the SPZZC may be an alternative substance for the management of AD.

Corrosion Characteristics of Welding Zone by Types of Repair Welding Filler Metals and Post Weld Heat Treatment

  • Lee, Sung-Yul;Moon, Kyung-Man;Lee, Yeon-Chang;Kim, Yun-Hae;Jeong, Jae-Hyun
    • International Journal of Ocean System Engineering
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    • v.2 no.4
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    • pp.209-213
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    • 2012
  • Recently, the fuel using in the diesel engines of marine ships has been changed to a low quality of heavy oil because of the steady increase in the price of oil. Therefore, the wear and corrosion in all parts of the engine such as the cylinder liner, piston crown, and spindle and seat ring of exhaust valves has correspondingly increased. The repair welding of a piston crown is a unique method for prolonging its lifetime from an economic point of view. In this case, filler metals with a high corrosion and wear resistance are mainly being used for repair welding. However, often at a job site on a ship, a piston crown is actually welded with mild filler metals. Therefore, in this study, mild filler metals such as CSF350H, E8000B2, and 435 were welded to SS401 steel as the base metal, and the corrosion properties of the weld metals with and without post weld heat treatment were investigated using some electrochemical methods in a 0.1% $H_2SO_4$ solution. The weld metal welded with CSF350H filler metal exhibited the best corrosion resistance among these filler metals, irrespective of the heat treatment. However, the weld metal zones of the E8000B2 and 435 filler metals exhibited better and worse corrosion resistance with the heat treatment, respectively. As a result, it is suggested that in the case of repair welding with CSF350H and 435 filler metals, no heat treatment is advisable, while heat treatment is desirable if E8000B2filler metal is used with repair welding.

NONLINEAR VARIATIONAL INEQUALITIES AND FIXED POINT THEOREMS

  • Park, Sehie;Kim, Ilhyung
    • Bulletin of the Korean Mathematical Society
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    • v.26 no.2
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    • pp.139-149
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    • 1989
  • pp.Hartman and G. Stampacchia [6] proved the following theorem in 1966: If f:X.rarw. $R^{n}$ is a continuous map on a compact convex subset X of $R^{n}$ , then there exists $x_{0}$ ..mem.X such that $x_{0}$ , $x_{0}$ -x>.geq.0 for all x.mem.X. This remarkable result has been investigated and generalized by F.E. Browder [1], [2], W. Takahashi [9], S. Park [8] and others. For example, Browder extended this theorem to a map f defined on a compact convex subser X of a topological vector space E into the dual space $E^{*}$; see [2, Theorem 2]. And Takahashi extended Browder's theorem to closed convex sets in topological vector space; see [9, Theorem 3]. In Section 2, we obtain some variational inequalities, especially, generalizations of Browder's and Takahashi's theorems. The generalization of Browder's is an earlier result of the first author [8]. In Section 3, using Theorem 1, we improve and extend some known fixed pint theorems. Theorems 4 and 8 improve Takahashi's results [9, Theorems 5 and 9], respectively. Theorem 4 extends the first author's fixed point theorem [8, Theorem 8] (Theorem 5 in this paper) which is a generalization of Browder [1, Theroem 1]. Theorem 8 extends Theorem 9 which is a generalization of Browder [2, Theorem 3]. Finally, in Section 4, we obtain variational inequalities for multivalued maps by using Theorem 1. We improve Takahashi's results [9, Theorems 21 and 22] which are generalization of Browder [2, Theorem 6] and the Kakutani fixed point theorem [7], respectively.ani fixed point theorem [7], respectively.

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A deformable section model for the dynamics of suspension bridges -Part I : Model and linear response

  • Sepe, Vincenzo;Augusti, Giuliano
    • Wind and Structures
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    • v.4 no.1
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    • pp.1-18
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    • 2001
  • The classical two-degree-of-freedom (2-d-o-f) "sectional model" is currently used to study the dynamics of suspension bridges. Taking into account the first pair of vertical and torsional modes of the bridge, it describes well global oscillations caused by wind actions on the deck and yields very useful information on the overall behaviour and the aerodynamic and aeroelastic response, but does not consider relative oscillation between main cables and deck. The possibility of taking into account these relative oscillations, that can become significant for very long span bridges, is the main purpose of the 4-d-o-f model, proposed by the Authors in previous papers and fully developed here. Longitudinal deformability of the hangers (assumed linear elastic in tension and unable to react in compression) and external loading on the cables are taken into account: thus not only global oscillations, but also relative oscillations between cables and deck can be described. When the hangers go slack, large nonlinear oscillations are possible; if the hangers remain taut, the oscillations are small and essentially linear. This paper describes the model proposed for small and large oscillations, and investigates in detail the limit condition for linear response under harmonic actions on the cables (e.g., like those that could be generated by vortex shedding). These results are sufficient to state that, with geometric and mechanical parameters in a range corresponding to realistic cases of large span suspension bridges, large relative oscillations between main cables and deck cannot be excluded, and therefore should not be neglected in the design. Forthcoming papers will investigate more general cases of loading and dynamic response of the model.

Optimization of coagulant dosage using response surface methodology with central composite design (반응표면분석법-중심합성계획을 이용한 최적 응집제 주입량 산정 연구)

  • Kim, Yeseul;Oh, Jeill
    • Journal of Korean Society of Water and Wastewater
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    • v.29 no.2
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    • pp.193-202
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    • 2015
  • The determining the appropriate dosage of coagulant is very important, because dosage of coagulant in the coagulation process for wastewater affects removing the amount of pollutants, cost, and producing sludge amount. Accordingly, in this study, in order to determine the optimal PAC dosage in the coagulation process, CCD (Central composite design) was used to proceed experimental design, and the quadratic regression models were constructed between independent variables (pH, influent turbidity, PAC dosage) and each response variable (Total coliform, E.coli, PSD (Particle size distribution) (< $10{\mu}m$), TP, $PO_4$-P, and $COD_{cr}$) by the RSM (Response surface methodology). Also, Considering the various response variables, the optimum PAC dosage and range were derived. As a result, in order to maximize the removal rate of total coliform and E.coli, the values of independent variables are the pH 6-7, the influent turbidity 100-200 NTU, and the PAC dosage 0.07-0.09 ml/L. For maximizing the removal rate of TP, $PO_4$-P, $COD_{cr}$, and PSD(< $10{\mu}m$), it is required for the pH 9, the influent turbidity 200-250 NTU, and the PAC dosage 0.05-0.065 ml/L. In the case of multiple independent variables, when the desirable removal rate for total coliform, E.coli, TP, and $PO_4$-P is 90-100 % and that for $COD_{cr}$ and PSD(< $10{\mu}m$) is 50-100 %, the required PAC dosage is 0.05-0.07 ml/L in the pH 9 and influent turbidity 200-250 NTU. Thus, if the influent turbidity is high, adjusting pH is more effective way in terms of cost since a small amount of PAC dosage is required.

Roles of Theca and Granulosa Cells in Follicular Steroidogenesis in Rana dybowskii (북방산 개구리 여포의 스테로이드생성과정에 협막세포와 난구세포의 역할)

  • 안련섭;소재목;권혁방
    • The Korean Journal of Zoology
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    • v.39 no.3
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    • pp.273-281
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    • 1996
  • Previously, we have proposed a two-cell type model for follicular steroidogenesis inamphibians with Rana nigromacu lota. Present experiments were carried out to ascertain whether the model Is applicable to R. dybowskii. The role of theca layer were also reassessed by using granulosa cell-free pure theca layer (P-THEP). Theca/epithelium (THEP) layers, P-THEP layers, and granulosa cell enclosed-oocytes () were obtained from ovarian follicles of R. dybowskii by microdissection. Intact follicles (IFs) and different types of tissues were cultured for 6 hour in amphibian Ringer's m the presence or absence of FPII (0.05 gland/mi) or various steroid precursor (100 ng/ml). The amounts of product steroids converted by the components were measured by RIA. Exogenously added pregnenolone (P5) resulted in a marked increase in progesterone (P$_4$) by GCEOs (2143 pg/follicle) and IFs (2346 pg/follicle) but a smaller increase in P4 by THEP layer (495 pg/follicle). Addition of P$_4$ increased 17 a-hydroxyprogesterone (17 $\alpha$-OHP$_4$) levels by GCEOs (1118 pg/follicle) and IFs (1333 pg/follicle) but less by THEP layer (290 pg/follicle). However, much less amounts of P$_4$ or 17 $\alpha$-OHP$_4$ were producad by P-THEP layers than THEP in the presence of P5. Exogenous 1 7$\alpha$-OIIP$_4$ increased androstenedione (AD) levels by GCEOs (1415 pg/follicle) and IFs (561 pg/follicle) but not by THEP layers. In contrast, addition of AD resulted m a marked increase in testosterone (T) levels by TIIEP (2594 pg/follicle) and IFs (2223 pg/follide) but much less by GCEOs (339 pg/follicle). Exogenous T increased estradiol (E$_2$) levels by GCEOs (551pg/follicle) and IFs (887 pg/follicle), but not by THEP layer (<10 pg/follicle). Without addition of FPH or steroid precursors, very low or nondetectable levels of steroids were produced (< 20 pg/follicle) by all the types of follicular components examined. The data presented here indicate that the two-cell type model based on the study with R. nigromacu Iota is applicable to R. dybowskii and also suggest that the minor pathway, which convert P5 to 17$\alpha$-OHP$_4$, is not present in theca layer.

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Shade Comparative Analysis of Natural tooth Measured by Visual and Two Colorimeters(ShadeEye®,Shadepilot®) (2종 측색기와 시각을 이용한 자연치아의 색조 비교 분석)

  • An, Jin-Hee;Choi, Mee-Ra;Shim, Hye-Won
    • Journal of Dental Rehabilitation and Applied Science
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    • v.29 no.1
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    • pp.81-93
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    • 2013
  • The objectives were to evaluate the accuracy of shade selection by human visual system(VS) and 2 different colorimeters ($ShadeEye^{(R)}$(SE) and Shadepilot (SP)). Maxillary anterior teeth of 30 volunteers which had no caries or restorations were included in the study. Firstly, the accordance in shade selection by 3 dentists and 2 colorimeters was investigated. Secondly, the color of the teeth were measured by 1 observer's naked eye and 2 colorimeters under different illumination conditions (Sunny versus cloudy day). Additionally testing of inter-observer variability selected colors by 2 novice and 2 experienced dentists were compared. For comparing visual and 2 different colorimeters, SP(60%) showed significantly highest rate of accordance than the visual (23.3%) or SE (16.7%) and lowest mean ${\Delta}E$ ($2.62{\pm}0.74$ versus $3.83{\pm}1.38$;SE or $4.04{\pm}1.61$;VS)(p<0.001). If accuracy of shade selection were measured using VS, the mean ${\Delta}E$ value of cloudy day was higher than that of sunny day ($4.35{\pm}1.70$ versus $3.53{\pm}1.31$; p<0.001). There were no significant difference of the mean ${\Delta}E$ value between sunny and cloudy day in both SE and SP. Inter- observer repeatability was higher in 2 experienced group (73.3%) than novice group (36.7%). The mean ${\Delta}E$ of experienced group was lower than that of novice group ($3.60{\pm}1.47$ versus $4.70{\pm}1.67$; p<0.001). Colorimeters (SE or SP) is more accurate and more reproducible compared with human shade assessment. Using visual system may be limited by cloudy and inexperience of tester, then more experience and using colorimeters may be helpful of raising the accurate repeatability of shade selection.

Supporting XML Materialized Views Using Materialized Views of RDBMS (관계 DBMS의 실체뷰 기능을 이용한 XML 실체뷰 지원)

  • Kim, Seung-Hun;Kang, Hyun-Chul
    • The Journal of Society for e-Business Studies
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    • v.11 no.4
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    • pp.33-48
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    • 2006
  • Since the emergence of XML as the standard for data exchange on the Web, XML warehousing technology is required to efficiently support Web business applications such as e-Commerce. When the RDBMS is employed as the storage for XML warehouse, XML materialized views of the XML warehouse could be provided by leveraging the materialized views of the RDBMS Because XML documents are mapped into relational tuples, an XML query defining an XML materialized view needs to be transformed into SQL. If relational materialized views were defined with the transformed SQL statements, the XML materialized view could be obtained just by XML-tagging the tuples of the corresponding relational materialized views. The foremost advantage of such a scheme is that the RDBMS does take care of XML materialized view consistency except XML tagging whenever their source XML documents are updated. In this paper, we proposed such a scheme of providing XML materialized views, and implemented it using a commercial RDBMS equipped with materialized view facility in Java on Windows 2000 Professional environment. XML documents in TPC-W, Web e-Commerce Benchmark, were used in performance experiments. The experimental results showed that our proposed scheme for XML materialized views was very effective.

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