• International Journal of Computer Science & Network Security
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• 제22권9호
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• pp.389-395
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• 2022

A Mobile Sensor Network is widely used in real time applications. A critical need in Mobile Sensor Network is to achieve energy efficiency during routing as the sensor nodes have scarce energy resource. The nodes' mobility in MWSN poses a challenge to design an energy efficient routing protocol. Clustering helps to achieve energy efficiency by reducing the organization complexity overhead of the network which is proportional to the number of nodes in the network. This paper proposes"EERA: Energy Efficient Routing Algorithm for Mobile Sensor Network" is divided into five phases. 1, Cluster Formation 2.Cluster head and Transmission head selection 3.Path Establishment / Route discovery and 4,Data Transmission. Experimental Analysis has been done and is found that the proposed method performs better than the existing method with respect to four parameters.

• IMMUNE NETWORK
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• 제22권6호
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• pp.46.1-46.25
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• 2022

T-helper-17 (Th17) cells and related IL-17-producing (type17) lymphocytes are abundant at the epithelial barrier. In response to bacterial and fungal infection, the signature cytokines IL-17A/F and IL-22 mediate the antimicrobial immune response and contribute to wound healing of injured tissues. Despite their protective function, type17 lymphocytes are also responsible for various chronic inflammatory disorders, including inflammatory bowel disease (IBD) and colitis associated cancer (CAC). A deeper understanding of type17 regulatory mechanisms could ultimately lead to the discovery of therapeutic strategies for the treatment of chronic inflammatory disorders and the prevention of cancer. In this review, we discuss the current understanding of the development and function of type17 immune cells at the intestinal barrier, focusing on the impact of microbiota-immune interactions on intestinal barrier homeostasis and disease etiology.

• IMMUNE NETWORK
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• 제21권1호
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• pp.7.1-7.24
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• 2021

The coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 has severely impacted global health and economy. There is currently no effective approved treatment for COVID-19; although vaccines have been granted emergency use authorization in several countries, they are currently only administered to high-risk individuals, thereby leaving a gap in virus control measures. The scientific and clinical communities and drug manufacturers have collaborated to speed up the discovery of potential therapies for COVID-19 by taking advantage of currently approved drugs as well as investigatory agents in clinical trials. In this review, we stratified some of these candidates based on their potential targets in the progression of COVID-19 and discuss some of the results of ongoing clinical evaluations.

• 한국컴퓨터정보학회논문지
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• 제25권6호
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• pp.109-117
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• 2020

에듀테인먼트 시스템은 학습자가 문제를 효과적으로 인식하고, 문제를 해결하는 데 필요한 중요한 정보를 파악 분류하고, 배운 내용을 전달할 수 있도록 돕는 것을 목표로 한다. 에듀테인먼트를 활용한 콘텐츠는 과학 및 산업 분야의 교육 및 훈련에 유용하게 적용될 수 있다. 본 논문에서는 직관적인 멀티 모달 인터페이스를 활용하여 신약개발에서 활용되고 있는 가상스크리닝에 적용될 수 있는 에듀테인먼트 시스템을 제안한다. 본 연구에서는 분자 구조의 3D 모델을 효과적으로 조작하기 위해 입체 모니터를 활용하여 3차원(3D)거대 분자 모델링을 시각화 하였으며, 멀티 모달 인터페이스를 활용하여 분자 모델을 조작하고 있다. 본 시스템은 신약 개발 혹은 백신 개발에 있어 매우 중요한 방법 중의 하나인 가상 약물 선별 방법 중 하나 인 도킹 시뮬레이션 실험을 게임적 요소를 활용하여 쉽게 해결하는 방법을 제안하고 있다. 레벨 업 개념은 게임 요소가 객체와 사용자의 수에 의해 의존되는 바이오 게임 접근법을 활용하여 구현하였다. 실험 방법으로는 제안된 시스템의 신약 개발 과정에서 인간 면역 결핍 바이러스 (HIV)의 새로운 후보물질을 활용하여 바이러스의 활동 억제를 스크리닝하는 도킹 과정에서의 시간 측정으로 성능 비교 평가하였다.

• 지능정보연구
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• 제29권2호
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• pp.285-301
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• 2023

비대면 교육의 중요성 및 필요에 따른 수요가 증가함에 따라 국내외 온라인 교육 오픈 플랫폼이 활성화되고 있다. 본 플랫폼은 대학 등 교육 전문기관과 달리 학습자의 자율성이 높은 특징을 가지며 이에 따라 개인화된 학습 도구를 지원하기 위한 학습 행동 데이터의 분석 연구가 중요시 되고 있다. 실제적인 학습 행동을 이해하고 패턴을 도출하기 위하여 프로세스 마이닝이 다수 활용되었지만 온라인 교육 플랫폼과 같이 자기 관리형(Self-regulated) 환경에서의 학습 로그를 기반한 사례는 부족하다. 또한, 대부분 프로세스 모델 도출 등의 모델 관점에서의 접근이며 분석 결과의 실제적인 적용을 위한 개별 패턴 및 인스턴스 관점에서의 방법 제시는 미흡하다. 본 연구에서는 온라인 교육 오픈 플랫폼 내 학습 패턴을 파악하기 위하여 프로세스 마이닝을 활용한 분석 방법을 제시한다. 학습 패턴을 다각도로 분석하기 위하여 모델, 패턴, 인스턴스 관점에서의 분석 방법을 제시하며, 프로세스 모델 발견, 적합도 검사, 군집화 기법, 예측 알고리즘 등 다양한 기법을 활용한다. 본 방법은 국내 오픈 교육 플랫폼 내 기계학습 관련 강좌의 학습 로그를 추출하여 분석하였다. 분석 결과 온라인 강의의 특성에 맞게 비구조화된 프로세스 모델을 도출할 수 있었으며 구체적으로 한 개의 표준 학습 패턴과 세 개의 이상 학습 패턴으로 세분화할 수 있었다. 또한, 인스턴스별 패턴 분류 예측 모델을 도출한 결과 전체 흐름 중 초기 30%의 흐름을 바탕으로 예측하였을 때 0.86의 분류 정확도를 보였다. 본 연구는 프로세스 마이닝을 활용하여 학습자의 패턴을 체계적으로 분석한다는 점에서 기여점을 가진다.

• Journal of Ecology and Environment
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• 제38권2호
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• pp.133-143
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• 2015

Freshwater macrophytes improve the structural heterogeneity of microhabitats in water, often providing an important habitat for zooplankton. Some studies have focused on the overall influence of macrophytes on zooplankton, but the effects of macrophyte in relation to different habitat characteristics of zooplankton (e.g., epiphytic and pelagic) have not been intensively studied. We hypothesized that different habitat structures (i.e., macrophyte habitat) would strongly affect zooplankton distribution. We investigated zooplankton density and diversity, macrophyte characteristics (dry weight and species number), and environmental parameters in 40 shallow wetlands in South Korea. Patterns in the data were analyzed using a self-organizing map (SOM), which extracts information through competitive and adaptive properties. A total of 20 variables (11 environmental parameters and 9 zooplankton groups) were patterned onto the SOM. Based on a U-matrix, 3 clusters were identified from the model. Zooplankton assemblages were positively related to macrophyte characteristics (i.e., dry weight and species number). In particular, epiphytic species (i.e., epiphytic rotifers and cladocerans) exhibited a clear relationship with macrophyte characteristics, while large biomass and greater numbers of macrophyte species supported high zooplankton assemblages. Consequently, habitat heterogeneity in the macrophyte bed was recognized as an important factor to determine zooplankton distribution, particularly in epiphytic species. The results indicate that macrophytes are critical for heterogeneity in lentic freshwater ecosystems, and the inclusion of diverse plant species in wetland construction or restoration schemes is expected to generate ecologically healthy food webs.

• Parasites, Hosts and Diseases
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• 제59권1호
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• pp.47-53
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• 2021

Echinostoma mekongi was reported as a new species in 2020 based on specimens collected from humans in Kratie and Takeo Province, Cambodia. In the present study, its metacercarial stage has been discovered in Filopaludina martensi cambodjensis snails purchased from a local market nearby the Tonle Sap Lake, Pursat Province, Cambodia. The metacercariae were fed orally to an experimental hamster, and adult flukes were recovered at day 20 post-infection. They were morphologically examined using light and scanning electron microscopes and molecularly analyzed by sequencing of their mitochondrial cox1 and nad1 genes. A total of 115 metacercariae (1-8 per snail) were detected in 60 (60.0%) out of 100 Filopaludina snails examined. The metacercariae were round, 174 ㎛ in average diameter (163-190 ㎛ in range), having a thin cyst wall, a head collar armed with 37 collar spines, and characteristic excretory granules. The adult flukes were elongated, ventrally curved, 7.3 (6.4-8.2)×1.4 (1.1-1.7) mm in size, and equipped with 37 collar spines on the head collar (dorsal spines in 2 alternating rows), being consistent with E. mekongi. In phylogenetic analyses, the adult flukes showed 99.0-100% homology based on cox1 sequences and 98.9-99.7% homology based on nad1 sequences with E. mekongi. The results evidenced that F. martensi cambodjensis snails act as the second intermediate host of E. mekongi, and hamsters can be used as a suitable experimental definitive host. As local people favor to eat undercooked snails, these snails seem to be an important source of human infection with E. mekongi in Cambodia.

• International journal of advanced smart convergence
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• 제12권4호
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• pp.98-103
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• 2023

As technology advanced dramatically in the late 20th century, a new era of science arrived. The emerging era of scientific discovery, variously described as e-Science, cyberscience, and the fourth paradigm, uses technologies required for computation, data curation, analysis, and visualization. The emergence of the fourth research paradigm will have such a huge impact that it will shake the foundations of science, and will also have a huge impact on the role of data-information infrastructure. In the digital age, the roles of data-information professionals are becoming more diverse. As eScience emerges as a sustainable and growing part of research, data-information professionals and centeres are exploring new roles to address the issues that arise from new forms of research. The functions that data-information professionals and centeres can fundamentally provide in the e-Science area are data curation, preservation, access, and metadata. Basically, it involves discovering and using available technical infrastructure and tools, finding relevant data, establishing a data management plan, and developing tools to support research. A further advanced service is archiving and curating relevant data for long-term preservation and integration of datasets and providing curating and data management services as part of a data management plan. Adaptation and change to the new information environment of the 21st century require strong and future-responsive leadership. There is a strong need to effectively respond to future challenges by exploring the role and function of data-information professionals in the future environment. Understanding what types of data-information professionals and skills will be needed in the future is essential to developing the talent that will lead the transformation. The new values and roles of data-information professionals and centers for 21st century researchers in STEAM are discussed.

• Journal of Microbiology and Biotechnology
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• 제30권4호
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• pp.540-551
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• 2020

Sporotrichosis is a chronic and subacute mycosis causing epidemiological outbreaks involving sick cats and humans in southeastern Brazil. The systemic disease prevails in cats and in humans, with the symptoms restricted to the skin of immunocompetent individuals. Under these conditions, the prolonged treatment of animals and cases of recurrence justify the discovery of new treatments for sporotrichosis. This work addresses the antifungal activity of silver salts of Keggin-type heteropolyacid salts (Ag-HPA salts) such as Ag₃[PW₁₂O₄₀], Ag₆[SiW₁₀V₂O₄₀], Ag₄[SiW₁₂O₄₀] and Ag₃[PMo₁₂O₄₀] and interactions with the antifungal drugs itraconazole (ITC), terbinafine (TBF) and amphotericin B (AMB) on the yeast and mycelia forms of Sporothrix spp. Sporothrix spp. yeast cells were susceptible to Ag-HPA salts at minimum inhibitory concentration (MIC) values ranging from 8 to 128 ㎍/ml. Interactions between Ag₃[PW₁₂O₄₀] and Ag₃[PMo₁₂O₄₀] with itraconazole and amphotericin B resulted in higher antifungal activity with a reduction in growth and melanization. Treated cells showed changes in cell membrane integrity, vacuolization, cytoplasm disorder, and membrane detachment. Promising antifungal activity for treating sporotrichosis was observed for the Ag-HPA salts Ag₃[PMo₁₂O₄₀] and Ag₃[PW₁₂O₄₀], which have a low cost, high yield and activity at low concentrations. However, further evaluation of in vivo tests is still required.

• 한국정보과학회논문지:정보통신
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• 제35권5호
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• pp.409-414
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• 2008

모바일 애드 혹 네트워크상에서 DSR, AODV등 대부분의 on demand 라우팅 프로토콜들은 경로 탐색 과정에서 트래픽 로드를 고려하고 있지 않다. 최근 혼잡을 해결하고 트래픽 로트 밸런싱을 이루기 위해서 여러 알고리즘들이 제시되었으나 대부분 경로 탐색과정에서 단순히 대체 경로를 찾거나 혼잡이 발생된 노드를 회피하여 라우팅하는 기법들이었다. 본 논문에서는 이러한 이슈들에 대한 성능을 향상시키기 위해 혼잡이 발생된 노드에서 패킷 버스팅 기법을 사용하여 혼잡을 해결하고자 한다. 패킷 버스팅 기법은 IEEE 802.11e QoS 동작에서 소개되었으며 한번의 채널획득으로 여러 패킷을 보낼 수 있도록 한다. 이로써 혼잡이 발생한 노드는 버퍼링된 패킷을 신속하게 전송할 수 있으며, 병목현상을 막을 수 있다. 또한 정확하고 동적으로 혼잡상태를 결정하기 위하여 두 가지의 임계값을 정의한다. 하나는 인터페이스 큐길이이며, 다른 하나는 버퍼링 시간이다. 마지막으로 실험을 통하여 네트워크 트래픽이 많을 때 제안된 알고리즘이 기존의 일반적인 on demand 프로토콜보다 더 효율적이고 우수한 성능을 가짐을 보인다.