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Urinary 1-hydroxypyrene glucuronide and genetic polymorphisms of xenobiotic metabolism enzymes in shipbuilding workers using coal tar paint (콜타르가 함유된 페인트 사용 조선업 근로자에서 요중 1-hydroxypyrene glucuronide와 대사효소 유전자 다형성에 관한 연구)

  • 이경호;이정미;최인미;김재용;임형준;이상윤;윤기정;고상백;최홍렬
    • Environmental Mutagens and Carcinogens
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    • 제20권1호
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    • pp.34-39
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    • 2000
  • Although shipbuilding workers were exposed to a variety of genotoxic compounds including polycyclic aromatic hydrocarbons (PAHs), limited number of studies were conducted to evaluate the biomarkers related to PAH exposure in painting workers in shipbuilding industry. One hundred and thirty three workers including 73 employees using coal tar paints were recruited from a shipbuilding company located in South Korea. Urinary 1-hydroxypyrene glucuronide (1-OHPG), as internal dose of PAH exposure, were measured by synchronous fluorescence spectroscopy after immunoaffinity purification using monoclonal antibody 8E11. Glutathione S-transferase (GST)M1 and GSTT1 genotypes were assessed by multiplex PCR. Information on demographic characteristics, smoking gabit, diet, job title, use of personal protective equipments were collected by self-administered questionnaire. Urinary 1-OHPG were higher in workers using coal tar paints than in workers using general paints, however, the difference was not statistically significant (p=0.20, Mann-Whitney U test). Urinary 1-OHPG levels in smokers were higher than in non-smokers (p<0.05 by Mann-Whitney U test) and there was a significant increase in urinary 1-OHPG levels with the numbers of cigarettes consumed per day (Spearman's correlation coefficient = 0.28, p=0.02). Genetic polymorphisms of GSTM1 and GSTT1 did not influence the level of 1-OHPG in study subjects. Multiple regression analysis show that smoking is the only significant predictor for lon-transformed 1-OHPG (overall model R2=0.1). These results suggest that workers using coal tar paints were exposed to significant amount of PAHs and individual difference in xenobiotic metabolism might affect the levels of internal dose of PAHs.

A Study on the Specialization of University Education about Healthcare Facility Design in USA (미국 대학에서 의료복지시설 디자인 교육 특성화에 대한 연구)

  • Moon, Changho
    • Journal of The Korea Institute of Healthcare Architecture
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    • 제17권1호
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    • pp.7-14
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    • 2011
  • This paper is intended to suggest some reference materials for future specialization of university education about healthcare facility design in Korea, by reviewing the degree systems and curriculum of 5 universities where architecture departments have specialized program for healthcare facility design in USA. Research method includes the navigation of related homepages, the e-mail contacts with the professors in charge, and the analysis of collected materials. Some conclusions can be summarized as following : Degrees of the specialized programs under concentration or track system are awarded as the same title as master program in the department of Architecture. Specialized education programs can be largely classified by concentration/track systems( Clemson University, University of Kansas and Arizona State University) which are operated independently in general and certificate system(Texas A&M University and Texas Tech University) which adds some healthcare related courses to general master program in the department of Architecture. As distinctive curriculum from 5 Universities, Clemson University which offers almost courses related to healthcare facility design, University of Kansas which provides internships(6 credits each) for summer term & fall semester of 2nd year, and Texas Tech University where certificate program is co-operated by architecture and nursing department can be mentioned. In order to pursuit the specialization of university education about healthcare facility design in the department of Architecture, it would be desirable to proceed it after setting the direction such as concentration, track or certificate system according to the various circumstances & conditions of the department concerned.

Synthesis and Evaluation O-Benzyl Oxime-ether Derivatives Containing β-Methoxyacrylate Moiety for Insecticidal and Fungicidal Activities

  • Hu, Zhi-Bin;Luo, He-An;Wang, Xiao-Guang;Huang, Ming-Zhi;Huang, Lu;Pang, Huai-Lin;Mao, Chun-Hui;Pei, Hui;Huang, Chao-Qun;Sun, Jiong;Liu, Ping-Le;Liu, Ai-Ping
    • Bulletin of the Korean Chemical Society
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    • 제35권4호
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    • pp.1073-1076
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    • 2014
  • In attempt to lead compounds exhibiting both insecticidal and fungicidal activities, a series of O-benzyl oximeether derivatives were designed and synthesized by introducing ${\beta}$-methoxyacrylate pharmacophore into a scaffold. The insecticidal activity against Aphis fabae and the fungicidal activity against Erysiphe graminis were screened. The title compounds exhibited remarkable insecticidal and fungicidal activities. The most potent compound 6d was identified. Its insecticidal $LC_{50}$ against A. fabae is 6.4 mg/L, which is lower than that of chlorfenapyr (19.4 mg/L) and even close to the level of imidacloprid (4.8 mg/L). Its fungicidal $EC_{90}$ in preventive and curative treatment against E. graminis are 2.2 and 4.8 mg/L, respectively, which are lower than azoxystrobin (7.0 and 5.9 mg/L). These results indicate that compound 6d can be considered as a lead for further developing new O-benzyl oxime-ether typed candidates with both fungicidal and insecticidal activities.

College Students' Preferences of Web-based OPAC Retrieval Techniques and their Blood Types: An Empirical Study (대학생들의 웹 기반 OPAC 검색기법 선호도와 혈액형에 대한 실험적 연구)

  • Kim, Hee-Sop
    • Journal of the Korean Society for Library and Information Science
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    • 제44권3호
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    • pp.81-102
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    • 2010
  • The purpose of this study was to investigate college students' preferences of Web-based OPAC retrieval techniques and their ABO blood types as an empirical survey. Data was collected through a self-designed questionnaire with a total of 101 undergraduate students from the College of Social Sciences responding. The collected data was analyzed using descriptive statistics, and One-way ANOVA. The results show that 'title' was most preferred among the access points, 'AND' was the most preferred Boolean operator, 'publication year' and 'subject' were the most favored techniques in limiting the scope of retrieval, and 'record number limit per page' was the most frequently used for displaying retrieval results. The results also show that there were little(3 out of 22, i.e. 13.6%) statistically significant differences between the college students' preferences of Web-based OPAC techniques and their blood type.

Top 50 cited articles on dental stem cell research

  • Kodonas, Konstantinos;Fardi, Anastasia;Gogos, Christos;Economides, Nikolaos
    • Restorative Dentistry and Endodontics
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    • 제45권2호
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    • pp.17.1-17.10
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    • 2020
  • Objectives: Citation analysis provides a unique insight into how scientific interests and research trends have changed over time. The aim of this study was to report on the 50 top-cited papers in dental stem cell research using the Science Citation Index Expanded provided by the Web of Science database to determine the academic importance of each contribution. Materials and Methods: After the screening, article title and type, total citations and citations per year, publication journal, publication year, first and senior authors, country of origin, institution, and university of reprint author were documented for the 50 top-cited articles in dental stem cell research. Keyword analysis was performed to determine which keywords were most/least popular. Results: Top 50-cited articles were cited between 179 to 2,275 times. The majority of papers were published in 2008 and originated from the United States with the highest contribution from the National Institute of Dental & Craniofacial Research. Journal of Dental Research published the highest number of top-cited articles, followed by Stem Cells and Journal of Endodontics. The greatest number of articles was published by two individual authors, Shi and Gronthos. Among 197 unique keywords, dental pulp stem cells and mesenchymal stem cells were the most frequently used. Thirty-eight of the 50 most cited articles were original articles, and 37 of them were in the field of basic science. Conclusions: Basic science studies in dental stem cell research published in high impact factor journals had the highest citation rates.

Vietnamese Annexation of Cambodia(1835-1847) with the Handling of the Queen Mei (베트남의 캄보디아 병합(1835-1847) - 여왕 메이(Mei)의 처리문제를 중심으로)

  • Choi, Byung-Wook
    • The Southeast Asian review
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    • 제20권2호
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    • pp.1-29
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    • 2010
  • In 1835, quickly after the Cambodian king Ang Chan died, Vietnamese emperor Minh Mang started to proceed his ambition to grab the territory of Cambodia. As the first step, he stationed big forces led by Truong Minh Giang in Phnom Phen, and appointed the Ang Chan's second daughter, Mei, as the successor of her father but with the humble title of Chan Lap Quan Chu, or the Prefecture sovereign of Cambodia. This article discusses the ways how the Vietnamese leaders manipulated the status of the Cambodian queen with each step of protection, assimilation, and finally a rupture. The author seeks for Vietnamese own theory of annexation in the process. In doing so, the author claims that Vietnamese tough policy of annexation was closely interwoven with the unequal relationship between the Vietnamese emperors and the Cambodian queen, i. e. men and woman. The first chapter discusses how and why the second daughter was chosen, and what in reality the status of the queen was under the protection of Vietnamese general Truong Minh Giang. Second chapter shows how much Mei was bullied by the Vietnamese. She was kidnapped to Vietnam, and was even regarded by the Cambodian people that she became the 'lover' or the 'concubine' of the general Truong Minh Giang. Third chapter deals with Vietnam's retreat forced by the Cambodian resistance together with the Thai intervention, and discusses how much Vietnam tried to maintain its authority over Cambodia through the queen Mei. Cambodia, in the 19th century, was a experimental place for the 'mission of civilization' from the side of Vietnam. Mei was a main character in this period from the beginning to the end. The conclusion of this article stresses that the desire of Vietnam ('civilized') to assimilate Cambodia ('barbarious') was strengthened by the psychology of the male master (Vietnam) to domesticate the female subject (Cambodia). The relationship between Vietnam and Cambodia was not only political but also gender oriented. In this epic, the existence of the queen Mei should be regarded as an important key to understanding of the Vietnamese theory for the annexation of Cambodia.

Treatments of Korean Medicine for Pediatric Growth: A Literature Review of Clinical Studies (소아 성장에 대한 한의학 치료: 국내 임상연구에 대한 문헌적 고찰)

  • Han, Ji-Eun;An, Tteul-E-Bom;Park, Jang-Kyung;Sung, Hyun Kyung;Yeon, Ji-Hye;Sung, Soo-Hyun
    • The Journal of Pediatrics of Korean Medicine
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    • 제35권1호
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    • pp.18-29
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    • 2021
  • Objectives The purpose of this study is to provide evidence of treatment of growth disorder Methods We have reviewed clinical studies of growth disorder in children and adolescent through 6 databases until February, 2020. The searching keywords were "short stature OR dwarfism OR growth disorder" AND "acupuncture OR electric acupuncture OR electroacupuncture OR moxibustion OR herb medicine OR cupping OR Korean medicine OR oriental medicine OR chuna OR pharmacopuncture OR qigong OR traditional medicine OR traditional Korean medicine OR Korean medicine". There was no limit to time and language. Results As a result of the initial search, a total of 270 papers from six domestic databases were found. Among these papers, 156 papers were selected after excluding duplicated papers, and 109 of them were further excluded after checking the title and the abstract. Additionally, 28 papers were excluded by reviewing the full text. The author, year, number of patients, treatment, evaluation tools, and results of a total of 19 papers were included in this study and were summarized. 90.5% of the studies have shown that herbal remedies have improved childhood growth. Conclusions Random control studies and large-scale observational studies are needed in future to show high-quality evidence for the treatment of Korean medicine in pediatric growth.

Archipeligiality as a Southeast Asian Poetic in Cirilo F. Bautista's Sunlight on Broken Stones

  • Sanchez, Louie Jon A.
    • SUVANNABHUMI
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    • 제6권1호
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    • pp.193-221
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    • 2014
  • Archipeligiality, a concept continuously being developed by the scholar, is one that attempts to articulate the Filipino sense of place as discoursed in/through its literatures. As a country composed of 7,107 islands, the very fragmentation and division of the country, as well as its multiculturality and multilinguality, have become the very means by which Filipino writers have "imagined" so to speak-that is, also, constructed, into a singular, united frame-the "nation." This, the author supposes, is an important aspect to explore when it comes to discoursing the larger Southeast Asian imagination, or poetic, as similar situations (i.e. Indonesia, Malaysia, and Singapore), may soon compel for a comparative critico-literary perspective. This paper continues this exploratory "geoliterary" discourse by looking at a Filipino canonical work in English by Cirilo F. Bautista, the epic The Trilogy of Saint Lazarus, the title of which already signals a geographic allusion to the first map-name granted by the Spanish colonizer to the Philippines in the region, and consequently the first signification of the country's subjected existence in the colonial imagination. The work, published between 1970 and 1998, is composed of three parts: The Archipelago, Telex Moon, and Sunlight on Broken Stones, which won the 1998 Philippine Independence Centennial Literary Prize. In these epics, notions of Philippine history and situation were discoursed, and Filipino historical figures were engaged in dialogue by the poet/the poet's voice, with the end of locating the place [where history and time had brought it; or its direction or trajectory as a nation, being true to the Filipino maxim of ang di lumingon sa pinanggalingan, di makararating sa paroroonan (the one who does not look back to his origins would not reach his destination)]. of the Philippines not only in the national imagination, but in this paper, in the wider regional consciousness. The paper proposes that the archipelagic concept is an important and unique characteristic of the Southeast Asian situation, and thus, may be a means to explicate the clearly connected landscapes of the region's imagination through literature. This paper focuses on Sunlight on Broken Stones.

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A study on the Sabu-Songyu-Mongnok(사부송유목록), or a Classified Catalogue for Recitation and Appreciation of Classics (사부송유목록에 대한 연구)

  • Lee Sang-Yong
    • Journal of the Korean Society for Library and Information Science
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    • 제25권
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    • pp.445-476
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    • 1993
  • This paper is written to clarify the specific details of the Sabu-Songyu­Mongnok(사부송유목록). which is a reading list for recitation and appreciation of Chinese classics edited by Hong Suk-Chu(1774-1842) when he was 56 years old for the stimulation of his younger brother Hyun-Ju (1793-1865)'s reading life. In this study the catalogue's title interpretation. the time of the editing, the motive for the editing and the analysis of the contents are revealed as what they actually are. The main details are as followings. There is no date written on the Sabu-Songyu-Mongnok but the writer estimate it to be around 1829. After Hong Suk-Chu recognized the fact that although his younger brother Hyun-Ju was interested in reading but felt that he was a little too old to begin to read all the books of the whole classes. he selected the classic works from whole subjects, i.e. history, philosophy and anthology, that he thought which would best represent each subject. From these selected works he then picked out the most important chapters or parts of the works. Another motivation of the editing was for the stimulation of the reading life for Hong Suk-chu himself and for people like himself who were getting old and losing their vitality. The Sabu-Songyu-Mongnok consists of four categories. i.e. classics category, history category, philosophy category and anthology category, and in the catalogue, 26 different works are entered. The classics category has ten, the history category has six, the philosophy category has six and the anthology category has four. Each of the works are entered under the title of the book, and hen the chapter heading. The Sabu-Songyu-Mongnok was edited 19 years later than Hong-ssi toksorok(홍씨독서록) or an Annotated Bibliography of Korean and Chinese Books. Comparing each category of the catalogue with the Hong-ssi toksorok, the writer could catch the following characteristics. 1. Although there was no indication of the class heading, the sequence of the arrangement of the entries in the classics categories was the same as the sequence of the classes in the Hong-ssi toksorok. 2. The Zuo-shi Chun-qiu-zhuan(좌씨춘추전) is recorded in the class of Chunqiu of the classics category in the Hong-ssi toksorok, but in the Sabu-Songyu­Mongnok, it belongs to the history category. 3. In the philosophy category of the catalogue, Chuangtzu(장자) writings are included because it is so well written. 4. Unlike the categories of classics, history and anthology, the philosophy category is recorded under the author's name. This is fascinating because it unites with the conventional cataloguing practice of the west. 5. In the anthology category, the writings with the best styles from the Chuci(초사) or the poems of Chou, Wen-xuan(문선), wen-yuan-ying-hua(문여영화) are selected and classified into four parts: (1) poems, (2) proses of Han, Wei and Pre-Qin dynasties. (3) Si-liu-pian-li-wen(사육병려문), (4) classic style of writings of Tang and Song dynasties (당송고문). 6. There was an unusually large number of Han Yu's writings selected from the great eight poets of Tang and Song dynasty writings. (20 categories out of $43: 47\%)$ After comparing the entries of the Sabu-Songyu-Mongnok, it can be concluded that all the entries were also included in the Hong-ssi tokrorok. The fact that the sequence of the entries in the classics category and that the literary works were sequenced under the same subject by the year of editing or writing like as the Hong-ssi toksorok Also it is unusual that there was not even one literary work of a Korean in the catalogue. Anyhow this catalogue is the first recitation catalogue in our country that was edited for the people in the prime of life as well as for old people and is the only one existing today.

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A Study on the Automated Compatibility Standard Test System for eBook DRM (전자책 DRM을 위한 자동화된 표준정합성 검사 시스템에 관한 연구)

  • Kim, Tae-Hyun;Kang, Ho-Gap;Ahn, Chang-Ju;Cho, Seong-Hwan
    • The Journal of the Institute of Internet, Broadcasting and Communication
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    • 제13권2호
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    • pp.127-136
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    • 2013
  • The study of the compatibility of EPUB DRM, granted by the Korea Copyright Commission, as a CT R & D project (Project Title: The Development of the standard reference software technology for International Standard EPUB-based eBook DRM) developed standards such as profile standards for encryption digital signature and authentication certificates and standards for technical terms of rights information. In 2012, these four standards have been established as the Korean Industrial Standards under the names of 'Encryption specification for EPUB DRM,' 'the Digital signature specification for EPUB DRM,' 'the Certificate specification for EPUB DRM,' and 'Definitions of Right Terms for EPUB DRM' through the ODPF(Open Digital Standardization Forum) and the TTA(Telecommunications Technology Association). The research project also proposed standards of ebook DRM license protocols in order for the four standards to practically apply to ebook DRM compatibility. It is necessary for technology standards to require a compatibility standard test process for testing whether implementations which were developed on the basis of the standard specification, comply with standards. This study suggests an automated compatible standard test method and a test model under the ebook DRM standard technical specification.