• Radiation Oncology Journal
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• v.37 no.4
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• pp.259-264
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• 2019

Purpose: Accurate localization of the lumpectomy cavity during accelerated partial breast radiation (APBR) is essential for daily setup to ensure the prescribed dose encompasses the target and avoids unnecessary irradiation to surrounding normal tissues. Three-dimensional ultrasound (3D-US) allows direct visualization of the lumpectomy cavity without additional radiation exposure. The purpose of this study was to evaluate the feasibility of 3D-US in daily target localization for APBR. Materials and methods: Forty-seven patients with stage I breast cancer who underwent breast conserving surgery were treated with a 2-week course of APBR. Patients with visible lumpectomy cavities on high quality 3D-US images were included in this analysis. Prior to each treatment, X-ray and 3D-US images were acquired and compared to images from simulation to confirm accurate position and determine shifts. Volume change of the lumpectomy cavity was determined daily with 3D-US. Results: A total of 118 images of each modality from 12 eligible patients were analyzed. The average change in cavity volume was 7.8% (range, -24.1% to 14.4%) on 3D-US from simulation to the end-of-treatment. Based on 3D-US, significantly larger shifts were necessary compared to portal films in all three dimensions: anterior/posterior (p = 7E-11), left/right (p = 0.002), and superior/inferior (p = 0.004). Conclusion: Given that the lumpectomy cavity is not directly visible via X-ray images, accurate positioning may not be fully achieved by X-ray images. Therefore, when the lumpectomy cavity is visible on US, 3D-US can be considered as an alternative to X-ray imaging during daily positioning for selected patients treated with APBR, thus avoiding additional exposure to ionizing radiation.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.12 no.1
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• pp.427-435
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• 2011

The information management system for the national R&D reports on the level of each government department have been operated in order to have special affiliated organizations collect detailed information, construct databases for R&D reports, and operate their information system; thus, the current classification system for the R&D reports on the governmental level is insufficient. Also, each department requires to prepare a standardized electronic original text service system since mutually different electronic original text services have been provided. therefore, this paper sets up the following research goals and detailed research contents. The goals of this study are to establish methods to standardize the forms of national R&D reports and suggest the framework for XML-based national R&D reports services by analyzing the problems in the forms of previous national R&D reports services. As detailed research contents, first, Identify the current R&D electronic original reports services by each government department. Second, this paper analyzed primary overseas science technology information service systems related with national research and development reports and related database schemata. this paper proposed the XML-based national R&D reports service framework through analyzing the problems in the framework of the existing national R&D reports service system and also established and suggested the methods to provide database schema design and report portal services. Lastly, it is expected that this paper will have academic contribution to enhancing R&D investment efficiency by utilizing collaboratively the information and resources related with national R&D through establishing the general information management system for national-dimension R&D reports and also managing science technology information efficiently and developing a user-centered integrated information system.

• Proceedings of the Technology Innovation Conference
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• 2003.06a
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• pp.116-135
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• 2003

우리나라는 최근에 IMF 에 재정적 지원을 요청하는 상황이 계기가 되어 국가경쟁력과 삶의 질 측면에 상당한 관심을 가지게 되었다. 이러한 환경변화는 사회저변에 효율성을 강조하는 풍토를 확산시키고, 위기상황의 재발방지를 위해 그 원인을 분석하고 대안을 마련하는 등 사회 전반적으로 각고의 노력을 촉발시키게 하는 계기가 되었다. 이러한 논의들 중에 눈에 띄는 한가지는 과학과 기술사이의 관계에 관한 논쟁인데, 최근에 활발히 논의되고 있는 과학과 기술사이의 연계는 미국을 중심으로 많은 연구가 진행되고 있으며, 이러한 연구들은 대체적으로 과학과 기술사이에는 상당한 정도의 상관관계가 있고, 이 둘 사이는 서로 상호작용하면서 경제성장을 이끄는 역할을 한다고 주장하고 있다. 본 연구에서는 이러한 논의들을 국내에 적용시킴으로써 해외의 사례가 우리에게 시사점이 될 수 있는지 체계적으로 분석하려고 시도하였다. 과학과 기술사이의 연관성을 알아보기 위하여, 과학의 연구성과를 대변하는 대용치로 SCI논문을 사용하였고, 이러한 연구성과가 얼마만큼 사회에 파급되어 산업화 또는 상업화되었는지를 측정하기 위해 특허출원수를 추출하여, 연구의 목적에 맞게 modify 하는 과정을 거쳤으며, 추세분석과, 상관관계분석 그리고 회귀분석을 실시하였다. 본 연구는 실증분석을 통하여, 과학과 기술사이에는 일부 소수의 영역을 제외하고 매우 높은 상관관계가 있음을 발견하였고, 우리나라의 주력산업이었던 기계분야의 쇠퇴를 실증적으로 확인 할 수 있었으며, 정부의 적극적인 지원아래 폭발적으로 성장하였던 IT분야의 증가추세를 확인할 수 있었다. 따라서 본 연구에서는 국가경쟁력의 근간이 되는 연구개발부문에 경제논리를 배제하는 지속적인 투자를 제언함으로써, 국가경쟁력 제고와 삶의 질 향상이라는 두 마리 토끼를 잡을 수 있는 방안은 과학과 기술의 유기적인 연계에 있음을 밝히고 있다. 건설을 위한 정책적 시사점과 동북아 연구개발정보 Portal 및 APEC APGrid 연구망 등의 구체적인 정보인프라 구축방안을 도출하였다.술 주기를 도출하고, 산업 내 평균 권리 청구 항목 수를 이용하여 각 산업의 기술 범위를 비교하였다. 각각의 동적 분석을 통해 시간에 따른 변화 양상이 관찰하였고, ANOVA 분석을 이용하여 통계적 유의성을 검증하였다. 본 연구는 현재의 기술 패러다임 내에서 Pavitt이 제시한 산업 분류의 근거를 보충 설명하였고 특허 정보를 이용하여 기술혁신의 산업별 유형에 대한 폭넓은 분석방법을 제시하였다.별 시간대별 효과분석을 통하여 정책의 시행여부가 결정되어야 할 것이다. 한편, 화물전용차선의 설치로 인한 물류비용의 절감을 보다 효과적으로 달성하기 위해서는 종합류류 전산망의 시급한 구축과 함께 화물차의 적재율을 높이고 공차율을 낮출 수 있는 운송체계의 수립이 필요한 것으로 판단된다. 그라나 이러한 화물전용차선의 효과는 단기적인 치유책일 수밖에 없기 때문에 물류유통 시설의 확충을 위한 사회간접자본의 구축을 서둘러 시행하여야 할 것이다.으로 처리한 Machine oil, Phenthoate EC 및 Trichlorfon WP는 비교적 약효가 낮았다.>$^{\circ}$E/$\leq$30$^{\circ}$NW 단열군이 연구지역 내에서 지하수 유동성이 가장 높은 단열군으로 추정된다. 이러한 사실은 3개 시추공을 대상으로 실시한 시추공 내 물리검층과 정압주입시험에서도 확인된다.. It was resulted from increase of weight of single cocoon. "Manta"2.5ppm produced 22.2kg of cocoon. It is equal to 9% increase in index, as compared to that

• Proceedings of the KOR-KST Conference
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• 2003.02a
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• pp.3-18
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• 2003

본 논문은 ATMS와 ATIS에서 요구되는 교통관리 및 정보제공의 효과분석을 위해, 운전자의 주행 및 경로선택 의사결정과 교통제어에 대한 반응등 운전자 행태를 모의실험에 반영함으로써 교통시스템의 실시간 특성을 모사할 수 있는 모형을 구축하고 이를 기반으로 하는 미시적 교통 모의실험기를 개발하는 것을 목적으로 하였다. 본 연구에서는 운전자, 차량, 교통망, 검지 및 신호시스템, 교통정보제공시스템 등을 교통시스템의 주요 구성요소로 설정하였으며 운전자 및 차량특성, 차두시간분포와 차량발생모형, 차량주행모형, 차로변경 및 간격수락모형, 경로선택모형을 주모의실험모형을 구성하는 부모형으로 결정하였다. 따라서 본 논문에서는 각각의 부모형들에 대한 최근의 연구결과들을 검토하고, 현실모사 능력과 함께 다른 부모형들과의 연계, 모의실험기의 구현상에서의 적합성 등을 고려하여 적정모형의 선정 및 수정, 새로운 부모형의 구축을 수행하였다. 구축된 부모형을 통합하여 교통모의실험기를 개발하였으며 구축된 모형의 타당성 및 적용성 검토를 위해 현장자료 및 가상자료를 이용한 검증을 수행하였다. 검증결과 모형의 목적인 교통제어 및 정보제공등의 시스템 대안의 평가에 이용 가능한 것으로 나타났다. 또한 본 논문의 연구결과는 교통제어 및 정보제공전략 대안의 평가뿐만 아니라 차량추종 및 차로변경 등의 미시적 교통모형 연구, 동적기종점 통행량 추정, 동적통행배정의 연구에도 활용할 수 있을 것으로 판단된다. 본 논문의 연구모형은 현단계에서는 현실의 모사 및 분석을 위한 도구보다는 새로운 대안들간의 비교평가를 위한 도구로 활용할 수 있을 것으로 판단된다. 이에 따라 현실모사의 정확도를 확보하기 위한 검증 및 개선이 필요할 것이며, 각 부모형들에 대한 계속적인 연구와 새롭게 발표되는 연구결과를 수용한 지속적인 개발이 필요할 것이다.유기적인 연계에 있음을 밝히고 있다. 건설을 위한 정책적 시사점과 동북아 연구개발정보 Portal 및 APEC APGrid 연구망 등의 구체적인 정보인프라 구축방안을 도출하였다.술 주기를 도출하고, 산업 내 평균 권리 청구 항목 수를 이용하여 각 산업의 기술 범위를 비교하였다. 각각의 동적 분석을 통해 시간에 따른 변화 양상이 관찰하였고, ANOVA 분석을 이용하여 통계적 유의성을 검증하였다. 본 연구는 현재의 기술 패러다임 내에서 Pavitt이 제시한 산업 분류의 근거를 보충 설명하였고 특허 정보를 이용하여 기술혁신의 산업별 유형에 대한 폭넓은 분석방법을 제시하였다.별 시간대별 효과분석을 통하여 정책의 시행여부가 결정되어야 할 것이다. 한편, 화물전용차선의 설치로 인한 물류비용의 절감을 보다 효과적으로 달성하기 위해서는 종합류류 전산망의 시급한 구축과 함께 화물차의 적재율을 높이고 공차율을 낮출 수 있는 운송체계의 수립이 필요한 것으로 판단된다. 그라나 이러한 화물전용차선의 효과는 단기적인 치유책일 수밖에 없기 때문에 물류유통 시설의 확충을 위한 사회간접자본의 구축을 서둘러 시행하여야 할 것이다.으로 처리한 Machine oil, Phenthoate EC 및 Trichlorfon WP는 비교적 약효가 낮았다.>$^{\circ}$E/$\leq$30$^{\circ}$NW 단열군이 연구지역 내에서 지하수 유동성이 가장 높은 단열군으로 추정된다. 이러한 사실은 3개 시추공을 대상으로 실시한 시추공 내 물리검층과 정압주입시험에서도 확인된다.. It was resulted from increase of weight of single cocoon. "Manta"2.5ppm produced 22.2kg of cocoon. It is equal to 9%

• Korean Journal of Veterinary Research
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• v.33 no.2
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• pp.269-275
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• 1993

Tissue distribution of RHDV in rabbits were examined by immunofluorescence and ABC methods. Tissues including liver, spleen, kidneys, lungs and brain were frozen, cut in a crycut, and fixed in 10% buffered formalin, embedded in paraplast, and cut $5{\sim}7{\mu}m$ thickness. Sections were immunostained Tissue distribution of RHDV in rabbits were examined by immunofluorescence and ABC methods. Tissues including liver, spleen, kidneys, lungs and brain were frozen, cut in a crycut, and fixed in 10% buffered formalin, embedded in paraplast, and cut $5{\sim}7{\mu}m$ thickness. Sections were immunostained with primary antiserum and conjugated second antibodies as recommended by manufacturer. None of the cultures tested showed virus-induced phenomena. Immunoreactive products were commonly found in the liver, in some cases there were also positive staining in the spleen and kidneys. Other organs showed weak or insignificant immunoreactions. By ABC method on the formalin-fixed, paraffin-embedded liver tissues, strong immunoreactivity was found in the periportal triad lesions and peripheral lesions of the hepatic lobules. Immunoreactive products showed diffuse fine granular in the cytoplasm of hepatocytes and sinusoidal cells. In some cells, immunoproducts marginate at the periphery of the cells. The intensive staining of the cytoplasm of infected cells allowed their exact differentiation from surrounding uninfected cells. The positive area involved coincided with histopathological lesion on serial liver sections. In conclusion, liver was proved to be a consistent target organ in RHD, and the immunoperoxidase method in the section of formalin-fixed, paraffin-embedded hepatic tissue could be broadly used for the routine diagnosis of the disease.

• Information Systems Review
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• v.6 no.2
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• pp.269-284
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• 2004

Induced from government policy to boost regional economic competitiveness, regional informatization forming e-community has been the subject included in the various regional informatization master plans in Korea. However, few cases are reported for its successful implementation mainly due to the lack of profitable business model to encourage investment. On the other hand, most efforts to build smart apartments, part of the home networking in a broad sense, has been pursued from the different directions. Telecommunication giant such as Korea Telecom tries to find new source of revenue exploiting enhanced broad band technology. Also, construction companies started constructing housing complexes equipped with built-in high speed network infrastructure as a means to differentiation to other competitors. The contents providing community portal has become mandatory in the sense of bearing the cost from customer side who are willing to adopt those services for new smart house. Our research motivation stems from exploring critical value aspects of realizing the profitability of this emerging new business model, that is, industry convergence model. In this paper, mainly from the survey results of the Korean smart apartment complexes, we reported recent home networking services development in Korea, and value propositions from the business model perspective. Merged business model components of telecommunications, construction, and internet contents are analyzed to provide the insights for future directions.

• Korean Journal of Food Science and Technology
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• v.11 no.4
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• pp.224-231
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• 1979

The safety of the sweetening component of stevia was studied by administrating it to the rats. The $LD_{50}$ determined by intraperitoneal injection was 3,400 mg/Kg as the stevia extract containing 50 % stevioside, i.e. $LD_{50}$ of stevioside was more than 1,700 mg/Kg. Oral administration of large quantities of the stevia extract for 56 days resulted in no effect on the growth of rats. The analyses of total blood (RBC, WBC, Hb and Hct), 17 blood serum components including total protein, glucose, cholesterol, GOT, and 11 items of findings on the liver tissues including nuclear deterioration of liver cells, proliferation of Kupffer cells, fibrosis of portal area showed no significant differences between control and treatments except lactate dehydrogenase activity after 56 day-oral administration of the extract. From the results obtained, it was supposed that the stevia extract/stevioside revealed no acute or sub-acute toxic effects on rats.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.32 no.4
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• pp.62-89
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• 2019

Objectives : The purpose of this study is to evaluate the effectiveness and safety of topical nasal application of Herbal medicine compared with Western medicine in the treatment of Allergic Rhinitis(AR). Methods : Electronic databases including Cochrane library, PubMed, EMBASE, CNKI, KMBASE, KISS, NDSL, OASIS, KISS and KJTK(Korean Traditional Knowledge Portal) were searched by the keywords such as 'allergic rhinitis', 'nasal sprays', 'herbal medicine', 'plant extracts', and 'external application'. The quality of each RCTs was assessed by Cochrane Collaboration of 'Risk of bias(RoB) Tool'. Results : 19 RCTs were finally selected from 1419 references screened. 19 RCTs were compared with the effects of topical nasal application of Herbal medicine and Western medicine. Based on the symptom scores from 13 RCTs, topical nasal application of herbal medicine generally has a better effect on relief of AR. The two treatments have similar effects on improving the level of specific factors like IgE, IgG, IL-13, $uLTD_4$ in blood and urine. 8 RCTs showed adverse effects(AEs) in both groups and severe AEs were not reported. Conclusions : This study shows that topical nasal application of herbal medicine can improve symptoms and related factors of allergic rhinitis. Well-designed RCT studies with low risk of bias should be conducted to confirm these findings.

• Journal of the Korea Society of Computer and Information
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• v.18 no.12
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• pp.103-111
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• 2013

At present, a variety of Korean news stories have been about important online content and its importance in the press is becoming higher. Diverse news from businesses are provided to the public as press releases through newspapers or broadcasting media. For such news to become information for a press release, enterprises visit reporters, use e-mails, faxes, or couriers to deliver the information. However, such methods have problems with time, human resources, expenses, and file damage. Also, with these methods it is bothersome for enterprises to check what has been released and for the press to make frequent contact with enterprises for interviews and for content to be released. Therefore, this study aimed to realize a distribution system which enterprises can use to distribute data to be released to the press and to easily check what is to be released while the press can ask for interview requests in a simple way, as well as a news gathering robot that can collects news on the enterprises involved from articles online or in portal sites.

• Journal of Digital Convergence
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• v.17 no.9
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• pp.23-30
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• 2019

The development of content for language education using AR/VR technology is a necessary task to be pursued in line with commercialization of 5G. Research on service platform for systematic management and service is currently being carried out by global companies competitively, The unique language education service model for unique areas of culture has the right to pursue R & D jointly with Korea and China. In this study, we applied the developed "Korean language education service platform for Chinese people based on e-learning" to improve the acceptance of AR/VR contents and applied AR/VR technology to video-based language education contents. And to present a new paradigm of language education. Contents development is to develop AR-based vocabulary learning services, develop experiential learning contents for VR-based step-by-step situations, and gradually develop contents to enable beginner / intermediate / advanced language education services. The service platform enables management of learning management and learning contents, and complies with metadata attributes to complete a platform capable of accommodating large capacity AR/VR contents. In the future, systematic research will be carried out in order to develop as a portal for educational services through development of various contents using mixed reality technology.