• Title/Summary/Keyword: dystrophy

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Arthroscopic Decompression in Stage II Subacromial Impingement - Five to Twelve Years Follow up - (제 2단계 견봉하 충돌증후군에서 관절경적 감압술(5년에서 12년의 장기추시관찰 결과))

  • Choi Chong-Hyuk;OJ Ogilvie-Harris
    • Clinics in Shoulder and Elbow
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    • v.2 no.2
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    • pp.99-105
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    • 1999
  • We investigated the effectiveness of arthroscopic decompression in stage Ⅱ subacromial impingement after long term follow up. Arthroscopic subacromial decompression was done in 104 consecutive patients who had stage Ⅱ sub­acromial impingement. After average of 8.4 years follow up, the final results were as following; 57 shoulders(55%) in excellent, 25(24%) in good, 16(15%) in fair and 6(6%) in poor. All parameters-pain, function, muscle strength and motion-were improved significantly(p<0.00l). Rotator cuff tear was developed in 10 shoulders after decompression. Among them, 8 shoulders had unfavorable results including two poor. In 6 failures, two had rotator cuff tear, three had recurrence of impingement with degenerative change and reflex sympathetic dystrophy was developed in one. Reoperations were done in 4 shoulders. Improvement of impingement symptoms was maintained in the most of patients(79%) after long term follow up. Arthroscopic decompression surgery was very effective means for stage Ⅱ impingement syndrome.

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Mutation Effects on FAS1 Domain 4 Related to Protein Aggregation by Molecular Dynamics Simulations and Solvation Free Energy Analysis

  • Cho, Sunhee;Ham, Sihyun
    • Proceeding of EDISON Challenge
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    • 2015.03a
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    • pp.70-75
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    • 2015
  • Fasciclin 1 (FAS1) is an extracellular protein whose aggregation in cornea leads to visual impairment. While a number of FAS1 mutants have been studied that exhibit enhanced/decreased aggregation propensity, no structural information has been provided so far that is associated with distinct aggregation potential. In this study, we have investigated the structural and thermodynamic characteristics of the wild-type FAS1 and its two mutants, R555Q and R555W, by using molecular dynamics simulations and three-dimensional reference interaction site model (3D-RISM) theory. We find that the hydrophobic solvent accessible surface area increases due to hydrophobic core repacking in the C-terminus caused by the mutation. We also find that the solvation free energy of the mutants increases due to the enhanced non-native H-bonding. These structural and thermodynamic changes upon mutation contribute to understand the aggregation of these mutants.

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Multiple congenital ocular defects in a Bedlington terrier dog (Bedlington terrier의 다발성 안기형 1례)

  • Yoo, Sukjong;Ji, Dongbeom;Kim, Hwiyool;Seo, Kangmoon;Jeong, Manbok
    • Korean Journal of Veterinary Research
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    • v.53 no.2
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    • pp.133-136
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    • 2013
  • To report multiple congenital ocular defects in a Bedlington terrier dog aged 2.5 months with blindness. Routine ophthalmic examinations were performed for the clinical signs. Menace responses and cotton ball test were absent in both eyes (OU), but pupillary light reflexes were normal in OU. Slit lamp biomicroscopy reveled corneal dystrophy, posterior subcapsular cataract, microphthalmia in OU and lenticular coloboma in the right eye. In indirect ophthalmoscopy and ultrasonography, retinal detachment and posterior lenticonus were shown in OU. It is the first report of lenticular coloboma and posterior lenticonus in a Bedlington terrier dog.

A Case of Erection Failure due to Unilateral Lumbar Sympathetic Block (편측 요부 교감신경절 차단에 의해 발생한 성기능 -증례 보고-)

  • Shin, Dong-Yeop;Moon, Soon-Hong;Hong, Ki-Hynk
    • The Korean Journal of Pain
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    • v.6 no.2
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    • pp.258-260
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    • 1993
  • We experienced a rare case of erection failure which developed after unilateral lumbar sympathetic block. A 43 year old male patient suffering from reflex sympathetic dystrophy, which had developed after multiple communitted fracture of the right ankle, underwent right lumbar sympathetic block with 99.9% alcohol. The effectiveness of the lumbar sympathetic block was evaluated by monitoring the clinical symptoms, signs and temperature changes by digital infrared thermographic imaging. Postoperatively, the temperature of the affected side limb rose about $2^{\circ}C$, but the patient's conditions gradually returned to normal. Ten days after the operation the patient complainted of difficulty in achieving an erection. The patient was examined by a urologst without much results. The patient gradually recovered his ability to achieve an erection approximately 5 weeks after the lumbar sympathetic block.

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Measurement and Treatment of Shoulder Subluxation in Hemiplegia (편마비 환자의 견관절 아탈구 측정법과 치료)

  • Kim, Soo-Min;Kwon, Mi-Ji
    • Journal of Korean Physical Therapy Science
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    • v.1 no.2
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    • pp.345-353
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    • 1994
  • Shoulder pain is probably the most frequent complication of hemiplegia. Many of the factors contributing to the occurrence of shoulder pain in hemiplegia have shown that the lesions of the rotator cuff tendon or the tendon of the long head of the biceps brachii, the reflex sympathetic dystrophy syndrome, shoulder-hand syndrome, subluxation and rupture of the rotator cuff. Subluxation has been measured by finger breadths, X-Ray, Radiological measure and jig device. The propose of this study decribes the sourse of shoulder pain with hemiplegia, method for subluxation measure and treatment of. hemiplegic shoulder pain.

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A Case of Lichenoid Drug Eruption Caused by Antituberculosis Drug (항결핵제에 의해 유발된 편평태선양 약진 1례)

  • Lee, Soo-Keoung;Choi, Jong-Soo;Kim, Ki-Hong
    • Journal of Yeungnam Medical Science
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    • v.12 no.2
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    • pp.405-411
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    • 1995
  • Lichenoid drug eruption is lichenoid skin eruptions caused by certain drugs and compounds, and can be identical or similiar to lichen planus. A 75-year-old woman who had taken antituberculosis medication(INH, ethambutol, rifampin) for 4 months developed pruritic generalized erythematous papular eruptions on the trunk and extremities, alopecia and nail dystropy. Histopathologic findings were hyperkeratosis, hypergranulosis, hydrophic degenaration of basal layer, band like lymphohistiocytic infiltration in the upper dermis and perivascular lymphohistiocytic infiltration in the deep dermis. She was treated with systemic corticosteroid, and then skin lesion were slightly improved. After termination of antituberculosis medication, skin lesions were markedly improved with residual hyperpigmentation. Alopecia and nail dystrophy were also improved.

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A Korean family with AGel amyloidosis presenting with progressive facial and bulbar palsies

  • Kang, Minsung;Shin, Jin-Hong;Kim, Dae-Seong
    • Annals of Clinical Neurophysiology
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    • v.24 no.2
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    • pp.90-92
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    • 2022
  • AGel amyloidosis is an autosomal dominantly inherited disease caused by a GSN mutation, and affected patients typically present with the clinical triad of corneal lattice dystrophy, progressive cranial neuropathy, and cutis laxa. We report a Korean family with AGel amyloidosis with predominant manifestations of facial and bulbar muscle weakness. Whole-exome sequencing revealed a common missense mutation (p.Asp214Tyr) in GSN. This case strongly suggests that AGel amyloidosis should be considered when a patient presents with progressive facial and bulbar palsies.

Successful Surgical Management of a Tracheo-Innominate Artery Fistula in a Patient with Duchenne Muscular Dystrophy: A Case Report

  • Yun, Ju Sik;Song, Sang Yun;Na, Kook Joo;Kim, Eunchong
    • Journal of Chest Surgery
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    • v.55 no.1
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    • pp.88-90
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    • 2022
  • Tracheo-innominate artery fistula (TIF) is a rare, life-threatening complication of tracheostomy that makes it difficult to secure the airway due to massive bleeding, constituting a medical emergency. Therefore, most successful surgical treatments include innominate artery debridement and tracheal fistula repair. Herein, we report a case of successful surgical treatment of a TIF while maintaining cerebral blood flow through an artificial vascular graft.