• KSCE Journal of Civil and Environmental Engineering Research
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• v.41 no.4
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• pp.331-340
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• 2021

The blast damage behavior of reinforced concrete (RC) structures exposed to unexpected extreme loading was investigated. To enhance the accuracy of numerical simulation for blast loading on RC structures with seven blast points, the calculation of blast loads using the Euler-flux-corrected-transport method, the proposed Euler-Lagrange coupling method for fluid-structure interaction, and the concrete dynamic damage constitutive model including the strain rate-dependent strength and failure models was implemented in the ANSYS-AUTODYN solver. In the analysis results, in the case of 20 kg TNT, only the slab member at three blast points showed moderate and light damage. In the case of 100 kg TNT, the slab and girder members at three blast points showed moderate damage, while the slab member at two blast points showed severe damage.

• Animal cells and systems
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• v.2 no.1
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• pp.1-8
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• 1998

Hepatocyte growth factor (HGF), originally discovered and cloned as a powerful mitogen for hepatocytes, is a four kringle-containing growth factor which specifically binds to membrane-spanning tyrosine kinase, c-Met/HGF receptor. HGF has mitogenic, motogenic (enhancement of cell movement), morphogenic (e.g., induction of branching tubulogenesis), and anti-apoptotic activities for a wide variety of cells. During embryogenesis, HGF supports organogenesis and morphogenesis of various tissues, including liver, kidney, lung, gut, mammary gland, and tooth. In adult tissues HGF elicits an organotrophic function which supports regeneration of organs such as liver, kidney, lung, and vascular tissues. HGF is also a novel member of neurotrophic factor in nervous systems. Together with the preferential expression of HGF in mesenchymal or stromal cells, and c-Met/HGF receptor In epithelial or endothelial cells, the HGF-Met coupling seems to orchestrate dynamic morphogenic processes through epithelial-mesenchymal (or-stromal) interactions for organogenesis and organ regeneration. HGF or HGF gene may well become unique therapeutic tools for treatment of patients with various organ failure, through its actions to reconstruct organized tissue architectures. This review focuses on recently characterized biological and physiological functions integrated by HGF-Met coupling during organogenesis and organ regeneration.

• Structural Engineering and Mechanics
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• v.59 no.2
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• pp.291-312
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• 2016

Seismic performance evaluation of shear wall is essential as it is the major lateral load resisting member of a structure. The ultimate load and ultimate drift of the shear wall are the two most important parameters which need to be assessed experimentally and verified analytically. This paper comprises the results of monotonic tests, quasi-static cyclic tests and shake-table tests carried out on a midrise shear wall. The shear wall considered for the study is 1:5 scaled model of the shear wall of the internal structure of a reactor building. The analytical simulation of these tests is carried out using micro and macro modeling of the shear wall. This paper mainly consists of modification in the hysteretic macro model, developed for RC structural walls by Lestuzzi and Badoux in 2003. This modification is made by considering the stiffness degradation effect observed from the tests carried out and this modified model is then used for nonlinear dynamic analysis of the shear wall. The outcome of the paper gives the variation of the capacity, the failure patterns and the performance levels of the shear walls in all three types of tests. The change in the stiffness and the damping of the wall due to increased damage and cracking when subjected to seismic excitation is also highlighted in the paper.

• Journal of the Korea Concrete Institute
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• v.21 no.5
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• pp.599-609
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• 2009

This paper discusses generalized modeling schemes for both reinforced concrete (RC) and post-tensioned (PT) flat plate buildings. In this modeling approach, nonlinear behavior due to slab flexure, moment and shear transfer at slab-column connections, and punching shear was included along with linear secant stiffness of each member or connection that accounts for concrete cracking. This generalized model was capable of simulating all different scenarios of slab-column connection failures such as brittle punching, flexure-shear interactive failure, and flexural failure followed by drift-induced punching. Furthermore, automatic detection of drift-induced punching shear and subsequent backbone curve modifications were realistically modelled by incorporating the limit state model, in which gravity shear versus drift capacity relations were adopted. The validation of the model was conducted using one-third scale two-story by two-bay RC and PT flat plate frames. The comparisons revealed that the model was robust and effective.

• Earthquakes and Structures
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• v.15 no.6
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• pp.667-685
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• 2018

In eccentrically braced steel frames (EBFs), the links are fuse members which enter inelastic phase before other structure members and dissipate the seismic energy. Based on the force-based seismic design method, damages and plastic deformations are limited to the links, and the main structure members are required tremendous sizes to ensure elastic with limited or no damage. Force-based seismic design method is very common and is found in most design codes, it is unable to determine the inelastic response of the structure and the damages of the members. Nowadays, methods of seismic design are emphasizing more on performance-based seismic design concept to have a more realistic assessment of the inelastic response of the structure. Links use ordinary steel Q345 (the nominal yielding strength $f_y{\geq}345MPa$) while other members use high strength steel (Q460 $f_y{\geq}460MPa$ or Q690 $f_y{\geq}690MPa$) in eccentrically braced frames with high strength steel combination (HSS-EBFs). The application of high strength steels brings out many advantages, including higher safety ensured by higher strength in elastic state, better economy which results from the smaller member size and structural weight as well as the corresponding welding work, and most importantly, the application of high strength steel in seismic fortification zone, which is helpful to popularize the extensive use of high strength steel. In order to comparison seismic behavior between HSS-EBFs and ordinary EBFs, on the basis of experimental study, four structures with 5, 10, 15 and 20 stories were designed by PBSD method for HSS-EBFs and ordinary EBFs. Nonlinear static and dynamic analysis is applied to all designs. The loading capacity, lateral stiffness, ductility and story drifts and failure mode under rare earthquake of the designs are compared. Analyses results indicated that HSS-EBFs have similar loading capacity with ordinary EBFs while the lateral stiffness and ductility of HSS-EBFs is lower than that of EBFs. HSS-EBFs and ordinary EBFs designed by PBSD method have the similar failure mode and story drift distribution under rare earthquake, the steel weight of HSS-EBFs is 10%-15% lower than ordinary EBFs resulting in good economic efficiency.

• Journal of the Korea institute for structural maintenance and inspection
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• v.25 no.4
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• pp.83-91
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• 2021

In this study, to improve the connection performance between the existing reinforced concrete (R/C) frame and the strengthening member, we proposed a new H-section steel frame with elastic pad (HSFEP) system for seismic rehabilitation of existing medium-to-low-rise reinforced concrete (R/C) buildings. This HSFEP strengthening system exhibits an excellent connection performance because an elastic pad is installed between the existing structure and reinforcing frame. The method shows a strength design approach implemented via retrofitting, to easily increase the ultimate lateral load capacity of R/C buildings lacking seismic data, which exhibit shear failure mechanism. Two full-size two-story R/C frame specimens were designed based on an existing R/C building in Korea lacking seismic data, and then strengthened using the HSFEP system; thus, one control specimen and one specimen strengthened with the HSFEP system were used. Pseudodynamic tests were conducted to verify the effects of seismic retrofitting, and the earthquake response behavior with use of the proposed method, in terms of the maximum response strength, response displacement, and degree of earthquake damage compared with the control R/C frame. Test results revealed that the proposed HSFEP strengthening method, internally applied to the R/C frame, effectively increased the lateral ultimate strength, resulting in reduced response displacement of R/C structures under large scale earthquake conditions.

• Journal of the Korea Concrete Institute
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• v.24 no.3
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• pp.293-303
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• 2012

Recently, as construction technology improved, concrete structures not only became larger, taller and longer but were able to perform various functions. However, if extreme loads such as impact, blast, and fire are applied to those structures, it would cause severe property damages and human casualties. Especially, the structural responses from extreme loading are totally different than that from quasi-static loading, because large pressure is applied to structures from mass acceleration effect of impact and blast loads. Therefore, the strain rate effect and damage levels should be considered when concrete structure is designed. In this study, the low velocity impact loading test of steel fiber reinforced concrete (SFRC) slabs including 0%~1.5% (by volume) of steel fibers, and strengthened with two types of FRP sheets was performed to develop an impact resistant structural member. From the test results, the maximum impact load, dissipated energy and the number of drop to failure increased, whereas the maximum displacement and support rotation were reduced by strengthening SFRC slab with FRP sheets in tensile zone. The test results showed that the impact resistance of concrete slab can be substantially improved by externally strengthening using FRP sheets. This result can be used in designing of primary facilities exposed to such extreme loads. The dynamic responses of SFRC slab strengthened with FRP sheets under low velocity impact load were also analyzed using LS-DYNA, a finite element analysis program with an explicit time integration scheme. The comparison of test and analytical results showed that they were within 5% of error with respect to maximum displacements.