• Journal of English Language & Literature
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• v.55 no.1
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• pp.3-24
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• 2009

The Harry Potter series is considered to represent the multicultural aspect of contemporary British society and to show critical perspectives of racism. This series, however, also includes many elements of British imperialism. This paper examines the ideas about education and Harry's role in relation to British imperialism. One of the main ideas prevalent in 19th century British boys' public schools was that people's blood origin is the most important element in determining their characteristics, ability and moral qualities. The students' inherited capacity and their family background are more highly regarded than their secondary learning and training. This reflects a 19th century concept that ultimately, inborn quality makes 'a hero', a truth presented in the educational policies of Hogwarts. Hogwarts' educational policies and systems can also be related to 'developmentalism', which defines children as imperfect, in-progress and incomplete, thus needing proper training and discipline. As this concept functioned to justify the control of children while educating them, Hogwarts adopts diverse controlling devices and oppressive policies, which are mainly justified in the name of education. On the one hand, child characters are controlled and oppressed by the school authorities, on the other hand, some of the students such as Harry have remarkable magic powers enough to resist the adult authority and even to save the magic society from the evil power. Harry plays dual roles, which the British boys of the Empire were assigned from their society; they are important heirs to conquer the 'evil' or 'barbarous' world but need to be obedient to a 'good' authority to achieve the mission. Harry's magic power and self-discipline ultimately contribute to fulfilling Dumbledore's mission, which mirrors 19th century British boys' roles as the heirs of the British Empire.

• Korea journal of population studies
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• v.33 no.1
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• pp.103-131
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• 2010

This study observes how the conjugal sharing of the roles such as breadwinning, housework/childcare, and leisure activities affects wives' marital satisfaction, and how the relationships among the considered variables are similar or different across age categories. Two dependent variables, the relationship satisfaction and the marital happiness, are measured and estimated as the concept of the marital satisfaction. Analysed is the Korean Longitudinal Survey of Women and Families 2008 collected by Korean Women's Development Institute. Among women in the ages of 30s-50s, full-time housewives with the breadwinning husbands feel happier with their marriage than the wives in dual career families, and those in dual career families are happier than the breadwinning women with the househusbands. Among the women in their 40s, the highest relationship satisfaction is reported by the those of the dual career families. Wives in their 30s prefer equal division of familywork in explaining the relationship satisfaction, while wives in the age of 40s and 50s show only the effect of reducing wives' portion. The co-spousal leisure activity is consistently significant in its positive relationship with the marital satisfaction across the age categories. There is a general tendency that the marital satisfaction is the highest in the youngest age bracket and the lowest in the oldest. For managing better marriages, individual efforts of both spouses as well as social support are required.

• BMB Reports
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• v.51 no.11
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• pp.602-607
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• 2018

Aberrant expression of microRNAs (miRNAs) plays important roles in carcinogenesis and tumor progression. However, the expression and biological role of miR-301b in triple-negative breast cancer (TNBC) remains unclear. Here we aimed to evaluate the roles and mechanisms of miR-301b in TNBC cells. miR-301b expression was assessed in TNBC specimens and cell lines by quantitative Real-Time PCR (qRT-PCR). TNBC cells were transfected with miR-301b mimics, inhibitors or Cylindromatosis (CYLD) small interfering RNA (siRNA) using Lipofectamine 2000. The functional roles of miR-301b were determined by cell proliferation, colony formation, and apoptosis assays. Western blots and qRT-PCR were used to measure the expression of mRNAs and proteins in the cells. We found that miR-301b was upregulated in TNBC specimens and cell lines. Overexpression of miR-301b promoted cell proliferation in TNBC cells, while inhibited the apoptosis induced by 5-FU. CYLD was downregulated by miR-301b at both mRNA and protein levels in TNBC cells. Dual-luciferase report assay confirmed that miR-301b downregulated CYLD by direct interaction with the 3'-untranslated region(3'-UTR) of CYLD mRNA. $NF-{\kappa}B$ activation was mechanistically associated with miR-301b-mediated downregulation of CYLD. However, inhibition of miR-301b reversed all the effects of miR-301b. In conclusion, miR-301b plays an oncogenic role in TNBC possibly by downregulating CYLD and subsequently activating $NF-{\kappa}B$ p65, and this may provide a novel therapeutic approach for TNBC.

• Animal cells and systems
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• v.2 no.4
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• pp.529-538
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• 1998

In order to analyze the intracellu1ar localization of specific RNA components of ribonucleoproteins (RNP) in Xenopus oocytes, a modified protocol of whole-mount in situ Hybridization is presented in this paper, Mitochondria specific 12S rRNA probe was used to detect the amplification and distribution of mitochondria in various stages of the oocyte life cycle, and the results were found to be consistent with previously known distribution of mitochondria. The results with other specific probes (U1 and U3 small nuclear RNAs, and 5S RNA) also indicate that this procedure is generally effective in localizing RNAs in RNP complexes even inside organelles. In addition, the RNA component of RNase MRP, the RNP with endoribo-nuclease activity, localize to the nucleus in various stages of the oocyte life cycle. Some of MRP RNA, however, were found to be localized to the special population of mitochondria near the nucleus, especially in the active stage of mitochondrial amplification. It suggests dual localization of RNase MRP in the nucleus and mitochondria, which is consistent with the proposed roles of RNase MRP in mitochondrial DNA replication and in rRNA processing in the nucleolus.

• Korean Journal Plant Pathology
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• v.14 no.3
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• pp.278-285
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• 1998

Effects of chitosan on growth of tomato plant, and suppression of Fusaruim wilt caused by Fusarium oxysporum f. sp. lycopersici and late blight casued by Phytophthora infestans, were examined. Both late blight and fusarium wilt were suppressed by spray and irrigation of chitosan, respectively. Inhibition of mycelial growth was not greatly affected by molecular size of chitosan but, concentration dependent effects was observed. Ninty percent of P. infestans and 80% of F. oxysporum f. sp. lycopersici of mycelial growth was inhibited by 1,000 ppm of chitosan (MW 30,000~50,000) when amended in plate media. Induction of defense-related gene expression in plant by chitosan treatments were observed when chitosan treated tobacco and tomato RNA samples were hybridized with several defense-related genes as probes. The results revealed that $\beta$-1,3-glucanase and chitinase genes were strongly induced, while pathogenesis-related protein-1, 3-hydroxy-3-methylglutaryl coenzyme A reductase, anionic peroxidase, phenylalanine ammonia lyase genes were weakly induced by chitosan treatment. These results suggest that chitosan have dual effects on these host-pathogen interactions. Possible roles of chitosan in suppression of tomato diseases by inhibition of mycelial growth and activation of plant defense responses are discussed.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.15
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• pp.6269-6273
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• 2014

Growing evidence suggests that miR-150-5p has an important role in regulating genesis of various types of cancer. However, the roles and the underlying mechanisms of miR-150-5p in development of colorectal cancer (CRC) remain largely unknown. Transwell chambers were used to analyze effects on cell migration and invasion by miR-150-5p. Quantitative real-time PCR (qRT-PCR), Western blotting and dual-luciferase 3' UTR reporter assay were carried out to identify the target genes of miR-150-5p. In our research, miR-150-5p suppressed CRC cell migration and invasion, and MUC4 was identified as a direct target gene. Its effects were partly blocked by re-expression of MUC4. In conclusiomn, miR-150-5p may suppress CRC metastasis through directly targeting MUC4, highlighting its potential as a novel agent for the treatment of CRC metastasis.

• Journal of Families and Better Life
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• v.14 no.1
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• pp.1-10
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• 1996

Researchers have largely overlooked the direct effects of household responsibil-ities on earnings in stead focusing attention the effect of woman's employment on the division of household labor or on family life. Given that a substantial proportion of married women already work outside the home and their numbers are likely to be increae to some extent those concerned with the well-being of employed-married women and of their households may focus their attention on how best to provide good policy to manage woman's dual roles. The purposes of the study are as follows; 1) To find out factors which affect women's housework time. 2) To examine the relationship between housework and market work. Data are obtained from 259 households with employed-married women living in Seoul. The results of this study are as follows: 1) women's wages are reduced by time spent on housework. Women's housework time is insignificantly related to women's wages. 2) women's occupation statues is signific ntly positively related to their wages. 3)women's age and other family income are generally negatively related to their housework time,. The results of this study indicate that housework has a direct effect on wages by reducing the amount of energy and efforts available for market work lowering economic status of women.

• Korean Journal of Social Welfare
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• v.47
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• pp.334-368
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• 2001

The purpose of this study is to apply to the phenomenological self-evaluation method in the social welfare agency. It means that the phenomenological self-evaluation method accepts "the reality" which occurs in the social welfare setting, and functions for the social worker to play dual role of practitioner-evaluator. This paper examines two dimensions of social work evaluation theory and practice. Firstly, this study is to investigate a trend of evaluation in social work setting, and seeks theoretical aspect of phenomenological self-evaluation method, with emphasis on the strength and limit of the positivism evaluation methods. Although qualitative evaluation was suggested to make an alternative to the positivism by qualitative researchers, they did not suggest the specific methods and roles of the practitioner-evaluator. In this study, two directions of the phenomenological self-evaluation method are suggested to overcome the limitations. which are "environment-relation self-evaluation" and "program-oriented self-evaluation". Secondly, the result of phenomenological self-evaluation studies for the social welfare community center program and organization in kangnam district from June, 1994 (Program-oriented self-evaluation) to march, 2000 (Environment-relation self-evaluation) are presented. the phenomenological self-evaluation study showed the expected outcome such as; reflective self-training, making a practice knowledge, enhancing service quality, and reinforcing the identity of social welfare profession.

• Animal cells and systems
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• v.14 no.2
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• pp.73-81
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• 2010

In this study, monoclonal antibodies against lysosomal acid phosphatase (LAP) of a salamander, Hynobius leechii, were used to determine the spatial and temporal expression of the LAP in the regenerating limbs. The Western blot and immunohistochemical analysis in the limb regeneration revealed that LAP was highly expressed at the dedifferentiation stage, especially in the wound epidermis and dedifferentiating limb tissues such as muscle and cartilage. With RA treatment, the LAP expression became upregulated in terms of both level and duration in the wound epidermis, blastemal cell and dedifferentiating limb tissues. In addition, in situ activity staining of LAP showed a similar result to that of immunohistochemistry. Thus, the activity profile of LAP activity coincides well with the expression profile of LAP during the dedifferentiation period. Furthermore, to examine the effects of lysosomal enzymes including LAP on salamander limb regeneration, lysosome extract was microinjected into limb regenerates. Interestingly, when the lysosome extract was microinjected into limb regenerates with a low dose of RA($50\;{\mu}g/g$ body wt.), skeletal pattern duplication occurred frequently in the proximodistal and transverse axes. Therefore, lysosomal enzymes might cause the regenerative environment and RA plays dual roles in the modification of positional value as well as evocation of extensive dedifferentiation for pattern duplication. In conclusion, these results support the hypothesis that dedifferentiation is a crucial event in the process of limb regeneration and RA-evoked pattern duplication, and lysosomal enzymes may play important role(s) in this process.

• Asian Journal of Innovation and Policy
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• v.7 no.3
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• pp.564-580
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• 2018

The creation of academic start-up firms is an important and practical issue in the management of technology in Japan. The present study designs a model for creating academic start-up firms that fits into the social context. It focuses on the case of FIRST Program, an initiative that consists of 30 projects in innovative arenas, analyses the presence of large-scale public funding, and investigates the role of venture capitalists as support personnel in each project. As a result, the presence and significance of 'long-term escort' by an 'entrepreneurial venture capitalist (EP-VCist)' were confirmed as common features across the cases observed. EP-VCist refers to a person who can maintain and fulfil dual roles at a university and a venture capital firm, and who can take the lead throughout the venturing process as a risk taker. 'Long-term escort' is a form of support that reduces risks in the venturing process by supporting university researchers in the pre-entrepreneurial stage and by exerting a robust bridging role between a university and an industry.