• Korean Journal of Child Studies
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• v.34 no.5
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• pp.17-41
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• 2013

The purpose of this research was to investigate meaning of teachers as they manifest themselves in the emotional regulation of 2year old infants in a daycare center. In addition, the research attempts to provide basic research data that can be used as a guideline for teacher's awareness, roles, attitudes, and classroom management for infant's emotional education in the future. To achieve this goal, participatory observation was conducted in a child care center class for infants under 2 years old from January 17 to January 29, 2012. The teacher is defined as follow : Teachers are authority figures whose image is that of absolute authority, and coupled with their dual role of passive caretakers. Additionally, they function as guides who guided infants through the process of emotional socialization, and played the central role of emotional contagion from whose expression speech and atmosphere the said infants receive much influence. Such results seemed to indicate that teachers today do not fully comprehend the importance of their roles in influencing the emotion regulation of infants.

• 한국균학회소식:학술대회논문집
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• 2014.10a
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• pp.43-43
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• 2014

The rice blast disease caused by of Magnaporthe oryzae is one of the most destructive diseases of rice. By the microarray analysis, we profiled expression changes of genes during conidiation and found out many putative genes that are up-regulated. Among those, we first selected MGG_06399 encoding a dual-specificity tyrosine-regulated protein kinase (DYRK), homologous to YAK1 in yeast. To investigate functional roles of MoYAK1, We made ${\Delta}Moyak1$ mutants by homology dependent gene replacement. The deletion mutant showed a remarkable reduction in conidiation and produced abnormally shaped conidia smaller than those of wild type. The conidia form ${\Delta}Moyak1$ were able to develop a germ tube, but failed to form apppressoria on a hydrophobic coverslip. The ${\Delta}Moyak1$ formed appressria on a hydrophobic cover slip when exogenous cAMP was induced, but the appressoria shape was abnormal. The ${\Delta}Moyak1$ also formed appressoria abberent in shape on onion epidermis and rice sheaths and failed to penetrate the surface of the plants. These data indicate that MoYAK1 is associated with cAMP/PKA pathway and important for conidiation, appressorial formation and pathogenic development in Magnaporthe oryzae. Detailed characterization of MoYAK1 will be presented.

• International journal of thyroidology
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• v.11 no.2
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• pp.143-151
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• 2018

Background and Objectives: Sirtuins (SIRTs) play important roles in cellular and organismal homeostasis. They have distinct gene expression patterns in various cancers; however, the relationship between SIRT expression and the progression of thyroid cancer is unclear. We investigated the expression of SIRTs in patients with papillary thyroid carcinoma (PTC) and their role as biomarkers for predicting the aggressiveness of this disease. Materials and Methods: We used immunohistochemical staining to evaluate the expression of SIRT1 and SIRT3 in tumor specimens from 270 patients with PTC. We also evaluated the potential association between SIRT expression and diverse clinicopathological features. Results: High SIRT1 expression was negatively correlated with lymphovascular invasion, central lymph node metastasis, and lateral lymph node metastasis. Multivariate analyses revealed that high SIRT1 expression was a negative independent risk factor for lateral lymph node metastasis. By contrast, high SIRT3 expression was positively correlated with locoregional recurrence. Interestingly, when patients were grouped by tumor SIRT expression patterns, the group with low SIRT1 expression and high SIRT3 expression was correlated with more aggressive cancer phenotypes including central lymph node metastasis and lateral lymph node metastasis. Conclusion: Our results suggest that SIRTs play dual roles in tumor progression, and the combination of decreased SIRT1 expression and increased SIRT3 expression is significantly associated with a poor prognosis in patients with PTC.

• Molecules and Cells
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• v.42 no.6
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• pp.448-459
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• 2019

The phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) signaling pathway is a promising target for gastric cancer (GC) treatment; however the efficacy of PI3K/mTOR dual inhibitors in GC has not yet been maximized. Additionally, the effect of autophagy regulation by PI3K/mTOR dual inhibitors has not been clearly elucidated in GC treatment. We aimed to show that our newly developed PI3K/mTOR dual inhibitor, CMG002, when combined with an autophagy inhibitor, chloroquine (CQ), potently induces effective cancer cell death in Epstein-Barr virus (EBV)-associated gastric cancer (EBVaGC) cells, where both the PI3K/AKT/mTOR and autophagy pathways play important roles in disease pathogenesis. EBV- and mock-infected AGS and NUGC3 GC cell lines were treated with CMG002 +/- CQ. PI3K/AKT/mTOR signaling pathway mediators, cellular apoptosis and autophagy markers were confirmed by Western blot assay. Cell viability was assessed using the Cell Counting Kit-8 (CCK-8) assay. CMG002 effectively blocked the PI3K/AKT/mTOR pathway by markedly decreasing phosphorylation of AKT and its downstream mediator S6. CMG002 induced G0/G1 cell cycle arrest and enhanced apoptotic cell death in AGS and NUGC3 cells, particularly EBV-infected cells compared with mock-infected cells, as confirmed by flow cytometric analyses and TUNEL (terminal deoxynucleotidyl transferase dUTP nick end labeling) assays. The combination of CMG002 plus CQ synergistically increased apoptotic cell death in EBV-infected GC cell lines when compared with CMG002 alone (P < 0.05). Our results suggest that the new PI3K/mTOR dual inhibitor, CMG002, when used in combination with the autophagy inhibitor, CQ, provides enhanced therapeutic efficacy against EBVaGC.

• Herbal Formula Science
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• v.32 no.1
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• pp.1-9
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• 2024

Objective : This study aims to assess the potential of utilizing large language models in pattern identification education by developing a simulated patient with fatigue and dual deficiency of the heart-spleen pattern. Methods : A simulated patient dataset was constructed using the clinical practice examination module provided by the National Institute for Korean Medicine Development. The dataset was divided into patient characteristics, sample questions, and responses, and utilized to design the system, assistant, and user prompts, respectively. A web-based interface was developed using the Django framework and WebSocket. Results : We developed a simulated fatigue patient representing dual deficiency of the heart-spleen pattern through prompt engineering. To make practical tools, we further implemented web-based interfaces for the examinee's and evaluator's roles. The interface for examinees allows one to examine the simulated patient and provides access to a personalized number for future access. In addition, the interface for evaluators included a page that provided an overview of each examinees' chat history and evaluation criteria in real-time. Conclusion : This study is the first development of an educational tool integrated with a large language model for pattern identification education, which is expected to be widely applied to Korean medicine education.

• Journal of Cadastre & Land InformatiX
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• v.44 no.1
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• pp.1-15
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• 2014

This paper, at first, intends to develop a conceptual model of spatial information eco-system based on the related literature reviews. The basic requirements in constructing the model are also specified. Next, the functional roles and interrelationships among the actors constituting the eco-system are analyzed to investigate the major reasons of inefficient and unsmooth flows of value-added process of Korean spatial information industry. Especially, the Korea Cadastral Survery Corp.(KCSC), which has dual organizational characteristics of public and private entity, is analyzed to be positioned as the most dominant actors in the eco-system. However, the KCSC needs to be changed and challenged to re-establish the missions and institutional roles for upcoming network societies. Here, we proposed 4 future-oriented development strategies and action plans to promote the Korean spatial information industry and to activate the eco-system.

• Journal of Pharmaceutical Investigation
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• v.1 no.1
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• pp.34-46
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• 1971

The existence of oxytocin in the pituitary gland of chicken has been ascertained, but its physiological roles are still obscure. In the study the action of oxytocin on renal function of the chicken was investigated during water diuresis, utilizing clearance and the Sperber technique. The results obtained are summarized as follows: Oxytocin, like in many species of mammals, elicited a profound diuretic response in the chicken. Urine flow, excretion of electrolytes, as well as glomerular filteration rate increased, with intravenous infusion of $3{\sim}10\;m{\mu}/kg/min$. Oxtocin, infused into the renal portal circulation via hindleg vein in a dose of $3{\sim}13\;m{\mu}/kg/min$. elicited marked increase in urine flow, glomerular filteration rate and sodium excreted in the urine. The diuretic effect was more pronounced in the infused side. It is suggested that diuretic response to oxytocin in the chicken results from dual action of oxytocin: increase of GFR and inhibition of sodium reabsorption on the renal tubule. The possibility that oxytocin might act through some endogenous substances could be ruled out.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.65 no.1
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• pp.122-127
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• 2016

In this paper, new spectrum sensing schemes based on analog/RF front-end processing are introduced for IoT wireless sensor networks. While the conventional approaches for wireless channel cognition have been issued in signal processing area, the RF spectrum cognition concept makes it feasible to achieve cognitive wireless sensor networks (C-WSNs). The spectrum cognition at RF processing is categorized as four kinds of sensing mechanisms. Two recent reseaches are described as promising candidates for the C-WSN. One senses spectrum by the frequency discriminating receiver, the other senses and detects from the frequency selective super-regenerative receiver. The introduced systems with simple and low-power RF architectures play dual roles of channel sensing and demodulation. simultaneously. Therefore, introduced spectrum sensing receivers can be one of the best candidates for IoT wireless sensor devices in C-WSN environments.

• The Bulletin of The Korean Astronomical Society
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• v.42 no.2
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• pp.59.2-59.2
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• 2017

The Submillimeter Array (SMA) has provided forefront capabilities for high spatial and spectral resolution observations at submillimeter wavelengths from its excellent site on Mauna Kea, Hawaii since 2004. The SMA has continuously enhanced its capability. It is now equipped with two receivers in the 1.3 mm band (Rx230/Rx240) and two in the 0.85 mm band (Rx345/Rx400). The total bandwidth available is 8+8 GHz (per receiver) in the dual band or polarization mode. To maintain a leading role in the ALMA era, the SMA project is now upgrading its receivers, IF signal transport and correlator system. The new wideband SMA - the wSMA - will provide the instantaneous coverage of 56 GHz. In this presentation, I will introduce the latest status of the SMA, upgrade plan to the w-SMA, the possible science cases with the w-SMA, and the roles of the w-SMA in the ALMA era.

• Journal of Preventive Medicine and Public Health
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• v.41 no.4
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• pp.214-218
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• 2008

Bioterrorism events have worldwide impacts, not only in terms of security and public health policy, but also in other related sectors. Many countries, including Korea, have set up new administrative and operational structures and adapted their preparedness and response plans in order to deal with new kinds of threats. Korea has dual surveillance systems for the early detection of bioterrorism. The first is syndromic surveillance that typically monitors non-specific clinical information that may indicate possible bioterrorism-associated diseases before specific diagnoses are made. The other is infectious disease specialist network that diagnoses and responds to specific illnesses caused by intentional release of biologic agents. Infectious disease physicians, clinical microbiologists, and infection control professionals play critical and complementary roles in these networks. Infectious disease specialists should develop practical and realistic response plans for their institutions in partnership with local and state health departments, in preparation for a real or suspected bioterrorism attack.