• 비교문화연구
• /
• 제38권
• /
• pp.65-87
• /
• 2015

This study has examined, first of all, one of unique characteristics of picturebook, so-called dual audience. To be more exact, this paper aimed at exploring the flexibility of picturebooks that allows both of children and adult reader to enjoy them. For this, we analysed Piggybook by Anthony Browne that so far has been read as a traditional picturebook with a single distinctive narrative rather than as a postmodern picturebook with multiple narratives, centering on paradox and irony. The results of this study were as fallows: Piggybook has the potential of multiple readings and meanings for a variety of audiences. Above all, this picturebook raises not only the question about the gender roles but also the one about representation of reality through the language.

• 대한약학회:학술대회논문집
• /
• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
• /
• pp.165.3-166
• /
• 2003

The c-Jun N-terminal kinase (JNK) plays essential roles in apoptosis and cell survival. Because apoptosis is promoted by blocking the MEK kinase1-mediated activation of JNK1, we tested whether JNK1 plays dual roles in apoptosis. We show here that JNK1 activity is differentially up-regulated in a two-tiered fashion by specific mechanisms during taxol- or ginsenoside Rh2-induced apoptosis. The early phase of JNK1 activation, but not apoptosis is prevented by expressing the dominant negative SEK1 mutant. (omitted)

• 통합자연과학논문집
• /
• 제5권1호
• /
• pp.22-26
• /
• 2012

Chemokine receptor antagonists have potential applications in field of drug discovery. Although the chemokine receptors are G-protein-coupled receptors, their cognate ligands are small proteins (8 to 12 kDa), and so inhibiting the ligand/receptor interaction has been challenging. In particular, CCR2 and CCR5 and their ligands have been implicated in the pathophysiology of a number of diseases, including rheumatoid arthritis and multiple sclerosis. Based on their roles in disease, they have been attractive targets for the pharmaceutical industry, targeting both CCR2 and CCR5 could be a useful strategy. Because of the importance of these receptors, providing information regarding the binding site is of prime importance. Herein, we report the comparison of CCR2 of CCR5 binding sites both sequentially as well as structurally. We also urged the importance of crucial residues in the binding site, to facilitate the development of dual antagonists targeting both the receptors. These results could also be useful for the design of novel and potent dual CCR2 and CCR5 antagonists using structure based drug design.

• Molecules and Cells
• /
• 제40권9호
• /
• pp.607-612
• /
• 2017

When mammalian cells and animals face a variety of internal or external stresses, they need to make homeostatic changes so as to cope with various stresses. To this end, mammalian cells are equipped with two critical stress responses, autophagy and cellular senescence. Autophagy and cellular senescence share a number of stimuli including telomere shortening, DNA damage, oncogenic stress and oxidative stress, suggesting their intimate relationship. Autophagy is originally thought to suppress cellular senescence by removing damaged macromolecules or organelles, yet recent studies also indicated that autophagy promotes cellular senescence by facilitating the synthesis of senescence-associated secretory proteins. These seemingly opposite roles of autophagy may reflect a complex picture of autophagic regulation on cellular senescence, including different types of autophagy or a unique spatiotemporal activation of autophagy. Thus, a better understanding of autophagy process will lead us to not only elucidate the conundrum how autophagy plays dual roles in the regulation of cellular senescence but also helps the development of new therapeutic strategies for many human diseases associated with cellular senescence. We address the pro-senescence and anti-senescence roles of autophagy while focusing on the potential mechanistic aspects of this complex relationship between autophagy and cellular senescence.

• Mycobiology
• /
• 제45권3호
• /
• pp.192-198
• /
• 2017

The green peach aphid (Myzus persicae), a plant pest, and gray mold disease, caused by Botrytis cinerea, affect vegetables and fruit crops all over the world. To control this aphid and mold, farmers typically rely on the use of chemical insecticides or fungicides. However, intensive use of these chemicals over many years has led to the development of resistance. To overcome this problem, there is a need to develop alternative control methods to suppress populations of this plant pest and pathogen. Recently, potential roles have been demonstrated for entomopathogenic fungi in endophytism, phytopathogen antagonism, plant growth promotion, and rhizosphere colonization. Here, the antifungal activities of selected fungi with high virulence against green peach aphids were tested to explore their potential for the dual control of B. cinerea and M. persicae. Antifungal activities against B. cinerea were evaluated by dual culture assays using both aerial conidia and cultural filtrates of entomopathogenic fungi. Two fungal isolates, Beauveria bassiana SD15 and Metarhizium anisopliae SD3, were identified as having both virulence against aphids and antifungal activity. The virulence of these isolates against aphids was further tested using cultural filtrates, blastospores, and aerial conidia. The most virulence was observed in the simultaneous treatment with blastospores and cultural filtrate. These results suggest that the two fungal isolates selected in this study could be used effectively for the dual control of green peach aphids and gray mold for crop protection.

• Human Ecology Research
• /
• 제60권4호
• /
• pp.507-520
• /
• 2022

The present study identified the effects of parents' work-family conflict on their and partners' co-parenting quality, as well as the mediating roles of co-parenting quality and children's executive function difficulties in linking parents' work-family conflict to their children's school adjustment. This study used data from 387 dual-earner parents and their first-grade elementary school children, who participated in the Panel Study on Korean Children. An actor-partner interdependence and mediation model analysis using structural equation modeling revealed the following findings: first, the actor and partner effects of parents' work-family conflict on co-parenting quality were significant for both fathers and mothers. Second, the effect of the fathers' work-family conflict on their co-parenting quality was found to be greater than that of the mothers' work-family conflict on the fathers' co-parenting quality. Third, fathers' and mothers' work-family conflict, respectively, exerted an indirect effect on their children's school adjustment through the serial mediation by the mothers' co-parenting quality and children's executive function difficulties, whereas the direct effects of fathers' and mothers' work-family conflict on children's school adjustment were not supported. Finally, this study suggests that co-parenting quality and children's executive function should be considered to facilitate children's school adjustment in the parent education of dual-earner families with first-grade elementary school children, and that continuous policy efforts for dual-earner parents' work-family balance are needed.

• 대한전기학회:학술대회논문집
• /
• 대한전기학회 1992년도 하계학술대회 논문집 B
• /
• pp.961-965
• /
• 1992

It is well-known that shock waves frequently occur inside the nozzle of the interrupter, and that they play important roles in the arc interruption. A model interrupter with two-dimensional dual-airflow nozzles was used for this experiment. The arc was ignited with 1.4 mil copper wire stretched between the electrodes which were spaced out 56 mm. The arc current of 60 to 230 A was achieved by adjusting the external resistance from 5.5 to 1.6 ohms. The arc tests have been conducted for investigating the air arc characteristics, and the effects of shock waves and nozzle pressure ratios on the arc voltage, the arc resistance, the arc power, and average electric field. The results of these tests have been analyzed to provide insights into the arc characteristics for gas circuit breakers. The average electric field is represented by the function of the arc current to show the negative E-I characteristic explicitly. The effects of shock waves and nozzle pressure ratios are shown to be significant for a circuit breaker performance.

• Journal of Power Electronics
• /
• 제16권1호
• /
• pp.238-248
• /
• 2016

The state-of-charge (SOC) and state-of-health (SOH) estimation of batteries play important roles in managing batteries for automotive applications. However, an accurate state estimation of a battery is difficult to achieve because of certain factors, such as measurement noise, highly nonlinear characteristics, strong hysteresis phenomenon, and diffusion effect of batteries. In certain vehicular applications, such as idle stop-start systems (ISSs), significant errors in SOC/SOH estimation may lead to a failure in restarting a combustion engine after the shut-off period of the engine when the vehicle is at rest, such as at a traffic light. In this paper, a dual extended Kalman filter algorithm with a dynamic equivalent circuit model of a lead-acid battery is proposed to deal with this problem. The proposed algorithm adopts a battery model by taking into account the hysteresis phenomenon, diffusion effect, and parameter variations for accurate state estimations of the battery. The validity of the proposed algorithm is verified through experiments by using an absorbed glass mat valve-regulated lead-acid battery and a battery sensor cable for commercial ISS vehicles.

• Biomolecules & Therapeutics
• /
• 제32권4호
• /
• pp.460-466
• /
• 2024

Asthma is characterized by chronic inflammation and respiratory tract remodeling. Peroxisome proliferator-activated receptors (PPARs) play important roles in the pathogenesis and regulation of chronic inflammatory processes in asthma. The role of PPARγ has been studied using synthetic PPARγ agonists in patients with asthma. However, involvement of PPARα/δ has not been studied in asthma. In the present study, we investigated if elafibranor, a PPARα/δ dual agonist, can modulate ovalbumin (OVA)-induced allergic asthma, which is a potential drug candidate for non-alcoholic fatty liver in obese patients. Elafibranor suppresses antigen-induced degranulation in RBL-2H3 mast cells without inducing cytotoxicity in vitro. In mice with OVA-induced allergic asthma, the administration of elafibranor suppressed OVA-induced airway hyper-responsiveness at a dose of 10 mg/kg. Elafibranor also suppressed the OVA-induced increase in immune cells and pro-inflammatory cytokine production in the bronchoalveolar lavage fluid (BALF). Histological studies suggested that elafibranor suppressed OVA-induced lung inflammation and mucin hyper-production in the bronchial airways. In addition, elafibranor suppressed OVA-induced increases in serum immunoglobulin E and IL-13 levels in BALF. Conversely, the present study suggests that elafibranor has the potential for use in patients with allergic asthma.

• 한국환경과학회지
• /
• 제22권4호
• /
• pp.385-396
• /
• 2013

National park, as a natural park, has a dual purpose, to promote both protection and enjoyment. The educational activities of the national park can be partly understood as one of the appropriate means to balance its double purposes. This study provides a review of environmental education in the US National Parks according to social transition. Taking historical perspective and case studies, environmental education has played roles in helping the balance between preservation and enjoyment. Since the environmental movement, environmental education goals, particularly understanding the natural processes observable at national parks, has become more a part of the interpretation and education missions of the parks. Also non-governmental and non-profit partners have played important educational-based roles in support of both the National Parks Service and environmental education goals. The two different models also differ in the public's perception of them. Federal employees are resented in some rural areas in the U.S., but the general population automatically attributes authority, friendliness, and national-interestedness to NPS Rangers. This may in turn limit how strongly such staff could serve as strong advocates for the environment. On the other hand, the non-profit may be seen by some as strongly liberally biased and associated with urban wealth. It is also not as universally recognized as the NPS. It can, however, go far to develop new partnerships and undertake public relations. Non-profits vary greatly in quality, also affecting public perception.