• BMB Reports
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• v.53 no.6
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• pp.335-340
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• 2020

Since cancer is the leading cause of death worldwide, there is an urgent need to understand the mechanisms underlying cancer progression and the development of cancer inhibitors. Signal transducer and activator of transcription 3 (STAT3) is a major transcription factor that regulates the proliferation and survival of various cancer cells. Here, dual-specificity phosphatase 3 (DUSP3) was identified as a regulator of STAT3 based on an interaction screening performed using the protein tyrosine phosphatase library. DUSP3 interacted with the C-terminal domain of STAT3 and dephosphorylated p-Y705 of STAT3. In vitro dephosphorylation assay revealed that DUSP3 directly dephosphorylated p-STAT3. The suppressive effects of DUSP3 on STAT3 were evaluated by a decreased STAT3-specific promoter activity, which in turn reduced the expression of the downstream target genes of STAT3. In summary, DUSP3 downregulated the transcriptional activity of STAT3 via dephosphorylation at Y705 and also suppressed the migratory activity of cancer cells. This study demonstrated that DUSP3 inhibits interleukin 6 (IL-6)/STAT3 signaling and is expected to regulate cancer development. Novel functions of DUSP3 discovered in IL-6/STAT3 signaling regulation would help expand the understanding of cancer development mechanisms.

• The Korean Journal of Physiology and Pharmacology
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• v.22 no.6
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• pp.679-688
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• 2018

Autism spectrum disorders (ASDs) are neurodevelopmental disorders that share behavioral features, the results of numerous studies have suggested that the underlying causes of ASDs are multifactorial. Behavioral and/or neurobiological analyses of ASDs have been performed extensively using a valid model of prenatal exposure to valproic acid (VPA). Abnormal synapse formation resulting from altered neurite outgrowth in neural progenitor cells (NPCs) during embryonic brain development has been observed in both the VPA model and ASD subjects. Although several mechanisms have been suggested, the actual mechanism underlying enhanced neurite outgrowth remains unclear. In this study, we found that VPA enhanced the expression of brain-derived neurotrophic factor (BDNF), particularly mature BDNF (mBDNF), through dual mechanisms. VPA increased the mRNA and protein expression of BDNF by suppressing the nuclear expression of methyl-CpG-binding protein 2 (MeCP2), which is a transcriptional repressor of BDNF. In addition, VPA promoted the expression and activity of the tissue plasminogen activator (tPA), which induces BDNF maturation through proteolytic cleavage. Trichostatin A and sodium butyrate also enhanced tPA activity, but tPA activity was not induced by valpromide, which is a VPA analog that does not induce histone acetylation, indicating that histone acetylation activity was required for tPA regulation. VPA-mediated regulation of BDNF, MeCP2, and tPA was not observed in astrocytes or neurons. Therefore, these results suggested that VPA-induced mBDNF upregulation was associated with the dysregulation of MeCP2 and tPA in developing cortical NPCs.

• Journal of the Korean Institute of Gas
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• v.11 no.4
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• pp.54-58
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• 2007

The trailers with electronically controlled diesel engine was converted to dual fuel engine system. To estimate economical efficiency, test vehicles have been operated on a certain driving route repeatedly. Fuel economy, mximum driving distance per refueling and driveability are examined on the road including a free way. Developed vehicle can be operated over 500 km with dual Hel and shows 85% of diesel substitution ratio. Driveability is similar with but passing acceleration. It will be improved by calibration process. Test engine was set up for investigating power output, thermal efficiency and emission. ND 13-mode tests were performed for the test cycle. The emission result of dual fuel meets K2006 regulation and the engine performance of dual fuel engine was equivalent to the performance of diesel engine.

• Korean Journal of Child Studies
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• v.34 no.5
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• pp.17-41
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• 2013

The purpose of this research was to investigate meaning of teachers as they manifest themselves in the emotional regulation of 2year old infants in a daycare center. In addition, the research attempts to provide basic research data that can be used as a guideline for teacher's awareness, roles, attitudes, and classroom management for infant's emotional education in the future. To achieve this goal, participatory observation was conducted in a child care center class for infants under 2 years old from January 17 to January 29, 2012. The teacher is defined as follow : Teachers are authority figures whose image is that of absolute authority, and coupled with their dual role of passive caretakers. Additionally, they function as guides who guided infants through the process of emotional socialization, and played the central role of emotional contagion from whose expression speech and atmosphere the said infants receive much influence. Such results seemed to indicate that teachers today do not fully comprehend the importance of their roles in influencing the emotion regulation of infants.

• The Journal of the Korea Contents Association
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• v.18 no.2
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• pp.520-532
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• 2018

Based on advanced research, this study examined the relations between savoring belief and gratitude, and identify a model of the mediating mechanisms of positive affect and cognitive emotion regulation in the relation between savoring belief and gratitude. For this purpose, savoring belief, positive affect, cognitive emotion regulation, and gratitude were measured, among 485 adults. Using a structural equation model, hypothesis and the patterns of variables was confirmed. The results showed that savoring belief, gratitude, positive affect, adaptive cognitive emotion regulation have the positive correlation and savoring belief, gratitude, positive affect was negatively correlated with maladaptive cognitive emotion regulation. The dual mediation effect by positive affect and adaptive cognitive emotion regulation was also verified. Implications for clinical practice, limitations of the study and suggestions for future researches are discussed.

• Progress in Medical Physics
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• v.19 no.4
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• pp.276-284
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• 2008

A computed tomography (CT) is a powerful system for the effectively fast and accurate diagnosis. The CT system, therefore, has used substantially and developed for improving the performance over the past decade, resulting in growing concerns over the radiation dose from the CT. Advanced CT techniques, such as a multidetector row CT scanner and dual energy or dual source CT, have led to new clinical applications that could result in further increases of radiation does for both patients and workers. The objective of this study was to review the international guidelines of the shielding requirements for a CT facility required for a new installation or when modifying an existing one. We used Google Search Engine to search the following keywords: computed tomography, CT regulation or shield or protection, dual energy or dual source CT, multidetector CT, CT radiation protection, and regulatory or legislation or regulation CT. In addition, we searched some special websites, that were provided for sources of radiation protection, shielding, and regulation, RSNA, AAPM, FDA, NIH, RCR, ICRP, IRPA, ICRP, IAEA, WHO (See in Table 1 for full explanations of the abbreviations). We finally summarized results of the investigated materials for each country. The shielding requirement of the CT room design was very well documented in the countries of Canada, United States of America, and United Kingdom. The wall thickness of the CT room could be obtained by the iso-exposure contour or the point source method. Most of documents provided by international organizations were explained in importance of radiation reduction in patients and workers. However, there were no directly-related documents of shielding and patient exposure dose for the dual energy CT system. Based international guidelines, the guideline of the CT room shielding and radiation reduction in patients and workers should be specified for all kinds of CT systems, included in the dual energy CT. We proposed some possible strategies in this paper.

• Journal of information and communication convergence engineering
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• v.6 no.3
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• pp.305-309
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• 2008

This paper presents an innovative prototype of a new conceptual electromagnetic induction eddy current based fluid heating appliance using voltage-fed quasi resonant zero voltage soft switching PWM high-frequency inverter using IGBTs, which can operate at a constant frequency variable power regulation scheme. The promising simple high efficient low noise inverter type electromagnetic induction eddy current based pipeline fluid heating appliance is proposed for saturated steam generator, superheated steam generator, hot water and hot air producer, metal catalyst heating for exhaust gas cleaning in engine. Under these technological backgrounds, a novel electromagnetic induction eddy current Dual Packs Heater(DPH) based pipeline fluid heating incorporates thin metal layer type package for continuous fluid heating appliances applying two types of voltage-fed quasi load resonant ZVS-PWM high frequency inverter. The unique features of a novel electromagnetic induction eddy current DPH based continuous pipeline fluid heating appliance is illustrated on the basis of simulation and discussed for the steady state operating characteristics and experimental results.

• Transactions of the Korean Society of Automotive Engineers
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• v.9 no.2
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• pp.202-209
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• 2001

As a part of stringent emission regulations, OBD on a converter is requested by EU and CARB. It demands that MIL is light-on to inform the failure to the driver when the converter is failed in its function. Usually dual oxygen sensor method is used for converter OBD. For this, detail methods, like amplitude ratio, time delay and frequency ratio methods are adapted for vehicle application. Actually, the cars produced later than MY94 for US market are using one of these methods. In this study, OSCs of converters are investigated with an absolute measuring method. The converters are aged with a furnace aging, an engine bench aging and vehicle aging method to represent various aging condition in field applications. An OBD index that is used for TLEVs regulation is also investigated to find a relation between two parameters. The relations of these parameters with THC emission on vehicle are evaluated.

• Transactions of the Korean Society of Automotive Engineers
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• v.15 no.4
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• pp.186-192
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• 2007

We research into the exhaust system volume what proving the optimum exhaust performance and combustion characteristics. Many automobile manufactures have developed complex exhaust system for environment regulation and noise reduction. This complex exhaust system provides acoustics silencing and low frequency noise for customers demand. Recently, automobile exhaust system have made the Dual muffler concerning to the noise and vibration reduction. Also it bring the engine performance down by decreasing the back pressure and temperature in the exhaust system. The experiments are carried out different volume of exhaust system. In order to establish the optimized conditions design factors which are taking exhaust system volume, it show how the exhaust performance influence on the engine performance in idling.

• Molecules and Cells
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• v.22 no.2
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• pp.127-132
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• 2006

In the post genome project era, it is well established that the human genome contains a smaller number of genes than expected. The complexity found in higher organisms can be explained if proteins are multifunctional. Indeed, recent studies are continuing to reveal proteins that are capable of a broad repertoire of functions. A good paradigm for multifunctionality can be found in the amino-acyl tRNA synthetases (aaRSs), an ancient conserved family of proteins. This unique family, which is comprised of 20 different enzymes, is well known for its participation in protein synthesis. Several studies have described numerous examples of these "housekeeping" proteins taking part in extensive critical cellular activities. In this review, we focus on a member of that family, lysyl-tRNA synthetase (LysRS), which has been shown to have a dual functionality. In addition to its contribution to the translation process, LysRS also takes part in the regulation of MITF and USF2 target genes. This phenomenon was first described in mast cells.