• 건축역사연구
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• 제20권4호
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• pp.135-156
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• 2011

Stupa in India divides into two: stupa in flatland temple with a character of tomb, and devotional stupa made for offering. The difference of such character is made by whether there is any Sari, and main center for worship is flatland stupa where Sari is settled. Stupa in flatland temple is targeted to that with Sari, whose character is applied into Relief-stupa. The characteristics of Relief-stupa can be divided into two: a relief with similar type of flatland stupa in the form, and a devotional relief in which drum and upper part of tower are developed. The Relief-stupa of flatland temple could be confirmed at tower gate of Sanchi tower, decoration of handrail, and the wall attached to Amaravati and Nagarjunakonda stupa. To the contrary, drum and upper wheel part in the Relief-stupa are developed in the votive stupa. Such characteristics had different features according to usage: The example of former is that there is an expression of landscape of stupa built at that time, and the example of latter is those which had similar type of stone cave temple or offering tower near stupa. Thus, the meaning is subject to the existing of Sari. Stupa building developed along with the development of Buddhist structural activity with the existing popular tradition. And its influence was expanded along with various cultures locally. And, the structure and tower reflected various types and thoughts. Stupa reflected its building site and method according to types, and was created in a new form by its usage.

• 디지털융복합연구
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• 제19권9호
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• pp.217-228
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• 2021

1970년대를 기점으로 부흥기를 맞이한 펑크 음악의 대표 아티스트를 중심으로 드럼 연주기법을 연구하고자 한다. 본 연구의 목적은 드럼 전공생들에게 펑크 드럼 연주기법으로 많은 영향을 미친 데이비드 가리발디의 연주기법에 나타난 창의성을 분석하는데 있다. 연구 방법으로 '제임스 브라운', '어스, 윈드 앤 파이어', 데이비드 가리발디가 드럼연주자로 있었던 '타워 오브 파워'를 대표 밴드로 선정하였다. 연구 기간은 해당하는 펑크 음악 발전이 시작된 1965년부터 1975년까지 발표한 대표 음악 2곡씩 선정하여 드럼 연주변화를 살펴보았다. 본 연구에서 데이비드 가리발디의 창의적 연주는 다음과 같다. 첫째, 동시대의 드럼 연주 형태의 틀에서 벗어나 연주 박을 변경하거나, 박자를 쉬는 형태의 새로운 리듬을 만들고자 하였다. 둘째, '패러디들(Paradiddle)', '악센트(Accent)', '스위스 아미 트리플렛 (Swiss Army triplet)' 루디먼트(Rudiment) 기법을 세트 드럼 전체에 적용하여 리듬에 혁신을 가져왔다. 셋째, 라틴 리듬의 삼바 패턴과 아프로-큐반(Afro-Cuban) 형식을 접목하였다. 넷째, 라틴 음악 구조에서 얻은 아이디어 유니즌 리듬을 펑크 음악에 적용하였다. 본 연구를 토대로 다양한 장르의 드럼 연주기법에 대한 연구가 이루어지기를 바란다.

• Asian Pacific Journal of Cancer Prevention
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• 제17권5호
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• pp.2705-2710
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• 2016

Recent evidence haas indicated that meningioma-associate protein (MAC30) exhibits different expression patterns in various tumors. However, little is known about the value of MAC30 in human squamous cell carcinoma of lung (SQCLC). The purpose of our study was to investigate the expression of MAC30 and to explore its clinical significance in SQCLC patients. A total of 156 Chinese patients diagnosed with SQCLC were selected for this study. The expression of MAC30 in all tissues was confirmed by immunohistochemical staining. Quantitative real-time PCR was performed to analyze MAC30 mRNA expression in 32 cases of SQCLC patients with corresponding non-tumor lung tissues. We observed enhanced mRNA expression of MAC30 in SQCLC as compared to control samples. Further, elevated MAC30 protein expression was strongly associated with poor tumor differentiation, TNM stage, and lymph node metastasis. In addition, we observed that patients with increased MAC30 expression demonstrated poor overall survival. Multivariate analysis explicated that increased MAC30 expression was a valuable independent predictable factor for poor tumor differentiation and short survival in SQCLC patients. Our present study suggests that MAC30 may serve as a biomarker for poor tumor differentiation and outcomes of patients with SQCLC.

• Earthquakes and Structures
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• 제19권5호
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• pp.331-345
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• 2020

The multi-story timber structure with high platform base is one of the important architectural types in the traditional Chinese buildings. To study the dynamic characteristics and seismic responses on this kind of traditional structure, the 3-D finite element models of Xi'an drum tower which included the high platform base, upper timber structure and whole structure was established considering the structural form and material performance parameters of the structure in this study. By the modal analysis, the main frequencies and mode shapes of this kind of traditional building were obtained and investigated. The three kinds of earthquake excitations included El-Centro wave, Taft wave and Lanzhou wave were separately imposed on the upper timber structure model and the overall structure model, and the seismic responses on the tops of columns were analyzed. The results of time history analysis show that the seismic response of the upper timber structure is obviously amplified by high platform base. After considering the effect of high platform base, the mean value on the lateral displacement increments of the top column in the overall structure is more than 20.478% and the increase of dynamic coefficients was all above 0.818 under the above three different earthquake excitations. Obviously, it shows that the existence of high platform base has a negative influence on the seismic responses of upper timber structure. And the high platform base will directly affect the safety of the upper timber structure. Therefore, the influence of high platform base on the dynamic response of its upper timber structure cannot be neglected.

• BMB Reports
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• 제52권6호
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• pp.379-384
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• 2019

Epithelial-mesenchymal transition (EMT) is widely-considered to be a modulating factor of anoikis and cancer metastasis. We found that, in MDA-MB-231 cells, TP53I11 (tumor protein P53 inducible protein 11) suppressed EMT and migration in vitro, and inhibited metastasis in vivo. Our findings showed that hypoxic treatment upregulated the expression of $HIF1{\alpha}$, but reduced TP53I11 protein levels and TP53I11 overexpression reduced $HIF1{\alpha}$ expression under normal culture and hypoxicconditions, and in xenografts of MDA-MB-231 cells. Considering $HIF1{\alpha}$ is a master regulator of the hypoxic response and that hypoxia is a crucial trigger of cancer metastasis, our study suggests that TP53I11 may suppress EMT and metastasis by reducing $HIF1{\alpha}$ protein levels in breast cancer cells.

• Asian Pacific Journal of Cancer Prevention
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• 제13권5호
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• pp.2369-2378
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• 2012

Objectives: To assess knowledge of HPV and attitudes towards HPV vaccination among the general female population, government officials, and healthcare providers in China to assist the development of an effective national HPV vaccination program. Methods: A cross-sectional epidemiologic survey was conducted across 21 urban and rural sites in China using a short questionnaire. 763 government officials, 760 healthcare providers, and 11,681 women aged 15-59 years were included in the final analysis. Data were analyzed using standard descriptive statistics and logistic regression. Results: Knowledge of HPV among the general female population was low; only 24% had heard of HPV. Less than 20% of healthcare providers recognized sexually na$\ddot{i}$ve women as the most appropriate population for HPV vaccination. There was high acceptance of the HPV vaccine for all categories of respondents. Only 6% of women were willing to pay more than US $300 for the vaccine. Conclusions: Aggressive education is necessary to increase knowledge of HPV and its vaccine. Further proof of vaccine safety and efficacy and government subsidies combined with increased awareness could facilitate development and implementation of HPV vaccination in China.

• Journal of Ginseng Research
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• 제44권4호
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• pp.580-592
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• 2020

Background: Radix et Rhizoma Ginseng (thereafter called ginseng) has been used as a medicinal herb for thousands of years to maintain people's physical vitality and is also a non-organ-specific cancer preventive and therapeutic traditional medicine in several epidemiologic and preclinical studies. Owing to few toxic side effects and strong enhancement on body immunity, ginseng has admirable application potential and value in cancer chemoprevention. The study aims at investigating the chemopreventive effects of ginseng on cutaneous carcinoma and the underlying mechanisms. Methods: The mouse skin cancer model was induced by 7,12-dimethylbenz[a]anthracene/12-O-tetradecanoylphorbol-13-acetate. Ultraperformance liquid chromatography/mass spectrometry was used for identifying various ginsenosides, the main active ingredients of ginseng. Comprehensive approaches (including network pharmacology, bioinformatics, and experimental verification) were used to explore the potential targets of ginseng. Results: Ginseng treatment inhibited cutaneous carcinoma in terms of initiation and promotion. The content of Rb1, Rb2, Rc, and Rd ginsenosides was the highest in both mouse blood and skin tissues. Ginseng and its active components well maintained the redox homeostasis and modulated the immune response in the model. Specifically, ginseng treatment inhibited the initiation of skin cancer by enhancing T-cell-mediated immune response through upregulating HSP27 expression and inhibited the promotion of skin cancer by maintaining cellular redox homeostasis through promoting nuclear translocation of Nrf2. Conclusion: According to the study results, ginseng can be potentially used for cutaneous carcinoma as a chemopreventive agent by enhancing cell-mediated immunity and maintaining redox homeostasis with multiple components, targets, and links.

• Korean Journal of Radiology
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• 제21권7호
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• pp.869-879
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• 2020

Objective: To evaluate the performance of a convolutional neural network (CNN) model that can automatically detect and classify rib fractures, and output structured reports from computed tomography (CT) images. Materials and Methods: This study included 1079 patients (median age, 55 years; men, 718) from three hospitals, between January 2011 and January 2019, who were divided into a monocentric training set (n = 876; median age, 55 years; men, 582), five multicenter/multiparameter validation sets (n = 173; median age, 59 years; men, 118) with different slice thicknesses and image pixels, and a normal control set (n = 30; median age, 53 years; men, 18). Three classifications (fresh, healing, and old fracture) combined with fracture location (corresponding CT layers) were detected automatically and delivered in a structured report. Precision, recall, and F1-score were selected as metrics to measure the optimum CNN model. Detection/diagnosis time, precision, and sensitivity were employed to compare the diagnostic efficiency of the structured report and that of experienced radiologists. Results: A total of 25054 annotations (fresh fracture, 10089; healing fracture, 10922; old fracture, 4043) were labelled for training (18584) and validation (6470). The detection efficiency was higher for fresh fractures and healing fractures than for old fractures (F1-scores, 0.849, 0.856, 0.770, respectively, p = 0.023 for each), and the robustness of the model was good in the five multicenter/multiparameter validation sets (all mean F1-scores > 0.8 except validation set 5 [512 x 512 pixels; F1-score = 0.757]). The precision of the five radiologists improved from 80.3% to 91.1%, and the sensitivity increased from 62.4% to 86.3% with artificial intelligence-assisted diagnosis. On average, the diagnosis time of the radiologists was reduced by 73.9 seconds. Conclusion: Our CNN model for automatic rib fracture detection could assist radiologists in improving diagnostic efficiency, reducing diagnosis time and radiologists' workload.