• The Korean Journal of Pain
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• 제34권2호
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• pp.210-216
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• 2021

Background: Postherpetic neuralgia (PHN) is the most common complication of acute herpes zoster. The treatment of PHN remains a challenge for clinical pain management. Despite the effectiveness of anticonvulsants, antidepressants, and lidocaine patches in reducing PHN, many patients still face intractable pain disorders. In this randomized controlled study, we evaluated whether hydromorphone through intravenous patient-controlled analgesia (IV PCA) was effective in relieving PHN. Methods: Patients with PHN were randomly divided into two groups, one group received oral pregabalin with IV normal saline, another group received oral pregabalin with additional IV PCA hydromorphone for two weeks. Efficacy was evaluated at 1, 4, and 12 weeks after the end of the treatments. Results: Two hundred and one patients were followed up for 12 weeks. After treatment, numerical rating scale (NRS) score of patients in the hydromorphone group was significantly lower than that of the control group, and the difference of NRS scores between the two groups was statistically significant at 4 and 12 weeks after treatment. The frequency of breakthrough pain in the hydromorphone group was significantly lower than that in the control group 1 and 4 weeks after treatment. After treatment, the quality of sleep in the hydromorphone group was significantly improved compared with the control group. The most common adverse reactions in the hydromorphone group were dizziness and nausea, with no significant respiratory depression. Conclusions: IV PCA hydromorphone combined with oral pregabalin provides superior pain relief in patients with PHN, which is worthy of clinical application and promotion.

• Wind and Structures
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• 제25권5호
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• pp.433-457
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• 2017

As a novel typical wind-sensitive structure, the wind load and wind-induced structural behaviors of super-large straight-cone cooling towers are in an urgent need to be addressed and studied. A super large straight-cone steel cooling tower (189 m high, the highest in Asia) that is under construction in Shanxi Power Plant in China was taken as an example, for which four finite element models corresponding to four structural types: the main drum; main drum + stiffening rings; main drum + stiffening rings + auxiliary rings (auxiliary rings are hinged with the main drum and the ground respectively); and main drum + stiffening rings + auxiliary rings (auxiliary rings are fixed onto the main drum and the ground respectively), were established to compare and analyze the dynamic properties and force transferring paths of different models. After that, CFD method was used to conduct numerical simulation of flow field and mean wind load around the cooling tower. Through field measurements and wind tunnel tests at home and abroad, the reliability of using CFD method for numerical simulation was confirmed. On the basis of this, the surface flow and trail characteristics of the tower at different heights were derived and the wind pressure distribution curves for the internal and external surfaces at different heights of the tower were studied. Finally, based on the calculation results of wind-induced responses of the four models, the effects of stiffening rings, auxiliary rings, and different connecting modes on the dynamic properties and wind-induced responses of the tower structure were derived and analyzed; meanwhile, the effect mechanism of internal suction on such kind of cooling tower was discussed. The study results could provide references to the structure selection and wind resistance design of such type of steel cooling towers.

• Asian Pacific Journal of Cancer Prevention
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• 제16권7호
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• pp.2953-2958
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• 2015

Although associations between thioredoxin interacting protein (TXNIP) and cancers have been recognized, the effects of TXNIP on non-small cell lung cancer (NSCLC) prognosis remained to be determined in detail. In addition, while hypoxia is a key characteristic of tumor cell growth microenvironment, the effect of hypoxia on TXNIP expression is controversial. In this study, formaldehyde fixed and paraffin embedded (FFPE) samples of 70 NSCLC patients who underwent resection between January 2010 and December 2011 were obtained. Evaluation of TXNIP and hypoxia inducible factor-$1{\alpha}$ ($HIF-1{\alpha}$) protein expression in FFPE samples was made by immunohistochemistry. By Kaplan-Meier method, patients with high TXNIP expression demonstrated a significantly shorter progression free survival (PFS) compared with those with low TXNIP expression (18.0 months, 95%CI: 11.7, 24.3 versus 23.0 months, 95%CI: 17.6, 28.4, P=0.02). High TXNIP expression level was also identified as an independent prognostic factor by Cox regression analysis (adjusted hazard ratio: 2.46; 95%CI: 1.08, 5.56; P=0.03). Furthermore, TXNIP expression was found to be significantly correlated with $HIF-1{\alpha}$ expression (Spearman correlation=0.67, P=0.000). To further confirm correlations, we established a tumor cell hypoxic culture model. Expression of TXNIP was up-regulated in all three NSCLC cell lines (A549, SPC-A1, and H1299) under hypoxic conditions. This study suggests that hypoxia induces increased TXNIP expression in NSCLC and high TXNIP expression could be a poor prognostic marker.

• 한국신재생에너지학회:학술대회논문집
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• 한국신재생에너지학회 2008년도 춘계학술대회 논문집
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• pp.157-160
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• 2008

Solar receiver in the solar power tower system has a similarity to a boiler of the thermal power plant in many aspects. However Boiler is operated long time without stopping while solar receiver repeats start and stop every day. The objective of this study is to investigate start-up characteristics of solar receiver. The experimental device was constructed in a bench scale. Basic experimental condition of water/steam was set by 25 bar and $223^{\circ}C$. Initially, the heat was added into risers only, then another experiment with input into drum additionally was done. When the heat flux was valid only risers, it took about 300 minutes until the water temperature in drum reached $223^{\circ}C$. Water temperature of drum was increased by $44^{\circ}C$/hr with 91.14 g/s of water circulation. With additional heat input into drum, 200 minutes was required to reach $223^{\circ}C$. In this case temperature was increased $66^{\circ}C$/hr with 96.5 g/s of water circulation.

• Computers and Concrete
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• 제28권6호
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• pp.605-619
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• 2021

Building Information Modeling (BIM) models are a powerful tool for preserving and using architectural history. Manually creating information models for such a significant number and variety of architectural monuments as Dong drum towers is challenging. The building logic based on "actual measurement construction" was investigated using the metamodel idea, and a metamodel-based automated modeling approach for the wood framework of Dong drum towers was presented utilizing programmable algorithms. Metamodels of fundamental frame kinds were also constructed. Case studies were used to verify the automated modeling's correctness, completeness, and efficiency using metamodel. The results suggest that, compared to manual modeling, automated modeling using metamodel may enhance the model's integrity and correctness by 5-10% while also reducing time efficiency by 10-20%. Metamodel and construction logic offer a novel way to investigate data-driven autonomous information-based modeling.

• 한국산림과학회지
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• 제97권1호
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• pp.61-70
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• 2008

본 연구는 급경사 지형과 간벌사업, 소규모 목재생산 등에 효율적인 가선계 집재기계인 트랙터 부착형 타워집재기를 개발하고자 수행하였다. 타워집재기의 유압동력원은 트랙터의 PTO를 이용한 3개의 유압펌프를 장착하여 4개의 드럼 구동용 모터와 인터록크용 클러치 실린더, 타워신장용 실린더, 아웃트리거 실린더를 작동시킬 수 있도록 설계 제작하였으며, 런닝스카이라인 삭장방식과 인터록크 기능을 채택하고 더블캡스턴드럼과 와이어로프 저장드럼, 인터록크 클러치를 장착한 타워집재기를 개발하였다. 또한 더블캡스턴 드럼의 윈치 구동력 및 견인력과 가선의 이송속도를 산출하여 윈치 구동력은 $191kg{\cdot}m$, 윈치 견인력은 1,910kgf, 더블캡스턴 드럼의 회전수는 220.5rpm, 가선의 이송속도는 138.5m/min의 타워집재기를 개발하였다. 메인라인 250m와 홀백라인 450m을 저장하기 위해서는 메인라인 및 홀백라인 저장드럼의 플랜지 직경은 각각 약 360mm와 약 460mm가 최적이라는 것을 알 수 있었다. 런닝스카이라인 삭장방식에 맞고 쵸킹작업이 용이하고 집재목의 처짐을 방지하기 위한 잠금장치를 장착한 반송기를 개발하였으며, 타워집재기의 인터록크 기능을 고려하고 조작의 수월성과 작업의 효율성을 위한 유선 리모트 콘트롤러를 개발하였다. 타워집재기의 견인 및 이동을 위해 트랙터의 후방 3점 히치 연결장치와 고무바퀴를 장착하였으며, 타워집재기의 안전성과 작업의 효율성을 높이기 위해 아우트리거와 버팀줄을 장착한 타워집재기를 개발하였다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권8호
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• pp.3687-3690
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• 2014

MicroRNA 200c is a microRNA 200 family member that plays an important role in regulation of the epithelial-to-mesenchymal transition (EMT). The prognostic value of microRNA 200c in solid tumors remains controversial because of inconsistent data. Here, we report a meta-analysis of the association of microRNA 200c expression and survival in patients with solid tumors. Pubmed was searched up to November 2013 for studies investigating microRNA 200c expression and overall survival (OS) in solid tumors. Hazard ratios (HRs) with 95% confidence intervals (CIs) for OS were extracted from each study. Pooled HR and CIs were calculated using the Mantel-Haenszel fixed-effects models. A total of five studies evaluating colorectal cancer, gastric cancer, ovarian cancer, pancreatic cancer and endometrial cancer were included in the analysis. Data were divided into tissue microRNA 200c expression group and serum microRNA 200c expression group. The combined HRs [95%CIs] estimated for OS were 0.62 [0.42-0.91] and 2.16 [1.32-3.52] respectively. Low expression of microRNA 200c in tumor tissue and high expression of microRNA 200c in serum are associated with worse survival in solid tumors. Further study is needed to elucidate this contradiction.

• Asian Pacific Journal of Cancer Prevention
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• 제15권1호
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• pp.139-143
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• 2014

Although correlations between platelets and lung cancer has been recognized, effects on non-small cell lung cancer (NSCLC) metastasis remain to be determined in detail. In the present study, wound healing assays revealed a role of platelets in NSCLC cell migration. Thus the mean migration rate of lung adenocarcinoma A549 cells was significantly elevated after co-culture with platelets ($81.7{\pm}0.45%$ vs $41.0{\pm}3.50%$, P<0.01). Expression of GAPDH was examined by reverse transcription-polymerase chain reaction to study the effect of platelets on NSCLC cell proliferation. The result showed that the proliferation of A549 and SPC-A1 cells was not affected. Mouse models were established by transfusing A549 cells and SPC-A1 cells into mice lateral tail veins. We found tumor metastasis nodules in lungs to be increased significantly after co-transfusion with platelets (in A549, $4.33{\pm}0.33$ vs $0.33{\pm}0.33$, P=0.01; in SPC-A1, $2.67{\pm}0.33$ vs $0.00{\pm}0.00$, P=0.01). In addition, consecutive inoperable patients with newly diagnosed NSCLC (TNM stage III or IV) between January 2009 and December 2011 were retrospectively reviewed. Using the Kaplan-Meier method, NSCLC patients with a high platelet counts demonstrated a significantly shorter progression free survival compared with those with a low platelet count (> $200{\times}10^9/L$, 3 months versus ${\leq}200{\times}10^9/L$, 5 months, P=0.001). An elevated platelet count was also identified as an independent prognostic factor by Cox regression analysis for prgression free survival (adjusted hazard ratio: 1.69; 95% CI: 1.16, 2.46; P=0.006). This study suggested that platelets might contribute to the hematogenous metastatic process by promoting cancer cell migration, which eventually affects the prognosis of NSCLC.

• 대한전기학회:학술대회논문집
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• 대한전기학회 1998년도 추계학술대회 논문집 학회본부 C
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• pp.935-937
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• 1998

The stringing load was added to tower design that consider the active load in 765kV transmission line construction. The nominal auxiliary members of steell tubular tower arm were altered into stress members by means of three dimensional design analysis method. 765kV transmission line construction also use self-standing tower that does not install temporary wire which support the section tower placed between drum field and engine field when stringing process.

• 한국태양에너지학회 논문집
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• 제28권2호
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• pp.1-9
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• 2008

This paper describes water circulation characteristics of a water/steam receiver at various heat fluxes. The water/steam receiver for a solar tower power system is a natural circulation type. Experimental conditions of water and steam were set at a pressure of 5 bar and temperature of $151.8^{\circ}C$. The experimental device for the water/steam receiver consisted of a steam drum, upper/lower header, riser tubes, and downcomer tube. The experiments were conducted by varying heat fluxes in terms of mass flow rate in each riser tube. However, the total mass flow rate on the riser tubes was fixed at 217.4 g/s. For the uniform heat flux, while the water temperature of the steam drum and upper header were kept at steady state, the temperature of the lower header was fluctuated. For the non-uniform heat flux, while the temperature of the steam drum was kept steady state, the temperature difference increased in the right and left side of the upper header, and the temperature of the lower header was fluctuated.