• 한국항해항만학회지
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• 제32권5호
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• pp.333-339
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• 2008

해상 상태가 거칠어짐에 따라 선체동요로 인하여 선박에 승선 증인 승객 및 승무원은 멀미 증상을 호소하기도 하고, 졸음 증상, 어지럼증, 두통 및 복통 등을 초래하기도 한다. 심한 경우에는 생리적으로 회복하기 힘들 정도의 심각한 장애를 겪기도 한다. 또한, 의욕(동기부여) 감소, 숙련도 저하, 인지능력 및 판단력 저하 등 정신적 활동의 지연이나 오류를 유발하는 등 활동성 및 작업수행 능력이 현저히 떨어지기도 한다. 본 논문에서는 멀미의 발생 및 작업수행과 관련된 대표적인 국제 표준안을 살펴보았고, 실습선에 승선 중인 실습생들을 대상으로 수차례에 걸쳐 설문조사를 실시하여 승선감을 평가하였다. 그 결과, 멀미 중상을 유발하는 주요소가 상하가속도임을 확인하였고, 그 크기(수준)는 0.2g 이상으로 분석되었다. 또한, 속력 또는 침로를 변경하여 파도와의 만남주기가 $4{\sim}8$초의 범위에서 벗어나도록 항해함으로써 멀미 증상을 완화시킬 수 있는 방안을 제시하였다.

• 한국생활과학회지
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• 제17권1호
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• pp.171-179
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• 2008

This study focuses on 130 estheticians currently working in and around Daegu and Gyeongbuk region, in order to find out the current state of affairs and side effects related to aromatherapy. This paper is based on a survey. SPSS win 11.0 program was used for the analysis of descriptive statistics and independent t-test. According to the result of analysis, about 33% of the estheticians have had allergy experience. And in terms of installation of an air ventilation fan, which is the most important facility in an treatment room, more than half (50.8%) replied they did not have one. There was a statistically significant difference between those estheticians suffering from allergy and those who did not, in symptoms of stuffy nose/rhinitis (P<0.01) and dry skin/itchiness (P<0.5). (Allergy symptoms from the 33% of estheticians were limited to those which occurred after he or she began career) On work related symptoms, those who had work history at hospitals/clinics or apothecaries were compared. A statistically relevant difference was confirmed between those estheticians with therapy experience and those who had none, in all symptoms except headaches and drowsiness/weariness. In other words, there was difference in symptoms such as dryness of skin/itchiness (P<0.01), stuffy nose/rhinitis, dry throat, tension/nervousness, dizziness, tired eyes(P<0.5), nausea, having trouble with focusing, and fatigue(P<0.1). Those estheticians who had a history of treatment especially suffered most from dryness of skin and itchiness. The rate of regular check-ups and the use of masks, employed for self protection, was lower than average (amounting to 5 points), with the use of masks especially having the lowest average (1.7) points.

• 대한임상독성학회지
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• 제9권2호
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• pp.105-108
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• 2011

Aconitine is an anti-inflammatory agent with therapeutic uses in oriental medicine as an analgesic and for treatment of stroke. Because of its sodium channel effect, aconitine can promote undesirable, wide complex tachyarrhythmia. If tachycardia develops during use of aconitine, class Ia and class III anti arrhythmic drugs can be utilized for treatment. However there are no single anti-arrhythmia agents which are uniformly effective. We report a case, characterized by wide complex tachyarrhythmia and severe hypotension, which was successfully treated by simultaneous injections of amiodarone and lidocaine. A 59-year-old woman exhibiting clinical signs of drowsiness as a result of ingesting 6 g of aconitine, was admitted to the emergency department. Initially, wide complex tachyarrhythmia (ventricular tachycardia and pulse rate of 180 beats/min) and severe hypotension (blood pressure of 53/26 mmHg) was observed. After simultaneous injection of amiodarone and lidocaine, the patient's rhythm pattern changed to an accelerated junctional rhythm with ventricular premature complex. Two hours later, the patient's heart pattern became a sinus rhythm. As demonstrated by this case, simultaneous injections of amiodarone and lidocaine can be useful in treating ventricular arrhythmia induced by aconitine.

• 한국직업건강간호학회지
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• 제9권2호
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• pp.86-93
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• 2000

This study was conducted to find out the degree of tiredness, accumulated tendencies of fatigues in accordance with 3 types of circadian rhythms and 3 types of perceived fatigue signs such as physical, psychological and neurosensory aspects in before and after work at night. Samples were chosen from the 217 intensive care units nurses working in 13 general hospitals which had 3 shift rotating systems, Data were collected from November to December in 1999. Two hundreds seventeen respondents were classified by 3 circadian types such as 59 morning, 110 middle and 48 evening. Circadian type was measured by the circadian type scale which was designed by ${\ddot{O}}stberg$ and Home (1976). in order to estimate the level of tiredness, the investigator used the fatigue checklist designed by the Labor and Health Institute of Japan(1970). Analysis was done by frequency a percentages, ${\chi}^2$ test and repeated measures ANOVA test. The result of this study were as follow: 1. In the general characteristics of the subjects circadian types, moderate type had the large proportion at 50.7% and morning type had 27.2% and evening type had 22.1%. 2. According to the 3 types of fatigue signs, the highest general tendency was 'General weakness' and 'Feeling of headsore' for physically perceived sign, 'Drowsiness' for psychological sign, and 'Uncomfortableness in sight seeing' for neurosensory sign. 3. The most frequently complained fatigue were observed in physical symptoms among physical, mental, and neurosensual symptoms. The percentage of complained was higher after night work than before the work started. 4. There was not any statistical significant difference between the circadian type and the degree of physical, mental, neurosensory fatigue. 5. There was not any statistical significant difference in regarding to each date of night shift except difference between 1st and 2nd days of fatigue perceived physically. Therefore, the study concluded that the fatigue perceived by night shift nurses might be related with shift working condition rather than circadian types.

• 한국통신학회논문지
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• 제37권8C호
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• pp.711-720
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• 2012

본 논문에서는 운전자 졸음 인식 시스템의 구현 방법과 그에 따른 결과를 소개한다. 영상 입력 장치로는 시중에 판매되는 웹캠 카메라를 사용하였다. 얼굴 검출 방법으로는 Haar 변환 기법을 이용하였으며, 다양한 조명 환경에 강건하게 적응하도록 조명정규화를 수행하였다. 조명정규화를 거친 얼굴 영상은 특징값 추출에 용이하다. 조명정규화를 통한 눈 후보영역은 인체측정학 정보를 이용하여 후보 영역을 줄인 이후에 PCA와 Circle Mask의 혼합 모델을 적용했다. 위 방법을 통해 차량 내부의 복잡한 조명 환경 속에서 강건히 눈 영역을 추출한다. 검출된 눈 영역은 고해상도의 조명 정규화 영상과 간단한 연산을 통하여 졸음 여부를 판별한다. 졸음 상태가 1단계로 판단 될 경우에는 통합 모니터링 인터페이스에서 운전자에게 경고음을 울리며 2단계일 경우에는 CAN(Controller Area Network)를 통하여 안전벨트를 진동하게 함으로써 운전자에게 경고를 준다. 본 논문에서 제안하는 졸음 인식 시스템은 낮은 계산 복잡도를 만족하는 동시에 높은 인식률을 보여준다. 실험 결과 차량 내에서 97%의 인식률이 나타났다.

• 한국임상약학회지
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• 제25권1호
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• pp.56-58
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• 2015

Summary: We report the first hepatic adverse effect of tosufloxacin tosylate in a muscle invasive bladder cancer patient with normal liver functions and with scheduling to undergo a surgical operation for a neobladder. Tosufloxacin tosylate 150 mg was administered to a 57-year-old man who maintained transurethral resection of bladder tumor (TUR-BT) postoperative multiple medications. His labs presented significant increases in alanine amino transferase (ALT) and aspartate amino transferase (AST) levels with 2-week compliance of 150 mg tablet three times a day. After discontinuing tosufloxacin tosylate, the levels slowly decreased and completely returned to normal ranges without any intervention in a few weeks. The Naranjo Causality Algorithm indicates a probable relationship between increased ALT and tosufloxacin. The patient was to have the second surgical operation as scheduled after getting normal range of ATL level. Therefore, tosufloxacin should be avoided in patients at risk for having liver dysfunctions or diseases if the patients have a schedule for any operation. Background: Tosufloxacin tosylate has been shown to have favorable benefits as an antibiotic. Tosufloxacin tosylate may be considered to have the adverse effects such as nauseas, vomiting, diarrhea, abdominal pain, stomatitis, tendonitis, tendon rupture, headache, dizziness, drowsiness, insomnia, weakness, agitation including hemolysis in the event of glucose-6-phosphate dehydrogenase deficiency as other fluoroquinolones. More severe adverse reactions of tosufloxacin tosylate over the above common adverse effects of fluoroquinolones were thrombocytopenia and nephritis. It also is not well known that tosufloxacin can cause hepatic problem. Here the study reports the first hepatic reaction from tosufloxacin and might arouse heath care providers' attention to appropriate drug choice for patients.

• 한국임상약학회지
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• 제30권2호
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• pp.92-101
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• 2020

Background: Delirium is a neuropsychiatric disorder characterized by sudden impairments in consciousness, attention, and perception. The evidence of successful pharmacological interventions for delirium is limited, and medication recommendations for managing delirium are not standardized. This study aimed to provide evidence of antipsychotics for symptomatic treatment of delirium in cancer patients receiving palliative care. Methods: We retrospectively reviewed adult cancer patients in palliative care who received antipsychotic delirium treatment at Severance Hospital between January 2016 and June 2019. The efficacy was evaluated primarily by resolution rates. The resolution of delirium was defined as neurological changes from drowsiness, confusion, stupor, sedation, or agitation to alertness or significant symptomatic improvements described in the medical records. The safety was studied primarily by adverse drug reaction incidence ratios. Results: Of the 63 enrolled patients, 60 patients were included in the statistical analysis and were divided into three groups based on which antipsychotic medication they were prescribed [quetiapine (n=27), haloperidol (n=25) and co-administration of quetiapine and haloperidol (n=8)]. The resolution ratio showed quetiapine to be more effective than haloperidol (p=0.001). No significant differences were seen in adverse drug reaction rates among the three groups (p=0.332). Conclusions: Quetiapine was considered the most effective medication for delirium, with no significant differences in adverse drug reaction rates. Therefore, quetiapine may be considered a first-line medication for treating delirium in cancer patients receiving palliative care. However, further studies comparing more diverse antipsychotics among larger populations are still needed.

• Clinical and Experimental Pediatrics
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• 제54권9호
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• pp.380-384
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• 2011

Purpose: To investigate the efficacy of topiramate monotherapy in West syndrome prospectively. Methods: The study population included 28 patients (15 male and 13 female children aged 2 to 18 months) diagnosed with West syndrome. After a 2-week baseline period for documentation of the frequency of spasms, topiramate was initiated at 2 mg/kg/day. The dose was increased by 2 mg/kg every week to a maximum of 12 mg/kg/day. Clinical assessment was based on the parents' report and a neurological examination every 2 weeks for the first 2 months of treatment. The baseline electroencephalograms (EEGs) were compared with the post-treatment EEGs at 2 weeks and 1 month. Results: West syndrome was considered to be cryptogenic in 7 of the 28 patients and symptomatic in 21 patients. After treatment, 11 patients (39%) became spasm-free, 6 (21%) had more than 50% spasms-reduction, 3 (11%) showed less than 50% reduction, and 8 (29%) did not respond. The effective daily dose for achieving more than 50% reduction in spasm frequency, including becoming spasm-free, was found to be $5.8{\pm}1.1$ mg/kg/day. Nine patients (32%) showed complete disappearance of spasms and hypsarrhythmia, and 11 (39%) showed improved EEG results. Despite adverse events (4 instances of irritability, 3 of drowsiness, and 1 of decreased feeding), no patients discontinued the medication. Conclusion: Topiramate monotherapy seems to be effective and well tolerated as a first line therapy for West syndrome and is not associated with serious adverse effects.

• Journal of Genetic Medicine
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• 제6권2호
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• pp.170-174
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• 2009

저자들은 생후 3개월에 전형적인 페닐케톤뇨증으로 진단받고 식사요법을 유지하였으나 지연된 발달 소견 및 지능 저하를 보이고 경련 증상이 있었던 9세 남자 환아에서 효소 검사와 유전자분석으로 dihydropterine reductase (DHPR) 결핍증을 진단하였다. 그리고 $BH_4$, 신경전달물질 전구체 투여 및 엽산 보충으로 DHPR 결핍증을 치료한 1례를 경험하였기에 문헌고찰과 함께 보고한다.

• Asian Pacific Journal of Cancer Prevention
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• 제17권1호
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• pp.171-176
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• 2016

Background: Much has been done to examine the psychological impact of cancer treatment, but it remains unclear to what extent anxiety and depression is related to symptom prevalence. The present study concerned the characteristics and frequency of distress as related to symptom prevalence in cancer patients undergoing chemotherapy in Malaysia. Materials and Methods: Participants were 303 consecutive adult cancer patients undergoing chemotherapy in an academic medical center. The short form Memorial Symptom Assessment Scale (MSAS-SF), which covers three domains of symptoms (global distress, physical- and psychological symptoms) was used to cross-sectionally measure symptom frequency and associated distress via self-reporting. One-way ANOVA and t-tests were used to test mean differences among MSAS-SF subscale scores. Results: Complete data were available for 303 patients. The mean number of symptoms was 14.5. The five most prevalent were fatigue, dry mouth, hair loss, drowsiness and lack of appetite. Overall, symptom burden and frequency were higher than in other published MSAS-SF studies. Higher symptom frequency was also found to be significantly related to greater distress in cancer patients undergoing chemotherapy. Conclusions: Patients undergoing chemotherapy suffer from multiple physical and psychological symptoms. Better symptom control or palliative care is needed. Greater frequency of reported symptoms may also indicate a subconscious bid by patients for care and reassurance - thus tailored intervention to manage distress should be offered.