• Journal of Microbiology and Biotechnology
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• 제31권8호
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• pp.1109-1114
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• 2021

Chlamydia pneumoniae is a type of pathogenic gram-negative bacteria that causes various respiratory tract infections including asthma. Chlamydia species infect humans and cause respiratory infection by rupturing the lining of the respiratory which includes the throat, lungs and windpipe. Meanwhile, the function of interleukin-4 (IL-4) in Ch. pneumoniae respiratory infection and its association with the development of airway hyperresponsiveness (AHR) in adulthood and causing allergic airway disease (AAD) are not understood properly. We therefore investigated the role of IL-4 in respiratory infection and allergy caused by early life Chlamydia infection. In this study, Ch. pneumonia strain was propagated and cultured in HEp-2 cells according to standard protocol and infant C57BL/6 mice around 3-4 weeks old were infected to study the role of IL-4 in respiratory infection and allergy caused by early life Chlamydia infection. We observed that IL-4 is linked with Chlamydia respiratory infection and its absence lowers respiratory infection. IL-4R α2 is also responsible for controlling the IL-4 signaling pathway and averts the progression of infection and inflammation. Furthermore, the IL-4 signaling pathway also influences infection-induced AHR and aids in increasing AAD severity. STAT6 also promotes respiratory infection caused by Ch. pneumoniae and further enhanced its downstream process. Our study concluded that IL-4 is a potential target for preventing infection-induced AHR and severe asthma.

• 대한의용생체공학회:의공학회지
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• 제43권3호
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• pp.170-176
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• 2022

Cell separation from a heterogenous mixture sample is an essential process for downstream analysis in biological, chemical, and clinical applications. This study demonstrates an integrated hybrid device of the viscoelastic focusing in a straight rectangular channel and subsequent size-based separation using acoustophoresis to attain high efficiency and separation tunability. For particle pre-alignment in a viscoelastic fluid, the flow rate higher than 10 μl/min was required. Surface acoustic wave-based lateral migration of particles with different sizes (13 and 27 ㎛) was examined at various applied voltages and flow rate conditions. Therefore, the flow rate of 100 μl/min and the applied voltage of 20 V_pp can be used for size-based particle separation.

• 한국산업보건학회지
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• 제33권3호
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• pp.365-374
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• 2023

Objectives: After the MSDS submission and non-disclosure review system was introduced in January 2021, there were compliance difficulties in the field. Accordingly, for the establishment of the MSDS system, the government intends to investigate what has been improved and what urgently needs to be improved in the future, and to suggest detailed improvement plans. Methods: The background and problems of urgent difficulties in the field handling chemicals were investigated, and realistic improvement plans were derived through review of other laws related to the MSDS system and overseas cases. Results: In order to guarantee the safety of the public while at the same time promoting corporate R&D, it is necessary to alleviate the non-disclosure screening system for chemical substances for R&D, and to improve the irrationality of failing to implement the non-disclosure screening system due to information on unclassified substances being circulated. For this reason, it seems necessary to ease the requirement to submit all ingredients. In addition, it is necessary to strengthen punishment to raise awareness so that health problems do not occur due to the harmfulness and danger of hidden substances among workers who handle chemical substances and downstream users due to false descriptions in MSDS. Conclusions: All members of our society, including chemical manufacturers/importers and handling companies, academia, civil society, and the government, each subject of chemicals, should take an interest in the entire process from production to disposal of chemicals and work together to prevent harm to the public.

• 한국수자원학회논문집
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• 제56권12호
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• pp.895-903
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• 2023

본 연구에서는 실내실험을 수행하여 홍수터 식생에 의한 하안의 안정성, 만곡부의 곡률 변화, 사행의 발달과 이동을 정량적으로 분석하였다. 홍수터에 식생이 있는 하도는 시간이 증가하면서 사행의 하폭이 일정하게 유지하지만, 선택적인 하안침식에 의해 사행이 발달하고 하류로 이동하였다. 이러한 과정에서 하안침식과 사주의 변화가 크지 않으며, 저수로가 일정하게 유지되면서 유사유출량은 감소하고 변동성이 거의 없이 일정하게 유지되고 있다. 식생의 밀도가 증가함에 따라, 하안침식률이 감소하였다. 식생의 밀도가 증가함에 따라 하안침식률이 감소하였고, 사행의 발달에 영향을 주었다. 이는 홍수터 식생이 하안의 안정성을 증가시키고, 하도의 평면변화에 영향을 미치는 주요 인자 중의 하나임을 의미한다. 하안침식률과 무차원 곡률반경은 홍수터에 식생이 없는 조건에서 가장 크고, 식생이 있는 조건에서는 작다. 또한 상대 측방이동률과 무차원 곡률반경도 하안침식률과의 관계가 유사하는 특성을 보였다. 따라서 홍수터 식생은 하도의 안정성을 증가시켜서 하안침식과 사행의 발달뿐만 아니라, 사행의 곡률 변화와 이동에 영향을 준다.

• 대기
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• 제34권2호
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• pp.153-176
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• 2024

At 0843 UTC 30 May 2021, a commercial aircraft encountered severe turbulence at z = 11.5 km associated with the rapid development of Mesoscale Convective System (MCS) in the Gyeonggi Bay of Korea. To investigate the generation mechanisms of Near-Cloud Turbulence (NCT) near the MCS, Weather Research and Forecasting model was used to reproduce key features at multiple-scales with four nested domains (the finest ∆x = 0.2 km) and 112 hybrid vertical layers. Simulated subgrid-scale turbulent kinetic energy (SGS TKE) was located in three different regions of the MCS. First, the simulated NCT with non-zero SGS TKE at z = 11.5 km at 0835 UTC was collocated with the reported NCT. Cloud-induced flow deformation and entrainment process on the downstream of the overshooting top triggered convective instability and subsequent SGS TKE. Second, at z = 16.5 km at 0820 UTC, the localized SGS TKE was found 4 km above the overshooting cloud top. It was attributed to breaking down of vertically propagating convectively-induced gravity wave at background critical level. Lastly, SGS TKE was simulated at z = 11.5 km at 0930 UTC during the dissipating stage of MCS. Upper-level anticyclonic outflow of MCS intensified the environmental westerlies, developing strong vertical wind shear on the northeastern quadrant of the dissipating MCS. Three different generation mechanisms suggest the avoidance guidance for the possible NCT events near the entire period of the MCS in the heavy air traffic area around Incheon International Airport in Korea.

• Journal of Microbiology and Biotechnology
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• 제34권5호
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• pp.1073-1081
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• 2024

Obesity is spawned by an inequality between the portion of energy consumed and the quantity of energy expended. Disease entities such as cardiovascular disease, arteriosclerosis, hypertension, and cancer, which are correlated with obesity, influence society and the economy. Suppression of adipogenesis, the process of white adipocyte generation, remains a promising approach for treating obesity. Oil Red O staining was used to differentiate 3T3-L1 cells for screening 20 distinct Lactobacillus species. Among these, Lactobacillus acidophilus DS0079, referred to as YBS1, was selected for further study. YBS1 therapy decreased 3T3-L1 cell development. Triglyceride accumulation and mRNA expression of the primary adipogenic marker, peroxisome proliferator-activated receptor gamma (PPARγ), including its downstream target genes, adipocyte fatty acid binding protein 4 and adiponectin, were almost eliminated. YBS1 inhibited adipocyte differentiation at the early stage (days 0-2), but no significant difference was noted between the mid-stage (days 2-4) and late-stage (days 4-6) development. YBS1 stimulated the activation of p38 mitogen-activated protein kinase (p38 MAPK) during the early stages of adipogenesis; however, this effect was eliminated by the SB203580 inhibitor. The data showed that YBS1 administration inhibited the initial development of adipocytes via stimulation of the p38 MAPK signaling pathway, which in turn controlled PPARγ expression. In summary, YBS1 has potential efficacy as an anti-obesity supplement and requires further exploration.

• 한국수자원학회논문집
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• 제49권6호
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• pp.459-467
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• 2016

홍수범람모의에 주로 활용되는 LISFLOOD-FP 모형은 하도에서 1차원 운동파 방정식을 이용하고, 상대적으로 평평하여 흐름이 확산되는 홍수터에서 단순화된 2차원 확산파 방정식을 이용하여 흐름을 해석한다. 본 연구에서는 분포형 수문모형인 LISFLOOD-FP 모형의 하천홍수위 예측 적용성을 검토하기 위하여 배수영향을 받는 만경강 하류구간에서 기 발생한 홍수사상을 대상으로 모형을 보정하고 검증하였다. 모형의 주요 매개변수인 Manning 조도계수와 하류단 경계조건의 민감도를 분석하였고, 초기조건 영향을 검토하기 위하여 warm-up 유무에 따른 해석결과를 비교하였다. 그 결과, 운동파 모형임에도 불구하고 배수영향을 받는 만경강 하류구간의 홍수위를 비교적 잘 재현하는 것을 확인하였고, 민감도 분석은 실제 홍수사상의 적용 시 여러 가지 매개변수와 경계 조건에 의해 홍수위 값이 상이한 결과를 나타났다. 이러한 결과를 바탕으로 운동파 수문모형의 적용시 홍수위 해석에 대한 충분한 검증 및 검토가 필요하다고 사료되며, 검증된 모형을 바탕으로 다양한 유역의 홍수범람모의에 적용이 된다면 향후 홍수피해 저감을 위한 정책적인 의사결정에 기여할 수 있을 것으로 판단된다.

• 한국지하수토양환경학회지:지하수토양환경
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• 제18권3호
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• pp.93-108
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• 2013

This study is aimed to prepare the effective detail survey methods(Phase II) of abandoned metal mines through the contamination assessment for mine types and facilities in the abandoned metal mine areas. The study sites of 12 abandoned mines are located in Gyeonggi-do and Gangwon-do and those were chosen among 310 sites that the Phase II survey was conducted from 2007 to 2009 after considering the results of Phase I for abandoned mines scattered all over the country. 12 study sites were classified into four types; Type I sites only have pit mouth. Type II sites have pit mouth and mine-waste field. Type III sites have pit mouth and tailing sorting field. Type IV sites have pit mouth, tailing sorting field and concentrator(s). In forest land, paddy soil and farm land of Type I, As and Cd were showed average concentration, and Cu and Pb were high on the pit mouth area in one mines where the pit mouth was developed within 500 m. In the mines of Type II, Cu and Pb were showed average concentration too, but As and Cd were slightly high in pit mouth and mine-waste field. The mines of Type III which had grinding particle process through physical separation milling or hitting showed similar tendency with Type II. However, mines of Type IV pit mouth, mine-waste field and showed various results depending on defining the contamination sources. For example, if contamination source was pit mouth, the mixed results of Type I, II, II were showed. In tailing sorting field which was regarded as the most important source and having high mobility, however, if there were no facilities or it was difficult to access directly, field sampling was missed occasionally during phase I and phase II survey. For that reason, the assessment for tailing sorting field is missed and it leads to completely different results. In the areas of Type I mines, the concentration of heavy metals exceeded precautionary standards of soil contamination or not within 1,000 meters of pit mouth. Nickel(Ni) was the largest factor of the heavy metal contamination in this type. The heavy metals except Arsenic(As) were shown high levels of concentration in Type II areas, where pit mouth and mine-waste field were operated for making powder in upriver region; therefore, to the areas in the vicinity of midstream and downstream, the high content of heavy metals were shown. The tendency of high level of heavy metals and toxic materials contained in flotation agent used during sorting process were found in soil around sorting and tailing field. In the abandoned-pit-mouth area, drygrinding area and tailing sorting field area, the content of Cupper(Cu) and Zinc(Zn) were higher than other areas. Also, the contaminated area were larger than mine reclamation area(2,000 m) and the location of tailing sorting field was one of the important factors to estimate contaminated area.

• 대한환경공학회지
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• 제34권2호
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• pp.73-78
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• 2012

낙동강 원수와 급속 사여과 처리수중에 함유된 인공 사향물질(Synthetic Musk Compounds, SMCs) 3종에 대해 오존처리 공정에서의 제거특성을 살펴본 결과, Musk Ketone (MK)이 AHTN (7-acetyl-1,1,3,4,4,6-hexamethyl-1,2,3,4-tetrahydronaphthalene)과 HHCB (1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylcyclopenta[c]-2-benzopyran)에 비해 오존처리에 의한 제거율이 낮게 나타났다. 그리고 동일한 운전조건에서 원수에 함유된 SMCs의 제거율은 원수 중에 함유된 오존 소모물질들에 의한 영향으로 급속 사여과처리수에 함유된 경우보다 제거율이 훨씬 낮았다. 오존 투입농도 0.5~10.0 mg/L에서 낙동강 원수와 급속 사여과 처리수 중에 함유된 3종의 SMCs에 대한 제거 속도상수(k)는 오존 투입농도가 증가할수록 급격히 증가하는 경향을 나타내었고, 반감기 역시 오존 투입농도 증가에 비례하여 급격히 감소하였다. 전/후오존 공정이 갖추어진 낙동강 하류에 위치한 정수장들의 경우, 전오존 공정은 최대 1.5~2.0 mg/L의 오존 투입농도로 2~4분 및 후오존 공정은 최대 2.0~2.5 mg/L의 오존 투입농도로 6~8분 정도의 체류시간을 가지도록 설계되어져 있어 비교적 고농도의 SMCs가 유입될 경우에는 오존처리만으로는 이들 물질들에 대한 제어가 어려운 것으로 나타났다.

• 환경정책연구
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• 제14권4호
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• pp.45-61
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• 2015

국내의 하천 환경은 4대강 사업 이후로 많은 변화가 예상되며, 이 과정에서 하천관리기법 역시 변화가 요구되고 있다. 준설이 그 대표적 예라고 할 수 있지만 준설은 2차 환경피해의 우려가 있다. 이를 위해서 준설의 사회 환경적으로 미치는 부정적인 영향을 최소화하기 위하여 미국의 환경창 제도를 한국에 적용시켜보았다. 자료의 부족을 극복하기 위해 통계학적 기법을 이용한 방안을 제시하였으며, 낙동강 강정고령보 하류부에 적용해보았다. 그 결과, 1개월 동안 준설하는 경우에는 3월에 수행하는 것이 최적으로 나타났으며, 8개월 동안 준설하는 경우에는 8월에 수행하는 것이 최적인 것으로 나타났다. 여기에 홍수기를 고려했을 경우에는 8개월 동안 준설에 대해서 10월에 시작하는 것이 최적인 것으로 나타났다. 환경창 제도와 같이 비구조적 방법은 친환경 준설장비를 개발하는 등의 구조적 방법보다 제도만 잘 정비된다면 단기간에 효과를 볼 수 있으며, 친환경 준설장비를 개발하면서 소요되는 막대한 예산을 절감할 수 있다는 장점이 있으므로 환경창을 준설규정을 수립하는 데 있어서 참고할 수 있을 것으로 판단된다. 환경창의 국내 적용은 하천준설에 대한 연구가 미비했던 국내에 기초자료로써 제공될 수 있을 것으로 판단된다.