• Archives of Plastic Surgery
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• 제46권6호
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• pp.572-579
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• 2019

Background Even with satisfactory anastomosis technique and adequate experience of the surgeon, flap loss due to thrombosis can still occur due to the patient's underlying condition. Patients with hypercoagulability due to etiologies such as malignancy, hereditary conditions, and acquired thrombophilia are among those who could benefit from free flap procedures. This review aimed to evaluate the risk of free flap thrombosis in patients with hypercoagulability and to identify the most effective thromboprophylaxis regimen. Methods This review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guideline. The PubMed, Embase, and Cochrane Library databases were explored. Types of free flaps, types of hypercoagulable states, thrombosis prevention protocols, thrombosis complication rates, and flap vitality outcomes were reviewed. Samples from the included studies were pooled to calculate the relative risk of free flap thrombosis complications in patients with hypercoagulability compared to those without hypercoagulability. Results In total, 885 articles underwent title, abstract, and full-text screening. Six articles met the inclusion criteria. The etiologies of hypercoagulability varied. The overall incidence of thrombosis and flap loss in hypercoagulable patients was 13% and 10.3%, respectively. The thrombosis risk was two times higher in hypercoagulable patients (P=0.074) than in controls. Thromboprophylaxis regimens were variable. Heparin was the most commonly used regimen. Conclusions Hypercoagulability did not significantly increase the risk of free flap thrombosis. The most effective thromboprophylaxis regimen could not be determined due to variation in the regimens. Further well-designed studies should be conducted to confirm this finding.

• 인터넷정보학회논문지
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• 제25권3호
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• pp.27-33
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• 2024

정보의 증가 속에서 학문 연구의 환경은 지속적으로 변화하고 있으며, 이에 따라 대량의 문서를 효과적으로 분석하는 방법의 필요성이 대두된다. 본 연구에서는 BART(Bidirectional and Auto-Regressive Transformers) 기반의 문서 요약 모델을 사용하여 텍스트를 정제하여 핵심 내용을 추출하고, 이를 LDA(Latent Dirichlet Allocation) 알고리즘을 통한 토픽 모델링의 성능 향상 방법을 제시한다. 이는 문서 요약을 통해 LDA 토픽 모델링의 성능과 효율성을 향상시키는 접근법을 제안하고 실험을 통해 검증한다. 실험 결과, 논문 데이터를 요약하는 BART 기반 모델은 Rouge-1, Rouge-2, Rouge-L 성능 평가에서 각각 0.5819, 0.4384, 0.5038의 F1-Score를 나타내어 원문의 중요 정보를 포착하고 있음을 보인다. 또한, 요약된 문서를 사용한 토픽 모델링은 Perplexity 지표를 통한 성능 비교에서 원문을 사용한 토픽 모델링의 경우보다 약 8.08% 더 높은 성능을 보인다. 이는 토픽 모델링 과정에서 데이터 처리량의 감소와 효율성 향상에 기여한다.

• International Journal of Heart Failure
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• 제6권1호
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• pp.36-43
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• 2024

Background and Objectives: Atrial fibrillation is common in patients with cardiac amyloidosis. However, the optimal anticoagulation strategy to prevent thromboembolic events in patients with cardiac amyloidosis and atrial fibrillation is unknown. This systematic review and meta-analysis compares direct oral anticoagulants (DOACs) vs. vitamin K antagonists (VKAs) in patients with cardiac amyloidosis and atrial fibrillation. Methods: We performed a systematic literature review to identify clinical studies of anticoagulation therapies for patients with cardiac amyloidosis and atrial fibrillation. The primary outcomes of major bleeding and thrombotic events were reported using random effects risk ratios (RRs) with 95% confidence interval (CI). Results: Our search yielded 97 potential studies and evaluated 14 full-text articles based on title and abstract. We excluded 10 studies that were review articles or did not compare anticoagulation. We included 4 studies reporting on 1,579 patients. The pooled estimates are likely underpowered due to small sample sizes. There was no difference in bleeding events for patients with cardiac amyloidosis and atrial fibrillation treated with DOACs compared to VKAs with a RR of 0.64 (95% CI, 0.38-1.10; p=0.10). There were decreased thrombotic events for patients with cardiac amyloidosis and atrial fibrillation treated with DOACs compared to VKAs with a RR of 0.50 (95% CI, 0.32-0.79; p=0.003). Conclusions: This systematic review and meta-analysis suggests that DOACs are as safe and effective as VKAs in patients with cardiac amyloidosis and atrial fibrillation. However, more data are needed to investigate clinical differences in anticoagulation therapy in this patient population.

• 디지털융복합연구
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• 제15권2호
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• pp.309-318
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• 2017

본 연구는 소셜 미디어 정치 뉴스의 논조와 프레임 유형 및 특성을 분석한 것이다. 소셜 미디어 뉴스는 트위터나 페이스북 등 SNS를 기반으로 자유롭게 정보를 공유하고 누구나 기사를 작성하고 편집할 수 있는 특성으로 인해 기존 미디어가 따라올 수 없을 만큼 의견의 다양성을 실현시키고 있다. 이에 구체적으로 소셜 미디어 뉴스가 어떻게 기존 미디어와 차별적으로 뉴스를 형성하고 있는지, 어떠한 뉴스 프레임으로 여론을 형성하고 있는지 살펴보고자 국내 소셜 뉴스매체인 '위키트리'를 대상으로 '대통령선거' 키워드 검색을 통해 총 419건의 기사를 추출한 후 내용분석을 실시하였다. 그 결과 소셜 미디어 정치 뉴스의 논조와 프레임 유형은 보도인물, 게재유형, 정보원, 주제범주, 현 정권에 대한 태도에 따라 유의미한 차이를 보였는데 심층성이 부족하고 연성화가 뚜렷해져 기존 미디어가 가지는 정치 뉴스의 한계를 여전히 벗어나지 못하고 있는 것으로 해석된다. 소셜 미디어 정치 뉴스의 논조는 개연적, 구체적이기 보다 당위적, 추상적인 것으로 나타났고 주로 감성, 전략, 일화 중심의 프레임을 사용하고 있는 것으로 나타났기 때문이다.

• Journal of Preventive Medicine and Public Health
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• 제56권2호
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• pp.111-127
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• 2023

Objectives: Pre-pregnancy diet has an important role in preparing for healthy generation. However, evidence on this issue has been scarce. A scoping review synthesising current evidence will support the demand to map 'what has been researched' on pre-pregnancy diet and maternal and child health. Methods: Systematic search was performed using PICOS (Population, Intervention, Comparison, Outcomes, and Study design) framework in electronic databases. Articles were screened for eligibility, summarized, and the quality was assessed using the National Institute of Health assessment tool. The review structure complies with Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews guide. Results: Forty-two articles were included after full-text screening. Twenty-five studies were in high-income countries (HICs), six in each upper-middle income, five in lower-middle income countries (LMICs), and one in low-income countries (LIC). Based on the regions: North America (n=16), Europe (n=5), South America (n=4), Australia (n=4), Asia (n=5), Middle East (n=2), and sub-Saharan Africa (n=1). The two-most observed diet-related exposures were dietary pattern (n=17) and dietary quality (n=12). The most assessed outcome was gestational diabetes mellitus (n=28) and fetal and newborn anthropometry (n=7). The average quality score±standard deviation was 70±18%. Conclusions: Research related to pre-pregnancy diet is still concentrated in HICs. The context of diet may vary; therefore, future research is encouraged in LMICs and LICs context, and Mediterranean, South-East Asia, Pacific, and African regions. Some maternal and child nutrition-related morbidity, such as anemia and micronutrient deficiencies, have not been discussed. Research on these aspects will benefit to fill in the gaps related to pre-pregnancy diet and maternal and child health.