• Title/Summary/Keyword: disulifiram

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METABOLISM AND DISPOSITION OF CHLORZOXAZONE IN RATS: EFFECTS OF ETHANOL AND DISULFIRAM

  • Kim, Dong-Hyun;Park, Misuk;Park, Jongsei
    • Toxicological Research
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    • v.9 no.1
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    • pp.35-44
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    • 1993
  • Role of rat cytochrome P-450 2E1(P-450 2E 1) in the metabolism of chlorzoxazone was examined by using several approaches' (1) selective inhibiton of catalytic activity in rat liver microsomes by diethyldithiocarbamate, (2) correlation of dimethylnitrosomine N-demethylation with chlorzoxazone 6-hydroxylation, and (3) immunoinhibition of catalytic activity with rabbit anti-rat P-450. The results indicated that P-450 2E1 is responsible for the metabolism of chlorzoxazone.

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