• 한국방사선학회논문지
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• 제5권5호
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• pp.223-229
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• 2011

X선은 X선관 내 음극측 전자(electron)를 빠른 속도로 가속시킨 다음 진행하는 전자의 흐름을 저지극(target)에서 차단시킬 때 에너지의 변환을 일으켜 발생한다. 가속된 고속의 전자가 저지면에 충돌하는 실제면적을 실초점(actual focal spot)이라 하고, 실초점의 크기를 X선이 나오는 방향인 중심선(central ray)측에서 관측할 경우 축소되어 작게 보이는데 이때의 초점을 실효초점(effective focal spot)이라고 한다. X선관 방사각에 따라 음극 측의 강도가 양극 측 보다 높게 나타나 X선 강도가 균등하지 않다. 이러한 효과를 경사각 효과(heel effect)라고 하며, 경사각 효과로 인하여 환자가 받는 피폭의 정도는 양극의 각도, 즉 실효초점의 크기에 따라 달라지게 된다. 본 논문에서는 실효초점의 크기와 그에 따른 환자 피폭선량의 상관관계를 알아보고 실효초점의 크기에 따른 균질선량 분포를 위한 효과적인 조사야를 제시하고자 한다. 결론적으로 초점크기에 따라서 평균적으로 -8cm ~ 0cm 범위에서 효과적인 조사야 범위를 찾을 수 있었고, 평균 선량률은 0.019 R/min이 나왔다. 이 범위를 이용하면 환자에게는 적은 피폭선량으로 균등한 흑화도 및 해상력을 가진 영상을 얻을 수 있을 것이다.

• 대한방사선기술학회지:방사선기술과학
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• 제16권1호
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• pp.101-106
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• 1993

In order to assure safety of both patient and operator, and to provide uniform quality radiographs, it is necessary to perform periodic calibration of diagnostic X-ray equipment. A basic parameter of diagnostic equipment's and its image sharpness is the size(and shape the energy distribution) of the focal spot as viewed along the central X-ray beam. This size determines the resolution possible with the equipment and also determines the heat characteristics of an anode. A fine focus tube gives high resolution but causes high local heating of target. In past, the pin-hole and star pattern image measurement for evaluation of resolution have been widely used, but it produced blurring and inaccuracy of image. So newly inverted Ug-meter has advantage in more convenient measurement method and less out-put bias than other image measurement. The authors intended to compare measured focal size between Ug-meter and focal spot test tool, changed state from setting to now of units.

• Journal of the Optical Society of Korea
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• 제11권2호
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• pp.76-81
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• 2007

The compound refractive X-ray lens (CRL) for focusing hard X-rays is investigated to determine the parameters such as the focal length, the focal spot size, and spatial distribution at the focal spot using a simple theoretical calculations and CRLs fabricated by the self-assembly method. The number of individual compound lenses are defined for the given focal length of 1 m. The X-ray energy of 1 to 40 keV is used in the calculations. The CRL for focusing hard X-rays which generated from the X-ray tube is fabricated by nanoparticle-polymer composite in the form of circular concaves. The self-assembly method is applied to form the nanoaluminum-poly (methly meth-acrylate) composite and carbon-polymer composite CRL lenses. Aluminum nanoparticles of 100 nm and carbon microparticles are diffused in the polymer solution then the high gravity up to 6000G is applied in it to form the concave lens shape. X-ray energy at 8 keV is used for characterization of the composite CRLs. The FWHM of intensity for the fabricated nanoaluminium composite CRL system, N=10 is measured as 1.8 mm, which would give about $70{\mu}m$ in FWHM at 1 m of the focal length.

• 한국자기학회지
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• 제25권2호
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• pp.52-57
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• 2015

텅스텐 타겟인 양극의 각도에 의존하는 X-선관 집속관의 전자빔 초점 크기를 오페라-3차원/스칼라(OPERA-3D/SCALAR) 프로그램을 이용하여 구하였다. 시뮬레이션 분석은 X-선관을 음극과 양극 그리고 4영역을 나누어 유한요소법을 적용하였다. X-선 집속관의 필라멘트로부터 방출되는 열전자 궤적은 전자밀도 분포함수에 따라 양극에 도달할 때 실초점으로 집속되고 양극에 부딪쳐서 유효 초점 크기로 X-선을 발생하게 된다. 전자빔 실초점 크기는 X-선 집속관 모양을 결정짓는 폭, 길이, 높이를 조절하여 줄일 수 있었고, 양극각도의 크기에 따라 미세하게 변하였다. 양극각도가 $10^{\circ}{\sim}17^{\circ}$에서는 전자빔 실초점 크기를 $70{\mu}m$ 이내로 유지하였고, 가장 최소 초점크기는 $15^{\circ}$에서 실초점 크기가 $40{\mu}m$로 나타났다. 최적화된 X-선 집속관의 변수들로 시뮬레이션하는 열전자의 방출 궤적을 분석하여 얻은 마이크로 크기인 실초점을 활용하는 새로운 의료 영상진단기기 개발이 가능할 것으로 보여진다.

• 한국광학회지
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• 제20권6호
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• pp.354-360
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• 2009

공초점 현미경 중 하나로 각광받는 MMM(multi-focal multi-photon microscope)의 핵심부분인 미세렌즈 배열판을 광섬유 다발로 대체한 간단한 형태의 광섬유 다발 다초점 현미경을 구성하여 그 성능을 분석하였다. 이 현미경의 성능 분석을 위하여 세 종류의 시료를 사용하였으며, 두 개의 편광판과 편광 빔 분리기를 사용하여 노이즈를 제거한 뚜렷한 상을 얻을 수 있었다. 표준격자 시료를 사용하여 1차 대물렌즈의 배율을 63배와 20배로 달리하면서 광점 상의 FWHM를 구하였고, 광점 상들의 분포 속에서 물체의 상을 볼 수 있었으며, 분포가 조밀한 저배율의 1차 대물렌즈를 사용할 경우에 보다 선명한 시료의 상을 얻을 수 있었다. 광섬유 다발 다초점 현미경의 분해능을 시험하기 위해서 표준격자 시료보다 격자 간격이 작은 USAF 1951을 시료로 사용하여 상을 측정하여 얻은 시료 상의 FWHM와 주어진 시료의 선폭 값이 서로 잘 일치함을 볼 수 있었다. 광섬유 다발 다초점 현미경은 1개의 광섬유 다발을 사용함으로써 시스템을 간소화시켰고, 마이크론 이하의 분해능을 가지며, 광섬유의 개수인 1600개의 광점 상을 동시에 얻을 수 있었다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권17호
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• pp.7795-7801
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• 2015

The aim of the present research was to establish primary characteristics of electron beams for a Varian 2100C/D linear accelerator with recently developed PRIMO Monte Carlo software and to verify relations between electron energy and dose distribution. To maintain conformity of simulated and measured dose curves within 1%/1mm, mean energy, Full Width at Half Maximum (FWHM) of energy and focal spot FWHM of initial beam were changed iteratively. Mean and most probable energies were extracted from validated phase spaces and compared with related empirical equation results. To explain the importance of correct estimation of primary energy on a clinical case, computed tomography images of a thorax phantom were imported in PRIMO. Dose distributions and dose volume histogram (DVH) curves were compared between validated and artificial cases with overestimated energy. Initial mean energies were obtained of 6.68, 9.73, 13.2 and 16.4 MeV for 6, 9, 12 and 15 nominal energies, respectively. Energy FWHM reduced with increase in energy. Three mm focal spot FWHM for 9 MeV and 4 mm for other energies made proper matches of simulated and measured profiles. In addition, the maximum difference of calculated mean electrons energy at the phantom surface with empirical equation was 2.2 percent. Finally, clear differences in DVH curves of validated and artificial energy were observed as heterogeneity indexes were 0.15 for 7.21 MeV and 0.25 for 6.68 MeV. The Monte Carlo model presented in PRIMO for Varian 2100 CD was precisely validated. IAEA polynomial equations estimated mean energy more accurately than a known linear one. Small displacement of R50 changed DVH curves and homogeneity indexes. PRIMO is a user-friendly software which has suitable capabilities to calculate dose distribution in water phantoms or computerized tomographic volumes accurately.

• 한국의학물리학회지:의학물리
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• 제27권4호
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• pp.272-276
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• 2016

To investigate the optimum x-ray tube design for the dental radiology, factors affecting x-ray beam characteristics such as tungsten target thickness and anode angle were evaluated. Another goal of the study was to addresses the anode heel effect and off-axis spectra for different target angles. MCNPX has been utilized to simulate the diagnostic x-ray tube with the aim of predicting optimum target angle and angular distribution of x-ray intensity around the x-ray target. For simulation of x-ray spectra, MCNPX was run in photon and electron using default values for PHYS:P and PHYS:E cards to enable full electron and photon transport. The x-ray tube consists of an evacuated 1 mm alumina envelope containing a tungsten anode embedded in a copper part. The envelope is encased in lead shield with an opening window. MCNPX simulations were run for x-ray tube potentials of 70 kV. A monoenergetic electron source at the distance of 2 cm from the anode surface was considered. The electron beam diameter was 0.3 mm striking on the focal spot. In this work, the optimum thickness of tungsten target was $3{\mu}m$ for the 70 kV electron potential. To determine the angle with the highest photon intensity per initial electron striking on the target, the x-ray intensity per initial electron was calculated for different tungsten target angles. The optimum anode angle based only on x-ray beam flatness was 35 degree. It should be mentioned that there is a considerable trade-off between anode angle which determines the focal spot size and geometric penumbra. The optimized thickness of a target material was calculated to maximize the x-ray intensity produced from a tungsten target materials for a 70 keV electron energy. Our results also showed that the anode angle has an influencing effect on heel effect and beam intensity across the beam.

• Current Optics and Photonics
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• 제7권6호
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• pp.701-707
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• 2023

In laser imaging, accurate extraction of the laser's center is essential. Several methods exist to extract the laser's center in an image, such as the geometric mean, the parabolic curve fitting, and the Gaussian curve fitting, etc. The Gaussian curve fitting is the most suitable because it is based on the physical properties of the laser. The width of the Gaussian laser beam depends on the distance from the laser source to the target object. It is assumed in general that the distance remains constant at a laser spot resulting in a symmetric Gaussian model for the laser image. However, on a curved surface of the object, the distance is not constant; The laser beam is narrower on the side closer to the focal point of the laser light and wider on the side closer to the laser source, which causes the distribution of the laser beam to skew. This study presents a modified Gaussian model in the laser imaging to incorporate the slant angle of a curved object. The proposed method is verified with simulation and experiments.

• Journal of Korean Neurosurgical Society
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• 제48권5호
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• pp.391-398
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• 2010

Objective : This study was designed to validate the cell trafficking efficiency of the in vivo bioluminescence image (BLI) study in the setting of transplantation of the luciferase expressing bone marrow-derived mesenchymal stem cells (BMSC), which were delivered at each different time after transient middle cerebral artery occlusion (MCAO) in a mouse model. Methods : Transplanting donor BMSC were prepared by primary cell culture from transgenic mouse expressing luciferase (LUC). Transient focal infarcts were induced in 4-6-week-old male nude mice. The experiment mice were divided into five groups by the time of MSC transplantation : 1) sham-operation group, 2) 2-h group, 3) 1-day group, 4) 3-day group, and 5) 1-week group. BLI for detection of spatial distribution of transplanted MSC was performed by detecting emitted photons. Migration of the transplanted cells to the infarcted area was confirmed by histological examinations. Differences between groups were evaluated by paired t-test. Results : A focal spot of bioluminescence was observed at the injection site on the next day after transplantation by Signal intensity of bioluminescence. After 4 weeks, the mean signal intensities of 2-h, 1-day, 3-day, and 1-week group were $2.6{\times}10^7{\pm}7.4{\times}10^6$. $6.1{\times}10^6{\pm}1.2{\times}10^6$, $1.7{\times}10^6{\pm}4.4{\times}10^5$, and $8.9{\times}10^6{\pm}9.5{\times}10^5$, respectively. The 2-h group showed significantly higher signal intensity (p<0.01). The engrafted BMSC showed around the infarct border zones on immunohistochemical examination. The counts of LUC-positive cells revealed the highest number in the 2-h group, in agreement with the results of BLI experiments (p<0.01). Conclusion : In this study, the results suggested that the transplanted BMSC migrated to the infarct border zone in BLI study and the higher signal intensity of LUC-positive cells seen in 2 hrs after MSC transplantation in MCAO mouse model. In addition, noninvasive imaging in real time is an ideal method for tracking stem cell transplantation. This method can be widely applied to various research fields of cell transplantation therapy.