• Title/Summary/Keyword: disintegrating

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Studies on Cellulase -Part 1. Isolation of Cellulase Forming Microorganisms and the Properties of Crude Enzymes- (Cellulase에 관(關)한 연구(硏究) -(제1보(第一報)) Cellulase 생성균(生成菌)의 분리(分離)와 조효소(粗酵素)의 제성질(諸性質)-)

  • Chung, Dong-Hyo
    • Applied Biological Chemistry
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    • v.11
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    • pp.109-117
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    • 1969
  • Out of some 400 strains of Microorganisms, cellulase forming organisms was isolated from night soil during the course of screening tests. Two strains, Ku-3371 and Ku-4383 were found capable of producing cellulase in the shaking culture. General properties of the crude enzyme were as the following results. 1. The optimum pH values on CMC-saccharifying, CMC-liquefying and filter paper disintegrating activities were 4.0 to 5.5. 2. The stable pH range was within 3.5 to 6.5, 3. The optimum temperature was $40-45^{\circ}C$, the thermal stability was below $50^{\circ}C$ except on paper disintegrating activity and completely inactivated at $70^{\circ}C$. 4. Dialyzed crude enzyme was activated by $Mn^{2+}\;and\;Co^{2+}$ repectively but $Hg^{2+}$ was strong inhibitor.

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pH-Sensitive Curdlan Acetate Microspheres를 이용한 Indomethacin의 방출 특성

  • Lee, Chang-Mun;Lee, Yeong-Jin;Lee, Gi-Yeong;Choe, Chun-Sun
    • 한국생물공학회:학술대회논문집
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    • 2003.04a
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    • pp.739-742
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    • 2003
  • Curdlan acetate was prepared from hydrophilic curdlan by chemical modification and it was used for pH-sensitive drug delivery system. Curdlan acetate microspheres were prepared by the solvent evaporation method. The size of the curdlan acetate microspheres was below $200\;{\mu}m$. The drug loading efficiency of microspheres was approximately 58.44%. In the swelling test, curdlan acetate microspheres were showed pH-sensitive behavior. The swelling capacity of microspheres at pH 7.4 was much greater than at pH 1.4. Also, Release rate of indomethacin (IND) at pH 7.4 from curdlan acetate microspheres was faster than that at pH 1.4. A pH-sensitive drug release pattern was due to the disintegrating after swelling.

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The Effects of Multiple Recycling on Deinkability, Optical and Physical Properties of Recycled Paper

  • Shin, Jun-Seop;Min, Choon-Ki
    • Journal of Korea Technical Association of The Pulp and Paper Industry
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    • v.31 no.5
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    • pp.18-23
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    • 1999
  • This study examined the effects of multiple recycling on deinkability and properties of recycled paper from laser computer printout(LCPO). First, alkaline paper with a 20% printed area was disintegrated by TAPPI standard disintegrator. After dewatering , the pulp was followed by flotation, handsheet making, and drying at room temperature, in order. A sequence of printing , disintegrating, flotating , handsheet making and drying was one recycling cycle and this cyclic treatment was repeateed from zero to five times. The residual ink content in recycled handsheets by SEM-EDXA and Py-GC analyseswas increased slightly as recycling number increase. After five cycles of recycling the ISO brightness of recycled handsheets dropped to about 90% of the original brightness. However, it had a gain of 10% in opacity. The most of physical properties of recycled handsheets were decreased as recycling numbers increase except of for tear strength.

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Bacterial Soft Rot of Cauliflower by Erwinia carotovora subsp. carotovora (Erwinia carotovora subsp. carotovora에 의한 흰색꽃양배추 세균성 무름병)

  • 박덕환;류경렬;김점순;임춘근
    • Korean Journal Plant Pathology
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    • v.14 no.4
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    • pp.364-366
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    • 1998
  • Bacterial soft rot was occurrenced on stems of cauliflower at a trial field of Alpine Agricultural Experiment Station, Kangwon-Do, Korea. the symptoms began as a small water-soaked lesion, which enlarged rapidly in diameter. The tissue within the affected region became slimy, disintegrating into a mushy mass of disorganized cells. The causal organism was isolated from the diseases lesions and was identified as Erwinia carotovora subsp. carotovora based on the morphological, physiological and chemical characteristics , and on the results of the Biolog program (Biolog Inc., U. S. A.). E. carotovora subsp. carotovora is the first described bacterium which causes bacterial soft rot on cauliflower in Korea.

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Effect of Additives on Disintegration of Enzyme Tablets (효소정제의 붕해에 미치는 첨가제의 영향)

  • Kim, Seung-Hwan;Choi, Moon-Sang;Cha, Bong-Jin;Kwon, Jong-Won;Min, Shin-Hong
    • Journal of Pharmaceutical Investigation
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    • v.20 no.1
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    • pp.7-12
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    • 1990
  • In case of the slowly disintegrating tablets such as enzyme preparations, disintegration time (DT) may be the important factor in formulating those preparations. The effects of tablet hardness, lubricants and disintegrants on DT were investigated in this approach. Disintegration time was significantly affected by disintegrants, moderately by lubricants, but not by tablet hardness. The effect was in the order of magnesium stearate >talc, PEG, sodium benzoate in case of lubricants, and of Ac-Di-Sol>LHPC>Primogel >Kollidon in case of disintegrants. Because lubricants and disintegrants influenced the tablet hardness and DT profile showed complicated pattern, it should be remembered that all factors mentioned above should be simultaneously considered in the formulation of enzyme tablets.

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Geometric Style and Two-Dimensional Transformation : Alois Riegl's Theory of Visual Perception and Vienna Art Nouveau Architecture (기하양식과 2차원적 각색 : 알로이스 리글(Alois Riegl)의 시지각이론과 비엔나 아르누보 건축)

  • Yim, Seock-Jae
    • Journal of architectural history
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    • v.3 no.2 s.6
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    • pp.125-141
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    • 1994
  • Alois Riegl's aesthetic theory of visual perception provided one of important conceptual backgrounds for Vienna Art Nouveau architecture. Riegls theory of visual perception consists of geometric style and two-dimensional transformation. Riegl's theory of geometric style is based on the modern aesthetic theory of abstraction, which says that the artistic perfection can be obtained not from a direct imitation of natural objects, but from an abstract transformation of them. Riegl's theory of two-dimensional transformation, on the other hand, aims at obtaining artistic perfection by disintegrating volumetric conditions of natural things into planes and combining the planes thus obtained into another new world of art. These two theories of Alois Rigl's provided an important aesthetical background for the design strategy of 'abstract ornamentaion of two-dimension' in Vienna Art Nouveau architecture. This paper is to review the basic concept of Alois Rigl's theory of geometric style and two-dimensional transformation.

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A Novel Drug Delivery Approach to Olanzapine Orally Dispersible Tablet (ODT) in the Phase of Schizophrenia and Its Pharmacokinetics

  • Kim, Hyun-Jo;Park, Jeong-Hwan
    • Journal of Pharmaceutical Investigation
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    • v.40 no.5
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    • pp.297-304
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    • 2010
  • The present work focuses on preparation of olanzapine, orally dispersing tablets by direct compression method. Effect of super disintegrant crospovidone, disintegration time, drug content on in vitro release has been studied. A factorial design was employed in formulating a prompt dispersible tablet. The selected independent variables crospovidone and fmelt showed significant effect on dependent variables i.e. disintegration time and percent drug dissolved. Disintegration time and percent drug dissolved decreased with increase in the level of crospovidone. The similarity factor $f_2$ was found to be 97.48 for the developed formulation indicating the release was similar to that of the marketed formulation. Pharmacokinetics of olanzapine after single-dose oral administration of orally disintegrating tablet in normal volunteers were evaluated and the results showed that PK parameters (Cmax, Tmax, AUC) of the designed ODT matrix were similar to those of commercial product, Zyprexa Zydis$^{(R)}$ as a reference.

The Effect of Viscosity on the Spray Characteristics of Pressure Swirl Atomizer (스월분무특성에 미치는 점성의 영향)

  • Yoon, S.J.;Cho, D.J.
    • Journal of ILASS-Korea
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    • v.4 no.4
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    • pp.24-29
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    • 1999
  • In the pressure swirl atomizer, the liquid is injected through tangential passages into a swirl chamber, from which it emerges with both tangential and axial velocity components to form a thin conical sheet at the nozzle exit. This sheet rapidly attenuates, finally disintegrating into ligaments and then drops. The purpose of this study is to measure the spray characteristics according to variation of viscosity of the spray produced by the pressure swirl atomizer. The nozzle tested here were especially designed for this investigation. The discharge coefficient is determined by measuring the volume flow rate with a flow meter and the cone angle of the liquid sheets issuing from the nozzle is obtained from series of photographs of the sheet for various liquid viscosity and injection pressure. And mean drop size is measured by image processing method. It is found that the geometrical characteristics of the nozzle and the variation of viscosity were the influential parameters to determine the spray characteristics such as the cone angle, discharge coefficients and SMD.

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Continuous Xanthan Fermentations in a Three-Phase Fluidized Bed Bioreactor (삼상유동층 생물반응기에서의 연속식 Xanthan 발효)

  • 서일순;노희찬;허충회
    • KSBB Journal
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    • v.17 no.1
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    • pp.26-32
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    • 2002
  • The aerobic bacterium Xanthomonas campestris was cultivated continuously in a three-phase fluidized bed bioreactor to produce extracellular polysaccharide xanthan, Fluidized particles of 8.0 mm glass beads were used for disintegrating the large air bubbles even at high viscosities to improve the gas-liquid oxygen transfer rate. Xanthin productivity [kg xanthan/kg cell dry mass·h] and molecular weight increased, with dilution rate in the continuous xanthan fermentations. The specific xanthan productivities were not limited by the oxygen transfer rate and were much higher in the continuous cultivations than those predicted by the results of the batch xanthan fermentations.

Healing of STEP AP214 Automotive CAD Data (STEP AP214 자동차 설계 데이터 정리 시스템)

  • 양정삼;한순흥
    • Korean Journal of Computational Design and Engineering
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    • v.7 no.3
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    • pp.170-176
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    • 2002
  • To exchange CAD data between heterogeneous CAD systems, we generally use a neutral format especially STEP, which is the international standard (ISO-10303) for product model data exchange. AP214 (Application Protocol) for the automotive industry not only takes into account geometry and organizational data, but also provides a classification mechanism for product modeling. When reading a STEP file during a design process that is exported from other CAD systems, it is a burden to a designer to go through the tedious process of removing duplicate or non-manifold entities, adjusting parts, and rearranging text. We analyze the structure of AP214 and develop a healing tool to solve the following problem. Without the assembly information in the Master workspace of CATIA, or to read a STEP file from Pro/Engineer, a designer should do a repetitive process of disintegrating an assembly into parts one by one. We have developed a post-processing tool for STEP AP214 that separates out a part from an assembly model and adjusts superfluous or useless entities using the ACIS kernel.